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Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
Open accessAbstract
Glioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by glioma stem cells (GSCs). Because hypoxia regulates angiogenesis, we examined hypoxic responses in GSCs. We now demonstrate that hypoxia-inducible factor HIF2alpha and multiple HIF-regulated genes are preferentially expressed in GSCs in comparison to non-stem tumor cells and normal neural progenitors. In tumor specimens, HIF2alpha colocalizes with cancer stem cell markers. Targeting HIFs in GSCs inhibits self-renewal, proliferation, and survival in vitro, and attenuates tumor initiation potential of GSCs in vivo. Analysis of a molecular database reveals that HIF2A expression correlates with poor glioma patient survival. Our results demonstrate that GSCs differentially respond to hypoxia with distinct HIF induction patterns, and HIF2alpha might represent a promising target for antiglioblastoma therapies.
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“Since HIF-2α is strongly expressed in the cytoplasm of NB tumor cells at physiological oxygen levels (5% O2), this could suggest additional largely unexplored functions of HIF-2α in the cytoplasm, independent of HIF-1β-dependent transcription, such as regulation of mRNA translation [9,43].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [43]
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“In NB clinical specimens, HIF-1α expression negatively correlates with the presence of blood vessels indicating that HIF-1α is expressed exclusively in hypoxic cells [43].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [43]
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“However, HIF-2α is located in dense clusters of cells adjacent to blood vessels, referred to as the perivascular niche, which have a neural crest-like phenotype, and are HIF-1α negative, suggesting they are not hypoxic [43].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [43]
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“However, treatment with PT2385 had no effect on tumor growth, did not impact transcription of HIF target genes and did not modulate chemotherapy response [43].”
From Revisiting the HIF switch in the tumor and its immune microenvironment. (2022) · cites this paper as [43]
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“Given that HIF-2α is an important transcription factor in cancer progression and leads to poor prognosis69,70”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [70]
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“Hypoxia was first shown to induce the CSC phenotype in glioma [77] and, subsequently, in breast cancer [78, 79], in a HIF-dependent manner.”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [77]
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Citations
Cites
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Identification of human brain tumour initiating cells
Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,564
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., & Rich, J. N. (2006) · Nature · doi:10.1038/nature05236 · Cited by 6,517
Self-citationHypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma
Galli, R., Binda, E., Orfanelli, U., Cipelletti, B., Gritti, A., Vitis, S. D., Fiocco, R., Foroni, C., DiMeco, F., & Vescovi, A. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1364 · Cited by 2,570
Plate, K. H., Breier, G., Weich, H. A., & Risau, W. (1992) · Nature · doi:10.1038/359845a0 · Cited by 2,262
A Perivascular Niche for Brain Tumor Stem Cells
Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,253
Hypoxia in cancer: significance and impact on clinical outcome
Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
