The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma
Open accessAbstract
SUMMARY Medulloblastomas that display a large cell/ anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and significantly differ from mouse models of the Sonic Hedgehog (SHH)- and WNT-disease subgroups. This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis.
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Identification of stem cells in small intestine and colon by marker gene Lgr5
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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
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Self-citationMyc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
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Self-citationDisruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
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Self-citationMath1-driven GFP expression in the developing nervous system of transgenic mice
Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N., et al. (2003) · Gene Expression Patterns · doi:10.1016/s1567-133x(03)00089-9 · Cited by 292
Cited by
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Northcott, P. A., Lee, C., Zichner, T., Stütz, A. M., Erkek, S., Kawauchi, D., Shih, D. J. H., Hovestadt, V., Zapatka, M., Sturm, D., et al. (2014) · Nature · doi:10.1038/nature13379 · Cited by 642
Self-citationChildhood cerebellar tumours mirror conserved fetal transcriptional programs
Vladoiu, M. C., El-Hamamy, I., Donovan, L. K., Farooq, H., Holgado, B. L., Sundaravadanam, Y., Ramaswamy, V., Hendrikse, L. D., Kumar, S., Mack, S. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1158-7 · Cited by 426
Target gene-independent functions of MYC oncoproteins
Baluapuri, A., Wolf, E., & Eilers, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0215-2 · Cited by 310
Medulloblastomics revisited: biological and clinical insights from thousands of patients
Hovestadt, V., Ayrault, O., Swartling, F. J., Robinson, G. W., Pfister, S. M., & Northcott, P. A. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0223-8 · Cited by 271
Self-citationThe prenatal origins of cancer
Marshall, G. M., Carter, D. R., Cheung, B. B., Liu, T., Mateos, M. K., Meyerowitz, J. G., & Weiss, W. A. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3679 · Cited by 281
Metadata
- Authors
- Kawauchi, D., Robinson, G., Uziel, T., Gibson, P., Rehg, J., Gao, C., Finkelstein, D., Qu, C., Pounds, S., Ellison, D. W., Gilbertson, R. J., & Roussel, M. F.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 21
- Issue
- 2
- Pages
- 168-180
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2094252236
- Cited by
- 305
- References
- 7
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kawauchi, D., Robinson, G., Uziel, T., Gibson, P., Rehg, J., Gao, C., Finkelstein, D., Qu, C., Pounds, S., Ellison, D. W., Gilbertson, R. J., & Roussel, M. F. (2012). A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma. Cancer Cell. https://doi.org/10.1016/j.ccr.2011.12.023
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