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Cited by 536

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

Open access
Yang, Pengyuan, Li, Qi-Jing, Feng, Yuxiong, Zhang, Yun, Markowitz, Geoffrey J., Ning, Shanglei, Deng, Yuezhen, Zhao, Jiangsha, Jiang, Shan, Yuan, Yunfei, Wang, Hong-Yang, Cheng, Shu-Qun, Xie, Dong, Wang, Xiao-Fan·2012·Cancer Cell
DOI 10.1016/j.ccr.2012.07.023
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Abstract

Portal vein tumor thrombus (PVTT) is strongly correlated to a poor prognosis for patients with hepatocellular carcinoma (HCC). In this study, we uncovered a causative link between hepatitis B virus (HBV) infection and development of PVTT. Mechanistically, elevated TGF-β activity, associated with the persistent presence of HBV in the liver tissue, suppresses the expression of microRNA-34a, leading to enhanced production of chemokine CCL22, which recruits regulatory T (Treg) cells to facilitate immune escape. These findings strongly suggest that HBV infection and activity of the TGF-β-miR-34a-CCL22 axis serve as potent etiological factors to predispose HCC patients for the development of PVTT, possibly through the creation of an immune-subversive microenvironment to favor colonization of disseminated HCC cells in the portal venous system.

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Crossref · 10.1016/j.ccr.2012.07.023

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Metadata

Authors
Yang, P., Li, Q.-J., Feng, Y., Zhang, Y., Markowitz, G. J., Ning, S., Deng, Y., Zhao, J., Jiang, S., Yuan, Y., Wang, H.-Y., Cheng, S.-Q., Xie, D., & Wang, X.-F.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2012-09
Volume
22
Issue
3
Pages
291-303
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccr.2012.07.023
OpenAlex
W2049964698
Cited by
536
References
39
FWCI
22.55
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma. https://app.cochat.ai/papers/10.1016/j.ccr.2012.07.023
The paper
Yang, P., Li, Q.-J., Feng, Y., Zhang, Y., Markowitz, G. J., Ning, S., Deng, Y., Zhao, J., Jiang, S., Yuan, Y., Wang, H.-Y., Cheng, S.-Q., Xie, D., & Wang, X.-F. (2012). TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma. Cancer Cell. https://doi.org/10.1016/j.ccr.2012.07.023

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.