Liu, G., Yuan, X., Zeng, Z., Tunici, P., Ng, H., Abdulkadir, I. R., Lu, L., Irvin, D. K., Black, K. L., & Yu, J. S. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-67 · Cited by 1,844
Cancerous stem cells can arise from pediatric brain tumors
Hemmati, H. D., Nakano, I., Lazareff, J. A., Masterman-Smith, M. D., Geschwind, D. H., Bronner-Fraser, M. E., & Kornblum, H. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2036535100 · Cited by 1,842
Cited by
Sorted by citations
Items 701–800 of 1,000
Soeda, A., Lathia, J. D., Williams, B. J., Wu, Q., Gallagher, J., Androutsellis‐Theotokis, A., Giles, A. J., Yang, C., Zhuang, Z., Gilbert, M. R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16741 · Cited by 29
Self-citationMills, B. N., Albert, G. P., & Halterman, M. W. (2017) · Cancer Microenvironment · doi:10.1007/s12307-017-0197-6 · Cited by 29
Bogeas, A., Morvan-Dubois, G., El-Habr, E. A., Lejeune, F., Defrance, M., Narayanan, A., Kuranda, K., Burel‐Vandenbos, F., Sayd, S., Delaunay, V., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1783-x · Cited by 29
Nishikawa, M., Inoue, A., Ohnishi, T., Yano, H., Ozaki, S., Kanemura, Y., Matsumoto, S., Suehiro, S., Ohtsuka, Y., Kohno, S., et al. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101137 · Cited by 29
Huang, H., Shah, H., Jing, H., Lin, J., Prayson, R. A., Xie, L., Bao, S., Chakraborty, A. A., Jankowsky, E., Zhao, J., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae036 · Cited by 28
Self-citationChoi, S. A., Wang, K., Phi, J. H., Lee, J. Y., Park, C., Park, S., & Kim, S. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.05.026 · Cited by 28
Lima, L., Gaiteiro, C., Peixoto, A., Soares, J., Neves, M., Santos, L. L., & Ferreira, J. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166120 · Cited by 28
Li, C., Liu, T., Bazhin, A. V., & Yang, Y. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25726 · Cited by 29
Novel lncRNA-ZNF281 regulates cell growth, stemness and invasion of glioma stem-like U251s cells
Li, X. T., Li, J. C., Feng, M., Zhou, Y., & Du, Z. (2018) · Neoplasma · doi:10.4149/neo_2018_180613n391 · Cited by 28
Fu, D., Wang, L., Chouairi, F. K., Rose, I. M., Abetov, D. A., Miller, A. D., Yamulla, R. J., Schimenti, J. C., Flesken‐Nikitin, A., & Nikitin, A. Y. (2020) · Nature Communications · doi:10.1038/s41467-019-13847-2 · Cited by 29
Endothelial Progenitors in the Tumor Microenvironment
Testa, U., Pelosi, E., & Castelli, G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-44518-8_7 · Cited by 28
Erçelik, M., Tekin, Ç., Tezcan, G., Aksoy, S. A., Bekâr, A., Kocaelı, H., Taşkapılıoğlu, M. Ö., Ocak, P. E., & Tunca, B. (2023) · Life · doi:10.3390/life13020470 · Cited by 28
ZHU, X. Y., Wang, L., LUAN, S. H., ZHANG, H. S., Huang, W., & WANG, N. H. (2014) · Neoplasma · doi:10.4149/neo_2014_049 · Cited by 28
Wang, D., Berglund, A., Kenchappa, R. S., Macaulay, R. J. B., Mulé, J. J., & Etame, A. B. (2017) · Scientific Reports · doi:10.1038/s41598-017-09503-8 · Cited by 31
Krawczynski, K., Godlewski, J. A., & Bronisz, A. (2020) · Antioxidants · doi:10.3390/antiox9080747 · Cited by 27
Arienti, C., Pignatta, S., Zanoni, M., Zamagni, A., Cortesi, M., Sarnelli, A., Romeo, A., Arpa, D., Longobardi, P., Bartolini, D., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.02.019 · Cited by 27
Giles, B., Nakhjavani, M., Wiesa, A., Knight, T., Shigdar, S. L., & Samarasinghe, R. M. (2023) · Cancers · doi:10.3390/cancers15174376 · Cited by 27
Rouault‐Pierre, K., Hamilton, A., & Bonnet, D. A. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1133582 · Cited by 29
MicroRNAs as Multifaceted Players in Glioblastoma Multiforme
Mercatelli, N., Galardi, S., & Ciafrè, S. A. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.03.002 · Cited by 27
GBM radiosensitizers: dead in the water…or just the beginning?
