A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer
Berns, Katrien, Horlings, Hugo M., Hennessy, Bryan T., Madiredjo, Mandy, Hijmans, E. Marielle, Beelen, Karin, Linn, Sabine C., Gonzalez-Angulo, Ana Maria, Stemke-Hale, Katherine, Hauptmann, Michael, Beijersbergen, Roderick L., Mills, Gordon B., van de Vijver, Marc J., Bernards, René·2007·Cancer Cell
Cited by (1,001)
Items 901–1,000 of 1,001
- Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancerAli Mussa, Nor Hayati Ismail, Mahasin Hamid, Mohammad A. I. Al-Hatamleh, Anthony J. Bragoli, Khalid Hajissa, Noor Fatmawati Mokhtar, Rohimah Mohamud, Vuk Uskoković, Rosline Hassan · 2024 · Journal of Experimental & Clinical Cancer Research
- From genomic landscapes to personalized cancer management—is there a roadmap?Charles Swanton, Carlos Caldas · 2010 · Annals of the New York Academy of Sciences
- A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatmentsAttila A. Seyhan, Usha Varadarajan, Sung E. Choe, Yan Liu, John McGraw, Matthew William Woods, Stuart Murray, Amy Eckert, Wei Liu, TERENCE EDWARD RYAN · 2011 · Molecular BioSystems
- HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to the novel investigational EGFR/HER2 kinase inhibitor TAK-285Shinji Takagi, Hiroshi Banno, Akira Hayashi, Toshiya Tamura, Tomoyasu Ishikawa, Yoshikazu Ohta · 2014 · Oncoscience
- Chemotherapeutics-resistance “arms” race: An update on mechanisms involved in resistance limiting EGFR inhibitors in lung cancerPankaj Kumar Singh, Om Silakari · 2017 · Life Sciences
- Phase Ib Trial of Copanlisib, A Phosphoinositide-3 Kinase (PI3K) Inhibitor, with Trastuzumab in Advanced Pre-Treated HER2-Positive Breast Cancer “PantHER”Niamh M. Keegan, Simon J. Furney, Janice Maria Walshe, Giuseppe Gullo, Megan Kennedy, Diarmuid Smith, John McCaffrey, Catherine Margaret Kelly, Keith Egan, Jennifer Kerr et al. · 2021 · Cancers
- The role of HER2 alterations in clinicopathological and molecular characteristics of breast cancer and HER2-targeted therapies: a comprehensive reviewShafighe Asgari-Karchekani, Armin Aryannejad, Seied Asadollah Mousavi, Shirin Shahsavarhaghighi, Seyed Mohammad Tavangar · 2022 · Medical Oncology
- The effect of the alpha-specific PI3K inhibitor alpelisib combined with anti-HER2 therapy in HER2+/PIK3CA mutant breast cancerMaria Letizia Cataldo, Pietro De Placido, Daniela Esposito, Luigi Formisano, Grazia Arpino, Mario Giuliano, Roberto Bianco, Carmine De Angelis, Bianca Maria Veneziani · 2023 · Frontiers in Oncology
- Dissociation of Epidermal Growth Factor Receptor and ErbB2 Heterodimers in the Presence of Somatostatin Receptor 5 Modulate Signaling PathwaysGeetanjali Kharmate, Padmesh S. Rajput, Heather L. Watt, R.K. Somvanshi, Nicole Chaudhari, Xiaofan Qiu, Ujendra Kumar · 2010 · Endocrinology
- Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatmentPau Castel, Eneda Toska, Zachary Stephan Zumsteg, F. Javier Carmona, Moshe Elkabets, Ana Bosch, Maurizio Scaltriti · 2014 · Molecular & Cellular Oncology
- PI3K pathway inhibitors for the treatment of brain metastases with a focus on HER2+ breast cancerParvin F. Peddi, Sara Alsterlind Hurvitz · 2014 · Journal of Neuro-Oncology
- Genome-based and transcriptome-based molecular classification of breast cancerIvan Bièche, Rosette Lidereau · 2010 · Current Opinion in Oncology
