The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis
Open accessAbstract
Understanding the mechanism by which tumor cells influence osteoclast differentiation is crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA (miRNA) expression changes in differentiating osteoclasts after exposure to tumor-conditioned media, in part through activation of NFκB signaling by soluble intracellular adhesion molecule (sICAM1) secreted from bone-metastatic cancer cells. Ectopic expression of multiple miRNAs downregulated during osteoclastogenesis suppresses osteoclast differentiation by targeting important osteoclast genes. Intravenous delivery of these miRNAs in vivo inhibits osteoclast activity and reduces osteolytic bone metastasis. Importantly, serum levels of sICAM1 and two osteoclast miRNAs, miR-16 and miR-378, which are elevated in osteoclast differentiation, correlate with bone metastasis burden. These findings establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, exosome transport solves the problem of easy degradation of miRNAs in vivo, implying a new tumor therapy [50].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039
Leukocyte-endothelial adhesion molecules
Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.bloodjournal8472068 · Cited by 2,687
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605
The Diverse Functions of MicroRNAs in Animal Development and Disease
Kloosterman, W. P., & Plasterk, R. H. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.009 · Cited by 2,082
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
Cancer to bone: a fatal attraction
Weilbaecher, K. N., Guise, T. A., & McCauley, L. K. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3055 · Cited by 1,325
Cited by
Sorted by citations
Items 101–200 of 266
Dual Effect of Cyanidin on RANKL‐Induced Differentiation and Fusion of Osteoclasts
Dou, C., Li, J., Kang, F., Cao, Z., Yang, X., Jiang, H., Yang, B., Xiang, J., Xu, J., & Dong, S. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24916 · Cited by 53
Cui, Y., Bradbury, R., Flamini, V., Wu, B., Jordan, N., & Jiang, W. G. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.156 · Cited by 52
Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis
Meng, X., Ark, A. V., Lee, P., Hostetter, G. H., Bhowmick, N. A., Matrisian, L. M., Williams, B. O., Miranti, C. K., & Li, X. (2015) · Oncogene · doi:10.1038/onc.2015.297 · Cited by 51
Use of Animal Models in Understanding Cancer-induced Bone Pain
Slosky, L. M., Largent‐Milnes, T. M., & Vanderah, T. W. (2015) · Cancer Growth and Metastasis · doi:10.4137/cgm.s21215 · Cited by 50
hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3
Dobson, J. R., Taipaleenmäki, H., Hu, Y., Hong, D., van Wijnen, A. J., Stein, J. L., Stein, G. S., Lian, J. B., & Pratap, J. (2014) · Cancer Cell International · doi:10.1186/s12935-014-0073-0 · Cited by 49
Papadaki, C., Stoupis, G., Tsalikis, L., Monastirioti, A. A., Papadaki, M. A., Maliotis, N., Stratigos, M., Mastrostamatis, G., Mavroudis, D., & Agelaki, S. (2019) · Oncotarget · doi:10.18632/oncotarget.26629 · Cited by 49
The best of both worlds — managing the cancer, saving the bone
Makhoul, I., Montgomery, C. O., Gaddy, D., & Suva, L. J. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.185 · Cited by 47
Rudnick‐Glick, S., Corem‐Salkmon, E., Grinberg, I., & Margel, S. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0233-6 · Cited by 48
Regulation of Osteoclastogenesis and Bone Resorption by miRNAs
Inoue, K., Ng, C., Xia, Y., & Zhao, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651161 · Cited by 50
Singla, R. K., Wang, X., Gundamaraju, R., Joon, S., Tsagkaris, C., Behzad, S., Khan, J., Gautam, R. K., Goyal, R., Rakmai, J., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2097196 · Cited by 52
Dissecting Tumor-Stromal Interactions in Breast Cancer Bone Metastasis
