Target gene-independent functions of MYC oncoproteins

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986 · see citing works

A Phase Separation Model for Transcriptional Control

Hnisz, D., Shrinivas, K., Young, R. A., Chakraborty, A. K., & Sharp, P. A. (2017) · Cell · doi:10.1016/j.cell.2017.02.007 · Cited by 1,753 · see citing works

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,498 · see citing works

MYC regulates the antitumor immune response through CD47 and PD-L1

Casey, S. C., Tong, L., Li, Y., Do, R., Walz, S., Fitzgerald, K. N., Gouw, A. M., Baylot, V., Gütgemann, I., Eilers, M., et al. (2016) · Science · doi:10.1126/science.aac9935 · Cited by 1,403 · see citing works

MYC, Metabolism, and Cancer

Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,375 · see citing works

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279 · see citing works

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D. R., Tessarollo, L., Casellas, R. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.033 · Cited by 1,063 · see citing works

Genomic targets of the human c-Myc proteinPreprint

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963 · see citing works

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Welcker, M., Orian, A., Jin, J., Grim, J. A., Harper, J. W., Eisenman, R. N., & Clurman, B. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402770101 · Cited by 942 · see citing works

Myc’s broad reach

Eilers, M., & Eisenman, R. N. (2008) · Genes & Development · doi:10.1101/gad.1712408 · Cited by 927 · see citing works

Modelling Myc inhibition as a cancer therapy

Soucek, L., Whitfield, J. R., Martins, C. P., Finch, A. J., Murphy, D. J., Sodir, N. M., Karnezis, A. N., Swigart, L. B., Nasi, S., & Evan, G. I. (2008) · Nature · doi:10.1038/nature07260 · Cited by 822 · see citing works

MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint

Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 808 · see citing works

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Yeh, E., Cunningham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, W. C., Stukenberg, P. T., Shenolikar, S., Uchida, T., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1110 · Cited by 791 · see citing works

R-Loops as Cellular Regulators and Genomic Threats

Crossley, M. P., Bocek, M. J., & Cimprich, K. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.024 · Cited by 732 · see citing works

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P.-C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.032 · Cited by 700 · see citing works

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

McMahon, S. B., Van Buskirk, H. A., Dugan, K. A., Copeland, T. D., & Cole, M. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81479-8 · Cited by 693 · see citing works

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

Seoane, J., Le, H.-V., & Massagué, J. (2002) · Nature · doi:10.1038/nature01119 · Cited by 683 · see citing works

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Grandori, C., Gomez-Roman, N., Felton-Edkins, Z. A., Ngouenet, C., Galloway, D. A., Eisenman, R. N., & White, R. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1224 · Cited by 659 · see citing works

Non-transcriptional control of DNA replication by c-Myc

Dominguez-Sola, D., Ying, C. Y., Grandori, C., Ruggiero, L., Chen, B., Li, M., Galloway, D. A., Gu, W. J., Gautier, J., & Dalla‐Favera, R. (2007) · Nature · doi:10.1038/nature05953 · Cited by 652 · see citing works

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

Nau, M. M., Brooks, B. J., Battey, J. F., Sausville, E. A., Gazdar, A. F., Kirsch, I. R., McBride, O. W., Bertness, V. L., Hollis, G. F., & Minna, J. D. (1985) · Nature · doi:10.1038/318069a0 · Cited by 649 · see citing works

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

Chipumuro, E., Marco, E., Christensen, C. L., Kwiatkowski, N. P., Zhang, T., Hatheway, C. M., Abraham, B. J., Sharma, B., Yeung, C. M., Altabef, A. B., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.024 · Cited by 631 · see citing works

Revisiting Global Gene Expression Analysis

Lovén, J., Orlando, D. A., Sigova, A. A., Lin, C. Y., Rahl, P. B., Burge, C. B., Levens, D. L., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.10.012 · Cited by 616 · see citing works

Myc deletion rescues Apc deficiency in the small intestine

Sansom, O. J., Méniel, V. S., Muncan, V., Phesse, T. J., Wilkins, J. A., Reed, K. R., Vass, J. K., Athineos, D., Clevers, H. C., & Clarke, A. R. (2007) · Nature · doi:10.1038/nature05674 · Cited by 614 · see citing works

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

Haffner, M. C., Aryee, M. J., Toubaji, A., Esopi, D., Albadine, R., Gürel, B., Isaacs, W. B., Bova, G. S., Liu, W., Xu, J., et al. (2010) · Nature Genetics · doi:10.1038/ng.613 · Cited by 606 · see citing works

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

Otto, T., Horn, S., Brockmann, M., Eilers, U., Schüttrumpf, L., Popov, N., Kenney, A. M., Schulte, J. H., Beijersbergen, R. L., Christiansen, H., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.005 · Cited by 574 · see citing works

Repression of p15INK4b expression by Myc through association with Miz-1

Staller, P., Peukert, K., Kiermaier, A. C., Seoane, J., Lukas, J., Karsunky, H., Möröy, T., Bártek, J., Massagué, J., Hänel, F., et al. (2001) · Nature Cell Biology · doi:10.1038/35070076 · Cited by 574 · see citing works

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression

Kortlever, R. M., Sodir, N. M., Wilson, C. H., Burkhart, D. L., Pellegrinet, L., Brown Swigart, L., Littlewood, T. D., & Evan, G. I. (2017) · Cell · doi:10.1016/j.cell.2017.11.013 · Cited by 553 · see citing works

X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA

Nair, S. K., & Burley, S. K. (2003) · Cell · doi:10.1016/s0092-8674(02)01284-9 · Cited by 551 · see citing works

Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R.-W. C., Wenzel, A., Hicks, J., Ballew, M., Stone, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.022 · Cited by 537 · see citing works

MYC: Connecting selective transcriptional control to global RNA production

Kress, T. R., Sabò, A., & Amati, B. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3984 · Cited by 521 · see citing works

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Walz, S., Lorenzin, F., Morton, J. P., Wiese, K. E., von Eyß, B., Herold, S., Rycak, L., Dumay‐Odelot, H., Karim, S. A., Bartkuhn, M., et al. (2014) · Nature · doi:10.1038/nature13473 · Cited by 502 · see citing works

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Hsu, T. Y. T., Simon, L. M., Neill, N. J., Marcotte, R., Sayad, A., Bland, C. S., Echeverria, G. V., Sun, T., Kurley, S. J., Tyagi, S., et al. (2015) · Nature · doi:10.1038/nature14985 · Cited by 493 · see citing works

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

Seoane, J., Pouponnot, C., Staller, P., Schader, M. B., Eilers, M., & Massagué, J. (2001) · Nature Cell Biology · doi:10.1038/35070086 · Cited by 489 · see citing works

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

Sabò, A., Kress, T. R., Pelizzola, M., de Pretis, S., Gorski, M. M., Tesi, A., Morelli, M. J., Bora, P., Doni, M., Verrecchia, A., et al. (2014) · Nature · doi:10.1038/nature13537 · Cited by 478 · see citing works

