Bock, Christoph

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

Klampfl, T., Gisslinger, H., Harutyunyan, A. S., Nivarthi, H., Rumi, E., Milosevic, J. D., Them, N. C. C., Berg, T., Gisslinger, B., Pietra, D., et al. (2013) · New England Journal of Medicine

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

Cited by 2,003

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 1,122

Pooled CRISPR screening with single-cell transcriptome readout.

Datlinger, P., Rendeiro, A. F., Schmidl, C., Krausgruber, T., Traxler, P., Klughammer, J., Schuster, L. C., Kuchler, A., Alpar, D., & Bock, C. (2017) · Nature Methods

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 1,096

Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

Bock, C., Kiskinis, E., Verstappen, G., Gu, H., Boulting, G., Smith, Z. D., Ziller, M., Croft, G. F., Amoroso, M. W., Oakley, D. H., et al. (2011) · Cell

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 1,009

Specification of tissue-resident macrophages during organogenesis

Mass, E., Ballesteros, I., Farlik, M., Halbritter, F., Günther, P., Crozet, L., Jacome-Galarza, C. E., Händler, K., Klughammer, J., Kobayashi, Y., et al. (2016) · Science

Phagocytosis and Immune RegulationImmune cells in cancer

Cited by 891

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 686

DNA methylation signatures link prenatal famine exposure to growth and metabolism

Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., et al. (2014) · Nature Communications

Birth, Development, and HealthEpigenetics and DNA Methylation

Cited by 630

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

Yu, Y.-R., Imrichova, H., Wang, H., Chao, T., Xiao, Z., Gao, M., Rincon-Restrepo, M., Franco, F., Genolet, R., Cheng, W.-C., et al. (2020) · Nature Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 593

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

Rosser, E. C., Piper, C. J. M., Matei, D. E., Blair, P. A., Rendeiro, A. F., Orford, M., Alber, D. G., Krausgruber, T., Catalan, D., Klein, N., et al. (2020) · Cell Metabolism

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 579

Spatiotemporal structure of cell fate decisions in murine neural crest

Soldatov, R., Kaucka, M., Kastriti, M. E., Petersen, J., Chontorotzea, T., Englmaier, L., Akkuratova, N., Yang, Y., Häring, M., Dyachuk, V., et al. (2019) · Science

Developmental Biology and Gene RegulationSingle-cell and spatial transcriptomics

Cited by 546

ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors

Schmidl, C., Rendeiro, A. F., Sheffield, N. C., & Bock, C. (2015) · Nature Methods

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 509

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M., et al. (2021) · Nature Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 506

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

Romanov, R. A., Zeisel, A., Bakker, J., Girach, F., Hellysaz, A., Tomer, R., Alpár, A., Mulder, J., Clotman, F., Keimpema, E., et al. (2017) · Nature Neuroscience

Single-cell and spatial transcriptomicsCircadian rhythm and melatonin

Cited by 502

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging

Beerman, I., Bock, C., Garrison, B. S., Smith, Z. D., Gu, H., Meissner, A., & Rossi, D. J. (2013) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 485

Structural cells are key regulators of organ-specific immune responses

Krausgruber, T., Fortelny, N., Fife-Gernedl, V., Senekowitsch, M., Schuster, L. C., Lercher, A., Nemc, A., Schmidl, C., Rendeiro, A. F., Bergthaler, A., et al. (2020) · Nature

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 434

Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics

Farlik, M., Sheffield, N. C., Nuzzo, A., Datlinger, P., Schönegger, A., Klughammer, J., & Bock, C. (2015) · Cell Reports

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 422

Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk

Brinkman, A. B., Gu, H., Bartels, S. J. J., Zhang, Y., Matarese, F., Simmer, F., Marks, H., Bock, C., Gnirke, A., Meissner, A., et al. (2012) · Genome Research

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 413

Recommendations for the design and analysis of epigenome-wide association studies

Michels, K. B., Binder, A. M., Dedeurwaerder, S., Epstein, C. B., Greally, J. M., Gut, I., Houseman, E. A., Izzi, B., Kelsey, K. T., Meissner, A., et al. (2013) · Nature Methods

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 378

Rational discovery of molecular glue degraders via scalable chemical profiling

Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I. H., Hahn, E., Seiler, K., Koren, A., et al. (2020) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 369

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

Kollmann, K., Heller, G., Schneckenleithner, C., Warsch, W., Scheicher, R., Ott, R. G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., et al. (2013) · Cancer Cell

Cancer-related Molecular PathwaysChronic Myeloid Leukemia Treatments

Cited by 313

Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

Puhm, F., Afonyushkin, T., Resch, U., Obermayer, G., Rohde, M., Penz, T., Schuster, M., Wagner, G., Rendeiro, A. F., Melki, I., et al. (2019) · Circulation Research

Extracellular vesicles in diseaseInflammasome and immune disorders

Cited by 306

Making sense of big data in health research: towards an EU action plan

Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, J., Bernal-Delgado, E., Blomberg, N., Bock, C., Conesa, A., et al. (2016) · Genome Medicine

Electronic Health Records SystemsBig Data Technologies and Applications

Cited by 286

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Grebien, F., Vedadi, M., Getlik, M., Giambruno, R., Grover, A., Avellino, R., Skucha, A., Vittori, S., Kuznetsova, E., Smil, D., et al. (2015) · Nature Chemical Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 284

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

Delacher, M., Imbusch, C. D., Hotz-Wagenblatt, A., Mallm, J.-P., Bauer, K., Simon, M., Riegel, D., Rendeiro, A. F., Bittner, S., Sanderink, L., et al. (2020) · Immunity

T-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

Cited by 261