Kang, Y. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.2.206 · Cited by 47
Gandellini, P., Doldi, V., & Zaffaroni, N. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.005 · Cited by 48
Plasma microRNA signature is associated with risk stratification in prostate cancer patients
Al-Qatati, A., Akrong, C., Stevic, I., Pantel, K., Awe, J. A., Saranchuk, J. W., Drachenberg, D., Mai, S., & Schwarzenbach, H. (2017) · International Journal of Cancer · doi:10.1002/ijc.30815 · Cited by 47
Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases
Roato, I., & Ferracini, R. (2018) · Cancers · doi:10.3390/cancers10020056 · Cited by 49
Epigenetic regulation of bone remodeling and bone metastasis
Sharma, G., Sultana, A., Abdullah, K. M., Pothuraju, R., Nasser, M. W., Batra, S. K., & Siddiqui, J. A. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.11.002 · Cited by 49
Navarro, A., Díaz, T., Tovar, N., Pedrosa, F., Tejero, R., Cibeira, M. T., Magnano, L., Rosiñol, L., Monzó, M., Bladé, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.2761 · Cited by 46
Cancer and bone: A complex complex
van Driel, M., & van Leeuwen, J. P. T. M. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.07.013 · Cited by 46
Regulators at Every Step—How microRNAs Drive Tumor Cell Invasiveness and Metastasis
Grzywa, T. M., Klicka, K., & Wlodarski, P. K. (2020) · Cancers · doi:10.3390/cancers12123709 · Cited by 46
Marton, N., Kovács, O. T., Baricza, E., Kittel, Á., Győri, D., Mócsai, A., Meier, F. M. P., Goodyear, C. S., McInnes, I. B., Buzás, E. I., et al. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2535-8 · Cited by 46
27‐Hydroxycholesterol enhanced osteoclastogenesis in lung adenocarcinoma microenvironment
Zhang, L., Liu, M., Liu, J., Li, X., Yang, M., Su, B., & Lin, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27883 · Cited by 42
Wang, S., Wu, W., Lin, X., Zhang, K. M., Wu, Q., Luo, M., & Zhou, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01171-8 · Cited by 47
Zhao, W., Shen, G., Ren, H. J., Liang, D., Yu, X., Zhang, Z., Huang, J., Qiu, T., Tang, J., Shang, Q., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26939 · Cited by 43
Wang, M., Zhao, M., Guo, Q., Lou, J., & Wang, L. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112834 · Cited by 43
Ling, Z., Yang, C. H., Tan, J., Dou, C., & Chen, Y. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03966-9 · Cited by 43
The role of microRNAs in bone metastasis
Zoni, E., & van der Pluijm, G. (2016) · Journal of bone oncology · doi:10.1016/j.jbo.2016.04.002 · Cited by 41
Ishii, H., Vodnala, S. K., Achyut, B. R., So, J. Y., Hollander, M. C., Greten, T. F., Lal, A., & Li, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-05023-9 · Cited by 41
microRNA‐Mediated Regulation of Bone Remodeling: A Brief Review
Liu, J., Dang, L., Wu, X., Li, D., Ren, Q., Lü, A., & Zhang, G. (2019) · JBMR Plus · doi:10.1002/jbm4.10213 · Cited by 41
Cancer-associated muscle weakness: What's bone got to do with it?
Waning, D. L., & Guise, T. A. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.59 · Cited by 40
The predictive link between matrix and metastasis
Barney, L. E., Jansen, L., Polio, S., Galarza, S., Lynch, M. E., & Peyton, S. R. (2016) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2016.01.001 · Cited by 41
Molecular predictors of brain metastasis-related microRNAs in lung adenocarcinoma
Sun, G., Ding, X. L., Bi, N., Wang, Z., Wu, L., Zhou, W., Zhao, Z., Wang, J., Zhang, W., Fan, J., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007888 · Cited by 40
RetractedMiR-221 Promotes Hepatocellular Carcinoma Cells Migration via Targeting PHF2
Fu, Y., Liu, M., Li, F., Li, Q., Zhang, P., Lv, F., Cheng, W., & Hou, R. (2019) · BioMed Research International · doi:10.1155/2019/4371405 · Cited by 42
