The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
Open accessAbstract
Pancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the most robust oncogenic insults including expression of K-Ras oncogenes and loss of p16Ink4a/p19Arf or Trp53 tumor suppressors. Yet, these acinar cells yield pancreatic intraepithelial neoplasias (mPanIN) and ductal adenocarcinomas (mPDAC) if exposed to limited bouts of non-acute pancreatitis, providing they harbor K-Ras oncogenes. Pancreatitis contributes to tumor progression by abrogating the senescence barrier characteristic of low-grade mPanINs. Attenuation of pancreatitis-induced inflammation also accelerates tissue repair and thwarts mPanIN expansion. Patients with chronic pancreatitis display senescent PanINs, providing they have received antiinflammatory drugs. These results support the concept that antiinflammatory treatment of people diagnosed with pancreatitis may reduce their risk of developing PDAC.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Tumor development in adult mice, however, can be greatly accelerated by chemically induced pancreatitis.”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [81]
In the citing paper
“Thus, inflammatory signaling is likely to play a critical role in pancreatic cancer development (80, 81).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [81]
In the citing paper
“pancreatic acinar cells, in which Kras-G12V is activated during adulthood, exhibit a low frequency of PanIN development and resistance to transformation, at least in part due to OIS 118”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [118]
In the citing paper
“episodic pancreatitis induced by caerulein, a decapeptide analog of the gastrointestinal peptide hormone cholecystokinin, inhibited the OIS program, thus facilitating malignant transformation in this model 118”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [118]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Hidalgo, M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0901557 · Cited by 2,570
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753
Rothwell, P. M., Fowkes, F. G. R., Belch, J. F., Ogawa, H., Warlow, C. P., & Meade, T. W. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62110-1 · Cited by 1,497
Senescence in premalignant tumours
Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482
Self-citationGuerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224
Self-citationSenescence in tumours: evidence from mice and humans
Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124 · cited 4×
“The Senescence Program Present in Low-Grade mPanIN Is Abrogated during Progression to High-Grade mPanIN Lesions Metaplasias and low-grade mPanINs observed in mice expressing K-RasG12V since embryonic development display senescence markers similar to those present in preneoplastic stages of other tumor types (Collado a…”
BackgroundInfluentialSelf-citation
Cited by
Sorted by citations
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632
Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681
EMT and Dissemination Precede Pancreatic Tumor Formation
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774
Signaling in innate immunity and inflammation
Newton, K., & Dixit, V. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006049 · Cited by 1,513
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265
Cellular Senescence: Aging, Cancer, and Injury
Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019) · Physiological Reviews · doi:10.1152/physrev.00020.2018 · Cited by 1,270
The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities
Ho, W. J., Jaffee, E. M., & Zheng, L. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0363-5 · Cited by 1,328
Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
Schwitalla, S., Fingerle, A. A., Cammareri, P., Nebelsiek, T., Göktuna, S. İ., Ziegler, P. K., Canli, Ö., Heijmans, J., Huels, D. J., Moreaux, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.12.012 · Cited by 1,098
Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
Buscail, L., Bournet, B., & Cordelier, P. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0245-4 · Cited by 721
Cancer-related inflammation: Common themes and therapeutic opportunities
Balkwill, F. R., & Mantovani, A. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.005 · Cited by 701
EGF Receptor is Required for KRAS-induced Pancreatic Tumorigenesis
Ardito, C. M., Grüner, B., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P., DelGiorno, K. E., Carpenter, E. S., Halbrook, C., Hall, J. C., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.07.024 · Cited by 522
Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts
Trinchieri, G. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075008 · Cited by 522
Genetically engineered mouse models in oncology research and cancer medicine
Kersten, K., de Visser, K. E., van Miltenburg, M. H., & Jonkers, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606857 · Cited by 502
Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance
Sherman, M. H., & Beatty, G. L. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031621-024600 · Cited by 501
Inflammation-induced DNA damage, mutations and cancer
Kay, J. E., Thadhani, E., Samson, L. D., & Engelward, B. P. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102673 · Cited by 495
Inside and out: the activities of senescence in cancer
Pérez-Mancera, P. A., Young, A. R. J., & Narita, M. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3773 · Cited by 462
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
Apte, M. V., Wilson, J. S., Lugea, A., & Pandol, S. J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.11.037 · Cited by 461
Tsai, S., McOlash, L., Palen, K., Johnson, B., Duris, C., Yang, Q., Dwinell, M. B., Hunt, B., Evans, D. B., Gershan, J., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-4238-4 · Cited by 400
NAD+ metabolism governs the proinflammatory senescence-associated secretome
Nacarelli, T., Lau, L., Fukumoto, T., Zundell, J., Fatkhutdinov, N., Wu, S., Aird, K. M., Iwasaki, O., Kossenkov, A. V., Schultz, D., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0287-4 · Cited by 402
A model for RAS mutation patterns in cancers: finding the sweet spot
Li, S., Balmain, A., & Counter, C. M. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0076-6 · Cited by 384
EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
Navas, C., Hernández-Porras, I., Schuhmacher, A. J., Sibilia, M., Guerra, C., & Barbacid, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.001 · Cited by 391
“Similar results have been obtained in the context of adult K-Ras oncogene expression followed by pancreatic damage (Guerra et al., 2011).”