Bindra, R. S., Chalmers, A. J., Evans, S. M., & Dewhirst, M. W. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2427-7 · Cited by 28
Bai, C., Liu, X., Qiu, C., & Zheng, J. (2018) · Gastric Cancer · doi:10.1007/s10120-018-0846-6 · Cited by 27
Treatment and management of malignant gliomas
Park, D. M., Sathornsumetee, S., & Rich, J. N. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.221 · Cited by 27
Self-citationNanocarrier-mediated drugs targeting cancer stem cells: an emerging delivery approach
Malhi, S. S., & Gu, X. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.998648 · Cited by 26
Solari, N. E. F., Belforte, F. S., Canedo, L., Videla-Richardson, G. A., Espinosa, J. M., Rossi, M., Serna, E., Riudavets, M. A., Martinetto, H., Sevlever, G. E., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3159 · Cited by 26
Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma through miR-210 delivery
Kling, M. J., Chaturvedi, N. K., Kesherwani, V., Coulter, D. W., McGuire, T. R., Sharp, J. G., & Joshi, S. S. (2020) · Oncotarget · doi:10.18632/oncotarget.27702 · Cited by 26
A vasculature-centric approach to developing novel treatment options for glioblastoma
Wirsching, H., Roth, P., & Weller, M. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1881062 · Cited by 26
Multiple Faces of the Glioblastoma Microenvironment
Șovrea, A. S., Boșca, B., Melincovici, C. S., Constantin, A.-M., Crintea, A., Mărginean, M., Dronca, E., Jianu, M. E., Suflețel, R., Gonciar, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020595 · Cited by 26
Glioblastoma Microenvironment: From an Inviolable Defense to a Therapeutic Chance
Nunno, V. D., Franceschi, E., Tosoni, A., Gatto, L., Bartolini, S., & Brandes, A. A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.852950 · Cited by 28
Qi, L., Bellail, A. C., Rossi, M. R., Zhang, Z., Pang, H., HUNTER, S. B., Cohen, C., Moreno, C. S., Olson, J. J., Li, S., et al. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0645-6 · Cited by 26
Beltrán-Povea, A. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i3.605 · Cited by 27
Nanoparticles for Targeting Intratumoral Hypoxia: Exploiting a Potential Weakness of Glioblastoma
Aldea, M. D., Florian, I. A., Kacsó, G., Craciun, L., Boca, S., Şoriţău, O., & Florian, I. Ş. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1947-8 · Cited by 26
MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer
Cui, J., Duan, B., Zhao, X., Chen, Y., Sun, S., Deng, W., Zhang, Y., Du, J., Chen, Y., & Gu, L. (2016) · Tumor Biology · doi:10.1007/s13277-016-5237-1 · Cited by 28
A Transgenic Mouse Model of Pacak–Zhuang Syndrome with An Epas1 Gain-of-Function Mutation
Wang, H., Cui, J., Yang, C., Rosenblum, J. S., Zhang, Q., Song, Q., Pang, Y. K., Fang, F. Y., Sun, M., Dmitriev, P., et al. (2019) · Cancers · doi:10.3390/cancers11050667 · Cited by 26
Self-citationTherapeutic potential of targeting glucose metabolism in glioma stem cells
Nakano, I. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.944899 · Cited by 26
Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness
Niechi, I., Uribe-Ojeda, A., Erices, J. I., Torres, Á., Uribe, D., Rocha, J. D., Silva, P., Richter, H. G., Martín, R. S., & Quezada, C. (2019) · Cells · doi:10.3390/cells8111353 · Cited by 25
Shen, Q., Hill, T., Cai, X., Bui, L., Barakat, R., Hills, E., Almugaiteeb, T., Babu, A., McKernan, P., Zalles, M., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.01.020 · Cited by 25
A Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas
Jandrey, E. H. F., Bezerra, M., Inoue, L. T., Furnari, F. B., Camargo, A. A., & Costa, É. T. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.652133 · Cited by 27
Transcription Factors with Targeting Potential in Gliomas
Giannopoulou, A.-I., Kanakoglou, D. S., & Piperi, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073720 · Cited by 25
The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer
Nozawa-Suzuki, N., Nagasawa, H., Ohnishi, K., & Morishige, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.053 · Cited by 25
Choi, Y. J., Heo, K., Park, H. S., Yang, K., & Jeong, M. H. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3647 · Cited by 25
Glioblastoma Multiforme and Adult Neurogenesis in the Ventricular‐Subventricular Zone: A Review
Capdevila, C., Rodríguez‐Vázquez, L., & Martı́, J. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25502 · Cited by 25
Wu, C., Gupta, N., Huang, Y.-H., Zhang, H., Alshareef, A., Chow, A., & Lai, R. L. (2018) · BMC Cancer · doi:10.1186/s12885-018-4300-2 · Cited by 26