Xu, S., Gong, Y., Yin, Y., Xing, H., & Zhang, N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110141 · Cited by 40
The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials
Cheng, X., Wei, J., Ge, Q., Xing, D., Zhou, X., Qian, Y., & Jiang, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1856225 · Cited by 40
Kagiya, T. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091741 · Cited by 39
Tumour-derived miRNAs and bone metastasis
Croset, M., Kan, C. W. S., & Clézardin, P. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.56 · Cited by 38
Roles of exosomes in diagnosis and treatment of colorectal cancer
Umwali, Y., Yue, C.-B., Gabriel, A. N. A., Zhang, Y., & Zhang, X. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i18.4467 · Cited by 38
Puppo, M., Taipaleenmäki, H., Hesse, E., & Clézardin, P. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14836 · Cited by 40
Kagiya, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081317 · Cited by 37
Dong, Q., Han, Z., & Tian, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.899503 · Cited by 36
Bone Pain and Muscle Weakness in Cancer Patients
Milgrom, D. P., Lad, N. L., Koniaris, L. G., & Zimmers, T. A. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0354-3 · Cited by 36
Targeting the Metastatic Bone Microenvironment by MicroRNAs
Haider, M., & Taipaleenmäki, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00202 · Cited by 36
Huang, H., Liu, Y., Yu, P., Qu, J., Guo, Y., Li, W., Wang, S., & Zhang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-25768-z · Cited by 34
Lin, C.-Y., Song, X., Ke, Y., Raha, A., Wu, Y., Wasi, M., Wang, L., Geng, F., & You, L. (2022) · Cancers · doi:10.3390/cancers14143395 · Cited by 41
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases
Buenrostro, D., Park, S. I., & Sterling, J. A. R. (2014) · BioMed Research International · doi:10.1155/2014/875305 · Cited by 33
MicroRNA-124 inhibits TNF-α- and IL-6-induced osteoclastogenesis
Ohnuma, K., Kasagi, S., Uto, K., Noguchi, Y., Nakamachi, Y., Saegusa, J., & Kawano, S. (2018) · Rheumatology International · doi:10.1007/s00296-018-4218-7 · Cited by 31
Asa’ad, F., Monje, A., & Larsson, L. (2019) · European Journal Of Oral Sciences · doi:10.1111/eos.12657 · Cited by 31
Profiling of Circulating microRNAs in Prostate Cancer Reveals Diagnostic Biomarker Potential
Fredsøe, J., Rasmussen, A. K. I., Mouritzen, P., Bjerre, M. T., Østergren, P. B., Fode, M. M., Borre, M., & Sørensen, K. D. (2020) · Diagnostics · doi:10.3390/diagnostics10040188 · Cited by 31
Improved protocol for plasma microRNA extraction and comparison of commercial kits
Sriram, H., Deshpande, N., Tembhare, P. R., Hasan, S. K., Gujral, S., Subramanian, P. G., Patkar, N. V., Rajpal, S., Chatterjee, G., Ghogale, S., et al. (2021) · Biochemia Medica · doi:10.11613/bm.2021.030705 · Cited by 30
Li, X., Jin, L., & Tan, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11708 · Cited by 31
Huang, Z., Chen, W., Du, Y., Guo, Q., Mao, Y., Xin Min, Z. H. O. U., & Hua, D. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02849-8 · Cited by 29
Ge, L., Jin, X., Yang, Y., Liu, X., Shao, Z., Di, G. H., & Jiang, Y. (2021) · Oncogene · doi:10.1038/s41388-021-01655-2 · Cited by 29
MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer
Cannistraci, A., Hascoët, P., Ali, A., Mundra, P. A., Clarke, N. W., Pavet, V., & Marais, R. (2022) · Oncogene · doi:10.1038/s41388-022-02178-0 · Cited by 28
Circulating microRNAs as Promising Tumor Biomarkers
(2014) · Advances in Clinical Chemistry · doi:10.1016/bs.acc.2014.09.007 · Cited by 40
Suppression of Bone Resorption by miR-141 in Aged Rhesus Monkeys
Yang, S., Zhang, W., Cai, M., Zhang, Y., Jin, F., Yan, S., Baloch, Z., Fang, Z., Xue, S., Tang, R., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3479 · Cited by 28
MicroRNAs in the skeleton: Cell-restricted or potent intercellular communicators?
