Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

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Targeting xCT-mediated glutamate release normalizes tumor angiogenesis in the brainPreprint

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Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapyPreprint

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Anticancer Effects of the Trivalent Organoarsenical 2-Amino-4-(dihydroxyarsinoyl) Butanoate

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Dynamic crosstalk between amino acid metabolism and cancer drug efficacy: From mechanisms to therapeutic opportunities

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Identification of small compounds targeting ferroptosis in triple-negative breast cancer by using an integrated computational approach

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Mitochondria ATP Pro‐Ferroptosis by Adjusting the Conversion of PUFA to PUFA‐PLs

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Nutrient-transporter driven cytotoxic potential: an emerging nanotherapeutic approach

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Development of the FGFR4-ADC bearing the ferroptosis inducer sulfasalazine for hepatocellular carcinoma

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Ferroptosis-triggered monodisperse microspheres for transcatheter arterial embolization of hepatocellular carcinoma

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Low KIF26B Expression Reduces Paclitaxel Resistance and Predicts Good Prognosis in Ovarian Cancer

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A metabolic-immune subtype of breast cancer defined by G6PD and SHMT2: From single‑cell dissection to dual-targeted therapy

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Dual targeting of SLC6A14 and autophagy/macropinocytosis enhances therapeutic efficacy in pancreatic ductal adenocarcinoma

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DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancer

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Metabolic reprogramming of cancer associated fibroblasts informs stromal heterogeneity and therapeutic targeting

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Epigenetics and One-Carbon Metabolism in Cancer: Mechanisms and Therapeutic Implications

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Characterization of Top Hub Genes in Breast and Lung Cancer Using Functional Association

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Ferroptosis

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The alkyl side chain of PACA nanoparticles dictates the impact on cellular stress responses and the mode of particle-induced cell deathPreprint

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Dissecting the impact of metabolic environment on three common cancer cell phenotypesPreprint

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PAPSS2 inhibits proliferation and metastasis of papillary thyroid cancer cells by mediating ferroptosis and disulfidptosis through the AKT signaling pathwayPreprint

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Glutamate-Handling Proteins Associate with Adverse Clinicopathologic Features and Comorbidities in Invasive Lobular CarcinomaPreprint

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ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis SensitivityPreprint

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The Role of Glutamine Synthetase in the Glutamine Independence in Mammary Tissue

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Residual breast cancer metabolic phenotype after docetaxel treatment

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Identifying gaps and relative opportunities for discovering membrane proteomic biomarkers of triple-negative breast cancer as a translational priority

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Transcriptômica e metabolômica como ferramentas para o entendimento do processo de adaptação metabólica tumoral dos tumores de mama triplo-negativo

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Tumor starvation by deprivation of glutamine and aspartate

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Construction of Reduced PPI Network for Breast and Lung Cancer Using Random Walk with Restart

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MiR-128-3p targets xCT gene in colorectal cancer: Molecular mechanism and correlation with patients’ clinicopathological features

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Glutamine metabolism in prostate cancer

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Glucolyse- und Glutaminase-Inhibition zur Therapieoptimierung von Tamoxifen bei ER-positivem Mammakarzinom

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Selenoprotein Sepp1 regulates Cysteine Dependence in Pancreatic CancerPreprint

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Biochemical mechanism of ferroptosis-mediated cancer cell death in triple-negative breast cancer

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The Roles of Iron and Ferroptosis in Human Chronic Diseases

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Estudo da via da glutaminolise em astrocitomas e mecanismo de ação do gene Glsiso2 (GAC)

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Novel Aza-podophyllotoxin Derivative Inhibits Growth of Triple-Negative Breast Cancer

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ELAVL1: A Novel Diagnostic and Prognostic Biomarker in Lung Adenocarcinoma Linked to FerroptosisPreprint

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Additional file 2 of Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models

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Additional file 1 of Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells

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Additional file 1 of Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models

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Additional file 1 of Simvastatin induced ferroptosis for triple-negative breast cancer therapy

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Additional file 1 of Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma

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Additional file 1 of Fe(II) and Tannic Acid-Cloaked MOF as Carrier of Artemisinin for Supply of Ferrous Ions to Enhance Treatment of Triple-Negative Breast Cancer

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Disulfidptosis-based cancer therapy: Opportunity and challenge

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Rôle de l'autophagie dans l'émergence des cellules souches cancéreuses : implication du métabolisme

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The CHD4 NuRD complex links epigenetics to glycolytic flux and proliferation of melanoma and a variety of cancer cells

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Plant virus-derived nanoparticles for the imaging and treatment of cancer

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Induction de la mort ferroptotique dans les cellules de cancer pancréatique : rôle essentiel de la cystéine et du transporteur xCT

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Étude de l'association entre la consommation d'alcool et le risque de cancer du sein à travers la méthylation de l’ADN

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Unraveling escape and metastasis mechanisms in triple negative breast cancer following chemotherapy treatment

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ALDH18A1 regulates glutamine metabolism and tumor microenvironment in the attenuation of clear cell renal cell carcinoma

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L -5-[11C]-glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine MetabolismPreprint

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Metabolic rewiring of the dendritic cell–T cell axis: tumour-derived barriers and therapeutic opportunities

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Valproic acid inhibits glutamine uptake to induce ferroptosis in triple-negative breast cancer

Yang, Y., Liu, J., Liu, Y., Zou, T., Tao, R., Tan, X., & Liu, S. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112890

Exploiting tumor amino acid metabolic heterogeneity: Biological principles and precision nanomedicine

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Amino acid transporters in hepatocellular carcinoma: Gatekeepers of metabolic reprogramming

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Subtype-Conditioned NRF2–KEAP1 Signaling in Breast Cancer: A Narrative Review and Hypothesis-Generating Framework from Chemoprevention to Therapy Resistance

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Glutamine metabolism in health and disease

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BindingDB Entry 50013553: Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer.

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BindingDB Entry 50009703: Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions.

BindingDB (2021) · UC San Diego · doi:10.7270/q2ng4v40

BindingDB Entry 50007250: Discovery and development of small molecule modulators targeting glutamine metabolism.

BindingDB (2021) · UC San Diego · doi:10.7270/q2n87f26

BindingDB Entry 50019889: Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer.

BindingDB (2024) · UC San Diego · doi:10.7270/q28p64x1

Glutamine metabolic interaction network reshapes tumor immunotherapy resistance

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Abstract B20: Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets

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Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation

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Abstract P3-02-09: Vulnerabilities in glutamine metabolism define triple-negative from Luminal A breast cancer subsets

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Glutamine Transporter Expression Profiling in Murine Breast Cancer Reveals Therapeutic Targets for Triple Negative Breast Cancer

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