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CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks

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The inflammatory cytokine profile of myelodysplastic syndromes

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Mitochondrial Contributions to Hematopoietic Stem Cell Aging

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Emerging roles of transit‐amplifying cells in tissue regeneration and cancer

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Sipa1 deficiency–induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm

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Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

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Proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3), play an oncogenic role in chronic myeloid leukemia by stabilizing nuclear factor-kappa B

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MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers

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Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment

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The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review

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Magnetic colorimetric immunoassay for human interleukin-6 based on the oxidase activity of ceria spheres

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Maternal inflammation regulates fetal emergency myelopoiesis

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Deletion of the RNA‐editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice

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Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia

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Maintenance of high-turnover tissues during and beyond homeostasis

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Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem

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Interleukin‐18 produced by bone marrow‐derived stromal cells supports T‐cell acute leukaemia progression

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A ‘telomere-associated secretory phenotype’ cooperates with BCR-ABL to drive malignant proliferation of leukemic cells

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Myeloproliferative Neoplasm Animal Models

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Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation

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The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

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Analysis of causes for poor persistence of CAR-T cell therapy in vivo

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Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells

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CD86-based analysis enables observation of bona fide hematopoietic responses

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Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML)Preprint

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Abnormal morphological and functional nature of bone marrow stromal cells provides preferential support for survival of acute myeloid leukemia cells

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Novel oral transforming growth factor‐β signaling inhibitor EW ‐7197 eradicates CML ‐initiating cells

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The role of host environment in cancer evolution

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Macrophage migration inhibitory factor is overproduced through EGR1 in TET2low resting monocytes

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Matrine suppresses cell growth of human chronic myeloid leukemia cells via its inhibition of the interleukin-6/Janus activated kinase/signal transducer and activator of transcription 3 signaling cohort

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Context-specific roles for paracrine IL-6 in lymphomagenesisPreprint

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Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

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Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia

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Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production

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The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment

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Hematopoietic Multipotent Progenitors and Plasma Cells: Neighbors or Roommates in the Mouse Bone Marrow Ecosystem?

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Regulation of hematopoietic and leukemia stem cells by regulatory T cells

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Druggable Biochemical Pathways and Potential Therapeutic Alternatives to Target Leukemic Stem Cells and Eliminate the Residual Disease in Chronic Myeloid Leukemia

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Targeting CD38 in acute myeloid leukemia interferes with leukemia trafficking and induces phagocytosis

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A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

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Immune Dysfunction, Cytokine Disruption, and Stromal Changes in Myelodysplastic Syndrome: A Review

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Signaling pathways governing the behaviors of leukemia stem cells

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Rac1 GTPase Promotes Interaction of Hematopoietic Stem/Progenitor Cell with Niche and Participates in Leukemia Initiation and Maintenance in Mouse

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Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity

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Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs)

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Transcriptional and Microenvironmental Regulation of Lineage Ambiguity in Leukemia

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Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts

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Cancer stem cells modulate patterns and processes of evolution in cancers

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Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches

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Cytokine-like protein 1–induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML

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Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis

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Nature or Nurture? Role of the Bone Marrow Microenvironment in the Genesis and Maintenance of Myelodysplastic Syndromes

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Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway

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Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

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Increasing recognition and emerging therapies argue for dedicated clinical trials in chronic myelomonocytic leukemia

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The role of Trib1 in myeloid leukaemogenesis and differentiation

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MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis

Zhao, H., Pomicter, A. D., Eiring, A. M., Franzini, A., Ahmann, J. M., Hwang, J. Y., Senina, A. V., Helton, B., Iyer, S. M., Yan, D., et al. (2021) · Blood · doi:10.1182/blood.2021011802 · Cited by 20

Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML

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Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia

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The ABNL-MARRO 001 study: a phase 1–2 study of randomly allocated active myeloid target compound combinations in MDS/MPN overlap syndromes

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Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice

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Overexpression of miR‑574‑3p suppresses proliferation and induces apoptosis of chronic myeloid leukemia cells via targeting IL6/JAK/STAT3 pathway

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Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia

Herrmann, O., Kuepper, M. K., Bütow, M., Costa, I. G., Appelmann, I., Beier, F., Luedde, T., Braunschweig, T. A., Koschmieder, S., Brümmendorf, T. H., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5871-2 · Cited by 19

Role of DNA Damage Response in Suppressing Malignant Progression of Chronic Myeloid Leukemia and Polycythemia Vera: Impact of Different Oncogenes

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Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice

Lysenko, V., van Wijk, N. W.-V., Zimmermann, K., Weller, M.-C., Bühler, M. M., Wildschut, M. H. E., Schürch, P. M., Fritz, C., Wagner, U., Calabresi, L., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019001364 · Cited by 19

Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor κ B-reactive oxygen species signaling axis

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Recent advances in understanding chronic myeloid leukemia: where do we stand?