- Targeting Cancer Stem Cells with Defined Compounds and DrugsCord Naujokat, Stefan Laufer · 2013 · Journal of cancer research updates
- Mycophenolic acid potentiates HER2-overexpressing SKBR3 breast cancer cell line to induce apoptosis: involvement of AKT/FOXO1 and JAK2/STAT3 pathwaysSafiyeh Aghazadeh, Razieh Yazdanparast · 2016 · APOPTOSIS
- Inhibition of PI3K signaling pathway enhances the chemosensitivity of APL cells to ATO: Proposing novel therapeutic potential for BKM120Davood Bashash, Mahda Delshad, Niknam Riyahi, Ava Safaroghli‐Azar, Atieh Pourbagheri‐Sigaroodi, Majid Momeny · 2018 · European Journal of Pharmacology
- Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patientsAuhood Abdel-Monem Nassar, Mohamed Ibrahim Abouelhoda, Osman Mohamed Mansour, Samah Aly Loutfy, Mohamed Mahmoud Hafez, Mohammed Mohammed Mohammed Gomaa, Abeer Ahmed Bahnassy, Amira Salah El-Din Youssef, Mai M. Lotfy, Hoda M Ismail et al. · 2020 · Journal of Advanced Research
- RNA interference screening demystifiedChristopher J. Lord, Sarah A. Martin, Alan Ashworth · 2009 · Journal of Clinical Pathology
- Interleukin 7 receptor alpha Thr244Ile genetic polymorphism is associated with susceptibility and prognostic markers in breast cancer subgroupsGlauco Akelinghton Freire Vitiello, Roberta Losi Guembarovski, Marla Karine Amarante, Jesus Roberto Ceribelli, Elaine Cristina Baraldi Carmelo, Maria Angélica Ehara Watanabe · 2017 · Cytokine
- Clinical Development of Phosphatidylinositol-3 Kinase Pathway InhibitorsCarlos L. Arteaga · 2010 · Current topics in microbiology and immunology
- A Lentivirus-Mediated Genetic Screen Identifies Dihydrofolate Reductase (DHFR) as a Modulator of β-Catenin/GSK3 SignalingRichard A. Klinghoffer, Jason P. Frazier, James E. Annis, Jason D. Berndt, Brian S. Roberts, William T. Arthur, Raul Lacson, Xiaohua Douglas Zhang, Marc Ferrer, Randall T. Moon et al. · 2009 · PLoS ONE
- Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell linesJulia Kneißl, Anja Hartmann, Nicole Pfarr, Franziska Erlmeier, Thomas Lorber, Simone Keller, Gwen Zwingenberger, Wilko Weichert, Birgit Luber · 2016 · Journal of Cancer Research and Clinical Oncology
- Single-Circulating Tumor Cell Whole Genome Amplification to Unravel Cancer Heterogeneity and Actionable BiomarkersTanzila Khan, Therese M. Becker, Joseph William Po, Wei Ming Chua, Yafeng Ma · 2022 · International Journal of Molecular Sciences
- Detailed curriculum vitae of HER2-targeted therapyXiaonan Zhang, Ya Gao, Xi-Ya Zhang, Ning-Jie Guo, Wenqing Hou, Shu-Wu Wang, Yi‐Chao Zheng, Ning Wang, Hong‐Min Liu, Bo Wang · 2023 · Pharmacology & Therapeutics
- Modulation of cell sensitivity to antitumor agents by targeting survival pathwaysPaola Perego, Giacomo Cossa, Valentina Zuco, Franco Zunino · 2010 · Biochemical Pharmacology
- Resistance to HER2-targeted therapies: a potential role for FOXM1Bridgette F. Peake, Rita Nahta · 2014 · Breast Cancer Management
- Correlation of Breast Cancer Axillary Lymph Node Metastases With Stem Cell MutationsCory Donovan, Rodney F. Pommier, Robynn V. Schillace, Steven O’Neill, Patrick Muller, Jennifer L. Alabran, Juliana E. Hansen, Jennifer A. Murphy, Arpana M. Naik, John T. Vetto et al. · 2013 · JAMA Surgery
