The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2
Open accessAbstract
SUMMARY Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the αVβ3 integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.
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Cited by
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
Teschendorff, A. E., Menon, U., Gentry-Maharaj, A., Ramus, S. J., Weisenberger, D. J., Shen, H., Campan, M., Noushmehr, H., Bell, C. G., Maxwell, A. P., et al. (2010) · Genome Research · doi:10.1101/gr.103606.109 · Cited by 855
BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
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Development and validation of an immune gene-set based Prognostic signature in ovarian cancer
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Metadata
- Authors
- Mok, S. C., Bonome, T., Vathipadiekal, V., Bell, A., Johnson, M. E., Wong, K.-K., Park, D.-C., Hao, K., Yip, D. K. P., Donninger, H., Ozbun, L., Samimi, G., Brady, J., Randonovich, M., Pise-Masison, C. A., Barrett, J. C., Wong, W. H., Welch, W. R., Berkowitz, R. S., & Birrer, M. J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 16
- Issue
- 6
- Pages
- 521-532
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2101242266
- Cited by
- 255
- References
- 30
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mok, S. C., Bonome, T., Vathipadiekal, V., Bell, A., Johnson, M. E., Wong, K.-K., Park, D.-C., Hao, K., Yip, D. K. P., Donninger, H., Ozbun, L., Samimi, G., Brady, J., Randonovich, M., Pise-Masison, C. A., Barrett, J. C., Wong, W. H., Welch, W. R., Berkowitz, R. S., & Birrer, M. J. (2009). A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2. Cancer Cell. https://doi.org/10.1016/j.ccr.2009.10.018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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