Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

Pancreatic Cancer

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Possible Involvement of Pancreatic Fatty Infiltration in Pancreatic Carcinogenesis

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Cellular Plasticity and Heterogeneity in Pancreatic Regeneration and Malignancy

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Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene–Deficient Mouse Model of Pancreatic Cancer

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Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia

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Pancreatitis promotes oncogenic KrasG12D-induced pancreatic transformation through activation of Nupr1

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Physiologie du pancréas exocrine

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Antimicrobial Peptide Human Neutrophil Peptide 1 as a Potential Link Between Chronic Inflammation and Ductal Adenocarcinoma of the Pancreas

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The Role of Tumor-Associated Macrophages (TAMs) in Tumor Progression

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Correction: Conditional Transgenic Expression of PIM1 Kinase in Prostate Induces Inflammation-Dependent Neoplasia

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Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

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Chemoprevention of Cancer: Past, Present, and Future

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Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice

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Premalignant lesions and cellular senescence

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Cellular Senescence

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Cellular Senescence

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LY6D identifies persistent stem-like cells driving pancreatic tumourigenesis

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Advances in tuft cells, a chemosensory cell in sequential diseases of the pancreas

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Protein kinase D1 — A targetable mediator of pancreatic cancer development

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Malignancies and IgG4‐related disease

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Single-Cell Omics: Strategies Towards Theranostic Biomarker Discovery Along the Continuum of Premalignant to Invasive Disease in Oncology

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Epigenetics in Health and Disease

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Animal Modeling of Pancreatitis-to-Cancer Progression

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Endoscopic Ultrasound-Guided Fine-Needle Biopsies to Generate Preclinical Disease Models to Study Inflammation in Pancreatic Ductal Adenocarcinoma

Lundy, J., & Croagh, D. G. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3331-1_4 · Cited by 1

A Humanized Patient-Derived Xenograft Model for Pancreatic Cancer

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Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma

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Downregulation of Sod2 increases atypical flat lesions and dysplasia to advance pancreatic ductal adenocarcinoma

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Spink1 promotes the survival of Kras-mutant pancreatic acinar cells

Hayashi, H., Hamada, S., Matsumoto, R., Takikawa, T., Xu, Y., Jie, R., Nakasuji, H., Abe, T., Kikuta, K., Motohashi, H., et al. (2026) · Pancreatology · doi:10.1016/j.pan.2026.03.014 · Cited by 1

Dissecting histological transformation

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Regulatory elements in the Sox9 locus license the initiation of pancreatic ductal adenocarcinoma

Ballester, M., Kurilla, A., Dai, Y., Bergara-Muguruza, L., Radke, K., Maurer, H. C., Espinet, E., Høj, K., Marisch-Delgado, A., Seymour, P. A., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117176 · Cited by 2

Improving the Outcomes: Developing Cancer Therapeutics

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Risk Factors for Pancreatic Cancer: Underlying Mechanisms and Potential Targets

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RalGAP complexes control secretion and primary cilia in pancreatic disease

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Pancreatic cancer vaccine: a unique potential therapy

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Animal Modeling of Pancreatitis-to-Cancer Progression

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Dexamethasone Inhibits Cytokine-Induced, DUOX2-Related VEGF-A Expression and DNA damage in Human Pancreatic Cancer Cells and Growth of Pancreatic Cancer XenograftsPreprint

Wu, Y., Konaté, M. M., Hollingshead, M. G., Karim, B. O., Diebold, B. A., Lu, J., Antony, S., Meitzler, J. L., Juhasz, A. N., Jiang, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.13.480277 · Cited by 1

From Tissue Turnover to the Cell of Origin of Pancreatic Cancer

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Population dynamics after pancreatitis dictates long-lasting epigenetic reprogramming and mediates tumor predispositionPreprint

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Pancreatic Inflammation and Carcinogenesis

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High-fat diet imprints a macrophage-tumor CAMP-P2RX7 axis driving pancreatic cancer initiation, plasticity and metastasisPreprint

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Active, Dormant, or on the Path to Elimination: What Does a Senescent Cell Do?

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The Biology of K-Ras Signaling Pathways in Pancreatic Cancer

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Chronic Pancreatitis as an Inductor of Pancreatic Cancer — Correlations With Inflammatory Pathways

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Stem Cells and Pancreatic Cancer

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The Molecular Frame of Pancreatic Carcinogenesis

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Neuroplastic changes in a mouse model of pancreatic ductal adenocarcinoma

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Mouse Models of Cancer

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Energy balance modulation and pancreatic tumor growth : the role of NF-kB

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Pancreatic Cancer Stem Cells

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Analysis of Transplanted Bone Marrow-Derived Cells in Chronic Pancreatitis

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Genetic Susceptibility and Risk of Pancreatic Cancer

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Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression

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膵癌：発生・進展の分子機構

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Signaling and Chromatin Networks in Cancer Biology

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Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer

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Disruptive chemicals, senescence and immortality

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L’inflammation générée par les pancréatites contribue à la formation d’adénocarcinomes pancréatiques

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DNA Mismatch Repair Dependent Damage Response in Human Pluripotent Stem Cells and Intestinal Organoids

Lin, B. (2017) · OpenCommons at University of Connecticut (University of Connecticut)

Elucidating the role of SMAD7 in pancreatic cancer through in vivo studies

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Caracterização de alvos moleculares em tumores associados ao Papilomavírus Humano