- Therapeutic targeting of ERBB2 in breast cancer: understanding resistance in the laboratory and combating it in the clinicAlessandra Fabi, Marcella Mottolese, Oreste Segatto · 2014 · Journal of Molecular Medicine
- Src Mutation Induces Acquired Lapatinib Resistance in ERBB2-Amplified Human Gastroesophageal Adenocarcinoma ModelsYong Sang Hong, Jihun Kim, Eirini Pectasides, Cameron Fox, Seungwoo Hong, Qiuping Ma, Gabrielle S. Wong, Shouyong Peng, Matthew D. Stachler, Aaron R. Thorner et al. · 2014 · PLoS ONE
- In vitro and in vivo studies of the combination of IGF1R inhibitor figitumumab (CP-751,871) with HER2 inhibitors trastuzumab and neratinibAshok K. Chakraborty, Cynthia A. Zerillo, Michael P. DiGiovanna · 2015 · Breast Cancer Research and Treatment
- Neoadjuvant therapy of early stage human epidermal growth factor receptor 2 positive breast cancer: latest evidence and clinical implicationsSònia Pernas · 2014 · Therapeutic Advances in Medical Oncology
- Development of a peptide by phage display for SPECT imaging of resistance-susceptible breast cancer.Benjamin M. Larimer, Susan L. Deutscher · 2014 · Europe PMC (PubMed Central)
- Monitoring Trastuzumab Resistance and CardiotoxicityMilos Dokmanovic, Wen Jin Wu · 2015 · Advances in clinical chemistry
- FOXOs Maintaining the Equilibrium for Better or for WorseSabina van Doeselaar, Boudewijn M.T. Burgering · 2018 · Current topics in developmental biology/Current Topics in Developmental Biology
- Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line modelSharon Glaysher, Louise M Bolton, Penny Johnson, Christopher J. Torrance, Ian A. Cree · 2014 · BMC Research Notes
- Everolimus in hormone receptor–positive advanced breast cancer: Targeting receptor-based mechanisms of resistanceMikhail I. Shtivelband · 2013 · The Breast
- MIDAS: Mining differentially activated subpaths of KEGG pathways from multi-class RNA-seq dataSangseon Lee, Youngjun Park, Sun Kim · 2017 · Methods
- Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1LHuarui Lu, Timothy Curtis Hallstrom · 2012 · PLoS ONE
- Mechanisms of resistance to trastuzumab in HER2-positive gastric cancerZhifei Li, Huan Zhao, Huihui Hu, Hai-Li Shang, Yongjing Ren, Wenhui Qiu, Hao Su, Huifang Lyu, Xiaobing Chen · 2024 · Chinese Journal of Cancer Research
- Mechanisms of resistance to antibody–drug conjugates in cancersYuya Murase, Shigeki Nanjo, Tsukasa Ueda, Liu Yifeng, Shunichi Nomura, Sachiko Arai, Nanao Terada, Hayato Koba, Yuichi Tambo, Seiji Yano · 2025 · Respiratory Investigation
- Pharmacogenomic Contribution to Drug ResponseRoshawn Watson, Howard L. McLeod · 2011 · The Cancer Journal
- Evaluation of the Tocilizumab therapy in human cancers: Latest evidence and clinical potentialKosar Ghasemi, Kosar Ghasemi · 2022 · Journal of Clinical Pharmacy and Therapeutics
- Molecular correlates of invasion pattern in HPV‐associated endocervical adenocarcinoma: emergence of two distinct risk‐stratified tiersAarti E. Sharma, Anjelica Hodgson, Brooke E. Howitt, Ekaterina Olkhov‐Mitsel, Bojana Djordevic, Kay J. Park, Marisa R. Nucci, Carlos Parra‐Herran · 2023 · Histopathology
