The DOI matches its Crossref record; 217 of the 217 references it cites were found in a registry or an index.
The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions
Open accessAbstract
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to explore alternative cell death pathways. Ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides on cellular membranes, has emerged as one such promising frontier in oncology. Induction of ferroptosis not only suppresses tumor growth but also holds potential for augmenting immunotherapy responses and surmounting resistance to existing cancer therapies. This review navigates the role of ferroptosis in tumor suppression. Furthermore, we delve into the complex role of ferroptosis within the tumor microenvironment and its interplay with antitumor immunity, offering insights into the prospect of targeting ferroptosis as a strategic approach in cancer therapy.
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Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
How mitochondria produce reactive oxygen species
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: mechanisms, biology and role in disease
Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,505
Understanding the tumor immune microenvironment (TIME) for effective therapy
Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Ferroptosis: molecular mechanisms and health implications
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Innate and adaptive immune cells in the tumor microenvironment
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Metadata
- Authors
- Lei, G., Zhuang, L., & Gan, B.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2024-04
- Volume
- 42
- Issue
- 4
- Pages
- 513-534
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W4394564046
- Cited by
- 586
- References
- 217
- FWCI
- 149.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lei, G., Zhuang, L., & Gan, B. (2024). The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions. Cancer Cell. https://doi.org/10.1016/j.ccell.2024.03.011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