The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription

von der Lehr, N., Johansson, S. M., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00193-x · Cited by 475 · see citing works

MYC degradation

Farrell, A. S., & Sears, R. C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014365 · Cited by 468 · see citing works

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

Eilers, M., Picard, D., Yamamoto, K. R., & Bishop, J. M. (1989) · Nature · doi:10.1038/340066a0 · Cited by 458 · see citing works

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

Mateyak, M. K., Obaya, Á. J., Adachi, S., & Sedivy, J. M. (1997) · PubMed · Cited by 445 · see citing works

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

Barna, M., Pusic, A., Zollo, O., Costa, M. J., Kondrashov, N., Rego, E., Rao, P., & Ruggero, D. (2008) · Nature · doi:10.1038/nature07449 · Cited by 434 · see citing works

Direct activation of RNA polymerase III transcription by c-Myc

Gomez-Roman, N., Grandori, C., Eisenman, R. N., & White, R. J. (2003) · Nature · doi:10.1038/nature01327 · Cited by 434 · see citing works

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

Kessler, J. D., Kahle, K. T., Sun, T., Meerbrey, K. L., Schlabach, M. R., Schmitt, E. M., Skinner, S. O., Xu, Q., Li, M. Z., Hartman, Z. C., et al. (2011) · Science · doi:10.1126/science.1212728 · Cited by 433 · see citing works

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Schaub, F. X., Dhankani, V., Berger, A. C., Trivedi, M., Richardson, A. B., Shaw, R., Zhao, W., Zhang, X., Ventura, A., Liu, Y., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.03.003 · Cited by 431 · see citing works

An Overview of MYC and Its Interactome

Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014357 · Cited by 408 · see citing works

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

Wu, C.-H., van Riggelen, J., Yetil, A., Fan, A. C., Bachireddy, P., & Felsher, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701953104 · Cited by 405 · see citing works

c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells

Hann, S., Thompson, C. B., & Eisenman, R. N. (1985) · Nature · doi:10.1038/314366a0 · Cited by 369 · see citing works

Myc-binding-site recognition in the human genome is determined by chromatin context

Guccione, E., Martinato, F., Finocchiaro, G., Luzi, L., Tizzoni, L., Olio, V. D., Zardo, G., Nervi, C., Bernard, L., & Amati, B. B. (2006) · Nature Cell Biology · doi:10.1038/ncb1434 · Cited by 365 · see citing works

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

Muhar, M., Ebert, A., Neumann, T., Umkehrer, C., Jude, J., Wieshofer, C., Rescheneder, P., Lipp, J., Herzog, V. A., Reichholf, B., et al. (2018) · Science · doi:10.1126/science.aao2793 · Cited by 364 · see citing works

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

Gorrini, C., Squatrito, M., Luise, C., Syed, N., Perna, D., Wark, L., Martinato, F., Sardella, D., Verrecchia, A., Bennett, S., et al. (2007) · Nature · doi:10.1038/nature06055 · Cited by 341 · see citing works

Transcription-dependent dynamic supercoiling is a short-range genomic force

Kouzine, F., Gupta, A., Baranello, L., Wójtowicz, D., Ben-Aissa, K., Liu, J., Przytycka, T. M., & Levens, D. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2517 · Cited by 329 · see citing works

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC

Goga, A., Yang, D., Tward, A. D., Morgan, D. O., & Bishop, J. M. (2007) · Nature Medicine · doi:10.1038/nm1606 · Cited by 324 · see citing works

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

Wu, S., Cetinkaya, C., Muñoz-Alonso, M. J., von der Lehr, N., Bahram, F., Beuger, V., Eilers, M., León, J., & Larsson, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206145 · Cited by 314 · see citing works

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Thomas, L. R., Wang, Q., Grieb, B. C., Phan, J., Foshage, A. M., Sun, Q., Olejniczak, E. T., Clark, T., Dey, S., Lorey, S., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.028 · Cited by 310 · see citing works

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

Herold, S., Wanzel, M., Beuger, V., Frohme, C., Beul, D., Hillukkala, T., Syväoja, J. E., Saluz, H., Haenel, F., & Eilers, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00633-0 · Cited by 305 · see citing works

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

Brockmann, M., Poon, E., Berry, T., Carstensen, A., Deubzer, H. E., Rycak, L., Jamin, Y., Thway, K., Robinson, S. P., Roels, F., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.05.005 · Cited by 300 · see citing works

A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma

Kawauchi, D., Robinson, G. W., Uziel, T., Gibson, P., Rehg, J. E., Gao, C., Finkelstein, D., Qu, C., Pounds, S. B., Ellison, D. W., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.12.023 · Cited by 300 · see citing works

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

Chen, L., Chen, J., Huang, Y.-J., Gu, Y., Qiu, J., Qian, H., Shao, C., Zhang, X., Hu, J., Li, H., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2017.12.029 · Cited by 295 · see citing works

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

Liu, L., Ulbrich, J., Müller, J., Wüstefeld, T., Aeberhard, L., Kress, T. R., Muthalagu, N., Rycak, L., Rudalska, R., Moll, R., et al. (2012) · Nature · doi:10.1038/nature10927 · Cited by 276 · see citing works

Conflict Resolution in the Genome: How Transcription and Replication Make It Work

Hamperl, S., & Cimprich, K. A. (2016) · Cell · doi:10.1016/j.cell.2016.09.053 · Cited by 275 · see citing works

A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

Dauch, D., Rudalska, R., Cossa, G., Nault, J., Kang, T.-W., Wüestefeld, T., Hohmeyer, A., Imbeaud, S., Yevsa, T., Hoenicke, L., et al. (2016) · Nature Medicine · doi:10.1038/nm.4107 · Cited by 274 · see citing works

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

Jacquet, K., Fradet‐Turcotte, A., Avvakumov, N., Lambert, J., Lopez‐Roques, C., PANDITA, R. K., Paquet, É. R., Herst, P. M., Gingras, A., Pandita, T. K., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.031 · Cited by 260 · see citing works

Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

Eberhardy, S. R., & Farnham, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207441200 · Cited by 259 · see citing works

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

Hydbring, P., Bahram, F., Su, Y., Tronnersjö, S., Högstrand, K., von der Lehr, N., Sharifi, H. R., Lilischkis, R., Hein, N., Wu, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900121106 · Cited by 224 · see citing works

The ConSurf-DB: pre-calculated evolutionary conservation profiles of protein structures

Goldenberg, O., Erez, E., Nimrod, G., & Ben‐Tal, N. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn822 · Cited by 221 · see citing works

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

Bermejo, R., Capra, T., Jossen, R., Colosio, A., Frattini, C., Carotenuto, W., Cocito, A., Doksani, Y., Klein, H. L., Gómez‐González, B., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.033 · Cited by 215 · see citing works