The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology
Libby, C. J., McConathy, J., Darley-Usmar, V. M., & Hjelmeland, A. B. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1169 · Cited by 25
Self-citationRegulation and dysregulation of astrocyte activation and implications in tumor formation
Yang, C.-Z., Rahimpour, S., Yu, A., Lonser, R., & Zhuang, Z. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1274-8 · Cited by 32
Advancing glioblastoma therapy: Learning from the past and innovations for the future
Rana, M., Liou, K.-C., Thakur, A., Nepali, K., & Liou, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217601 · Cited by 28
Development of a Sox2 reporter system modeling cellular heterogeneity in glioma
Stoltz, K., Sinyuk, M., Hale, J. S., Wu, Q., Otvos, B., Walker, K. D., Vasanji, A., Rich, J. N., Hjelmeland, A. B., & Lathia, J. D. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou320 · Cited by 24
Self-citationYamada, K., Tso, J. L., Ye, F., Choe, J., Liu, Y., Liau, L. M., & Tso, C.-L. (2011) · Cancers · doi:10.3390/cancers3021975 · Cited by 24
Park, K. J., Kim, J., Testoff, T. T., Adams, J. R., Poklar, M., Zborowski, M., Venere, M., & Chalmers, J. J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26973 · Cited by 24
Waker, C. A., & Lober, R. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9636-7_18 · Cited by 24
Anti-angiogenic therapies in the management of glioblastoma
Schulte, J. D., Aghi, M. K., & Taylor, J. W. (2020) · Chinese Clinical Oncology · doi:10.21037/cco.2020.03.06 · Cited by 24
Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis
Batara, D. C., Choi, M., Shin, H.-U., Kim, H., & Kim, S.-H. (2021) · Cells · doi:10.3390/cells10061411 · Cited by 24
Scherschinski, L., Prem, M., Kremenetskaia, I., Tinhofer, I., Vajkoczy, P., Karbe, A.-G., & Onken, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020982 · Cited by 24
Chen, S., Zhao, H., Deng, J., Liao, P., Xu, Z., & Cheng, Y. Z. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24626 · Cited by 24
Zhang, S., Luo, X., Wan, F., & Lei, T. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0879-x · Cited by 27
Corno, D., Pala, M., Cominelli, M., Cipelletti, B., Leto, K., Croci, L., Barili, V., Brandalise, F., Melzi, R., Gregorio, A. D., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0199 · Cited by 24
Glioma Stem Cells and Immunotherapy for the Treatment of Malignant Gliomas
Toda, M. (2013) · ISRN Oncology · doi:10.1155/2013/673793 · Cited by 24
Glioblastoma stem-like cells: approaches for isolation and characterization
Molina, E. D. S., Pillat, M. M., Moura‐Neto, V., Lah, T. T., & Ulrich, H. (2014) · Journal of Cancer Stem Cell Research · doi:10.14343/jcscr.2014.2e1007 · Cited by 26
Hypoxia-induced EPHB2 promotes invasive potential of glioblastoma.
Qiu, W., Song, S., Chen, W., Zhang, J., Yang, H., & Chen, Y. (2019) · Europe PMC (PubMed Central) · Cited by 24
Espinoza, F. I., Tankov, S., Chliate, S., Couto, J. P., Marinari, E., Vermeil, T., Lecoultre, M., Harane, N. E., Dutoit, V., Migliorini, D., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05642-8 · Cited by 25
Understanding the role of tumor stem cells in glioblastoma multiforme: a review article
Fatoo, A., Nanaszko, M. J., Allen, B. B., Mok, C. L., Bukanova, E. N., Beyene, R. T., Moliterno, J. A., & Boockvar, J. A. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0406-3 · Cited by 23
Yu, Y., Chen, C., Huo, G., Deng, J., Zhao, H., Xu, R. C., Li, J., Chen, S., & Wang, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00320 · Cited by 23
Molecular modulation of autophagy: New venture to target resistant cancer stem cells
Mandhair, H. K., Arambasic, M., Novak, U., & Radpour, R. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i5.303 · Cited by 23
TRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion
Zhang, Q., Zheng, J., Wu, W., Lian, H., Iranzad, N., Wang, E., Yang, L., Wang, X., & Jiang, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05702-6 · Cited by 23
Tumor Niches: Perspectives for Targeted Therapies in Glioblastoma
Srivastava, R., Dodda, M., Zou, H., Li, X., & Hu, B. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0187 · Cited by 23
Exploiting Metabolic Differences in Glioma Therapy
Galeffi, F., & Turner, D. A. (2012) · Current Drug Discovery Technologies · doi:10.2174/157016312803305906 · Cited by 23
How do tumor stem cells actively escape from host immunosurveillance?