- Circulating tumor cells and circulating tumor DNA in breast cancer diagnosis and monitoringEffat Alemzadeh, Leila Allahqoli, Hamideh Dehghan, Afrooz Mazidimoradi, Alireza Ghasempour, Hamid Salehiniya · 2023 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Long road towards effective HER3 targeting in breast cancerFrancesca Papa, Thomas Grinda, Elie Rassy, Rasha Cheikh-Hussin, Joana Mourato Ribeiro, Lorenzo Antonuzzo, Barbara Pistilli · 2024 · Cancer Treatment Reviews
- Integration of cancer genomics with treatment selectionThomas Julian Ow, Vlad Constantin Sandulache, Heath Devin Skinner, Jeffrey N. Myers · 2013 · Cancer
- Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cellsChi Zhang, Xuening Duan, Ling Xu, Jingming Ye, Jianxin Zhao, Yinhua Liu · 2012 · Breast Cancer Research and Treatment
- PTEN expression as a predictor for the response to trastuzumab-based therapy in Her-2 overexpressing metastatic breast cancerDaphne Gschwantler‐Kaulich, Yen Y. Tan, Eva‐Maria Fuchs, Gernot Hudelist, Wolfgang J. Köstler, Reiner Angelika, Carmen Leser, Mohamed Mamdouh Salama, Johannes Attems, Christine Deutschmann et al. · 2017 · PLoS ONE
- The role of neratinib in HER2-driven breast cancerMathew Amprayil Cherian, Cynthia X. Ma · 2017 · Future Oncology
- Pathways Linked to Cancer Chemoresistance and Their Targeting by NutraceuticalsAlok Chandra Bharti, Kanchan Vishnoi, Sukh Mahendra Singh, Bharat Bhushan Aggarwal · 2017 · Elsevier eBooks
- Targeted agents for HER2-positive breast cancer in older adults: current and future perspectivesEnrique Soto‐Pérez‐de‐Celis, Kah Poh Loh, Capucine Baldini, Nicolò Matteo Luca Battisti, Yanin Chávarri-Guerra, Nienke A. de Glas, Tina Hsu, Arti Hurria · 2018 · Expert Opinion on Investigational Drugs
- Durable Clinical Response to Pyrotinib After Resistance to Prior Anti-HER2 Therapy for HER2-Positive Advanced Gastric Cancer: A Case ReportLe‐Tian Huang, Jie‐Tao Ma, Shuling Zhang, Xiaohan Li, Li Sun, Wei Jing, Jianzhu Zhao, Yan-Ru Wang, Cheng‐Bo Han · 2019 · Frontiers in Oncology
- PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinomaDaiju Yokoyama, Shigeo Hisamori, Yasunori Deguchi, Tatsuto Nishigori, Hiroshi Okabe, Seiichiro Kanaya, Dai Manaka, Yoshio Kadokawa, Hiroaki Hata, Sachiko Minamiguchi et al. · 2021 · Scientific Reports
- Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathwaysMaryam Farzaneh Behelgardi, Zahra Gholami Shahvir, Seyed Mohsen Asghari · 2022 · Molecular Biology Reports
- Potent CD4+ T-cell epitope P30 enhances HER2/neu-engineered dendritic cell-induced immunity against Tg1-1 breast cancer in transgenic FVBneuN mice by enhanced CD4+ T-cell-stimulated CTL responsesYufeng Xie, Y Chen, Khawaja Ashfaque Ahmed, W Li, Shahid Ahmed, Amer Sami, Rajni Chibbar, Xiaoying Tang, Min Tao, Jianqing Xu et al. · 2013 · Cancer Gene Therapy
- Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancersRamón González Manzano, E. Martinez-Navarro, Jerónimo Forteza, Antonio Brugarolas · 2014 · International Journal of Oncology
- The Dark Side of the Moon: The PI3K/PTEN/AKT Pathway in Colorectal CarcinomaNicola Silvestris, Stefania Tommasi, Daniela Petriella, Daniele Santini, Ettore Fistola, Antonio Dello Russo, Gianmauro Numico, Giuseppe Tonini, Evaristo Maiello, Giuseppe Colucci · 2009 · Oncology
- “The Infinite Maze” of breast cancer, signaling pathways and radioresistanceOrit Kaidar‐Person, Christine S. Lai, Abraham Kuten, Yazid Belkacémi · 2013 · The Breast
- Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinibAline Geneste, Minh Ngoc Duong, L. Molina, Louise Conilh, Sabine Beaumel, Aurore Cleret, Kamel Chettab, Maëlle Lachat, Lars Petter Jordheim, Eva‐Laure Matera et al. · 2020 · BMC Pharmacology and Toxicology
- Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive casesDaniel R Owen, Hui‐Li Wong, Melika Bonakdar, Martin R. Jones, Christopher S. Hughes, Gregg B. Morin, Steven J.M. Jones, Daniel John Renouf, Howard John Lim, Janessa J. Laskin et al. · 2018 · Molecular Case Studies
- A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cellsGege Qin, Xiying Shao, Xiaolong Liu, Jiachao Xu, Xiaojia Wang, Wenxi Wang, Lu Gao, Yuxin Liang, Lina Xie, Dan Su et al. · 2025 · Proceedings of the National Academy of Sciences
- YAP increases response to Trastuzumab in HER2-positive Breast Cancer by enhancing P73-induced apoptosisLanqing Cao, Min Yao, Hironobu Sasano, Ping-Li Sun, Hongwen Gao · 2020 · Journal of Cancer
- Discriminating Origin Tissues of Tumor Cell Lines by Methylation Signatures and Dys-Methylated RulesShiqi Zhang, Tao Zeng, Bin Hu, Yuhang Zhang, Kaiyan Feng, Lei Chen, Zhibin Niu, Jianhao Li, Tao Huang, Yu‐Dong Cai · 2020 · Frontiers in Bioengineering and Biotechnology
- PIK3CAMutations in Breast Cancer Subtypes Other Than HR-Positive/HER2-NegativeLiliana Ascione, Paola Zagami, Eleonora Nicolò, Edoardo Crimini, Giuseppe Curigliano, Carmen Criscitiello · 2022 · Journal of Personalized Medicine
- Role of HER2-Targeted Agents in Adjuvant Treatment for Breast CancerToru Mukohara · 2011 · Chemotherapy Research and Practice
- Exploration of Synthetic Lethal Interactions as Cancer Drug TargetsHendrik J. Kuiken, Roderick L. Beijersbergen · 2010 · Future Oncology
- Molecular effects of lapatinib in patients with HER2 positive ductal carcinoma in situLaura García‐Estévez, Ana Suárez‐Gauthier, Elena García, Cristina Martínez Miró, Isabel Calvo, María Fernández-Abad, Mercedes Herrero, Manuel Marcos, Cristina Márquez, Fernando López Ríos et al. · 2014 · Breast Cancer Research
- Involvement of microRNAs in HER2 signaling and trastuzumab treatmentLing Mao, Aijun Sun, Jian-zhong Wu, Jinhai Tang · 2016 · Tumor Biology
- Co-targeting the HER and IGF/insulin receptor axis in breast cancer, with triple targeting with endocrine therapy for hormone-sensitive diseaseAshok K. Chakraborty, Christos Hatzis, Michael P. DiGiovanna · 2017 · Breast Cancer Research and Treatment
- Antitumor activity of NAX060: A novel semisynthetic berberine derivative in breast cancer cellsElisa Pierpaoli, Gaetano Fiorillo, Paolo Lombardi, Carmela Salvatore, Cristina Geroni, Francesco Piacenza, Mauro Provinciali · 2018 · BioFactors
- Clinical application of circulating tumor DNA in breast cancerJeffrey Chun Hin Chan, James Chung Hang Chow, Connie Hoi Man Ho, Therese Yue Man Tsui, William Chi Shing Cho · 2021 · Journal of Cancer Research and Clinical Oncology
- New developments in the treatment of HER2-positive breast cancerRita Nahta · 2012 · Breast Cancer Targets and Therapy
- In vivo activity of novel anti-ErbB2 antibody chA21 alone and with Paclitaxel or Trastuzumab in breast and ovarian cancer xenograft modelsGuodong Shen, Hui Huang, Anli Zhang, Ting Zhao, Siyi Hu, Liansheng Cheng, Jing L. Liu, Weihua Xiao, Bin Ling, Qiang Wu et al. · 2010 · Cancer Immunology Immunotherapy