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Borderline and locally advanced pancreatic cancer : redefining the biological and technical profile of the disease

Rangelova, E. B. (2019) · Figshare

Role of stromal SPARC in PDAC tumorigenesis and drug delivery

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Combating pancreatic cancer during its Rip Van Winkle sleep

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MicroRNAs as bile-based biomarkers for pancreatic and biliary-tract cancers

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A Case of Ectopic Pancreatic Cancer in the Stomach after Recurrent Phlegmonous Gastritis

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Tracing tumor evolution and subtype specification in pancreatic cancerPreprint

Rajbhandari, N., Hamilton, M., Quintero, C. M., Ferguson, L. P., Fox, R., Schürch, C. M., Wang, J., Nakamura, M., McDermott, M. L., Pettit, H. W., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-101578/v1

Cancer Microenvironments as Therapeutic Targets

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Occurrence of Malignant Neoplasms

Shimizu, K. (2014) · Springer eBooks · doi:10.1007/978-3-642-55086-7_26

Faculty Opinions recommendation of EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

Offringa, R. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717956882.793461428

Mouse Models of Cancer

Ikehara, Y. (2014) · Springer eBooks · doi:10.1007/978-4-431-54841-6_194

Mouse Models of Cancer

Ikehara, Y., Yamaguchi, T., & Ikehara, S. K. (2014) · Springer eBooks · doi:10.1007/978-4-431-54836-2_194-1

Faculty Opinions recommendation of Cell of origin influences pancreatic cancer subtype.

Sosa‐Pineda, B. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.739647870.793585324

Faculty Opinions recommendation of Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.

Sosa‐Pineda, B., & Martínez-Ramírez, A. S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737383506.793574902

Efeito da modulação de DUSP11 na sensibilização à gemcitabina em linhagens celulares de adenocarcinoma ductal pancreático

Santos, V. S. (2018) · doi:10.11606/d.17.2018.tde-29092022-092407

The Loss of the E3 ubiquitin ligase TRIP12 inhibits Pancreatic Acinar Cell Plasticity and Tumor Cell Metastatic CapacityPreprint

Brunet, M., Vargas, C., Fanjul, M., Pieruccioni, L., Varry, D., Labrousse, G., Lulka, H., Capilla, F., Couvelard, A., Gigoux, V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.08.531649

Data from ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Urosevic, J., Blasco, M. T., Lope, A. L., Bellmunt, A., Berenguer, A., Guiu, M., Cañellas-Socias, A., Fernández, E., Burkov, I., Clapés, M., et al. (2023) · doi:10.1158/0008-5472.c.6512596.v1

Data from Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A

Zhao, Y., Wu, Z., Chanal, M., Guillaumond, F., Goehrig, D., Bachy, S., Principe, M., Ziverec, A., Flaman, J., Collin, G., et al. (2023) · doi:10.1158/0008-5472.c.6511539.v1

Data from Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence

Garnett, S., de Bruyns, A., Provencher-Tom, V., Dutchak, K., Shu, R., & Dankort, D. L. (2023) · doi:10.1158/1541-7786.c.6545253

Data from Cell of Origin Influences Pancreatic Cancer Subtype

Flowers, B. M., Xu, H., Mulligan, A. S., Hanson, K. J., Seoane, J. A., Vogel, H. S., Curtis, C. N., Wood, L. D., & Attardi, L. D. (2023) · doi:10.1158/2159-8290.c.6547895.v1

Data from MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway

Dutchak, K., Garnett, S., Nicoll, M., de Bruyns, A., & Dankort, D. L. (2023) · doi:10.1158/1541-7786.c.6545418.v1

Data from Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence

Garnett, S., de Bruyns, A., Provencher-Tom, V., Dutchak, K., Shu, R., & Dankort, D. L. (2023) · doi:10.1158/1541-7786.c.6545253.v1

Biology of Cancer

Alsiary, R., Katouah, H. A., Al-Amodi, H. S. A. B., & Al-Toub, M. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815080384123010007

A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotypePreprint

Söderqvist, S., Viljamaa, A., Geyer, N., Strell, C., Hekmati, N., Engstrand, J., Sparrelid, E., Salmén, C., Heuchel, R. L., Zacharouli, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.14.584614

Additional file 3 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13551075

Additional file 4 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13551078

Additional file 2 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13551072

Relationship of pancreatitis to pancreatic cancer: from population-based observations to preclinical and mechanistic insights

Zhang, X., Chen, Z., Zhao, X. H., Pan, J., Pandol, S. J., & Li, W. (2024) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000188

On the Effects of Gene Mutations in Pancreatic Tumorigenesis, Depending on the Cell Types and Times When They Are Induced

Jacquemin, P. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101394

KRAS-driven cancer models for in vivo pharmacology and drug discovery

Chugh, S., Dow, L. E., Singh, M., & Aguirre, A. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21861-3.00004-8

Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular OriginPreprint

Zoi, I., Rajput, M., Holguín-Horcajo, A., Haidar, M., Brusa, D., Chu, K., Xie, J., Shields, M. A., Ferreira, S., Stanger, B. Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.07.642043

Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinomaPreprint

Ballester, M., Kurilla, A., Dai, Y., Maurer, H. C., Espinet, E., Høj, K., Delgado, A. M., Seymour, P. A., Omar, S., Rift, C. V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.06.658264

Inflammation and Cancer

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