A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer

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Items 301–400 of 1,001

  1. Impact of PTEN protein expression on benefit from adjuvant trastuzumab in early-stage human epidermal growth factor receptor 2-positive breast cancer in the North Central Cancer Treatment Group N9831 trial
    Perez, Edith A., Dueck, Amylou C., McCullough, Ann E., Chen, Beiyun, Geiger, Xochiquetzal J., Jenkins, Robert B., Lingle, Wilma L., Davidson, Nancy E., Martino, Silvana, Kaufman, Peter A. et al. · 2013 · Journal of Clinical Oncology
  2. Trastuzumab Emtansine (T-DM1): A Novel Agent for Targeting HER2+ Breast Cancer
    Howard A. Burris, Jay Tibbitts, Scott N. Holden, Mark X. Sliwkowski, Gail D. Lewis Phillips · 2011 · Clinical Breast Cancer
  3. A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors
    Clifford A. Hudis, Charles Swanton, Yelena Yuriy Janjigian, Ray Lee, Stephanie Sutherland, Robert James Lehman, Sarat Chandarlapaty, Nicola Hamilton, Devika Gajria, James Knowles et al. · 2013 · Breast Cancer Research
  4. Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study
    Filippo Pietrantonio, Giovanni Fucà, Federica Morano, Annunziata Gloghini, Simona Corso, Giuseppe Aprile, Federica Perrone, Ferdinando De Vita, Elena Tamborini, Gianluca Tomasello et al. · 2017 · Clinical Cancer Research
  5. Self-Assembly of Lithographically Patterned Nanoparticles
    Jeong‐Hyun Cho, David H. Gracias · 2009 · Nano Letters
  6. HER2-positive advanced breast cancer: optimizing patient outcomes and opportunities for drug development
    Jasmeet Chadha Singh, Komal L. Jhaveri, Francisco J. Esteva · 2014 · British Journal of Cancer
  7. Use of molecular markers for predicting therapy response in cancer patients
    Michael Joe Duffy, Norma O’Donovan, John Paul Crown · 2010 · Cancer Treatment Reviews
  8. A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments
    Kenta Masui, Beatrice Gini, J. Wykosky, Ciro Zanca, Paul S. Mischel, Frank B. Furnari, Webster K. Cavenee · 2013 · Carcinogenesis
  9. Our changing view of the genomic landscape of cancer
    Daphne W. Bell · 2009 · The Journal of Pathology
  10. Trastuzumab Emtansine: A Novel Antibody–Drug Conjugate for HER2-Positive Breast Cancer
    Ian E. Krop, Eric P. Winer · 2013 · Clinical Cancer Research
  11. The prognostic value of PI3K mutational status in breast cancer: A meta‐analysis
    Navid Sobhani, Giandomenico Roviello, Silvia Paola Corona, Maurizio Scaltriti, Anna Ianza, Marina Bortul, Fabrizio Zanconati, Daniele Generali · 2018 · Journal of Cellular Biochemistry
  12. Should individual PI3 kinase isoforms be targeted in cancer?
    Shidong Jia, Thomas M. Roberts, Jean J. Zhao · 2009 · Current Opinion in Cell Biology
  13. Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?