- From man to mouse and back again: advances in defining tumor AKTivities in vivoDavid F. Restuccia, Brian A. Hemmings · 2010 · Disease Models & Mechanisms
- Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interactionAkram Sadeghirizi, Razieh Yazdanparast, Safiyeh Aghazadeh · 2015 · Tumor Biology
- New Insights Into Cellular Stress Responses to Environmental Metal ToxicantsHae‐Ryung Park, Raymond S. Oh, P. Wagner, Ronald Allan M. Panganiban, Quan Lu · 2016 · International review of cytology
- PIK3CA Mutations and Neoadjuvant Therapy Outcome in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: A Sequential AnalysisYoujeong Seo, Yeon Hee Park, Jin Seok Ahn, Young‐Hyuck Im, Seok Jin Nam, Soo Youn Cho, Eun Yoon Cho · 2018 · Journal of Breast Cancer
- Molecular alterations and poziotinib efficacy, a pan‐HER inhibitor, in human epidermal growth factor receptor 2 (HER2)‐positive breast cancers: Combined exploratory biomarker analysis from a phase II clinical trial of poziotinib for refractory HER2‐positive breast cancer patientsJi‐Yeon Kim, Eunjin Lee, Kyunghee Park, Hae Hyun Jung, Woong‐Yang Park, Kyung‐Hun Lee, Joohyuk Sohn, Keun Seok Lee, Kyung Hae Jung, Jee Hyun Kim et al. · 2019 · International Journal of Cancer
- Rapid, Cost-Effective Peptide/Nucleic Acid-Based Platform for Therapeutic Antibody Monitoring in Clinical SamplesMarco Mocenigo, Alessandro Porchetta, Marianna Rossetti, Erik Brass, Lucia Tonini, Luca Puzzi, Elda Tagliabue, Tiziana Triulzi, Bruna Marini, Francesco Ricci et al. · 2020 · ACS Sensors
- Therapeutic options for HER-2 positive breast cancer: Perspectives and future directionsGonzálo Recondo · 2014 · World Journal of Clinical Oncology
- The application of gene silencing in proteomics: from laboratory to clinicMaura Brioschi, Cristina Banfi · 2018 · Expert Review of Proteomics
- A Novel Mechanism Underlying the Inhibitory Effects of Trastuzumab on the Growth of HER2-Positive Breast Cancer CellsHamid Maadi, Zhixiang Wang · 2022 · Cells
- YAP inhibition overcomes adaptive resistance in HER2-positive gastric cancer treated with trastuzumab via the AKT/mTOR and ERK/mTOR axisJiao Qiao, Mei Feng, Wenyuan Zhou, Yuan Tan, Shuo Yang, Qi Liu, Qingchen Wang, Weimin Feng, Yisheng Pan, Liyan Cui · 2024 · Gastric Cancer
- Evolving Management of Breast Cancer in the Era of Predictive Biomarkers and Precision MedicineMuhammad Zubair Afzal, Linda T. Vahdat · 2024 · Journal of Personalized Medicine
- Evaluation of HER2 in breast cancer: reality and expectationsFernanda Milanezi, Dina Leitão, Sara Alexandra Vinhas Ricardo, Isabel Augusto, Fernando Carlos Schmitt · 2009 · Expert Opinion on Medical Diagnostics
- E‐cadherin expression on human carcinoma cell affects trastuzumab‐mediated antibody‐dependent cellular cytotoxicity through killer cell lectin‐like receptor G1 on natural killer cellsChisako Yamauchi, Satoshi Fujii, Taichi Kimura, Takeshi Kuwata, Noriaki Wada, Hirofumi Mukai, Naoki Matsumoto, Masashi Fukayama, Atsushi Ochiai · 2010 · International Journal of Cancer
- BCL-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic responseLuke A. Gilbert, Corbin E. Meacham, Hai Jiang, Michael T. Hemann, Justin R. Pritchard, Shingleton, Jennifer R., Douglas A. Lauffenburger · 2011 · DSpace@MIT (Massachusetts Institute of Technology)
