The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
Precision treatment in advanced hepatocellular carcinoma
Open accessAbstract
The past decade has witnessed significant advances in the systemic treatment of advanced hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies have not achieved universal success and HCC patients frequently exhibit therapeutic resistance to these therapies. Precision treatment represents a paradigm shift in cancer treatment in recent years. This approach utilizes the unique molecular characteristics of individual patient to personalize treatment modalities, aiming to maximize therapeutic efficacy while minimizing side effects. Although precision treatment has shown significant success in multiple cancer types, its application in HCC remains in its infancy. In this review, we discuss key aspects of precision treatment in HCC, including therapeutic biomarkers, molecular classifications, and the heterogeneity of the tumor microenvironment. We also propose future directions, ranging from revolutionizing current treatment methodologies to personalizing therapy through functional assays, which will accelerate the next phase of advancements in this area.
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Cites
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Metadata
- Authors
- Yang, X., Yang, C., Zhang, S., Geng, H., Zhu, A. X., Bernards, R., Qin, W., Fan, J., Wang, C., & Gao, Q.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2024-02
- Volume
- 42
- Issue
- 2
- Pages
- 180-197
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W4391743535
- Cited by
- 429
- References
- 183
- FWCI
- 96.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yang, X., Yang, C., Zhang, S., Geng, H., Zhu, A. X., Bernards, R., Qin, W., Fan, J., Wang, C., & Gao, Q. (2024). Precision treatment in advanced hepatocellular carcinoma. Cancer Cell. https://doi.org/10.1016/j.ccell.2024.01.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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