The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia
Open accessAbstract
SUMMARY The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of human T-cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3 and RUNX1. We show that TAL1 forms a positive interconnected auto-regulatory loop with GATA3 and RUNX1, and that the TAL1 complex directly activates the MYB oncogene, forming a positive feed-forward regulatory loop that reinforces and stabilizes the TAL1-regulated oncogenic program. One of the critical downstream targets in this circuitry is the TRIB2 gene, which is oppositely regulated by TAL1 and E2A/HEB and is essential for the survival of T-ALL cells.
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Cites
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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
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Self-citationControl of the Embryonic Stem Cell State
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Self-citationOncogenic Transcription Factors in the Human Acute Leukemias
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Self-citationGene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
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Self-citationEarly T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
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Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662
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“Various examples have been reported on the overexpression of bHLH factors in cancer, including c-Myc,Tal1, andOlig2 (Lin et al., 2012; Nie et al., 2012; Palii et al., 2011; Sanda et al., 2012; Suvà et al., 2014).”
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
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Self-citationAn oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
Mansour, M. R., Abraham, B. J., Anders, L., Berezovskaya, A., Gutierrez, A., Durbin, A. D., Etchin, J., Lawton, L., Sallan, S. E., Silverman, L. B., et al. (2014) · Science · doi:10.1126/science.1259037 · Cited by 801
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Metadata
- Authors
- Sanda, T., Lawton, L. N., Barrasa, M. I., Fan, Z. P., Kohlhammer, H., Gutierrez, A., Ma, W., Tatarek, J., Ahn, Y., Kelliher, M. A., Jamieson, C. H. M., Staudt, L. M., Young, R. A., & Look, A. T.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 22
- Issue
- 2
- Pages
- 209-221
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2088990880
- Cited by
- 334
- References
- 59
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sanda, T., Lawton, L. N., Barrasa, M. I., Fan, Z. P., Kohlhammer, H., Gutierrez, A., Ma, W., Tatarek, J., Ahn, Y., Kelliher, M. A., Jamieson, C. H. M., Staudt, L. M., Young, R. A., & Look, A. T. (2012). Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia. Cancer Cell. https://doi.org/10.1016/j.ccr.2012.06.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