Qi, Y., Li, R.-M., Kong, F.-M., Li, H. Z., Yu, J.-P., & Ren, X.-B. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.086 · Cited by 23
A Cancer Stem Cell Potent Cobalt(III)–Cyclam Complex Bearing Two Tolfenamic Acid Moieties
Cressey, P., Eskandari, A., & Suntharalingam, K. (2017) · Inorganics · doi:10.3390/inorganics5010012 · Cited by 23
Regulation of T cell antitumor immune response by tumor induced metabolic stress
Chalmin, F., Bruchard, M., Végran, F., & Ghiringhelli, F. (2019) · Cell Stress · doi:10.15698/cst2019.01.171 · Cited by 23
Qiu, G., Liu, Q., Wang, X.-G., Xu, G.-Z., Zhao, T., & Lou, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117438 · Cited by 24
Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies
Sokolov, A. V., Dostdar, S. A., Attwood, M. M., Krasilnikova, A. A., Ilina, A. A., Nabieva, A. S., Lisitsyna, A. A., Chubarev, V. N., Tarasov, V. V., & Schiöth, H. B. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000317 · Cited by 27
Liang, Y., ZHOU, C., Wang, B., Chen, T., Xu, M., Xu, L., & Feng, H. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1962 · Cited by 23
Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors
Muñoz-Galván, S., Verdugo‐Sivianes, E. M., Santos-Pereira, J. M., Estévez-García, P., & Carnero, A. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-02988-y · Cited by 24
Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities
Zhang, J., Jinan, Z., & Chen, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06063-0 · Cited by 24
Chiang, J.-H., Cheng, W.-S., Hood, L., & Tian, Q. (2014) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2013.0084 · Cited by 23
Epigenetic regulation in adult stem cells and cancers
Tarayrah, L., & Chen, X. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-41 · Cited by 22
TLX controls angiogenesis through interaction with the von Hippel-Lindau protein
Zeng, Z.-J., Johansson, E., Hayashi, A., Chavali, P. L., Akrap, N., Yoshida, T., Kohno, K., Izumi, H., & Funa, K. (2012) · Biology Open · doi:10.1242/bio.2012893 · Cited by 22
Park, S. J., Kim, H., Kim, S. H., Joe, E.-H., & Jou, I. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0798-z · Cited by 22
The potential of advanced MR techniques for precision radiotherapy of glioblastoma
Tang, P. L. Y., Romero, A. M., Jaspers, J. P. M., & Warnert, E. A. H. (2022) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-021-00997-y · Cited by 22
ADAR3 activates NF-κB signaling and promotes glioblastoma cell resistance to temozolomide
Kurup, R. R., Oakes, E. K., Vadlamani, P., Nwosu, O. I., Danthi, P., & Hundley, H. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-17559-4 · Cited by 22
Non-coding RNAs and glioma: Focus on cancer stem cells
Rajabi, A., Kayedi, M., Rahimi, S., Dashti, F., Mirazimi, S. M. A., Homayoonfal, M., Mahdian, S. M. A., Hamblin, M. R., Tamtaji, O. R., Afrasiabi, A., et al. (2022) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2022.09.005 · Cited by 22
Aggressive invasion is observed in CD133−/A2B5+ glioma-initiating cells
Sun, T., Chen, G., Li, Y., Xie, X., Zhou, Y., & Du, Z. (2015) · Oncology Letters · doi:10.3892/ol.2015.3823 · Cited by 22
Suppression of Glioma Progression by Egln3
Sciorra, V. A., Sanchez, M. A., Kunibe, A., & Wurmser, A. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040053 · Cited by 23
Biologically Targeted Therapeutics in Pediatric Brain Tumors
Rao, A. A. N., Scafidi, J., Wells, E. M., & Packer, R. J. (2012) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2012.02.005 · Cited by 22
Hypoxia‐inducible factors – regulation, role and comparative aspects in tumourigenesis
Hansen, A. E., Kristensen, A. T., Law, I. G., Jørgensen, J. T., & Engelholm, S. A. (2010) · Veterinary and Comparative Oncology · doi:10.1111/j.1476-5829.2010.00233.x · Cited by 23
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Kulkarni, S., Goel-Bhattacharya, S., Sengupta, S., & Cochran, B. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0146 · Cited by 24
Mehrabi, M., Amini, F., & Mehrabi, S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00235 · Cited by 24
