The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
Open accessAbstract
The receptor tyrosine kinase HER2 enhances tumor metastasis; however, its role in homing to metastatic organs is poorly understood. The chemokine receptor CXCR4 has recently been shown to mediate the movement of malignant cancer cells to specific organs. Here, we show that HER2 enhances the expression of CXCR4, which is required for HER2-mediated invasion in vitro and lung metastasis in vivo. HER2 also inhibits ligand-induced CXCR4 degradation. Finally, a significant correlation between HER2 and CXCR4 expression was observed in human breast tumor tissues, and CXCR4 expression correlated with a poor overall survival rate in patients with breast cancer. These results provide a plausible mechanism for HER2-mediated breast tumor metastasis and establish a functional link between HER2 and CXCR4 signaling pathways.
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Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684
Detection, clinical relevance and specific biological properties of disseminating tumour cells
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CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers
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Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study
Wu, Q., Li, J., Zhu, S., Wu, J., Chen, C., Liu, Q., Wei, W., Zhang, Y., & Sun, S. (2017) · Oncotarget · doi:10.18632/oncotarget.15856 · Cited by 355
Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan
Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338
Metadata
- Authors
- Li, Y. M., Pan, Y., Wei, Y., Cheng, X., Zhou, B. P., Tan, M., Zhou, X., Xia, W., Hortobagyi, G. N., Yu, D., & Hung, M.-C.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 6
- Issue
- 5
- Pages
- 459-469
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2018939316
- Cited by
- 537
- References
- 47
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Y. M., Pan, Y., Wei, Y., Cheng, X., Zhou, B. P., Tan, M., Zhou, X., Xia, W., Hortobagyi, G. N., Yu, D., & Hung, M.-C. (2004). Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell. https://doi.org/10.1016/j.ccr.2004.09.027
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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