Recent developments on 3-hydroxy-4-pyridinones with respect to their clinical applications
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Even though deferiprone has a C log P value of 1.4, which is too negligible to cross the blood-brain barrier, its low molecular weight and suitable structure render it relatively easy to optimize, and it has been used as a lead compound in the development of multi-target directed ligands for the treatment of Alzheimer's disease.
“Even though DFP has a C log P value of 1.4, which is too negligible to cross the BBB, its low molecular weight as well as its suitable structure render it relatively easy to optimize, and it has been used as a lead compound in the development of multi-target directed ligands (MTDL) for the treatment of AD (Santos 2008).”
From An update on the novel and approved drugs for Alzheimer disease (2022) · cites this paper as Santos 2008
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“4, which is too negligible to cross the BBB, its low molecular weight as well as its suitable structure render it relatively easy to optimize, and it has been used as a lead compound in the development of multi-target directed ligands (MTDL) for the treatment of AD (Santos 2008).”
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Gama, S., Dron, P. I., Chaves, S., Farkas, E., & Santos, M. A. (2009) · Dalton Transactions · doi:10.1039/b904950a · Cited by 21 · see citing works
Synthesis and intestinal transport of the iron chelator maltosine in free and dipeptide form
Geißler, S., Hellwig, M., Markwárdt, F., Henle, T., & Brandsch, M. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.12.032 · Cited by 21 · see citing works
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Protonation and lanthanide(iii) complexation equilibria of a new tripodal polyaza-polycatechol-amine
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Chaves, S., Capelo, A., Areias, L. R. P., Marques, S. M., Gano, L., Esteves, M. A., & Santos, M. A. (2012) · Dalton Transactions · doi:10.1039/c2dt32361c · Cited by 15 · see citing works
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Irto, A., Cardiano, P., Chand, K., Cigala, R. M., Crea, F., Stefano, C. D., Gano, L., Gattuso, G., Sammartano, S., & Santos, M. A. (2018) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2018.09.107 · Cited by 15 · see citing works
Chaves, S., Dron, P. I., Danalache, F. A., Sacoto, D., Gano, L., & Santos, M. A. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.07.026 · Cited by 14 · see citing works
Hanif, M., Meier, S. M., Adhireksan, Z., Henke, H., Martić, S., Movassaghi, S., Labib, M., Kandioller, W., Jamieson, S. M. F., Hejl, M., et al. (2017) · ChemPlusChem · doi:10.1002/cplu.201700050 · Cited by 14 · see citing works
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New hydroxypyridinone-functionalized sepharoses as sorbing agents for hard metal ions
Grazina, R., & Santos, M. A. (2010) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2010.12.084 · Cited by 10 · see citing works
The Literature of Heterocyclic Chemistry, Part XI, 2008–2009
Belen’kii, L. I., & Evdokimenkova, Y. B. (2012) · Advances in heterocyclic chemistry · doi:10.1016/b978-0-12-404598-9.00003-1 · Cited by 10 · see citing works
Aluminium, gallium, indium and thallium
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Synthesis and characterization of a new 4-pyridone derivative and its complexation of iron(III)
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Epoxidation of strained alkenes catalysed by (1,2-dimethyl-4(1H)pyridinone-3-olate)2MnIIICl
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Coordination and solution chemistry of the metals: biological, medical and environmental relevance.
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Defined and refined: development of a minimal medium for Clostridium pasteurianum
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- Authors
- Santos, M. A.
- Affiliations
- Instituto Superior Técnico (PT)
- Corresponding author
- Santos, M. Amélia
- ORCID
- Santos, M. Amélia
- Venue
- Coordination Chemistry Reviews
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 252
- Issue
- 10-11
- Pages
- 1213-1224
- ISSN
- 0010-8545 (ISSN-L)
- OpenAlex
- W63653538
- Cited by
- 54
- References
- 85
- Citations by year
- 2025: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Coordination Chemistry Reviews (publishedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Keywords
- iron chelators, iron overload, lipophilicity, gallium-67, organ distribution, metal excretion
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