    Sérgio Rizzo, Giuseppe Bronte, Daniele Fanale, Lidia Rita Corsini, Nicola Silvestris, Daniele Santini, Gaspare Gulotta, Viviana Bazan, Nicola Gebbia, Fabio Fulfaro et al. · 2010 · Cancer Treatment Reviews
  14. Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells
    Giuliana Cassinelli, Valentina Zuco, Laura Gatti, Cinzia Lanzi, Nadia Zaffaroni, Diego Colombo, Paola Perego · 2013 · Current Medicinal Chemistry
  15. The Therapeutic Potential of PI3K/Akt/mTOR Inhibitors in Breast Cancer: Rational and Progress
    Afsane Bahrami, Majid Khazaei, Soodabeh Shahidsales, Seyed Mahdi Hassanian, Malihe Hasanzadeh, Mina Maftouh, Gordon A. Ferns, Amir Avan · 2017 · Journal of Cellular Biochemistry
  16. Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop
    Zhengyan Yang, Liang Guo, Dan Liu, Limin Sun, Hongyu Chen, Que Deng, Yanjun Liu, Ming Yu, Yuan-fang Ma A, Ning Guo et al. · 2014 · Oncotarget
  17. HER2 Status in High-Risk Endometrial Cancers (PORTEC-3): Relationship with Histotype, Molecular Classification, and Clinical Outcomes
    Lisa Vermij, Nanda Horeweg, Alicia León‐Castillo, Tessa A. Rutten, Linda Mileshkin, Helen J MacKay, Alexandra F. Leary, Melanie E. B. Powell, Naveena Singh, Emma Jayne Crosbie et al. · 2020 · Cancers
  18. Antibody-Drug Conjugates for the Treatment of HER2-Positive Breast Cancer
    Mariana K. Najjar, Sara G. Manore, Angelina T. Regua, Hui‐Wen Lo · 2022 · Genes
  19. Trastuzumab deruxtecan in breast cancer
    Martín, Miguel, Pandiella, Atanasio, Vargas-Castrillón, Emilio, Díaz-Rodríguez, Elena, Iglesias-Hernangómez, Teresa, Martínez Cano, Concha, Fernández-Cuesta, Inés, Winkow, Elena, Perelló, Maria Francesca · 2024 · Critical Reviews in Oncology/Hematology
  20. Taming the dragon: genomic biomarkers to individualize the treatment of cancer
    Ian J. Majewski, René Bernards · 2011 · Nature Medicine
  21. mTOR as a therapeutic target in patients with gastric cancer
    Salah Eddin Al-Batran, Michel Pierre Ducreux, Atsushi Ohtsu · 2011 · International Journal of Cancer
  22. Role of Alpelisib in the Treatment of PIK3CA-Mutated Breast Cancer: Patient Selection and Clinical Perspectives
    Dwan‐Ying Chang, Weili Ma, Yen‐Shen Lu · 2021 · Therapeutics and Clinical Risk Management
  23. H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3
    Chakrabarty, A, Rexer, B N, Wang, S E, Cook, R S, Engelman, J A, Arteaga, C L · 2010 · Oncogene
  24. Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma
    Zengjin Liu, Huamin Han, Xin He, Shouwei Li, Chenxing Wu, Chunjiang Yu, Shengdian Wang · 2016 · Oncology Letters
  25. Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T‐DM1) vs. treatment of physician's choice in previously treated HER2‐positive advanced breast cancer
    Sung‐Bae Kim, Hans P. M. W. Wildiers, Ian E. Krop, Melanie C. Smitt, Ron Yu, Sanne Lysbet de Haas, Antonio González-Martı́n · 2016 · International Journal of Cancer
  26. Dual Blockade of HER2 in HER2-Overexpressing Tumor Cells Does Not Completely Eliminate HER3 Function
    Joan T. Garrett, Cammie R. Sutton, María Gabriela Kuba, Rebecca S. Cook, Carlos L. Arteaga · 2012 · Clinical Cancer Research
  27. Efficacy of HER2-targeted therapy in metastatic breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors
    Dorte Lisbet Nielsen, Iben Kümler, Jesper Andreas Palshof, Michael Andersson · 2012 · The Breast