InfluentialSelf-citationRoles for KRAS in Pancreatic Tumor Development and Progression
di Magliano, M. P., & Logsdon, C. D. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.071 · Cited by 412
Mazur, P. K., Herner, A., Mello, S. S., Wirth, M., Hausmann, S., Rivera, F. J. S., Lofgren, S., Kuschma, T., Hahn, S. A., Vangala, D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3952 · Cited by 413
Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
Thomas, D., & Radhakrishnan, P. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0927-5 · Cited by 409
Zhang, Y., Lazarus, J., Steele, N. G., Yan, W., Lee, H.-J., Nwosu, Z. C., Halbrook, C. J., Menjivar, R. E., Kemp, S. B., Sirihorachai, V. R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0958 · Cited by 385
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
Störz, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.12 · Cited by 401
The Significance of Mitochondrial Dysfunction in Cancer
Luo, Y., Ma, J., & Lu, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165598 · Cited by 380
KRAS mutation in pancreatic cancer
Luo, J. (2021) · Seminars in Oncology · doi:10.1053/j.seminoncol.2021.02.003 · Cited by 360
Mancusi, R. A., & Monje, M. (2023) · Nature · doi:10.1038/s41586-023-05968-y · Cited by 388
Gukovsky, I., Li, N., Todoric, J., Gukovskaya, A. S., & Karin, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.007 · Cited by 347
Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma
Zheng, L., Xue, J., Jaffee, E. M., & Habtezion, A. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.12.042 · Cited by 323
Tissue-specific tumorigenesis: context matters
Schneider, G., Schmidt‐Supprian, M., Rad, R., & Saur, D. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.5 · Cited by 322
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
Liou, G., Döppler, H. R., Necela, B. M., Krishna, M., Crawford, H. C., Raimondo, M., & Störz, P. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201301001 · Cited by 292
Stromal disrupting effects of nab-paclitaxel in pancreatic cancer
Álvarez, R., Musteanu, M., Garcia-Garcia, E., Lopez-Casas, P. P., Megı́as, D., Guerra, C. E., Muñoz, M., Quijano, Y., Cubillo, A., Rodríguez-Pascual, J., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.415 · Cited by 294
Self-citationZhang, Y., Yan, W., Collins, M. A., Bednar, F., Rakshit, S., Zetter, B. R., Stanger, B. Z., Chung, I., Rhim, A. D., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1558-t · Cited by 268
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
Poggetto, E. D., Ho, I.-L., Balestrieri, C., Yen, E.-Y., Zhang, S., Citron, F., Shah, R., Corti, D., Diaferia, G. R., Li, C.-Y., et al. (2021) · Science · doi:10.1126/science.abj0486 · Cited by 259
A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.005 · Cited by 239
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236
Panciera, T., Citron, A., Biagio, D. D., Battilana, G., Gandin, A., Giulitti, S., Forcato, M., Bicciato, S., Panzetta, V., Fusco, S., et al. (2020) · Nature Materials · doi:10.1038/s41563-020-0615-x · Cited by 236
Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Stopczynski, R. E., Normolle, D. P., Hartman, D. J., Ying, H., DeBerry, J. J., Bielefeldt, K., Rhim, A. D., DePinho, R. A., Albers, K. M., & Davis, B. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2050 · Cited by 216
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
Burdziak, C., Alonso‐Curbelo, D., Walle, T., Reyes, J. S., Barriga, F. M., Haviv, D., Xie, Y., Zhao, Z., Zhao, C. J., Chen, H.-A., et al. (2023) · Science · doi:10.1126/science.add5327 · Cited by 213
ERKs in cancer: friends or foes?