van der Eerden, B. C. J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.04.016 · Cited by 28
Deng, Y., Zhu, Y., Wang, H., Khadka, V. S., Hu, L., Ai, J., Dou, Y., Li, Y., Dai, S., Mason, C. E., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00821 · Cited by 27
Dhawan, A., Friedrichs, J., Bonin, M. V., Bejestani, E. P., Werner, C., Wobus, M., Chavakis, T., & Bornhäuser, M. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw057 · Cited by 25
Costé, É., & Rouleux‐Bonnin, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-74685-7 · Cited by 26
Validation of downregulated microRNAs during osteoclast formation and osteoporosis progression
Ma, Y., SHAN, Z., Ma, J., Wang, Q., Chu, J., Xu, P., Qin, A., & Fan, S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4765 · Cited by 28
Choi, J. U., Park, I., Lee, Y.-K., & Hwang, S. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197363 · Cited by 27
Tumor–Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic ImplicationsPreprint
Zheng, H., Li, W., & Kang, Y. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030775 · Cited by 25
Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway
Zhou, J., Deng, S., Fang, H., Yu, G., & Peng, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.026 · Cited by 24
Zhao, M., Zhang, L.-F., Sun, Z., Qiao, L.-H., Yang, T., Ren, Y.-Z., Zhang, X.-Z., Wu, L., Qian, W., Guo, Q., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05819-8 · Cited by 24
Gordon, J. A. R., Montecino, M. A., Aqeilan, R. I., Stein, J. L., Stein, G. S., & Lian, J. B. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0240-1 · Cited by 24
Ouyang, Z., Guo, X., Chen, X., Liu, B., Zhang, Q., Yin, Z., Zhai, Z., Liu, X., Liu, X., Peng, D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22930 · Cited by 23
Feurer, E., Kan, C. W. S., Croset, M., Sornay‐Rendu, E., & Chapurlat, R. D. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3685 · Cited by 23
Li, C., Li, R., Hu, X., Zhou, G., & Jiang, G. (2022) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06433-y · Cited by 24
Wang, Y., Chu, Y., Ren, X., Xiang, H., Xi, Y., Ma, X., Zhu, K., Guo, Z., Zhou, C., Zhang, G., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1280-3 · Cited by 23
miRNA-149* suppresses liver cancer progression by down-regulating TRADD protein expression.
Feng, Q., Zhang, H.-L., Nie, X.-B., Li, Y., Chen, W.-D., & Wang, Y.-D. (2019) · American Journal of Pathology · doi:10.1016/j.ajpath.2019.10.010 · Cited by 22
Regulation of osteoclast-mediated bone resorption by microRNA
Ji, L., Li, X., He, S., & Chen, S. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04298-y · Cited by 22
Role of miR-222-3p in c-Src-Mediated Regulation of Osteoclastogenesis
Takigawa, S., Chen, A. B., Wan, Q., Na, S., Sudo, A., Yokota, H., & Hamamura, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020240 · Cited by 22
Tsai, C., Chen, J.-H., Wu, C.-T., Chang, P.-C., Wang, S., & Yeh, W. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919846806 · Cited by 23
Chengling, L., Zhang, Y., Xiaoyu, X., Lu, X., Zhang, S., Ziming, W., & Xianming, C. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00282-7 · Cited by 21
Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis
Shen, G., Ren, H. J., Qiu, T., Liang, D., Xie, B., Zhang, Z., Yao, Z., Yang, Z., & Jiang, X. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0122-x · Cited by 21
Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment
Jeong, H. M., Cho, S. W., & Park, S. I. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.4.485 · Cited by 21
Microarray Analysis of Differentially-expressed MicroRNAs in Acquired Middle Ear Cholesteatoma
Xie, S., Liu, X., Pan, Z., Chen, X., Peng, A., Yin, T., Ren, J., & Liu, W. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.26329 · Cited by 21
CaSR Induces Osteoclast Differentiation and Promotes Bone Metastasis in Lung Adenocarcinoma
Liu, L., Fan, Y., Chen, Z., Zhang, Y., & Yu, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00305 · Cited by 21
Mechanisms Supporting the Use of Beta-Blockers for the Management of Breast Cancer Bone Metastasis
Madel, M., & Elefteriou, F. (2021) · Cancers · doi:10.3390/cancers13122887 · Cited by 25
Epigenetic Aspects of Osteoporosis
Grebennikova, T. A., Belaya, Z. E., Rozhinskaya, L. Y., Mel'nichenko, G. A., & Dedov, I. I. (2015) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn.v70.i5.1440 · Cited by 21
Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening
Dou, Y., Zhu, Y., Ai, J., Chen, H., Liu, H., Borgia, J. A., Li, X., Yang, F., Jiang, B., Wang, J., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4862-z · Cited by 20
MicroRNAs: Emerging Regulators of Metastatic Bone Disease in Breast Cancer