  28. Defining biomarkers to predict sensitivity to PI3K/Akt/mTOR pathway inhibitors in breast cancer
    Ana Maria Gonzalez-Angulo, George R. Blumenschein · 2012 · Cancer Treatment Reviews
  29. Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer
    Mothaffar Fahed Rimawi, Carmine De Angelis, Alejandro Contreras, Fresia G. Pareja, Felipe Correa Geyer, Kathleen A. Burke, Sabrina Herrera, Tao Wang, Ingrid A. Mayer, Andres Forero et al. · 2017 · Breast Cancer Research and Treatment
  30. HER2 Protein and Gene Variation between Primary and Metastatic Breast Cancer: Significance and Impact on Patient Care
    Alessandra Fabi, Anna Di Benedetto, Giulio Metro, Letizia Perracchio, Cecilia Nisticò, Franco Di Filippo, Cristiana Ercolani, Gianluigi Ferretti, Elisa Melucci, Simonetta Buglioni et al. · 2011 · Clinical Cancer Research
  31. Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction
    Andrea Bertotti, Mike F. Burbridge, Stefania Gastaldi, Francesco Galimi, Davide Torti, Enzo Médico, Silvia Giordano, Simona Corso, Gaëlle Rolland-Valognes, Brian Paul Lockhart et al. · 2009 · Science Signaling
  32. The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations
    Hiroshi Tanaka, Miyuki Yoshida, Hiromi Tanimura, Toshihiko Fujii, Kiyoaki Sakata, Yukako Tachibana, Jun Ohwada, Hirosato Ebiike, Shino Kuramoto, Keiichi Morita et al. · 2011 · Clinical Cancer Research
  33. The Nuclear Receptor Coactivator Amplified in Breast Cancer-1 Is Required for Neu (ErbB2/HER2) Activation, Signaling, and Mammary Tumorigenesis in Mice
    Mark Fereshteh, Maddalena T. Tilli, Sung Eun Kim, Jianming Xu, Bert W. O’Malley, Anton Wellstein, Priscilla A. Furth, Anna Tate Riegel · 2008 · Cancer Research
  34. Evolving Strategies for Overcoming Resistance to HER2-Directed Therapy: Targeting the PI3K/Akt/mTOR Pathway
    Rita Nahta, Ruth M O'Regan · 2010 · Clinical Breast Cancer
  35. β2-AR signaling controls trastuzumab resistance-dependent pathway
    Daifang Liu, Zhengyan Yang, Tianxun Wang, Zhengyan Yang, H Chen, Yi Hu, C Hu, Liang Guo, Qinqin Deng, Y Liu et al. · 2015 · Oncogene
  36. The Emerging Genomic Landscape of Endometrial Cancer
    Matthieu Le Gallo, Daphne W. Bell · 2013 · Clinical Chemistry
  37. p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex
    Rosalia Rabinovsky, Panisa Pochanard, Chontelle J. McNear, Saskia M. Brachmann, Jonathan S. Duke‐Cohan, Levi A. Garraway, William R. Sellers · 2009 · Molecular and Cellular Biology
  38. Antibody‐Incorporated Nanomedicines for Cancer Therapy
    Shun‐Yu Wu, Fu‐Gen Wu, Xiaoyuan Shawn Chen · 2022 · Advanced Materials
  39. Potential of overcoming resistance to HER2-targeted therapies through the PI3K/Akt/mTOR pathway
    Sharon T. Wilks · 2015 · The Breast
  40. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells
    Kristine Kleivi Sahlberg, Vesa Hongisto, Henrik Edgren, Rami Mäkelä, Kirsi Hellström, Eldri Undlien Due, Hans Kristian Moen Vollan, Niko Sahlberg, Maija Wolf, Anne‐Lise Børresen‐Dale et al. · 2012 · Molecular Oncology
  41. Dysregulation of the Phosphatidylinositol 3-Kinase Pathway in Thyroid Neoplasia
    John E. Paes, Matthew David Ringel · 2008 · Endocrinology and Metabolism Clinics of North America
  42. HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway