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

Nilsson, J. A., Keller, U. B., Baudino, T. A., Yang, C., Norton, S., Old, J. B., Nilsson, L. M., Neale, G. A. M., Kramer, D. L., Porter, C. W., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.036 · Cited by 210 · see citing works

c-Myc Phosphorylation Is Required for Cellular Response to Oxidative Stress

Benassi, B., Fanciulli, M., Fiorentino, F., Porrello, A., Chiorino, G., Loda, M. F., Zupi, G., & Biroccio, A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.009 · Cited by 207 · see citing works

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaPreprint

Huang, C., Lujambio, A., Zuber, J. A., Tschaharganeh, D. F., Doran, M. G., Evans, M. J., Kitzing, T. M., Zhu, N., de Stanchina, E., Sawyers, C. L., et al. (2014) · Genes & Development · doi:10.1101/gad.244368.114 · Cited by 201 · see citing works

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

Kalkat, M., Resetca, D., Lourenco, C., Chan, P.-K., Wei, Y., Shiah, Y.-J., Vitkin, N., Tong, Y., Sunnerhagen, M., Done, S. J., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.09.031 · Cited by 201 · see citing works

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

Annibali, D., Whitfield, J. R., Favuzzi, E., Jauset, T., Serrano, E., Cuartas, I., Redondo-Campos, S., Folch, G., Gonzàlez-Juncà, A., Sodir, N. M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5632 · Cited by 200 · see citing works

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

Richards, M. W., Burgess, S. G., Poon, E., Carstensen, A., Eilers, M., Chesler, L., & Bayliss, R. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610626113 · Cited by 184 · see citing works

Isolation of Mammalian 26S Proteasomes and p97/VCP Complexes Using the Ubiquitin-like Domain from HHR23B Reveals Novel Proteasome-Associated Proteins

Besche, H. C., Haas, W., Gygi, S. P., & Goldberg, A. L. (2009) · Biochemistry · doi:10.1021/bi802198q · Cited by 183 · see citing works

Endogenous Myc maintains the tumor microenvironmentPreprint

Sodir, N. M., Swigart, L. B., Karnezis, A. N., Hanahan, D., Evan, G. I., & Soucek, L. (2011) · Genes & Development · doi:10.1101/gad.2038411 · Cited by 177 · see citing works

Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival

Xiao, D., Yue, M., Su, H., Ren, P., Jiang, J., Li, F., Hu, Y., Du, H., Liu, H., & Qing, G. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.016 · Cited by 174 · see citing works

Different promoter affinities account for specificity in MYC-dependent gene regulation

Lorenzin, F., Benary, U., Baluapuri, A., Walz, S., Jung, L. A., von Eyß, B., Kisker, C., Wolf, J., Eilers, M., & Wolf, E. (2016) · eLife · doi:10.7554/elife.15161 · Cited by 162 · see citing works

Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover

Popov, N., Schülein‐Völk, C., Jaenicke, L. A., & Eilers, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2104 · Cited by 151 · see citing works

PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy

Tan, J. Y., Li, Z., Lee, P. L., Guan, P., Aau, M. Y., Lee, S. T., Feng, M., Lim, C. Z., Lee, E. Y. J., Wee, Z. N., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0595 · Cited by 150 · see citing works

BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation

Shivji, M. K., Renaudin, X., Williams, C. H., & Venkitaraman, A. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.086 · Cited by 150 · see citing works

The Cdk1 Complex Plays a Prime Role in Regulating N-Myc Phosphorylation and Turnover in Neural Precursors

Sjostrom, S. K., Finn, G., Hahn, W. C., Rowitch, D. H., & Kenney, A. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.014 · Cited by 147 · see citing works

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

Gothe, H. J., Bouwman, B. A. M., Gusmao, E. G., Piccinno, R., Petrosino, G., Sayols, S., Drechsel, O., Minneker, V., Josipović, N., Mizi, A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.05.015 · Cited by 147 · see citing works

MYC Is a Major Determinant of Mitotic Cell Fate

Topham, C. H., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., Ridgway, R. A., Huels, D. J., Littler, S., Schandl, C., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.06.001 · Cited by 142 · see citing works

C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia†

Blanco‐Bose, W. E., Murphy, M. J., Ehninger, A., Offner, S., Dubey, C., Huang, W., Moore, D. D., & Trumpp, A. (2008) · Hepatology · doi:10.1002/hep.22475 · Cited by 138 · see citing works

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Heidelberger, J. B., Voigt, A., Borisova, M. E., Petrosino, G., Ruf, S., Wagner, S., & Beli, P. (2018) · EMBO Reports · doi:10.15252/embr.201744754 · Cited by 138 · see citing works

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

Baluapuri, A., Hofstetter, J., Dudvarski Stankovic, N., Endres, T., Bhandare, P., Vos, S. M., Adhikari, B., Schwarz, J. D., Narain, A., Vogt, M., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.031 · Cited by 138 · see citing works

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma

Berwanger, B., Hartmann, O., Bergmann, E., Bernard, S., Nielsen, D., Krause, M., Kartal, A., Flynn, D. C., Wiedemeyer, R., Schwab, M., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00179-4 · Cited by 136 · see citing works

Taming of the beast: shaping Myc-dependent amplification

Wolf, E., Lin, C. Y., Eilers, M., & Levens, D. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.10.006 · Cited by 135 · see citing works

Down-regulation of LFA-1 Adhesion Receptors by C- myc Oncogene in Human B Lymphoblastoid Cells

Inghirami, G., Grignani, F., Sternas, L. A., Lombardi, L., Knowles, D. M., & Dalla‐Favera, R. (1990) · Science · doi:10.1126/science.2237417 · Cited by 135 · see citing works

Human THO–Sin3A interaction reveals new mechanisms to prevent R‐loops that cause genome instability

Salas‐Armenteros, I., Calero, C. P., Bayona‐Feliú, A., Tumini, E., Luna, R., & Aguilera, A. (2017) · The EMBO Journal · doi:10.15252/embj.201797208 · Cited by 133 · see citing works

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stressPreprint

Poli, J., Gerhold, C., Tosi, A., Hustedt, N., Seeber, A., Sack, R., Herzog, F., Pasero, P., Shimada, K., Hopfner, K., et al. (2016) · Genes & Development · doi:10.1101/gad.273813.115 · Cited by 129 · see citing works

c-Myc Overexpression Uncouples DNA Replication from Mitosis

Li, Q., & Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5339 · Cited by 128 · see citing works

Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP

Chiu, A., Suzuki, H. I., Wu, X., Mahat, D. B., Kriz, A. J., & Sharp, P. A. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.006 · Cited by 124 · see citing works

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

Tu, W. B., Shiah, Y.-J., Lourenco, C., Mullen, P. J., Dingar, D. D., Redel, C., Tamachi, A., Ba-Alawi, W., Aman, A. M., Al‐awar, R., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.09.001 · Cited by 119 · see citing works