Kumar, R., & Krause, D. S. (2021) · Faculty Reviews · doi:10.12703/r/10-35 · Cited by 20

From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment

Soto, C. A., Celso, C. L., Purton, L. E., & Frisch, B. J. (2021) · JBMR Plus · doi:10.1002/jbm4.10516 · Cited by 19

Necroinflammation emerges as a key regulator of hematopoiesis in health and disease

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Predictive short/long-term efficacy biomarkers and resistance mechanisms of CD19-directed CAR-T immunotherapy in relapsed/refractory B-cell lymphomas

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Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways for Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future Perspectives

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TNF-α–Dependent Hematopoiesis following Bcl11b Deletion in T Cells Restricts Metastatic Melanoma

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Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells

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Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis

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Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment

Trojani, A., Pungolino, E. M., Molin, A. D., Lodola, M., Rossi, G., D’Adda, M., Perego, A., Elena, C., Turrini, M., Borin, L. M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218444 · Cited by 17

IGF-IR determines the fates of BCR/ABL leukemia

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Inflammatory diseases in hematology: a review

Henrie, R., Cherniawsky, H. M., Marcon, K. M., Zhao, E. J., Marinkovic, A., Pourshahnazari, P., Parkin, S., & Chen, L. Y. C. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00356.2021 · Cited by 17

Preleukemic and leukemic evolution at the stem cell level

Stauber, J., Greally, J. M., & Steidl, U. G. (2020) · Blood · doi:10.1182/blood.2019004397 · Cited by 20

The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment

Snyder, R. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12333 · Cited by 16

15-Deoxy-Δ12,14-prostaglandin J2Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells

Trindade‐da‐Silva, C. A., Reis, C. F., Vecchi, L., Napimoga, M. H., Sperandio, M., Colombo, B. F. M., Alves, P. T., Ward, L. S., Ueira‐Vieira, C., & Goulart, L. R. (2016) · PPAR Research · doi:10.1155/2016/4106297 · Cited by 15

PU.1 is required to restrain myelopoiesis during chronic inflammatory stress

Chavez, J. S., Rabe, J. L., Niño, K. E., Wells, H. H., Gessner, R. L., Mills, T. S., Hernandez, G., & Pietras, E. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1204160 · Cited by 14

Immunology of chronic myeloid leukemia: current concepts and future goals

Vonka, V., & Petráčková, M. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.1019474 · Cited by 14

Genetic and epigenetic factors interacting with clonal hematopoiesis resulting in chronic myelomonocytic leukemia

Carr, R. M., & Patnaik, M. M. (2019) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000553 · Cited by 14

The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease

Gustafsson, K. U., Jamalpour, M., Trinh, C., Kharas, M. G., & Welsh, M. (2014) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-7-45 · Cited by 14

Putting the brakes on anticancer therapies: suppression of innate immune pathways by tumor-associated myeloid cells

Jinushi, M., Yagita∥, H., Yoshiyama, H., & Tahara, H. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.06.001 · Cited by 15

Stem cell maintenance and disease progression in chronic myeloid leukemia

Ito, T. (2013) · International Journal of Hematology · doi:10.1007/s12185-013-1318-8 · Cited by 14

Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation

Ramdas, B., Mali, R. S., Palam, L. R., Pandey, R., Cai, Z., Pasupuleti, S. K., Burns, S. S., & Kapur, R. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.05.002 · Cited by 14

CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia

Deschamps, P., Wacheux, M., Gosseye, A., Morabito, M., Pagès, A., Lyne, A.-M., Alfaro, A., Rameau, P., Imanci, A., Chelbi, R., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180738 · Cited by 14

Tetracycline-Regulated Mouse Models of CancerPreprint

Yeh, E. S., Vernon-Grey, A., Martin, H. L., & Chodosh, L. A. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top069823 · Cited by 13