    Alison Elizabeth Smith, Emanuela Ferraro, Anton Mikhailovich Safonov, Cristina Bernadó Morales, Enrique Javier Arenas, Qing Li, Amanda R. Kulick, Dara S. Ross, David B. Solit, Elisa de Stanchina et al. · 2021 · Nature Communications
  43. Her2 cross talk and therapeutic resistance in breast cancer
    Laura, M. Bender · 2008 · Frontiers in bioscience
  44. Cell-Autonomous and Non–Cell-Autonomous Mechanisms of HGF/MET–Driven Resistance to Targeted Therapies: From Basic Research to a Clinical Perspective
    Simona Corso, Silvia Giordano · 2013 · Cancer Discovery
  45. Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution
    Subramanian Venkatesan, Charles Swanton, Barry S. Taylor, J Costello · 2017 · Cold Spring Harbor Perspectives in Medicine
  46. ERBB2 -Mutated Metastatic Non–Small Cell Lung Cancer: Response and Resistance to Targeted Therapies
    Jody C. Chuang, Henning Stehr, Ying Liang, Millie Snigdha Das, Jane Q. Huang, Maximilian Diehn, Heather A. Wakelee, Joel W. Neal · 2017 · Journal of Thoracic Oncology
  47. Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab
    M Cizkova, M.E. Dujaric, Jacqueline Lehmann‐Che, Véronique Scott, Olivier Tembo, Bernard Jean Roger Asselain, Jean‐Yves Pierga, Michel E. Marty, Patricia de Crémoux, F. Spyratos et al. · 2013 · British Journal of Cancer
  48. Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer
    Mohd Syahizul Nuhairy Mohd Sharial, John Paul Crown, Bryan T. Hennessy · 2012 · Annals of Oncology
  49. Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer
    Roger Y. Tsang, Richard S. Finn · 2012 · British Journal of Cancer
  50. Safety, Efficacy, and Biomarker Analysis of Pyrotinib in Combination with Capecitabine in HER2-Positive Metastatic Breast Cancer Patients: A Phase I Clinical Trial
    Qiao Li, Xiuwen Guan, Shanshan Chen, Zongbi Yi, Bo Lan, Puyuan Xing, Ying Fan, Jiayu Wang, Yang Luo, Peng Yuan et al. · 2019 · Clinical Cancer Research
  51. Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110α Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers
    Joan T. Garrett, Cammie R. Sutton, Richard Kurupi, Carl Uli Bialucha, Seth A. Ettenberg, Scott D. Collins, Qing Sheng, Jerry Wallweber, Lisa D. Eli, Carlos L. Arteaga · 2013 · Cancer Research
  52. Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches
    Xueda Hu, Zemin Zhang · 2015 · Trends in Genetics
  53. β1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2–Positive Breast Cancer
    David M. Lesniak, Yaoxian Xu, Jean Deschênes, Raymond L. Lai, John Thoms, David Murray, Sunita Gosh, John Robert Mackey, Siham Sabri, Bassam Abdulkarim · 2009 · Cancer Research
  54. Towards systematic functional characterization of cancer genomes
    Jesse S. Boehm, William C. Hahn · 2011 · Nature Reviews Genetics
  55. The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition
    Jiaolong Shi, Fengping Li, Xingxing Yao, Tingyu Mou, Zhijun Xu, Zheng Han, Siyu Chen, Wende Li, Jiang Yu, Xiaolong Qi et al. · 2018 · Oncogene
  56. Molecular Mechanisms of Trastuzumab-Based Treatment in HER2-Overexpressing Breast Cancer
    Rita Nahta · 2012 · ISRN Oncology
  57. Novel Approaches for Molecular Targeted Therapy of Breast Cancer: Interfering with PI3K/AKT/mTOR Signaling
    Thomas W. Grunt, Gabriella Lucia Mariani · 2013 · Current Cancer Drug Targets