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

Gebhardt, A., Frye, M., Herold, S., Benitah, S. A., Braun, K., Samans, B., Watt, F. M., Elsässer, H.-P., & Eilers, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506057 · Cited by 118 · see citing works

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation

Jaenicke, L. A., von Eyß, B., Carstensen, A., Wolf, E., Xu, W., Greifenberg, A. K., Geyer, M., Eilers, M., & Popov, N. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.007 · Cited by 110 · see citing works

Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier

Martins, F. C., de Santiago, I., Trinh, A. C., Xian, J., Guo, A., Sayal, K., Jimenez‐Liñan, M., Deen, S., Driver, K. E., Mack, M. L., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0526-8 · Cited by 108 · see citing works

Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase

Herold, S., Kalb, J., Büchel, G., Ade, C. P., Baluapuri, A., Xu, J., Köster, J., Solvie, D., Carstensen, A., Klotz, C., et al. (2019) · Nature · doi:10.1038/s41586-019-1030-9 · Cited by 107 · see citing works

The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenancePreprint

van Riggelen, J., Müller, J., Otto, T., Beuger, V., Yetil, A., Choi, P. S., Kosan, C., Möröy, T., Felsher, D. W., & Eilers, M. (2010) · Genes & Development · doi:10.1101/gad.585710 · Cited by 105 · see citing works

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

Büchel, G., Carstensen, A., Mak, K. Y., Röschert, I., Leen, E. N., Sumara, O., Hofstetter, J., Herold, S., Kalb, J., Baluapuri, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.090 · Cited by 103 · see citing works

Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

Iwai, K., Yaguchi, M., Nishimura, K., Yamamoto, Y., Tamura, T., Nakata, D., Dairiki, R., Kawakita, Y., Mizojiri, R., Ito, Y., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708289 · Cited by 101 · see citing works

Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer

Zhang, Y., Liu, B., Wu, W., Li, L., Broom, B. M., Basourakos, S. P., Korentzelos, D. K., Luan, Y., Wang, J., Yang, G., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1872 · Cited by 99 · see citing works

RNA Pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD Phosphorylation, and Transcriptional Direction

Fong, N., Saldi, T., Sheridan, R. M., Cortazar, M. A., & Bentley, D. L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.016 · Cited by 98 · see citing works

Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function

Dubois, N. C., Adolphe, C., Ehninger, A., Wang, R. A., Robertson, E. J., & Trumpp, A. (2008) · Development · doi:10.1242/dev.022707 · Cited by 95 · see citing works

Inverse regulation of cyclin B1 by c-Myc and p53 and induction of tetraploidy by cyclin B1 overexpression.

Yin, X. Y., Grove, L. E., Datta, N. S., Katula, K. S., Long, M. W., & Prochownik, E. V. (2001) · PubMed · Cited by 93 · see citing works

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

Ricke, R. M., Jeganathan, K. B., Malureanu, L. A., Harrison, A. M., & van Deursen, J. M. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201205115 · Cited by 93 · see citing works

Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

Hurlin, P. J., Zhou, Z., Toyo‐oka, K., Ota, S., Walker, W. L., Hirotsune, S., & Wynshaw-Boris, A. J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg442 · Cited by 86 · see citing works

Sequence specificity incompletely defines the genome-wide occupancy of Myc

Guo, J., Li, T., Schipper, J. L., Nilson, K. A., Fordjour, F. K., Cooper, J. J., Gordân, R., & Price, D. H. (2014) · Genome biology · doi:10.1186/s13059-014-0482-3 · Cited by 84 · see citing works

MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase

Kaur, M., & Cole, M. D. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2522 · Cited by 84 · see citing works

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity

Vo, B. T., Wolf, E., Kawauchi, D., Gebhardt, A., Rehg, J. E., Finkelstein, D., Walz, S., Murphy, B. L., Youn, Y. H., Han, Y.-G., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2015.12.003 · Cited by 82 · see citing works

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

Dammert, M. A., Brägelmann, J., Olsen, R. R., Böhm, S., Monhasery, N., Whitney, C. P., Chalishazar, M. D., Tumbrink, H. L., Guthrie, M. R., Klein, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11371-x · Cited by 82 · see citing works

Akt and 14-3-3η regulate Miz1 to control cell-cycle arrest after DNA damage

Wanzel, M., Kleine‐Kohlbrecher, D., Herold, S., Hock, A., Berns, K., Park, J., Hemmings, B. A., & Eilers, M. (2004) · Nature Cell Biology · doi:10.1038/ncb1202 · Cited by 77 · see citing works

An early Myc‐dependent transcriptional program orchestrates cell growth during B‐cell activation

Tesi, A., de Pretis, S., Furlan, M., Filipuzzi, M., Morelli, M. J., Andronache, A., Doni, M., Verrecchia, A., Pelizzola, M., Amati, B. B., et al. (2019) · EMBO Reports · doi:10.15252/embr.201947987 · Cited by 71 · see citing works

The MYC mRNA 3′‐UTR couples RNA polymerase II function to glutamine and ribonucleotide levels

Dejure, F. R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C. P., Mastrobuoni, G., Vanselow, J. T., Schlösser, A., Wolf, E., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796662 · Cited by 69 · see citing works

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signalsPreprint

Su, Y., Pelz, C., Huang, T., Torkenczy, K. A., Wang, X., Cherry, A. E., Daniel, C. J., Liang, J. B., Nan, X., Dai, M., et al. (2018) · Genes & Development · doi:10.1101/gad.314377.118 · Cited by 65 · see citing works

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Thomas, L. R., Wang, Q., Grieb, B. C., Phan, J., Bryan, A. F., Sun, Q., Olejniczak, E. T., Clark, T. G., Dey, S., Lorey, S. L., et al. (2018) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · doi:10.2210/pdb6dak/pdb · Cited by 64 · see citing works

Multiple direct interactions of TBP with the MYC oncoprotein

Wei, Y., Resetca, D., Li, Z., Johansson-Åkhe, I., Ahlner, A., Helander, S., Wallenhammar, A., Morad, V., Raught, B., Wallner, B., et al. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0321-z · Cited by 63 · see citing works

The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas

D’Andrea, A., Gritti, I., Nicoli, P., Giorgio, M., Doni, M., Conti, A., Bianchi, V., Casoli, L., Sabò, A., Mironov, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11719 · Cited by 63 · see citing works

Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors

Kress, T. R., Pellanda, P., Pellegrinet, L., Bianchi, V., Nicoli, P., Doni, M., Recordati, C., Bianchi, S., Rotta, L., Capra, T., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0316 · Cited by 62 · see citing works

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

Cossa, G., Röschert, I., Prinz, F., Baluapuri, A., Vidal, R. S., Schülein‐Völk, C., Chang, Y.-C., Ade, C. P., Mastrobuoni, G., Girard, C., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.01.008 · Cited by 62 · see citing works

Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activationPreprint

de Pretis, S., Kress, T. R., Morelli, M. J., Sabò, A., Locarno, C. V., Verrecchia, A., Doni, M., Campaner, S., Amati, B. B., & Pelizzola, M. (2017) · Genome Research · doi:10.1101/gr.226035.117 · Cited by 59 · see citing works

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

Yustein, J. T., Liu, Y.-C., Gao, P., Jie, C., Le, A., Vuica‐Ross, M., Chng, W. J., Eberhart, C. G., Bergsagel, P. L., & Dang, C. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901230107 · Cited by 58 · see citing works

MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits

Zhang, N., Ichikawa, W., Faiola, F., Lo, S.-Y., Liu, X., & Martinez, E. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.03.017 · Cited by 54 · see citing works

<i>Max</i> deletion destabilizes MYC protein and abrogates Eµ- <i>Myc</i> lymphomagenesis

Mathsyaraja, H., Freie, B., Cheng, P.-F., Babaeva, E., Catchpole, J. T., Janssens, D., Henikoff, S., & Eisenman, R. N. (2019) · Genes &amp; Development · doi:10.1101/gad.325878.119 · Cited by 54 · see citing works

Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif

Thomas, L. R., Foshage, A. M., Weissmiller, A. M., Popay, T. M., Grieb, B. C., Qualls, S. J., Ng, V. H., Carboneau, L., Lorey, S. L., Eischen, C. M., et al. (2015) · Oncogene · doi:10.1038/onc.2015.416 · Cited by 48 · see citing works

Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

Lewis, L. M., Edwards, M. C., Meyers, Z. R., Talbot, C. C., Hao, H., Blum, D. L., Reproducibility Project: Cancer Biology, Iorns, E. J., Tsui, R., Denis, A., et al. (2018) · eLife · doi:10.7554/elife.30274 · Cited by 36 · see citing works

A fusion protein formed by L‐myc and a novel gene in SCLC.

Mäkelä, T. P., Saksela, K., Evan, G. I., & Alitalo, K. K. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07652.x · Cited by 34 · see citing works

PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters

Gerlach, J. M., Furrer, M., Gallant, M., Birkel, D., Baluapuri, A., Wolf, E., & Gallant, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705816114 · Cited by 31 · see citing works

Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis

Murphy, D. M., Buckley, P. G., Bryan, K. R., Watters, K. M., Köster, J., Sluis, P. V., Molenaar, J. J., Versteeg, R., & Stallings, R. L. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20722 · Cited by 27 · see citing works

Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocationsPreprint

Gothe, H. J., Bouwman, B. A. M., Gusmao, E. G., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/485763 · Cited by 22 · see citing works

Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models

Ross, J., Rashkovan, M., Fraszczak, J., Joly-Beauparlant, C., Vadnais, C., Winkler, R., Droit, A., Kosan, C., & Möröy, T. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3038 · Cited by 22 · see citing works

Metabolism and cancer

Szent‐Györgyi, A. (2009) · International Journal of Quantum Chemistry · doi:10.1002/qua.560280725 · Cited by 18 · see citing works

Inference of cell cycle-dependent proteolysis by laser scanning cytometry

Chakraborty, A. A., & Tansey, W. P. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.01.011 · Cited by 12 · see citing works

Wheezing in the child under two years.

Af, F. (1973) · PubMed · Cited by 1 · see citing works

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

Dhanasekaran, R., Deutzmann, A., Mahauad‐Fernandez, W. D., Hansen, A. S., Gouw, A. M., & Felsher, D. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00549-2 · Cited by 1,010 · see citing works

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

Madden, S. K., de Araujo, A. D., Gerhardt, M., Fairlie, D. P., & Mason, J. M. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01291-6 · Cited by 404 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer

Labrie, M., Brugge, J. S., Mills, G. B., & Zervantonakis, I. K. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00454-5 · Cited by 388 · see citing works

MYC protein interactors in gene transcription and cancer

Lourenco, C., Resetca, D., Redel, C., Lin, P., MacDonald, A. S., Ciaccio, R., Kenney, T. M. G., Wei, Y., Andrews, D. W., Sunnerhagen, M., et al. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00367-9 · Cited by 341 · see citing works

Targeted protein degradation: advances in drug discovery and clinical practice

Zhong, G., Chang, X., Xie, W., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02004-x · Cited by 326 · see citing works

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Wang, J., Yu, X., Gong, W., Liu, X., Park, K., Ma, A., Tsai, Y., Shen, Y., Onikubo, T., Pi, W., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00850-x · Cited by 187 · see citing works

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Topatana, W., Juengpanich, S., Li, S., Cao, J., Hu, J., Lee, J., Suliyanto, K., Ma, D., Zhang, B., Chen, M., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00956-5 · Cited by 182 · see citing works

MYCN Function in Neuroblastoma Development

Otte, J., Dyberg, C. H., Pepich, A., & Johnsen, J. I. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.624079 · Cited by 181 · see citing works

MYC: a complex problem

Das, S., Lewis, B. A., & Levens, D. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.07.006 · Cited by 166 · see citing works

Targeting transcription cycles in cancer

Vervoort, S., Devlin, J., Kwiatkowski, N., Teng, M.-X., Gray, N., & Johnstone, R. (2021) · Nature Reviews. Cancer · doi:10.1038/s41568-021-00411-8 · Cited by 140 · see citing works

Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines

Liu, M., Wang, Y., Zhang, Y.-B., Hu, D., Tang, L., Zhou, B., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02112-8 · Cited by 174 · see citing works

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Wang, L., Chen, C., Song, Z., Wang, H., Ye, M., Wang, D., Kang, W., Liu, H., & Qing, G. (2022) · Nature Communications · doi:10.1038/s41467-021-27609-6 · Cited by 149 · see citing works

Human embryonic genome activation initiates at the one-cell stage

Asami, M., Lam, B., Ma, M. K. L., Rainbow, K., Braun, S., VerMilyea, M. D., Yeo, G. S. H., & Perry, A. C. F. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.11.012 · Cited by 138 · see citing works

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Yang, L., Jia, R., Ge, T., Ge, S., Zhuang, A., Chai, P., & Fan, X. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01176-8 · Cited by 128 · see citing works

Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

Beaulieu, M.-È., Castillo, F., & Soucek, L. (2020) · Cells · doi:10.3390/cells9041038 · Cited by 110 · see citing works

MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”

Das, S., Kuzin, V., Cameron, D. P., Sanford, S., Jha, R. K., Nie, Z., Rosello, M. T., Holewinski, R. J., Andrésson, Þ., Wiśniewski, J., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.11.016 · Cited by 113 · see citing works

Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer

Xu, H., Luo, H., Zhang, J., Li, K., & Lee, M. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2186114 · Cited by 110 · see citing works

Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery

Liu, H., Liu, K., & Dong, Z. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2245 · Cited by 99 · see citing works

Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis

Han, X., Ren, C., Lü, C., Qiao, P., Yang, T., & Yu, Z. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00971-8 · Cited by 101 · see citing works

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma

Röschert, I., Poon, E., Henssen, A. G., García, H. D., Gatti, M., Giansanti, C., Jamin, Y., Ade, C. P., Gallant, P., Schülein‐Völk, C., et al. (2021) · Nature Cancer · doi:10.1038/s43018-020-00171-8 · Cited by 96 · see citing works

Targeting MYCN in Pediatric and Adult Cancers

Liu, Z., Chen, S. S., Clarke, S., Veschi, V., & Thiele, C. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.623679 · Cited by 94 · see citing works

MYC multimers shield stalled replication forks from RNA polymerase

Solvie, D., Baluapuri, A., Uhl, L., Fleischhauer, D., Endres, T., Papadopoulos, D., Aziba, A., Gaballa, A., Mikičić, I., Isaakova, E. A., et al. (2022) · Nature · doi:10.1038/s41586-022-05469-4 · Cited by 95 · see citing works

A review of healthy role of dietary fiber in modulating chronic diseases

Li, M., & Ma, S. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114682 · Cited by 101 · see citing works

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

Popay, T. M., Wang, J., Adams, C. M., Howard, G. C., Codreanu, S. G., Sherrod, S. D., MCLEAN, J. A. J., Thomas, L. R., Lorey, S. L., Machida, Y., et al. (2021) · eLife · doi:10.7554/elife.60191 · Cited by 90 · see citing works

Interaction modules that impart specificity to disordered protein

Čermáková, K., & Hodges, H. C. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.01.004 · Cited by 92 · see citing works

GEPIA3: Enhanced drug sensitivity and interaction network analysis for cancer research

Kang, Y.-J., Pan, L., Liu, Y., Rong, Z., Liu, J., & Liu, F. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf423 · Cited by 94 · see citing works

Molecular Crosstalk Between MYC and HIF in Cancer

Li, Y., Sun, X., Qian, D. Z., & Dai, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590576 · Cited by 90 · see citing works

LncRNA SNHG17 interacts with LRPPRC to stabilize c-Myc protein and promote G1/S transition and cell proliferation

Liu, J.-Y., Chen, Y., Feng, H.-H., Chen, Z., Wang, Y., Yang, J., & Zhuang, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04238-x · Cited by 75 · see citing works

Current Status and Prospects of Targeted Therapy for Osteosarcoma

Hu, Z., Wen, S., Huo, Z., Wang, Q., Zhao, J., Wang, Z., Chen, Y., Zhang, L., Zhou, F., Guo, Z., et al. (2022) · Cells · doi:10.3390/cells11213507 · Cited by 73 · see citing works

MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint

Smith, B. A. H., Deutzmann, A., Correa, K. M., Delaveris, C. S., Dhanasekaran, R., Dove, C. G., Sullivan, D. K., Wisnovsky, S., Stark, J. C., Pluvinage, J. V., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215376120 · Cited by 73 · see citing works

Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer

Yang, K., Zhang, W., Zhong, L., Xiao, Y., Sahoo, S., Fassan, M., Zeng, K., Magee, P., Garofalo, M., & Shi, L. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01160-x · Cited by 71 · see citing works

High-throughput PRIME-editing screens identify functional DNA variants in the human genome

Ren, X., Yang, H., Nierenberg, J. L., Sun, Y., Chen, J., Beaman, C., Pham, T., Nobuhara, M., Takagi, M. A., Narayan, V., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.021 · Cited by 70 · see citing works

MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

Papadopoulos, D., Solvie, D., Baluapuri, A., Endres, T., Ha, S. A., Herold, S., Kalb, J., Giansanti, C., Schülein‐Völk, C., Ade, C. P., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.11.002 · Cited by 58 · see citing works

Molecular Mechanisms of MYCN Dysregulation in Cancers

Liu, R., Shi, P., Wang, Z., Yuan, C., & Cui, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.625332 · Cited by 63 · see citing works

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor Microenvironment

Liu, T., Han, S., Yao, Y., & Zhang, G. (2023) · Cancer Management and Research · doi:10.2147/cmar.s421771 · Cited by 64 · see citing works

Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective

Chen, X., Xu, J., Wang, X., Long, G., You, Q., & Guo, X. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00037 · Cited by 63 · see citing works

In vivo interactome profiling by enzyme‐catalyzed proximity labeling

Xu, Y., Fan, X., & Hu, Y. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00542-3 · Cited by 59 · see citing works

Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor

Welcker, M., Wang, B., Rusnac, D.-V., Hussaini, Y., Swanger, J., Zheng, N., & Clurman, B. E. (2022) · Science Advances · doi:10.1126/sciadv.abl7872 · Cited by 57 · see citing works

Orphan quality control shapes network dynamics and gene expression

Mark, K. G., Kolla, S., Aguirre, J. D., Garshott, D. M., Schmitt, S., Haakonsen, D. L., Xu, C., Kater, L., Kempf, G., Martínez-González, B., et al. (2023) · Cell · doi:10.1016/j.cell.2023.06.015 · Cited by 58 · see citing works

MYC phase separation selectively modulates the transcriptome

Yang, J., Chung, C.-I., Koach, J., Liu, H., Navalkar, A., He, H., Ma, Z., Zhao, Q. C., Yang, X., He, L., et al. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01322-6 · Cited by 56 · see citing works

Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

Endres, T., Solvie, D., Heidelberger, J. B., Andrioletti, V., Baluapuri, A., Ade, C. P., Muhar, M., Eilers, U., Vos, S. M., Cramer, P., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.035 · Cited by 54 · see citing works

Targeting Myc-driven stress addiction in colorectal cancer

Saeed, H., Leibowitz, B. J., Zhang, L., & Yu, J. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100963 · Cited by 53 · see citing works

Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy

Sun, X., Li, Y., Sears, R. C., & Dai, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.679445 · Cited by 49 · see citing works

Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer

Shi, W., Wang, Y., Xu, C., Li, Y., Ge, S., Bai, B., Zhang, K., Wang, Y., Zheng, N., Wang, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35797-6 · Cited by 50 · see citing works

Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma

Nakauma‐González, J. A., Rijnders, M., van Riet, J., van der Heijden, M. S., Voortman, J., Cuppen, E. P. J. G., Mehra, N., van Wilpe, S., Oosting, S. F., Rijstenberg, L. L., et al. (2022) · European Urology · doi:10.1016/j.eururo.2022.01.026 · Cited by 48 · see citing works

Tilting MYC toward cancer cell death

Harrington, C. T., Sotillo, E., Dang, C. V., & Thomas‐Tikhonenko, A. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.08.002 · Cited by 47 · see citing works