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Dalloul, A. H. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-508-8_17 · Cited by 22
Haynes, J., McKee, T. D., Haller, A., Wang, Y., Leung, C., Gendoo, D. M. A., Lima-Fernandes, E., Kreso, A., Wolman, R., Szentgyorgyi, E., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1715 · Cited by 22
Boyd, N., Walker, K. D., Ayokanmbi, A., Gordon, E. R., Whetsel, J., Smith, C. M., Sánchez, R. G., Lubin, F. D., Chakraborty, A., Tran, A. N., et al. (2019) · Stem Cells · doi:10.1002/stem.2969 · Cited by 21
Self-citationAlva, R., Moradi, F., Liang, P., & Stuart, J. A. (2022) · Biomolecules · doi:10.3390/biom12111684 · Cited by 23
Lee, E. Q., & Wen, P. Y. (2010) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2010.04.007 · Cited by 21
Hashimoto, Y., Tazawa, H., Teraishi, F., Kojima, T., Watanabe, Y., Uno, F., Yano, S., Urata, Y., Kagawa, S., & Fujiwara, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039292 · Cited by 24
Wouters, J., Stas, M., Govaere, O., Barrette, K., Dudek, A. M., Vankelecom, H. E. J., Haydu, L. E., Thompson, J. F., Scolyer, R. A., & van den Oord, J. J. (2014) · Modern Pathology · doi:10.1038/modpathol.2013.228 · Cited by 21
Pathological features of highly invasive glioma stem cells in a mouse xenograft model
Sadahiro, H., Yoshikawa, K., Ideguchi, M., Kajiwara, K., Ishii, A., Ikeda, E., Owada, Y., Yasumoto, Y., & Suzuki, M. (2013) · Brain Tumor Pathology · doi:10.1007/s10014-013-0149-x · Cited by 21
Epigenetic mechanisms of tumorigenicity manifesting in stem cells
Tung, P. X., & Knoepfler, P. S. (2014) · Oncogene · doi:10.1038/onc.2014.172 · Cited by 23
Modeling Microenvironmental Regulation of Glioblastoma Stem Cells: A Biomaterials Perspective
Heffernan, J. M., & Sirianni, R. W. (2018) · Frontiers in Materials · doi:10.3389/fmats.2018.00007 · Cited by 21
Zhu, H., Wang, H., Huang, Q., Liu, Q., Guo, Y., Lu, J., Li, X., Xue, C., & Han, Q. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00187 · Cited by 22
Self-citationTarade, D., Lee, J. E., & Ohh, M. (2019) · Nature Communications · doi:10.1038/s41467-019-11149-1 · Cited by 21
Inoue, A., Ohnishi, T., Kohno, S., Ohue, S., Nishikawa, M., Suehiro, S., Matsumoto, S., Ozaki, S., Fukushima, M., Kurata, M., et al. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01258-7 · Cited by 21
Alhaddad, L., Osipov, A. N., & Leonov, S. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113577 · Cited by 21
Metadata
- Authors
- Li, Z., Bao, S., Wu, Q., Wang, H., Eyler, C., Sathornsumetee, S., Shi, Q., Cao, Y., Lathia, J., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N.
- Affiliations
- Duke Medical Center (US)
- Cleveland Clinic (US)
- Corresponding author
- Rich, Jeremy N.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 15
- Issue
- 6
- Pages
- 501-513
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC2693960
- OpenAlex
- W2039075677
- Cited by
- 1,354
- References
- 65
- Citations by year
- 2026: 41 · 2025: 40 · 2024: 49 · 2023: 72 · 2022: 92 · 2021: 98 · 2020: 72 · 2019: 75 · 2018: 74 · 2017: 93 · 2016: 97 · 2015: 97 · 2014: 96 · 2013: 80 · 2012: 101
- FWCI
- 30.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 116659, R01CA116659, CA112958, R01CA129958)
- National Institute of Neurological Disorders and Stroke (K02NS047409, R01NS054276, NS054276, NS047409)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- HIF-2α, glioma stem cells, glioblastoma, hypoxia, angiogenesis, self-renewal, tumor initiation, cancer stem cell markers, patient survival, therapeutic target
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Animals, Brain Neoplasms, Cell Survival, Cells, Cultured, Glioblastoma, Humans, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Neovascularization, Pathologic, Stem Cells, Biomarkers, Tumor, Neoplastic Stem Cells, Cell Hypoxia, Vascular Endothelial Growth Factor A, Cell Proliferation, Mice, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit
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