Cited by 314Cancer-related Molecular PathwaysChronic Myeloid Leukemia TreatmentsAngiogenesis and VEGF in Cancer

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A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

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Kollmann, Karoline, Heller, Gerwin, Schneckenleithner, Christine, Warsch, Wolfgang, Scheicher, Ruth, Ott, Rene G., Schäfer, Markus, Fajmann, Sabine, Schlederer, Michaela, Schiefer, Ana-Iris, Reichart, Ursula, Mayerhofer, Matthias, Hoeller, Christoph, Zöchbauer-Müller, Sabine, Kerjaschki, Dontscho, Bock, Christoph, Kenner, Lukas, Hoefler, Gerald, Freissmuth, Michael, Green, Anthony R., Moriggl, Richard, Busslinger, Meinrad, Malumbres, Marcos, Sexl, Veronika·2013·Cancer Cell

DOI 10.1016/j.ccr.2013.07.012PMC PMC5637299

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Abstract

In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels in lymphoid malignancies. In a model for p185BCR-ABL+ B-acute lymphoid leukemia, we show that CDK6 is part of a transcription complex that induces the expression of the tumor suppressor p16INK4a and the pro-angiogenic factor VEGF-A. This function is independent of CDK6's kinase activity. High CDK6 expression thus suppresses proliferation by upregulating p16INK4a, providing an internal safeguard. However, in the absence of p16INK4a, CDK6 can exert its full tumor-promoting function by enhancing proliferation and stimulating angiogenesis. The finding that CDK6 connects cell-cycle progression to angiogenesis confirms CDK6's central role in hematopoietic malignancies and could underlie the selection pressure to upregulate CDK6 and silence p16INK4a.

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Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
González, S., Klatt, P., Delgado, S., Conde, E., López‐Ríos, F., Sánchez‐Céspedes, M., Méndez, J., Antequera, F., & Serrano, M. (2006) · Nature · doi:10.1038/nature04585 · Cited by 186
Retracted
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,585
Vascular endothelial growth factor (VEGF) and its receptors
Neufeld, G., Cohen, T., Gengrinovitch, S., & Gluzman‐Poltorak, Z. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.9 · Cited by 3,511
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 1×
“Although p16 is also able to promote oncogene-induced senescence (Campisi, 2012), we failed to obtain any evidence of senescence.”
Background
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,711
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., & Carson, D. A. (1994) · Nature · doi:10.1038/368753a0 · Cited by 1,742
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81079-x · Cited by 1,585
To cycle or not to cycle: a critical decision in cancer
Malumbres, M., & Barbacid, M. (2001) · Nature reviews. Cancer · doi:10.1038/35106065 · Cited by 1,510
Self-citation
Cyclin D as a therapeutic target in cancer
Musgrove, E. A., Caldon, C. E., Barraclough, J., Stone, A., & Sutherland, R. L. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3090 · Cited by 1,370

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Authors: Kollmann, K., Heller, G., Schneckenleithner, C., Warsch, W., Scheicher, R., Ott, R. G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., Kenner, L., Hoefler, G., Freissmuth, M., Green, A. R., Moriggl, R., Busslinger, M., Malumbres, M., & Sexl, V.
Affiliations: University of Veterinary Medicine Vienna (AT)
Comprehensive Cancer Center Vienna (AT)
Research Institute of Molecular Pathology (AT)
Medical University of Vienna (AT)
Austrian Academy of Sciences (AT)
Ludwig Boltzmann Institute for Cancer Research (AT)
Wellcome/MRC Cambridge Stem Cell Institute (GB)
Spanish National Cancer Research Centre (ES)
Corresponding author: Sexl, Veronika
ORCID: Kollmann, Karoline
Heller, Gerwin
Schlederer, Michaela
Schiefer, Ana-Iris
Reichart, Ursula
Kerjaschki, Dontscho
Bock, Christoph
Kenner, Lukas
Freissmuth, Michael
Green, Anthony R.
Moriggl, Richard
Busslinger, Meinrad
Malumbres, Marcos
Sexl, Veronika
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2013-08
Volume: 24
Issue: 2
Pages: 167-181
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2013.07.012
PMC: PMC5637299
OpenAlex: W2152600133
Cited by: 313
References: 81
Citations by year: 2026: 16 · 2025: 22 · 2024: 27 · 2023: 23 · 2022: 35 · 2021: 33 · 2020: 42 · 2019: 25 · 2018: 20 · 2017: 20 · 2016: 17 · 2015: 19 · 2014: 10 · 2013: 4
FWCI: 8.93
Type: journal article
Language: en
Update notices: erratum (2016-08-08)
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cancer Cell (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Wellcome Trust (079249, 100140)
Medizinische Universität Wien
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: CDK6, CDK4, p16INK4a, VEGF-A, tumor angiogenesis, B-cell acute lymphoblastic leukemia, BCR-ABL, transcriptional regulation, cell cycle, kinase-independent function, lymphoid malignancies, cell proliferation, hematologic malignancies
MeSH terms: Animals, Cell Cycle, Humans, Mice, Inbred C57BL, Mice, Nude, Mice, Transgenic, Neoplasms, Neovascularization, Pathologic, Leukemia, B-Cell, Lymphoma, B-Cell, Cyclin-Dependent Kinase 6, Mice

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A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

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