  58. HER2 as a target for breast cancer therapy
    Elda Tagliabue, Andrea Balsari, Manuela Campiglio, Serenella Maria Pupa · 2010 · Expert Opinion on Biological Therapy
  59. Actionable gene-based classification toward precision medicine in gastric cancer
    Hiroshi Ichikawa, Masayuki Nagahashi, Yoshifumi Shimada, Takaaki Hanyu, Takashi Ishikawa, Hitoshi Kameyama, Takashi Kobayashi, Jun Sakata, Hiroshi Yabusaki, Satoru Nakagawa et al. · 2017 · Genome Medicine
  60. A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility
    Loredana Vecchione, Valentina Gambino, Jonne A. Raaijmakers, Andreas Schlicker, Arianna Fumagalli, Mariangela Russo, Alberto Villanueva, Evelyne Beerling, Alice Bartolini, David G. Mollevı́ et al. · 2016 · Cell
  61. Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer
    Yinnan Chen, Yanmin Zhang · 2018 · Advanced Science
  62. Novel ADCs and Strategies to Overcome Resistance to Anti-HER2 ADCs
    Elena Dı́az-Rodrı́guez, Lucía Gandullo‐Sánchez, Alberto Ocaña, Atanasio Pandiella · 2021 · Cancers
  63. Optical imaging of metabolism in HER2 overexpressing breast cancer cells
    Alex J. Walsh, Rebecca S. Cook, Brent Neil Rexer, Carlos L. Arteaga, Melissa C. Skala · 2011 · Biomedical Optics Express
  64. HER2-family signalling mechanisms, clinical implications and targeting in breast cancer
    Naomi Elster, Denis Martin Collins, Sinéad Toomey, John Paul Crown, Alex J. Eustace, Bryan T. Hennessy · 2014 · Breast Cancer Research and Treatment
  65. Anti-HER agents in gastric cancer: from bench to bedside
    Lorenzo Fornaro, M Lucchesi, Chiara Caparello, Enrico Vasile, S. Caponi, Laura Ginocchi, Gianluca Masi, Alfredo Falcone · 2011 · Nature Reviews Gastroenterology & Hepatology
  66. Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer
    Yasutaka Sukawa · 2012 · World Journal of Gastroenterology
  67. Dacomitinib (PF-00299804), an Irreversible Pan-HER Inhibitor, Inhibits Proliferation of HER2-Amplified Breast Cancer Cell Lines Resistant to Trastuzumab and Lapatinib
    Ondrej Kalous, Dylan F. Conklin, Amrita J. Desai, Neil A. O’Brien, Charles Ginther, Lee A. Anderson, David J. Cohen, Carolyn D. Britten, Ian W. Taylor, James G. Christensen et al. · 2012 · Molecular Cancer Therapeutics
  68. CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients
    Sylvain Lefort, Aurélie Thuleau, Yann Kieffer, Philémon Sirven, Ivan Bièche, Elisabetta Marangoni, Anne Vincent‐Salomon, Fatima Mechta‐Grigoriou · 2016 · Oncogene
  69. HER2 Expression and PI3K-Akt Pathway Alterations in Gastric Cancer
    Yasutaka Sukawa, Hiroyuki Yamamoto, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Takafumi Naito, Kei Mitsuhashi, Yasutaka Matsunaga, Taiga Takahashi, Masashi Mikami et al. · 2014 · Digestion
  70. Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase
    Huan Pang, Rory J. Flinn, Antonia Patsialou, Jeffrey B. Wyckoff, Evanthia T. Roussos Torres, Haiyan Wu, Maria Pozzuto, Sumanta Kumar Goswami, John S. Condeelis, Anne R. Bresnick et al. · 2009 · Cancer Research
  71. Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer
    Liyun Luo, Zhijie Zhang, Ni Qiu, Li Ling, Xiaoting Jia, Ying Song, Hongsheng Li, Jiansheng Li, Hui Lyu, Hao Liu et al. · 2021 · Nature Communications
  72. Everolimus in the Treatment of Metastatic Breast Cancer