Dual-role transcription factors stabilize intermediate expression levels

He, J., Huo, X., Pei, G., Jia, Z., Yan, Y., Yu, J., Qu, H., Xie, Y., Yuan, J., Zheng, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.023 · Cited by 45 · see citing works

MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation

Ma, J., Li, L., Ma, B., Liu, T., Wang, Z., Ye, Q., Peng, Y., Wang, B., Chen, Y., Xu, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45796-w · Cited by 44 · see citing works

MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation

Wu, G., Suo, C., Yang, Y., Shen, S., Sun, L., Li, S., Zhou, Y., Yang, D., Wang, Y., Cai, Y., et al. (2021) · EMBO Reports · doi:10.15252/embr.202051519 · Cited by 44 · see citing works

Integrated requirement of non‐specific and sequence‐specific DNA binding in Myc‐driven transcription

Pellanda, P., Dalsass, M., Filipuzzi, M., Loffreda, A., Verrecchia, A., Cano, V. C., Thabussot, H., Doni, M., Morelli, M. J., Soucek, L., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020105464 · Cited by 43 · see citing works

T cells at work: How post‐transcriptional mechanisms control T cell homeostasis and activation

Jurgens, A. P., Popović, B., & Wolkers, M. C. (2021) · European Journal of Immunology · doi:10.1002/eji.202049055 · Cited by 39 · see citing works

Drugging the ‘undruggable’. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods

Radaeva, M., Ton, A., Hsing, M., Ban, F., & Cherkasov, A. R. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.07.018 · Cited by 44 · see citing works

Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer

Fairlie, W. D., & Lee, E. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062841 · Cited by 43 · see citing works

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Huang, P., Zhu, S., Liang, X., Zhang, Q., Luo, X., Liu, C., & Song, L. (2021) · Cancer Management and Research · doi:10.2147/cmar.s314502 · Cited by 42 · see citing works

Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

Mathsyaraja, H., Catchpole, J., Freie, B. W., Eastwood, E., Babaeva, E., Geuenich, M., Cheng, P. F., Ayers, J., Yu, M., Wu, N., et al. (2021) · eLife · doi:10.7554/elife.64212 · Cited by 39 · see citing works

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

Ruan, H., Li, X., Xu, X. M., Leibowitz, B. J., Tong, J., Chen, L., Ao, L., Xing, W., Luo, J., Yu, Y., et al. (2020) · eLife · doi:10.7554/elife.60151 · Cited by 40 · see citing works

Strategies to target the cancer driver MYC in tumor cells

Weber, L. I., & Hartl, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1142111 · Cited by 40 · see citing works

Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis

Gao, M., Yang, J., Gong, H., Lin, Y., & Liu, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.760055 · Cited by 39 · see citing works

A Focus on Regulatory Networks Linking MicroRNAs, Transcription Factors and Target Genes in Neuroblastoma

Perri, P., Ponzoni, M., Corrias, M. V., Ceccherini, I., Candiani, S., & Bachetti, T. (2021) · Cancers · doi:10.3390/cancers13215528 · Cited by 39 · see citing works

MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

Krenz, B., Gebhardt-Wolf, A., Ade, C. P., Gaballa, A., Roehrig, F., Vendelova, E., Baluapuri, A., Eilers, U., Gallant, P., D’Artista, L., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1677 · Cited by 37 · see citing works

Role of c-Myc in lung cancer: Progress, challenges, and prospects

Wallbillich, N. J., & Lu, H. (2023) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2023.07.001 · Cited by 36 · see citing works

Ubiquitin-dependent regulation of transcription in development and disease

Mark, K. G., & Rapé, M. (2021) · EMBO Reports · doi:10.15252/embr.202051078 · Cited by 37 · see citing works

Mitochondrial fragmentation is crucial for c-Myc-driven hepatoblastoma-like liver tumors

Wang, D., Tian, J., Yan, Z., Yuan, Q., Wu, D., Liu, X., Yang, S., Guo, S., Wang, J., Yang, Y., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.032 · Cited by 34 · see citing works

Beyond gene expression: how MYC relieves transcription stress

Papadopoulos, D., Uhl, L., Ha, S. A., & Eilers, M. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.06.008 · Cited by 34 · see citing works

Targeting MYC: From understanding its biology to drug discovery

Ross, J., Miron, C. E., Plescia, J., LaPlante, P., McBride, K. M., Moitessier, N., & Möröy, T. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.113137 · Cited by 34 · see citing works

Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer

Bai, L., Ma, Y., Wang, X., Feng, Q., Zhang, Z., Wang, S., Zhang, H., Lu, X., Xu, Y., Zhao, E., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.587218 · Cited by 34 · see citing works

Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer

Guan, X., Yang, J., Wang, W., Zhao, B., Hu, S., Yu, D., Yuan, L., Shi, Y., Xu, J., Dong, J., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106703 · Cited by 33 · see citing works

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity

Sahoo, S. S., Ramanand, S. G., Gao, Y., Abbas, A., Kumar, A., Cuevas, I., Li, H., Aguilar, M., Xing, C., Mani, R. S., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157574 · Cited by 33 · see citing works

Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring

Anatskaya, O. V., & Vinogradov, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179691 · Cited by 27 · see citing works

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

Wyn, J. D., Zimmerman, M. W., Weichert‐Leahey, N., Nunes, C., Cheung, B. B., Abraham, B. J., Beckers, A., Volders, P., Decaesteker, B., Carter, D. R., et al. (2021) · Cancers · doi:10.3390/cancers13194783 · Cited by 30 · see citing works

Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy

Zhou, Y., Gao, X., Meng, Y. G., Yang, B., He, Q., & Cao, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.748852 · Cited by 29 · see citing works

Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen

Schukur, L., Zimmermann, T., Niewoehner, O., Kerr, G., Gleim, S., Bauer-Probst, B., Knapp, B., Galli, G. G., Liang, X., Mendiola, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76960-z · Cited by 28 · see citing works

High-Level MYCN-Amplified RB1-Proficient Retinoblastoma Tumors Retain Distinct Molecular Signatures

Roohollahi, K., de Jong, Y., van Mil, S. E., Fabius, A. W. M., Moll, A. C., & Dorsman, J. C. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100188 · Cited by 27 · see citing works

The initiation of mammalian embryonic transcription: to begin at the beginning

Perry, A. C. F., Asami, M., Lam, B., & Yeo, G. S. H. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.08.008 · Cited by 26 · see citing works

A program of successive gene expression in mouse one-cell embryos

Asami, M., Lam, B., Hoffmann, M., Suzuki, T., Lu, X., Yoshida, N., Ma, M. K. L., Rainbow, K., Gužvić, M., VerMilyea, M. D., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112023 · Cited by 26 · see citing works

E-box binding transcription factors in cancer

Pan, Y., van der Watt, P. J., & Kay, S. A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1223208 · Cited by 25 · see citing works

HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression

Luo, C., Yu, T., Young, K. H., & Yu, L. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200016 · Cited by 24 · see citing works

The “Superoncogene” Myc at the Crossroad between Metabolism and Gene Expression in Glioblastoma Multiforme

Cencioni, C., Scagnoli, F., Spallotta, F., Nasi, S., & Illi, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044217 · Cited by 24 · see citing works

Arenobufagin inhibits lung metastasis of colorectal cancer by targeting c-MYC/Nrf2 axis

Wang, M., Hu, S., Yang, J., Liang, Y., Han, L., Liang, F., Zhang, F., Zhao, H., Liu, Y., & Gao, N. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155391 · Cited by 23 · see citing works

Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile

Shibasaki, H., Kinoh, H., Cabral, H., Quader, S., Mochida, Y., Liu, X., Toh, K., Miyano, K., Matsumoto, Y., Yamasoba, T., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c00364 · Cited by 23 · see citing works

MYC as a Target for Cancer Treatment: from Undruggable to Druggable?

