The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
Open accessAbstract
Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome features that affect chemoradiation response in patients with cervical cancer using a combined approach of deep microbiome sequencing, targeted bacterial culture, and in vitro assays. We identify that an obligate L-lactate-producing lactic acid bacterium found in tumors, Lactobacillus iners, is associated with decreased survival in patients, induces chemotherapy and radiation resistance in cervical cancer cells, and leads to metabolic rewiring, or alterations in multiple metabolic pathways, in tumors. Genomically similar L-lactate-producing lactic acid bacteria commensal to other body sites are also significantly associated with survival in colorectal, lung, head and neck, and skin cancers. Our findings demonstrate that lactic acid bacteria in the tumor microenvironment can alter tumor metabolism and lactate signaling pathways, causing therapeutic resistance. Lactic acid bacteria could be promising therapeutic targets across cancer types.
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1 retracted
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Cited by
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Metadata
- Authors
- Colbert, L. E., El Alam, M. B., Wang, R., Karpinets, T., Lo, D., Lynn, E. J., Harris, T. A., Elnaggar, J. H., Yoshida-Court, K., Tomasic, K., Bronk, J. K., Sammouri, J., Yanamandra, A. V., Olvera, A. V., Carlin, L. G., Sims, T., Delgado Medrano, A. Y., Napravnik, T. C., O’Hara, M., Lin, D., Abana, C. O., Li, H. X., Eifel, P. J., Jhingran, A., Joyner, M., Lin, L., Ramondetta, L. M., Futreal, A. M., Schmeler, K. M., Mathew, G., Dorta-Estremera, S., Zhang, J., Wu, X., Ajami, N. J., Wong, M., Taniguchi, C., Petrosino, J. F., Sastry, K. J., Okhuysen, P. C., Martinez, S. A., Tan, L., Mahmud, I., Lorenzi, P. L., Wargo, J. A., & Klopp, A. H.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2023-11
- Volume
- 41
- Issue
- 11
- Pages
- 1945-1962.e11
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W4387783936
- Cited by
- 270
- References
- 122
- FWCI
- 26.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Colbert, L. E., El Alam, M. B., Wang, R., Karpinets, T., Lo, D., Lynn, E. J., Harris, T. A., Elnaggar, J. H., Yoshida-Court, K., Tomasic, K., Bronk, J. K., Sammouri, J., Yanamandra, A. V., Olvera, A. V., Carlin, L. G., Sims, T., Delgado Medrano, A. Y., Napravnik, T. C., O’Hara, M., . . . Klopp, A. H. (2023). Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring. Cancer Cell. https://doi.org/10.1016/j.ccell.2023.09.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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