The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation
Open accessAbstract
Summary Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for a large portion of cancer-related deaths worldwide. It is well established that tobacco smoke is a tumor initiator, but we asked whether it also acts as a tumor promoter once malignant initiation, such as caused by K-ras activation, has taken place. Here we demonstrate that repetitive exposure to tobacco smoke promotes tumor development both in carcinogen-treated mice and in transgenic mice undergoing sporadic K-ras activation in lung epithelial cells. Tumor promotion is due to induction of inflammation that results in enhanced pneumocyte proliferation and is abrogated by IKKβ ablation in myeloid cells or inactivation of JNK1.
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Self-citationNF-κB: linking inflammation and immunity to cancer development and progression
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Self-citationIKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
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Immunity, Inflammation, and Cancer
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Self-citationInflammation and cancer: triggers, mechanisms, and consequences
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Self-citationNeutrophils in cancer: Neutral no more
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Metadata
- Authors
- Takahashi, H., Ogata, H., Nishigaki, R., Broide, D. H., & Karin, M.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 17
- Issue
- 1
- Pages
- 89-97
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2121296674
- Cited by
- 438
- References
- 34
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Takahashi, H., Ogata, H., Nishigaki, R., Broide, D. H., & Karin, M. (2010). Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation. Cancer Cell. https://doi.org/10.1016/j.ccr.2009.12.008
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