Duffy, M. J., Tang, M., & Crown, J. P. (2025) · Targeted Oncology · doi:10.1007/s11523-025-01169-x · Cited by 22 · see citing works

Integrative bioinformatics analysis of WDHD1: a potential biomarker for pan-cancer prognosis, diagnosis, and immunotherapy

Cui, Z., Zou, F., Wang, R., Wang, L., Cheng, F., Wang, L., Pan, R., Guan, X., Zheng, N., & Wang, W. (2023) · World Journal of Surgical Oncology · doi:10.1186/s12957-023-03187-3 · Cited by 22 · see citing works

Targeting oncogenic transcriptional factor c-myc by oligonucleotide PROTAC for the treatment of hepatocellular carcinoma

Ai, M., Ma, H., He, J., Xu, F., Ming, Y., Ye, Z., Zheng, Q., Luo, D., Yang, K., Li, J., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116978 · Cited by 21 · see citing works

Circulating Tumor Cells in Breast Cancer Patients: A Balancing Act between Stemness, EMT Features and DNA Damage Responses

Heitmeir, B., Deniz, M., Janni, W., Rack, B. K., Schochter, F., & Wiesmüller, L. (2022) · Cancers · doi:10.3390/cancers14040997 · Cited by 22 · see citing works

Lactobacillus paracasei BD5115-Derived 2-Hydroxy-3-Methylbutyric Acid Promotes Intestinal Epithelial Cells Proliferation by Upregulating the MYC Signaling Pathway

Qiao, Z., Wang, X., Wang, C., Jin, H., Qi, W., Zhang, H., Liu, Z., & You, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.799053 · Cited by 22 · see citing works

Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation

Zielke, N., Vähärautio, A., Liu, J., Kivioja, T., & Taipale, J. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.03.018 · Cited by 21 · see citing works

Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma

Yuan, J., Weng, Z., Tan, Z., Luo, K., Zhong, J., Xie, X., Qu, C., Lin, X., Yang, H., Wen, J., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215959 · Cited by 21 · see citing works

The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex

Papadopoulos, D., Ha, S. A., Fleischhauer, D., Uhl, L., Russell, T. J., Mikičić, I., Schneider, K., Brem, A., Valanju, O. R., Cossa, G., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.04.007 · Cited by 21 · see citing works

Targeting MYC: Multidimensional regulation and therapeutic strategies in oncology

Duan, Y., Liu, Z., Wang, Q., Zhang, J., Liu, J., Zhang, Z., & Li, C. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101435 · Cited by 21 · see citing works

Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers

Liu, C., Chen, L., Cong, Y., Cheng, L., Shuai, Y., Lv, F., Chen, K., Song, Y., & Xing, Y. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06489-w · Cited by 18 · see citing works

HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC

Zhang, G., Zhu, Q., Yan, X., Ci, M., Zhao, E., Hou, J., Wan, S., Lü, M., & Cui, H. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01001-9 · Cited by 19 · see citing works

Platycodin-D exerts its anti-cancer effect by promoting c-Myc protein ubiquitination and degradation in gastric cancer

Xu, Q., Pan, G., Wang, Z., Wang, L., Tang, Y., Dong, J., & Qin, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1138658 · Cited by 18 · see citing works

Structure-guided discovery of novel potent and efficacious proteolysis targeting chimera (PROTAC) degrader of BRD4

Wang, X., Wang, Q., Ran, K., Ren, J., Shi, Y., & Yu, L. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105238 · Cited by 18 · see citing works

Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs

Ciaccio, R., Rosa, P. D., Aloisi, S., Viggiano, M., Cimadom, L., Zadran, S. K., Perini, G., & Milazzo, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312883 · Cited by 18 · see citing works

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Wu, Y., Chen, Z., Hu, Y., Zengin, G., Zhang, Q., Li, M., & Sun, W. (2026) · Interdisciplinary medicine · doi:10.1002/inmd.70120 · Cited by 17 · see citing works

SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation

Hu, X., Liu, R., Hou, J., Peng, W., Wan, S., Xu, M., Li, Y., Zhang, G., Zhai, X., Liang, P., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02428-1 · Cited by 17 · see citing works

Regulation of SUMOylation on RNA metabolism in cancers

Cao, Y., Huang, C., Zhao, X., & Yu, J. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1137215 · Cited by 17 · see citing works

MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma

Pitolli, C., Marini, A., Guerra, M., Pieraccioli, M., Marabitti, V., Palluzzi, F., Giacò, L., Tamburrini, G., Cecconi, F., Nazio, F., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02790-2 · Cited by 16 · see citing works

The N-terminal α2 helix element is critical for the activity of the rice transcription factor MYC2

Zu, H., Jin, G., Kong, Y., Li, Z., Lou, Y., & Li, R. (2024) · Plant Molecular Biology · doi:10.1007/s11103-023-01411-y · Cited by 17 · see citing works

Tales of destruction and repair: the changing view of MYC proteins in tumorigenesisPreprint

Baranello, L., Papadopoulos, D., & Eilers, M. (2026) · Genes & Development · doi:10.1101/gad.353899.126

Beyond gene expression: how MYC relieves transcription stress

Papadopoulos, D., Uhl, L., Ha, S. A., & Eilers, M. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.06.008 · Cited by 34 · see citing works

Transcription-independent functions of MYC: regulation of translation and DNA replication

Cole, M. D., & Cowling, V. H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2467 · Cited by 160 · see citing works

MYC protein interactors in gene transcription and cancer

Lourenco, C., Resetca, D., Redel, C., Lin, P., MacDonald, A. S., Ciaccio, R., Kenney, T. M. G., Wei, Y., Andrews, D. W., Sunnerhagen, M., et al. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00367-9 · Cited by 341 · see citing works

Mechanism of transcriptional activation by the Myc oncoproteins

Cowling, V. H., & Cole, M. D. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.08.001 · Cited by 171 · see citing works