    Melanie Royce, Diaa I. Osman · 2015 · Breast Cancer Basic and Clinical Research
  73. Overcoming resistance to tyrosine kinase inhibitors: Lessons learned from cancer cells treated with EGFR antagonists
    Brent Neil Rexer, Jeffrey A. Engelman, Carlos L. Arteaga · 2009 · Cell Cycle
  74. Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir
    Joong Sup Shim, Rajini Rao, Kristin E. Beebe, Len Neckers, Inkyu Han, Rita Nahta, Jun O. Liu · 2012 · JNCI Journal of the National Cancer Institute
  75. The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer
    Elisabeth Diver, Rosemary Foster, Bo R. Rueda, Whitfield B. Growdon · 2015 · The Oncologist
  76. HER2-targeted gold nanoparticles potentially overcome resistance to trastuzumab in gastric cancer
    Tetsushi Kubota, Shinji Kuroda, Nobuhiko Kanaya, Toshiaki Morihiro, Katsuyuki Aoyama, Yoshihiko Kakiuchi, Satoru Kikuchi, Masahiko Nishizaki, Shunsuke Kagawa, Hiroshi Tazawa et al. · 2018 · Nanomedicine Nanotechnology Biology and Medicine
  77. An RNA Interference Screen Identifies Metabolic Regulators NR1D1 and PBP as Novel Survival Factors for Breast Cancer Cells with the ERBB2 Signature
    Antonis Kourtidis, Ritu Jain, Richard D. Carkner, Cheryl Eifert, M. Julia Brosnan, Douglas S. Conklin · 2010 · Cancer Research
  78. Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients
    Helen Schneck, Christina Blassl, Franziska Meier-Stiegen, Rui P. Neves, Wolfgang Janni, Tanja Natascha Fehm, Hans J. Neubauer · 2013 · Molecular Oncology
  79. Direct inhibition of PI3K in combination with dual HER2 inhibitors is required for optimal antitumor activity in HER2+ breast cancer cells
    Brent Neil Rexer, Siprachanh Chanthaphaychith, Kimberly Brown Dahlman, Carlos L. Arteaga · 2014 · Breast Cancer Research
  80. An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients
    Geny Piro, Carmine Carbone, Ivana Cataldo, Federica Di Nicolantonio, Simone Giacopuzzi, Giuseppe Aprile, Francesca Simionato, Federico Boschi, Marco Zanotto, Maria Mihaela Mina et al. · 2016 · Clinical Cancer Research
  81. The Role of Cancer Stem Cells in Breast Cancer Initiation and Progression: Potential Cancer Stem Cell-Directed Therapies
    Panagiota Economopoulou, Virginia Kaklamani, Kalliopi P. Siziopikou · 2012 · The Oncologist
  82. Anti-cancer drug resistance: Understanding the mechanisms through the use of integrative genomics and functional RNA interference
    Daniel S.W. Tan, Marco Gerlinger, Bin Tean Teh, Charles Swanton · 2010 · European Journal of Cancer
  83. Advances in the Management of HER2-positive Advanced Gastric and Gastroesophageal Junction Cancer
    Yung‐Jue Bang · 2012 · Journal of Clinical Gastroenterology
  84. HER2 expression patterns in paired primary and metastatic endometrial cancer lesions
    Mari K. Halle, Ingvild Løberg Tangen, Hege Fredriksen Berg, Erling André Høivik, Karen Klepsland Mauland, Kanthida Kusonmano, Anna Berg, Antoni Hurtado, Karl‐Henning Kalland, Anne Margrete Oyan et al. · 2017 · British Journal of Cancer
  85. Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer
    Andrea Li‐Ann Wong, Soo Chin Lee · 2012 · International Journal of Breast Cancer
  86. Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
    Guangchao Li, Likun Zhao, Wěi Li, Kexing Fan, Weizhu Qian, Sheng Hou, Hao Wang, Jianxin Dai, Huafeng Wei, Yajun Guo · 2014 · Oncotarget
