The distribution of secondary growths in cancer of the breast.
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Paget observed that certain cancer cells had a predilection to metastasize to bone and proposed that the bone microenvironment provided fertile soil for localization and growth of particular cancer cells.
“British surgeon Stephen Paget observed that certain cancer cells had a predilection to metastasize to bone, and he proposed that the bone microenvironment provided a fertile”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [299]
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- Authors
- Paget, S.
- Corresponding author
- Paget, Stephen
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1889-03
- Volume
- 133
- Issue
- 3421
- Pages
- 571-573
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1985727076
- Cited by
- 5,277
- References
- 1
- Citations by year
- 2026: 78 · 2025: 192 · 2024: 235 · 2023: 273 · 2022: 292 · 2021: 326 · 2020: 294 · 2019: 260 · 2018: 237 · 2017: 240 · 2016: 205 · 2015: 207 · 2014: 202 · 2013: 215 · 2012: 213
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Metastasis and carcinoma case studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- breast cancer, secondary growth, metastasis, ataxia, muscle weakness, disuse atrophy, reflexes
- MeSH terms
- Breast Neoplasms, Female, Humans, Neoplasm Metastasis, History, 19th Century
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