Deschênes-Simard, X., Kottakis, F., Meloche, S., & Ferbeyre, G. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2381 · Cited by 186
KRAS Oncogenic Signaling Extends beyond Cancer Cells to Orchestrate the Microenvironment
Dias Carvalho, P., Guimarães, C. F., Cardoso, A. P., Mendonça, S., Costa, Â. M., Oliveira, M. J., & Velho, S. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2084 · Cited by 202
Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
Zhang, Y., Morris, J. P., Yan, W., Schofield, H. K., Gurney, A. L., Simeone, D. M., Millar, S. E., Hoey, T., Hebrok, M., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4384 · Cited by 207
Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer
Falcomatà, C., Bärthel, S., Schneider, G., Rad, R., Schmidt‐Supprian, M., & Saur, D. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0876 · Cited by 224
Carcinogenesis: Failure of resolution of inflammation?
Fishbein, A., Hammock, B. D., Serhan, C. N., & Panigrahy, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107670 · Cited by 218
Liou, G., Döppler, H. R., Necela, B. M., Edenfield, B. H., Zhang, L., Dawson, D. W., & Störz, P. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0474 · Cited by 205
Neat1 is a p53-inducible lincRNA essential for transformation suppressionPreprint
Mello, S. S., Sinow, C., Raj, N., Mazur, P. K., Bieging-Rolett, K. T., Brož, D. K., Conklin, J. F., Vogel, H. S., Wood, L. D., Sage, J., et al. (2017) · Genes & Development · doi:10.1101/gad.284661.116 · Cited by 209
Liu, P., Li, F., Lin, J., Fukumoto, T., Nacarelli, T., Hao, X., Kossenkov, A. V., Simon, M. C., & Zhang, R. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00656-3 · Cited by 185
Genetically engineered mouse models of pancreatic adenocarcinoma
Guerra, C. E., & Barbacid, M. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.02.002 · Cited by 179
Self-citationLessard, F., Igelmann, S., Trahan, C., Huot, G., Saint-Germain, E., Mignacca, L., Del Toro, N., Lopes-Paciencia, S., Le Calvé, B., Montero, M., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0127-y · Cited by 174
What We Have Learned About Pancreatic Cancer From Mouse Models
Pérez-Mancera, P. A., Guerra, C. E., Barbacid, M., & Tuveson, D. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.002 · Cited by 178
Self-citationPancreatic Cancer, Inflammation, and Microbiome
Zambirinis, C. P., Pushalkar, S., Saxena, D. B., & Miller, G. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000045 · Cited by 171
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma
Mainardi, S., Mijimolle, N., Francoz, S., Vicente‐Dueñas, C., Sánchez-Garcı́a, I., & Barbacid, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320383110 · Cited by 170
Self-citationCaught in the cross fire: p53 in inflammation
Cooks, T., Harris, C. C., & Oren, M. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu134 · Cited by 162
Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk
Orozco, C. A., Martínez‐Bosch, N., Guerrero, P. E., Vinaixa, J., Dalotto‐Moreno, T., Iglesias, M., Moreno, M., Djurec, M., Poirier, F., Gabius, H., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722434115 · Cited by 158
Self-citationEpithelial-Mesenchymal Transition in Pancreatic Cancer: A Review
Wang, S., Huang, S., & Sun, Y. (2017) · BioMed Research International · doi:10.1155/2017/2646148 · Cited by 152
Carcinogenesis of Pancreatic Ductal Adenocarcinoma
Störz, P., & Crawford, H. C. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.02.059 · Cited by 154
Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma
Lee, A. Y. L., Dubois, C. L., Sarai, K., Zarei, S., Schaeffer, D. F., Sander, M., & Kopp, J. L. (2019) · Gut · doi:10.1136/gutjnl-2017-314426 · Cited by 139
Senescent cells communicate via intercellular protein transfer
Biran, A., Perelmutter, M., Gal, H., Burton, D. G. A., Ovadya, Y., Vadai, E., Geiger, T., & Krizhanovsky, V. (2015) · Genes & Development · doi:10.1101/gad.259341.115 · Cited by 139
Interleukin-6 in inflammatory and malignant diseases of the pancreas
Lesina, M., Wörmann, S. M., Neuhöfer, P., Song, L., & Algül, H. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.002 · Cited by 149
Mills, J. C., & Sansom, O. J. (2015) · Science Signaling · doi:10.1126/scisignal.aaa7540 · Cited by 145
Collins, M. A., Yan, W., Sebolt–Leopold, J. S., & Pasca di Magliano, M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.052 · Cited by 133
PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice
Wu, C.-Y. C., Carpenter, E. S., Takeuchi, K. K., Halbrook, C. J., Peverley, L. V., Bien, H., Hall, J. C., DelGiorno, K. E., Pal, D., Song, Y., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.032 · Cited by 135
GEMMs as preclinical models for testing pancreatic cancer therapies
Gopinathan, A., Morton, J. P., Jodrell, D. I., & Sansom, O. J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.021055 · Cited by 141
Hidalgo, M. M., Plaza, C., Musteanu, M., Illei, P. B., Brachmann, C. B., Heise, C. C., Pierce, D. W., Lopez-Casas, P. P., Menéndez, C., Tabernero, J. M., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3222 · Cited by 140
Chronic pancreatitis: A path to pancreatic cancer
Pinho, A. V., Chantrill, L. A., & Rooman, I. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.015 · Cited by 138
Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer
Leal, A. S., Williams, C. R., Royce, D. B., Pioli, P. A., Sporn, M. B., & Liby, K. T. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.021 · Cited by 135
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
Todoric, J., Antonucci, L., Caro, G. D., Li, N., Wu, X., Lytle, N. K., Dhar, D., Banerjee, S., Fagman, J. B., Browne, C. D., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.10.011 · Cited by 129
Pancreatic cancer: A comprehensive review and update
Muniraj, T., Jamidar, P. A., & Aslanian, H. R. (2013) · Disease-a-Month · doi:10.1016/j.disamonth.2013.08.001 · Cited by 132
Lesina, M., Wörmann, S. M., Morton, J. P., Diakopoulos, K. N., Korneeva, O., Wimmer, M., Einwächter, H., Sperveslage, J., Demir, İ. E., Kehl, T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86477 · Cited by 134
Liou, G., Bastea, L. I., Martinez, A. K. F., Döppler, H. R., Edenfield, B. H., Dawson, D. W., Zhang, L., Bardeesy, N. M., & Störz, P. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.052 · Cited by 126
Pancreatic cancer and its stroma: A conspiracy theory
Xu, Z. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11216 · Cited by 127
Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Pelosi, E., Castelli, G., & Testa, U. (2017) · Biomedicines · doi:10.3390/biomedicines5040065 · Cited by 128
Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
Chen, K., Qian, W., Jiang, Z., Cheng, L., Li, J., Sun, L., Zhou, C., Gao, L., Lei, M., Yan, B., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0701-0 · Cited by 125
Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?
Rooman, I., & Real, F. X. (2012) · Gut · doi:10.1136/gut.2010.235804 · Cited by 120
Baumgart, S., Chen, N., Siveke, J. T., König, A. O., Zhang, J., Singh, S. K., Wolf, E., Bartkuhn, M., Esposito, I., Heßmann, E., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0593 · Cited by 122
Emerging roles for the IL-6 family of cytokines in pancreatic cancer
van Duijneveldt, G., Griffin, M. D. W., & Putoczki, T. L. (2020) · Clinical Science · doi:10.1042/cs20191211 · Cited by 126
Belle, J. I., Sen, D., Baer, J. M., Liu, X., Lander, V. E., Ye, J., Sells, B. E., Knolhoff, B. L., Ahmad, F. F., Kang, L., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0428 · Cited by 124
Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., & David, G. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00586-18 · Cited by 119
Cell of origin influences pancreatic cancer subtype
Flowers, B. M., Xu, H., Mulligan, A. S., Hanson, K. J., Seoane, J. A., Vogel, H., Curtis, C., Wood, L. D., & Attardi, L. D. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0633 · Cited by 118
Blood biomarkers for differential diagnosis and early detection of pancreatic cancer
Al-Shaheri, F. N., Alhamdani, M. S. S., Bauer, A. S., Giese, N. A., Büchler, M. W., Hackert, T., & Hoheisel, J. D. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102193 · Cited by 119
Blasco, M. T., Navas, C., Martín-Serrano, G., Graña-Castro, O., Lechuga, C. G., Martín-Díaz, L., Djurec, M., Li, J., Morales-Cacho, L., Esteban-Burgos, L., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.03.002 · Cited by 115
“6 RESULTS Mutational complexity of PDACs driven by Kras/Trp53 mutations GEM PDAC models driven by a resident Kras oncogene and loss or inactivation of Trp53 closely reproduce the natural history and histopathology of human tumors (Guerra et al., 2011; Hingorani et al., 2005).”
