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Cited by 55Multiple Myeloma Research and TreatmentsChronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and Treatment

Single cell clonotypic and transcriptional evolution of multiple myeloma precursor disease

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Dang, Minghao, Han, Guangchun, Lee, Hans C., Patel, Krina K., Becnel, Melody R., Wang, Ruiping, Thomas, Sheeba K., Hao, Dapeng +22 more·2023·Cancer Cell
DOI 10.1016/j.ccell.2023.05.007PMC PMC10317474
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Abstract

Multiple myeloma remains an incurable disease, and the cellular and molecular evolution from precursor conditions, including monoclonal gammopathy of undetermined significance and smoldering multiple myeloma, is incompletely understood. Here, we combine single-cell RNA and B cell receptor sequencing from fifty-two patients with myeloma precursors in comparison with myeloma and normal donors. Our comprehensive analysis reveals early genomic drivers of malignant transformation, distinct transcriptional features, and divergent clonal expansion in hyperdiploid versus non-hyperdiploid samples. Additionally, we observe intra-patient heterogeneity with potential therapeutic implications and identify distinct patterns of evolution from myeloma precursor disease to myeloma. We also demonstrate distinctive characteristics of the microenvironment associated with specific genomic changes in myeloma cells. These findings add to our knowledge about myeloma precursor disease progression, providing valuable insights into patient risk stratification, biomarker discovery, and possible clinical applications.

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  • Several patterns of immune dysregulation have been reported in MGUS and SMM using single cell RNA sequencing.

    “Several patterns of dysregulation have been reported using single cell RNA sequencing.82,83,91-93”

    From Evolution of Multiple Myeloma from a Genomic Perspective (2026) · cites this paper as [82]

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Cited by

Sorted by citations

Authors
Dang, M., Han, G., Lee, H. C., Patel, K. K., Becnel, M. R., Wang, R., Thomas, S. K., Hao, D., Chu, Y., Weber, D. M., Lin, P., Lutter-Berka, Z., Berrios Nolasco, D. A., Huang, M., Bansal, H., Song, X., Zhang, J., Futreal, A., Moreno Rueda, L. Y., Symer, D. E., Green, M. R., Rojas Hernandez, C. M., Kroll, M., Afshar-Khargan, V., Ndacayisaba, L. J., Kuhn, P., Neelapu, S. S., Orlowski, R. Z., Wang, L., & Manasanch, E. E.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • University of Southern California (US)
Corresponding author
  • Wang, Linghua
  • Manasanch, Elisabet E.
ORCID
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2023-06
Volume
41
Issue
6
Pages
1032-1047.e4
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccell.2023.05.007
PMC
PMC10317474
OpenAlex
W4380321863
Cited by
55
References
5
Citations by year
2026: 19 · 2025: 21 · 2024: 12 · 2023: 3
FWCI
11.36
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancer Cell (publishedVersion)
  • SSRN Electronic Journal (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Funders
  • Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
  • National Institutes of Health (1S10OD024977-01)
  • University of Texas MD Anderson Cancer Center (P30 CA016672)
  • Leukemia & Lymphoma Society (SCOR-12206-17)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords
multiple myeloma, monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, clonal evolution, B cell receptor repertoire, hyperdiploidy, malignant transformation, intrapatient heterogeneity, tumor microenvironment, risk stratification, biomarkers
MeSH terms
Smoldering Multiple Myeloma, Aneuploidy, Humans, Multiple Myeloma, Disease Progression, Biomedical Research, Tumor Microenvironment

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