The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Immune phenotypic linkage between colorectal cancer and liver metastasis
Open accessAbstract
The tumor microenvironment (TME) is connected to immunotherapy responses, but it remains unclear how cancer cells and host tissues differentially influence the immune composition within TME. Here, we performed single-cell analyses for autologous samples from liver metastasized colorectal cancer to disentangle factors shaping TME. By aligning CD45 + cells across different tissues, we classified exhausted CD8 + T cells (Texs) and activated regulatory T cells as M-type, whose phenotypes were associated with the malignancy, while natural killer and mucosal-associated invariant T cells were defined as N-type, whose phenotypes were associated with the niche. T cell receptor sharing between Texs in primary and metastatic tumors implicated the presence of common peripheral non-exhausted precursors. For myeloid cells, a subset of dendritic cells (DC3s) and SPP1 + macrophages were M-type, and the latter were predominant in liver metastasis, indicating its pro-metastasis role. Our analyses bridge immune phenotypes of primary and metastatic tumors, thereby helping to understand the tumor-specific contexture and identify the pro-metastasis components.
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Cited by
Gerstberger, S., Jiang, Q., & Ganesh, K. (2023) · Cell · doi:10.1016/j.cell.2023.03.003 · Cited by 913
Colonna, M. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00837-1 · Cited by 394
Werba, G., Weissinger, D., Kawaler, E. A., Zhao, E., Kalfakakou, D., Dhara, S., Wang, L., Lim, H. B., Oh, G., Jing, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36296-4 · Cited by 283
Borràs, D. M., Verbandt, S., Ausserhofer, M., Sturm, G., Lim, J., Verge, G. A., Vanmeerbeek, I., Laureano, R. S., Govaerts, J., Sprooten, J., et al. (2023) · Cell Discovery · doi:10.1038/s41421-023-00605-4 · Cited by 67
SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases
Trehan, R., Huang, P., Zhu, X. B., Wang, X., Soliman, M., Strepay, D., Nur, A., Kedei, N., Arhin, M., Ghabra, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59529-0 · Cited by 74
Metadata
- Authors
- Liu, Y., Zhang, Q., Xing, B., Luo, N., Gao, R., Yu, K., Hu, X., Bu, Z., Peng, J., Ren, X., & Zhang, Z.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 40
- Issue
- 4
- Pages
- 424-437.e5
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W4221120384
- Cited by
- 451
- References
- 45
- FWCI
- 35.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
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