BackgroundSelf-citationKras as a key oncogene and therapeutic target in pancreatic cancer
Collins, M. A., & di Magliano, M. P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00407 · Cited by 114
Leidal, A. M., Cyr, D. P., Hill, R. J., Lee, P. W. K., & McCormick, C. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.005 · Cited by 113
Infiltrating immune cells and gene mutations in pancreatic ductal adenocarcinoma
Wang, W.-Q., Liu, L., Xu, H.-X., Wu, C.-T., Xiang, J.-F., Xu, J., Liu, C., Long, J., Ni, Q.-X., & Yu, X. (2016) · British journal of surgery · doi:10.1002/bjs.10187 · Cited by 114
Lineage Plasticity in Cancer Progression and Treatment
Magnen, C. L., Shen, M. M., & Abate-Shen, C. T. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050224 · Cited by 105
Cellular Pliancy and the Multistep Process of Tumorigenesis
Puisieux, A., Pommier, R. M., Morel, A., & Lavial, F. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.007 · Cited by 114
Pancreatic cancer tumor microenvironment is a major therapeutic barrier and target
Hartupee, C. D., Nagalo, B. M., Chabu, C. Y., Tesfay, M. Z., Coleman‐Barnett, J., West, J. T., & Moaven, O. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1287459 · Cited by 116
Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
Heinrich, M. A., Mostafa, A. M. R. H., Morton, J. P., Hawinkels, L. J. A. C., & Prakash, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.018 · Cited by 117
Poh, A. R., & Ernst, M. (2021) · Cancers · doi:10.3390/cancers13122860 · Cited by 106
Yamamoto, K., Tateishi, K., Kudo, Y., Sato, T., Yamamoto, S., Miyabayashi, K., Matsusaka, K., Asaoka, Y., Ijichi, H., Hirata, Y., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu136 · Cited by 104
Liou, G., Döppler, H. R., Braun, U. B., Panayiotou, R., Scotti, M. L., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7200 · Cited by 104
Direct reprogramming by oncogenic Ras and Myc
Ischenko, I., Zhi, J., Moll, U. M., Nemajerová, A., & Petrenko, O. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219592110 · Cited by 102
The acinar regulator Gata6 suppresses Kras G12V -driven pancreatic tumorigenesis in mice
Martinelli, P., Madriles, F., Cañamero, M., Pau, E. C. D. S., del Pozo, N., Guerra, C. E., & Real, F. X. (2015) · Gut · doi:10.1136/gutjnl-2014-308042 · Cited by 102
Self-citationLiu, Y., Hawkins, O. E., Su, Y., Vilgelm, A. E., Sobolik, T., Thu, Y. M., Kantrow, S. M., Splittgerber, R. C., Short, S. P., Amiri, K. I., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201378 · Cited by 104
Chen, N., Singh, G., König, A. O., Liou, G., Störz, P., Zhang, J., Regul, L., Nagarajan, S., Kühnemuth, B., Johnsen, S. A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.033 · Cited by 102
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations
Magnus, N., Garnier, D., Meehan, B., McGraw, S., Lee, T. H., Caron, M., Bourque, G., Milsom, C., Jabado, N., Trasler, J. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314118111 · Cited by 102
The Role of Inflammation in Pancreatic Cancer
Hausmann, S., Kong, B., Michalski, C. W., Erkan, M., & Frieß, H. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-0348-0837-8_6 · Cited by 101
Metadata
- Authors
- Guerra, C., Collado, M., Navas, C., Schuhmacher, A. J., Hernández-Porras, I., Cañamero, M., Rodriguez-Justo, M., Serrano, M., & Barbacid, M.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- Corresponding author
- Guerra, Carmen
- Barbacid, Mariano
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 19
- Issue
- 6
- Pages
- 728-739
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC4890723
- OpenAlex
- W1965887568
- Cited by
- 516
- References
- 40
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 31 · 2023: 40 · 2022: 22 · 2021: 44 · 2020: 36 · 2019: 41 · 2018: 27 · 2017: 36 · 2016: 22 · 2015: 37 · 2014: 65 · 2013: 38 · 2012: 33
- FWCI
- 22.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 813 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- European Research Council (ERC-AG/250297-RAS AHEAD)
- Ministerio de Ciencia e Innovación (CSD2007-00017, SAF2006-11773)
- INCLIVA Instituto de Investigación Sanitaria (ERC-AG/233270, GR/SAL/0349/2004, PI042124, SAF2008-02959)
- Fundación Mutua Madrileña
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- pancreatitis, pancreatic cancer, oncogene-induced senescence, inflammation, pancreatic intraepithelial neoplasia, K-ras oncogene, chronic pancreatitis, anti-inflammatory agents, tissue repair, tumor progression, p16INK4a, Trp53, pancreatic ductal adenocarcinoma
- MeSH terms
- Adenocarcinoma, Animals, Anti-Inflammatory Agents, Cell Transformation, Neoplastic, Humans, Pancreatic Neoplasms, Pancreatitis, Genes, ras, Genes, p53, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Carcinoma, Pancreatic Ductal, Pancreas, Exocrine, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