Haider, M., Smit, D. J., & Taipaleenmäki, H. (2022) · Cancers · doi:10.3390/cancers14030729 · Cited by 19
The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer
Chi, Y., Yao, L., Hu, X., Huang, S., Huang, N., Li, S., Shao, Z., & Wu, J. (2016) · Oncotarget · doi:10.18632/oncotarget.7498 · Cited by 19
Bone Tropism in Cancer MetastasesPreprint
Wang, H., Zhang, W., Bado, I. L., & Zhang, X. H.-F. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036848 · Cited by 20
Xue, C., Gao, Y., Sun, Z., Li, X., Zhang, M., Yang, Y., Han, Q., Bai, C., & Zhao, R. C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.837781 · Cited by 18
Aravindraja, C., Jeepipalli, S. P. K., Vekariya, K. M., Botello-Escalante, R., Chan, E. K. L., & Kesavalu, L. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512105 · Cited by 18
Kallikreins are involved in an miRNA network that contributes to prostate cancer progression
Samaan, S. F., Lichner, Z., Ding, Q., Saleh, C., Samuel, J. N., Streutker, C., & Yousef, G. M. (2014) · Biological Chemistry · doi:10.1515/hsz-2013-0288 · Cited by 18
Liu, Y., Zhang, R., Yuan, W., Chen, H.-Q., Tian, D.-D., Li, H., Jiang, X., Deng, Z., & Wang, Y. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000487784 · Cited by 18
miR-452 promotes the development of gastric cancer via targeting EPB41L3
He, X., & Shu, Y. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.152725 · Cited by 18
Osteoclastic microRNAs and their translational potential in skeletal diseases
Inoue, K., Nakano, S., & Zhao, B. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00761-4 · Cited by 18
Pyroptosis in Periprosthetic Osteolysis
Yin, J., Yin, Z., Lai, P., Liu, X., & Ma, J. (2022) · Biomolecules · doi:10.3390/biom12121733 · Cited by 16
Liu, Z., Wang, H., He, J., Yuan, X., & Sun, W. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37241 · Cited by 15
Cappariello, A., & Capulli, M. (2018) · Current Molecular Biology Reports · doi:10.1007/s40610-018-0099-5 · Cited by 14
Cancer-Associated Osteoclast Differentiation Takes a Good Look in the miR(NA)ror
Waning, D. L., Mohammad, K. S., & Guise, T. A. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.001 · Cited by 15
Hiraga, T. (2016) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2016.1142972 · Cited by 15
A novel nano delivery system targeting different stages of osteoclasts
Zhang, B., Zhao, J., Yan, H., Zhao, Y., Tian, H., Cao, W. F., Wang, R. L., Jin, J., Chen, Y., Yang, C., et al. (2022) · Biomaterials Science · doi:10.1039/d2bm00076h · Cited by 16
Sun, P., Antwi, S. O., Sartorius, K., Zheng, X., & Li, X. (2022) · Cancers · doi:10.3390/cancers14194888 · Cited by 14
ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome
Broggini, T., Czabanka, M., Piffkó, A., Harms, C., Hoffmann, C. J., Mrowka, R., Wenke, F., Deutsch, U., Grötzinger, C., & Vajkoczy, P. (2015) · European Spine Journal · doi:10.1007/s00586-015-3811-7 · Cited by 14
Shen, X., Sun, X., Chen, H., Lu, B., Qin, Y., Zhang, C., Liang, G., Wang, J., Yu, P., Su, L., et al. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-020-04198-7 · Cited by 14
Progress of mesenchymal stem cell-derived exosomes in targeted delivery of antitumor drugs
Huang, D., Huang, W., Liu, M., Chen, J., Xiao, D., Peng, Z., He, H., Shen, H., Jin, Q., Chen, L., et al. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03795-x · Cited by 17
The multiple therapeutic applications of miRNAs for bone regenerative medicine
Scimeca, J., & Verron, É. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.04.007 · Cited by 13
Metadata
- Authors
- Ell, B., Mercatali, L., Ibrahim, T., Campbell, N., Schwarzenbach, H., Pantel, K., Amadori, D., & Kang, Y.
- Affiliations
- Princeton University (US)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Rutgers Cancer Institute (US)
- Universität Hamburg (DE)
- Corresponding author
- Kang, Yibin
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 24
- Issue
- 4
- Pages
- 542-556
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3832956
- OpenAlex
- W2054148405
- Cited by
- 266
- References
- 41
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 27 · 2020: 25 · 2019: 23 · 2018: 31 · 2017: 22 · 2016: 30 · 2015: 31 · 2014: 33 · 2013: 2
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA141062, R01CA134519, P30CA072720)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- osteoclastogenesis, osteolytic bone metastasis, microRNA, tumor-conditioned medium, NF-κB signaling, miR-16, miR-378, serum biomarkers, microRNA delivery, therapeutic target
- MeSH terms
- Animals, Bone Neoplasms, Bone Resorption, Humans, Neoplasm Metastasis, Osteoclasts, Osteolysis, Biomarkers, Tumor, NF-kappa B, Culture Media, Conditioned, Intercellular Adhesion Molecule-1, CD18 Antigens, MicroRNAs, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review