Nuclear factor-κB in cancer development and progression
Abstract
Nuclear factor-kappaB (NF-kappaB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kappaB signalling also has a critical role in cancer development and progression. NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-kappaB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.
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NF-κB activation drives transcription of genes like Tnfα and Il1, producing proinflammatory cytokines that coordinate inflammation.
“When NF-κB is activated, transcription of proinflammatory immune response genes such as Tnfα and Il1 occurs, which leads to translation and production of proinflammatory cytokines that serve to coordinate the inflammatory response (Karin, 2006).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Karin, 2006
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- Authors
- Karin, M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Karin, Michael
- ORCID
- Karin, Michael
- Venue
- Nature
- Published
- 2006-05
- Volume
- 441
- Issue
- 7092
- Pages
- 431-436
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2315613727
- Cited by
- 3,519
- References
- 71
- Citations by year
- 2026: 60 · 2025: 97 · 2024: 111 · 2023: 118 · 2022: 118 · 2021: 159 · 2020: 162 · 2019: 133 · 2018: 168 · 2017: 149 · 2016: 192 · 2015: 235 · 2014: 203 · 2013: 231 · 2012: 250
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- NF-κB, carcinogenesis, tumor progression, inflammation and cancer, apoptosis resistance, tumor surveillance, tumor angiogenesis, tumour invasiveness, chemoprevention, chemotherapeutic target, NF-κB signaling
- MeSH terms
- Animals, Humans, Inflammation, Liver Neoplasms, Neoplasms, Skin Neoplasms, NF-kappa B, Disease Progression
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