Pietras, Eric M.

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

Pietras, E. M., Reynaud, D., Kang, Y.-A., Carlin, D., Calero-Nieto, F. J., Leavitt, A. D., Stuart, J. M., Göttgens, B., & Passegué, E. (2015) · Cell stem cell

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 723

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 689

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

Cho, J. S., Pietras, E. M., Garcia, N. C., Ramos, R. I., Farzam, D. M., Monroe, H. R., Magorien, J. E., Blauvelt, A., Kolls, J. K., Cheung, A. L., et al. (2010) · Journal of Clinical Investigation

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 658

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Flach, J., Bakker, S. T., Mohrin, M., Conroy, P. C., Pietras, E. M., Reynaud, D., Alvarez, S., Diolaiti, M. E., Ugarte, F., Forsberg, E. C., et al. (2014) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 650

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche

Schepers, K., Pietras, E. M., Reynaud, D., Flach, J., Binnewies, M., Garg, T., Wagers, A. J., Hsiao, E. C., & Passegué, E. (2013) · Cell stem cell

Myeloproliferative Neoplasms: Diagnosis and TreatmentHematopoietic Stem Cell Transplantation

Cited by 614

Cell cycle regulation in hematopoietic stem cells

Pietras, E. M., Warr, M. R., & Passegué, E. (2011) · Journal of Cell Biology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 447

Inflammation: a key regulator of hematopoietic stem cell fate in health and disease

Pietras, E. M. (2017) · Blood

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 417

IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development

Reynaud, D., Pietras, E., Barry-Holson, K., Mir, A., Binnewies, M., Jeanne, M., Sala-Torra, O., Radich, J. P., & Passegué, E. (2011) · Cancer Cell

Chronic Myeloid Leukemia TreatmentsAcute Myeloid Leukemia Research

Cited by 335

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

Pietras, E. M., Lakshminarasimhan, R., Techner, J.-M., Fong, S., Flach, J., Binnewies, M., & Passegué, E. (2014) · Journal of Experimental Medicine

Hematopoietic Stem Cell Transplantationinterferon and immune responses

Cited by 323

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

Caiado, F., Pietras, E. M., & Manz, M. G. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 289

Pro-inflammatory cytokines: Emerging players regulating HSC function in normal and diseased hematopoiesis

Mirantes, C., Passegué, E., & Pietras, E. M. (2014) · Experimental Cell Research

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 211

Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction

Wang, Y., Sano, S., Yura, Y., Ke, Z., Sano, M., Oshima, K., Ogawa, H., Horitani, K., Min, K.-D., Miura-Yura, E., et al. (2020) · JCI Insight

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 167

Clonal hematopoiesis: Mutation-specific adaptation to environmental change

Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 129

Two CD95 tumor classes with different sensitivities to antitumor drugs

Algeciras-Schimnich, A., Pietras, E. M., Barnhart, B. C., Legembre, P., Vijayan, S., Holbeck, S. L., & Peter, M. E. (2003) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 118

Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies

Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 112

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 91

Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

Hernandez, G., Mills, T. S., Rabe, J. L., Chavez, J. S., Kuldanek, S., Kirkpatrick, G., Noetzli, L., Jubair, W. K., Zanche, M., Myers, J. R., et al. (2020) · Haematologica

Rheumatoid Arthritis Research and TherapiesHematopoietic Stem Cell Transplantation

Cited by 58

Chronic interleukin-1 exposure triggers selection for Cebpa -knockout multipotent hematopoietic progenitors

Higa, K. C., Goodspeed, A., Chavez, J. S., De Dominici, M., Danis, E., Zaberezhnyy, V., Rabe, J. L., Tenen, D. G., Pietras, E. M., & DeGregori, J. (2021) · Journal of Experimental Medicine

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 57

CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions

Rabe, J. L., Hernandez, G., Chavez, J. S., Mills, T. S., Nerlov, C., & Pietras, E. M. (2020) · Experimental Hematology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 49

PI3K alpha and delta promote hematopoietic stem cell activation

Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R. O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., et al. (2019) · JCI Insight

Hematopoietic Stem Cell TransplantationPI3K/AKT/mTOR signaling in cancer

Cited by 40

PU.1 is required to restrain myelopoiesis during chronic inflammatory stress

Chavez, J. S., Rabe, J. L., Niño, K. E., Wells, H. H., Gessner, R. L., Mills, T. S., Hernandez, G., & Pietras, E. M. (2023) · Frontiers in Cell and Developmental Biology

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 14

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation

Ahmed, N., Etzrodt, M., Dettinger, P., Kull, T., Loeffler, D., Hoppe, P. S., Chavez, J. S., Zhang, Y., Camargo Ortega, G., Hilsenbeck, O., et al. (2022) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 9

Inflammatory changes in the bone marrow microenvironment drive both niche and blood system remodeling during aging

Verovskaya, E., Calero-Nieto, F., Reynaud, D., Zhang, S. Y., Herault, A., Bakker, S., Pietras, E., Svendsen, A. F., Wang, X., Kinston, S., et al. (2018) · Experimental Hematology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 4

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

Chavez, J., Rabe, J. L., Higa, K., Loeffler, D., Nouraiz, A., Mills, T., Idler, B. M., Stevens, B. M., Fleenor, C., Nerlov, C., et al. (2019) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 1