- Predictive and Prognostic Significance of p27, Akt, PTEN and PI3K Expression in HER2-Positive Metastatic Breast CancerKerem Okutur, Nuray Başsülü, Levent Dalar, Kübra Aydın, Mustafa Bozkurt, Kezban Nur Pilancı, Gülen Doğusoy, C. Tecimer, Nil Molinas Mandel, Gökhan Demir · 2015 · Asian Pacific Journal of Cancer Prevention
- Current views on inducing synthetic lethal RNAi responses in the treatment of cancerApollo D. Kacsinta, Steven F. Dowdy · 2015 · Expert Opinion on Biological Therapy
- An anti-ErbB2 fully human antibody circumvents trastuzumab resistanceQiong Lu, Lingfei Wang, Yajun Zhang, Xiaojie Yu, Chao Wang, Huajing Wang, Yang� Yang, Xiaodan Chong, Tian Xia, Yanchun Meng et al. · 2016 · Oncotarget
- Novel Targeted Agents and Immunotherapy in Breast CancerIngrid A. Mayer, Rebecca Alexandra Dent, Tira J. Tan, Peter Stephen Savas, Sherene Loi · 2017 · American Society of Clinical Oncology Educational Book
- Tumor Heterogeneity Index to Detect Human Epidermal Growth Factor Receptor 2 Amplification by Next-Generation SequencingSangjoon Choi, Jinah Chu, Binnari Kim, Sang Yun Ha, Seung Tae Kim, Jeeyun Lee, Won Ki Kang, Heewon Han, Insuk Sohn, Kyoung‐Mee Kim · 2019 · Journal of Molecular Diagnostics
- Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA -E545K MutationWei Jiang, Yutuan Wu, Tiancong He, Hanting Zhu, Guihao Ke, Libing Xiang, Huijuan Yang · 2019 · Molecular Cancer Therapeutics
- Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancerJoseph T. Decker, Pridvi Kandagatla, Lei Wan, Regan Bernstein, Jeffrey A. Ma, Lonnie D. Shea, Jacqueline Sara Jeruss · 2020 · Cancer Biology & Therapy
- The Biophysics of Cancer: Emerging Insights from Micro‐ and Nanoscale ToolsPeter E. Beshay, Marcos G. Cortes-Medina, Miles M. Menyhert, Jonathan W. Song · 2021 · Advanced NanoBiomed Research
- Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathwaysHanchao Zhang, Meng Wang, Di Chen, Chengyu Luo · 2022 · Journal of Investigative Medicine
- Novel Targeted Agents for the Treatment of Advanced Breast CancerMartha Vega, Enrique A. Diaz-Canton, Ricardo H. Álvarez · 2012 · Future Medicinal Chemistry
- n-3 polyunsaturated fatty acids and HER2-positive breast cancer: Interest of the fat-1 transgenic mouse model over conventional dietary supplementationZuquan Zou, Célia Bidu, Sandrine Bellenger, Michel Narce, Jérôme Bellenger · 2013 · Biochimie
- HER2-positive gastric cancer with paraaortic nodal metastasis successfully resected after chemotherapy with trastuzumab: a case report.Naoki Ikari, Go Nakajima, Kiyoaki Taniguchi, Tsuyoshi Sasagawa, Kosuke Narumiya, Takuji Yamada, Kenji Kudo, Yoichi Kitamura, Kazuhiko Hayashi, Toshio Nishikawa et al. · 2014 · PubMed
- Biomarkers That Predict Sensitivity to Heat Shock Protein 90 InhibitorsKomal L. Jhaveri, Sarat Chandarlapaty, Neil M. Iyengar, Patrick Glyn Morris, Adriana Dionigi Corben, Sujata N Patil, Muzaffar M. Akram, Russell Towers, Rita A. Sakr, Tari A. King et al. · 2015 · Clinical Breast Cancer
- Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cellsSonja Thaler, Martina Schmidt, Sven Roßwag, Gitta Thiede, Arno Schad, Jonathan Paul Sleeman · 2017 · Oncotarget