The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation
Open accessAbstract
Summary Metastasis is the major cause of cancer death and the development of therapy resistance is common. The tumor microenvironment can confer chemotherapy resistance (chemoresistance), but little is known about how specific host cells influence therapy outcome. We show that chemotherapy induces neutrophil recruitment and Neutrophil Extracellular Trap (NET) formation, which reduces therapy response in mouse models of breast cancer lung metastasis. We reveal that chemotherapy-treated cancer cells secrete IL-1β, which in turn triggers NET formation. Two NET-associated proteins are required to induce chemoresistance: integrin-αvβ1, which traps latent TGFβ, and matrix metalloproteinase 9, which cleaves and activates the trapped latent TGFβ. TGFβ activation causes cancer cells to undergo epithelial-to-mesenchymal transition and correlates with chemoresistance. Our work demonstrates that NETs regulate activities of neighboring cells by trapping and activating cytokines and suggests that chemoresistance in the metastatic setting can be reduced or prevented by targeting the IL-1β-NET-TGFβ axis.
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Cited by
Neutrophil extracellular traps in homeostasis and disease
Wang, H., Kim, S. J., Lei, Y., Wang, S., Wang, H., Huang, H., Zhang, H., & Tsung, A. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01933-x · Cited by 537
Fierro-Salgado, Y. T., Reiriz, M., Beltrán-Velasco, A. I., Calleja-Conde, J., Hernández-Oñativia, X., Uceda, S., & Echeverry-Alzate, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010074 · Cited by 7
Metadata
- Authors
- Mousset, A., Lecorgne, E., Bourget, I., Lopez, P., Jenovai, K., Cherfils-Vicini, J., Dominici, C., Rios, G., Girard-Riboulleau, C., Liu, B., Spector, D. L., Ehmsen, S., Renault, S., Hego, C., Mechta-Grigoriou, F., Bidard, F.-C., Terp, M. G., Egeblad, M., Gaggioli, C., & Albrengues, J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 41
- Issue
- 4
- Pages
- 757-775.e10
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W4362736962
- Cited by
- 266
- References
- 75
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Mousset, A., Lecorgne, E., Bourget, I., Lopez, P., Jenovai, K., Cherfils-Vicini, J., Dominici, C., Rios, G., Girard-Riboulleau, C., Liu, B., Spector, D. L., Ehmsen, S., Renault, S., Hego, C., Mechta-Grigoriou, F., Bidard, F.-C., Terp, M. G., Egeblad, M., Gaggioli, C., & Albrengues, J. (2023). Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation. Cancer Cell. https://doi.org/10.1016/j.ccell.2023.03.008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