JAK2V617F Mutant Megakaryocytes Contribute to Hematopoietic Aging in a Murine Model of Myeloproliferative Neoplasm

Lee, S., Wong, H., Castiglione, M. A., Murphy, M. M., Kaushansky, K., & Zhan, H. (2022) · Stem Cells · doi:10.1093/stmcls/sxac005 · Cited by 12

VEXAS syndrome, a new kid on the block of auto-inflammatory diseases: A hematologist's point of view

Heiblig, M., Patel, B. A., & Jamilloux, Y. (2023) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2023.101861 · Cited by 12

Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

Ai, C.-J., Chen, L.-J., Guo, L., Wang, Y., & Zhao, Z.-Y. (2024) · World Journal of Stem Cells · doi:10.4252/wjsc.v16.i4.444 · Cited by 12

Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review

Torres-Barrera, P., Mayani, H., & Chávez‐González, A. (2021) · Current Research in Translational Medicine · doi:10.1016/j.retram.2021.103295 · Cited by 12

Patient-specific molecular response dynamics can predict the possibility of relapse during the second treatment-free remission attempt in chronic myelogenous leukemia

Kim, E., Hwang, E.-J., Lee, J., Kim, D., Kim, J.-Y., & Kim, D.-W. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100817 · Cited by 12

Low c-Kit expression identifies primitive, therapy-resistant CML stem cells

Shah, M., Kumar, H., Qiu, S., Li, H., Harris, M., He, J., Abraham, A., Crossman, D. K., Paterson, A., Welner, R. S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.157421 · Cited by 11

Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis

Wang, V. E., Blaser, B. W., Patel, R. K., Behbehani, G. K., Rao, A. A., Durbin-Johnson, B., Jiang, T., Logan, A. C., Settles, M., Mannis, G. N., et al. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0055 · Cited by 11

Integrins, anchors and signal transducers of hematopoietic stem cells during development and in adulthood

Krenn, P. W., Montañez, E., Costell, M., & Fässler, R. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.02.009 · Cited by 11

Chemoselection of Allogeneic HSC After Murine Neonatal Transplantation Without Myeloablation or Post-transplant Immunosuppression

Falahati, R., Zhang, J., Flebbe-Rehwaldt, L., Shi, Y., Gerson, S. L., & Gaensler, K. M. L. (2012) · Molecular Therapy · doi:10.1038/mt.2012.136 · Cited by 11

Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling

Himburg, H. A., Roos, M. M., Fang, T., Zhang, Y., Termini, C. M., Schlussel, L., Kim, M., Pang, A., Kan, J., Zhao, L., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129061 · Cited by 12

Treatment of Chronic Myelogenous Leukemia by Blocking Cytokine Alterations Found in Normal Stem and Progenitor Cells

Welner, R. S., Amabile, G., Bararia, D., Czibere, A. G., Yang, H. H., Zhang, H., de Figueiredo‐Pontes, L. L., Ye, M., Levantini, E., Ruscio, A. D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.004 · Cited by 135

Sociology of Normal Stem and Progenitor Cells in CML Niche

Welner, R. S., Amabile, G., Bararia, D., Staber, P. B., Czibere, A. G., & Tenen, D. G. (2012) · Blood · doi:10.1182/blood.v120.21.1234.1234

Leukemic Stem Cells and Progenitors Demonstrate Impaired Interaction with the Hematopoietic Microenvironment in Vivo in An Inducible Murine Model of Chronic Myelogenous Leukemia

Sengupta, A., & Cancelas, J. A. (2008) · Blood · doi:10.1182/blood.v112.11.191.191

Leukemic Hierarchy and Systemic Factors Dictating Disease Evolution In Chronic Myelogenous Leukemia

Reynaud, D., Pietras, E. M., Jeanne, M., Barry-Holson, K. Q., & Passegue, E. A. (2010) · Blood · doi:10.1182/blood.v116.21.886.886

Leukemia-Induced Alterations in Bone Marrow Cytokine and Chemokine Levels Contribute to Altered Stem Cell Lodgment and Impairment of Normal Stem Cell Growth in CML

Zhang, B., Ho, Y., Holyoake, T. L., Huettner, C. S., & Bhatia, R. (2011) · Blood · doi:10.1182/blood.v118.21.962.962