  87. Evaluation and Clinical Analyses of Downstream Targets of the Akt Inhibitor GDC-0068
    Yibing Yan, Violeta Serra, Ludmila Prudkin, Maurizio Scaltriti, Sumati Murli, Olga Rodríguez, Marta Guzmán, Deepak Sampath, Michelle Nannini, Yuanyuan Xiao et al. · 2013 · Clinical Cancer Research
  88. Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase
    Heather E. Metz, A. McGarry Houghton · 2010 · Clinical Cancer Research
  89. MyPathway Human Epidermal Growth Factor Receptor 2 Basket Study: Pertuzumab + Trastuzumab Treatment of a Tissue-Agnostic Cohort of Patients With Human Epidermal Growth Factor Receptor 2–Altered Advanced Solid Tumors
    Christopher J. Sweeney, John Daniel Hainsworth, Ron Bose, Howard A. Burris, Razelle Kurzrock, Charles Swanton, Claire Frances Friedman, David Robert Spigel, Tania Szado, Katja Schulze et al. · 2023 · Journal of Clinical Oncology
  90. Ethics of Mandatory Research Biopsy for Correlative End Points Within Clinical Trials in Oncology
    Jeffrey M. Peppercorn, Iuliana Shapira, Deborah E. Collyar, Teresa L. Deshields, NU Lin, Ian E. Krop, HANS W. GRUNWALD, Paula N. Friedman, Ann H. Partridge, Richard L. Schilsky et al. · 2010 · Journal of Clinical Oncology
  91. Integrating Molecular Mechanisms and Clinical Evidence in the Management of Trastuzumab Resistant or Refractory HER-2+ Metastatic Breast Cancer
    Hilda Wong, Roland Ching-Yu Leung, Ava Kwong, Joanne Wing Yan Chiu, Raymond Hin-Suen Liang, Charles Swanton, Thomas C. C. Yau · 2011 · The Oncologist
  92. The PTEN tumor suppressor gene and its role in lymphoma pathogenesis
    Xiaoxiao Wang, Huiqiang Huang, Ken H. Young · 2015 · Aging
  93. Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial
    Wenhao Shi, Tingting Jiang, Paolo Giovanni Nuciforo, Christos Hatzis, Eileen McCormick Holmes, Nadia Harbeck, Christos Sotiriou, L. Peña, Sherene Loi, Daniela D. Rosa et al. · 2016 · Annals of Oncology
  94. HER2-positive breast cancer is lost in translation: time for patient-centered research
    Isabelle Gingras, Géraldine Gebhart, Evandro de Azambuja, Martine J Piccart · 2017 · Nature Reviews Clinical Oncology
  95. Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers
    Bowen Sun, Seth Mason, Robert C. Wilson, E. Starr Hazard, Yubao Wang, Rong Fang, Qiwei Wang, Elizabeth Shinmay Yeh, Meixiang Yang, Thomas M. Roberts et al. · 2019 · Oncogene
  96. PTEN Deficiency in a Luminal ErbB-2 Mouse Model Results in Dramatic Acceleration of Mammary Tumorigenesis and Metastasis
    Babette Schade, Trisha Rao, Nathalie Dourdin, Robert Lesurf, Michael T. Hallett, Robert D. Cardiff, William J. Muller · 2009 · Journal of Biological Chemistry
  97. Optimal targeting of the mTORC1 kinase in human cancer
    Heidi A. Lane, Madlaina Breuleux · 2009 · Current Opinion in Cell Biology
  98. Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cells.
    Peter P. Sordillo, Lawrence Helson · 2015 · PubMed
  99. Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment
    Sílvia Cufí, Alejandro Vázquez‐Martín, Cristina Oliveras‐Ferraros, Bruna Corominas-Faja, Ander Urruticoechea, Begoña Martı́n-Castillo, Javier Abel Menéndez · 2012 · Oncotarget
  100. Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer
    Jasper Mullenders, René Bernards · 2009 · Oncogene