The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis
Open accessAbstract
Understanding the mechanism by which tumor cells influence osteoclast differentiation is crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA (miRNA) expression changes in differentiating osteoclasts after exposure to tumor-conditioned media, in part through activation of NFκB signaling by soluble intracellular adhesion molecule (sICAM1) secreted from bone-metastatic cancer cells. Ectopic expression of multiple miRNAs downregulated during osteoclastogenesis suppresses osteoclast differentiation by targeting important osteoclast genes. Intravenous delivery of these miRNAs in vivo inhibits osteoclast activity and reduces osteolytic bone metastasis. Importantly, serum levels of sICAM1 and two osteoclast miRNAs, miR-16 and miR-378, which are elevated in osteoclast differentiation, correlate with bone metastasis burden. These findings establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, exosome transport solves the problem of easy degradation of miRNAs in vivo, implying a new tumor therapy [50].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039
Leukocyte-endothelial adhesion molecules
Carlos, T., & Harlan, J. (1994) · Blood · doi:10.1182/blood.v84.7.2068.bloodjournal8472068 · Cited by 2,687
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605
The Diverse Functions of MicroRNAs in Animal Development and Disease
Kloosterman, W. P., & Plasterk, R. H. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.009 · Cited by 2,082
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
Cancer to bone: a fatal attraction
Weilbaecher, K. N., Guise, T. A., & McCauley, L. K. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3055 · Cited by 1,325
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–266 of 266
Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis
Curtaz, C. J., Schmitt, C., Blecharz-Lang, K. G., Roewer, N., Wöckel, A., & Burek, M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200316151720 · Cited by 13
MicroRNAs Possibly Involved in the Development of Bone Metastasis in Clear-Cell Renal Cell Carcinoma
Kinget, L., Roussel, E., Lambrechts, D., Boeckx, B., Vanginderhuysen, L., Albersen, M., Rodríguez‐Antona, C., Graña‐Castro, O., Inglada‐Pérez, L., Verbiest, A., et al. (2021) · Cancers · doi:10.3390/cancers13071554 · Cited by 14
Yang, Q., Wang, W. T., Cheng, D., Wang, Y., Han, Y., Huang, J., & Peng, X. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102002 · Cited by 12
Kitayama, K., Kawamoto, T., Kawakami, Y., Hara, H., Takemori, T., Fujiwara, S., Yahiro, S., Miyamoto, T., Mifune, Y., Hoshino, Y. Y., et al. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5277 · Cited by 13
Bone Metastasis in Bladder Cancer
Lei, Y., Ai, K., Li, X., Li, Z., & Li, Y. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm13010054 · Cited by 11
Macrophage heterogeneity in bone metastasis
Guo, J., Ma, R., & Qian, B. (2024) · Journal of bone oncology · doi:10.1016/j.jbo.2024.100598 · Cited by 11
Secreted microRNAs in bone metastasis
Taipaleenmäki, H. (2023) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-023-01424-z · Cited by 10
Spadazzi, C., Recine, F., Mercatali, L., Miserocchi, G., Liverani, C., Vita, A. D., Bongiovanni, A., Fausti, V., & Ibrahim, T. (2019) · Journal of bone oncology · doi:10.1016/j.jbo.2019.100227 · Cited by 10
Zhang, Y., Liu, Y., Li, Z., Zhang, Q., & Li, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202412165 · Cited by 9
Alečković, M., & Kang, Y. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.38 · Cited by 9
Involvement of Noncoding RNAs in the Differentiation of Osteoclasts
Zhao, Y., Jia, L., Zheng, Y., & Li, W. (2020) · Stem Cells International · doi:10.1155/2020/4813140 · Cited by 9
The Roles of Bone Marrow-Resident Cells as a Microenvironment for Bone Metastasis
Shiozawa, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-36214-0_5 · Cited by 9
PECAM1 plays a role in the pathogenesis and treatment of bone metastases
Liang, Z., Li, J.-K., Li, J., Tang, H., Guo, C., & Zhang, H. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1151651 · Cited by 8
Following MicroRNAs Through the Cancer Metastatic Cascade
Grisard, E., & Nicoloso, M. S. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.04.005 · Cited by 8
Jeong, H., Jeong, J. H., Kim, J. E., Ahn, J., Jung, K. H., Koh, S., Cheon, J., Sohn, J., Kim, G. M., Lee, K. S., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33613 · Cited by 8
Beg, M. M. A., Guru, S. A., Abdullah, S. M., Ahmad, I. S., Rizvi, A., Akhter, J., Goyal, Y., & Verma, A. K. (2021) · Oncology Research and Treatment · doi:10.1159/000518722 · Cited by 8
Kim, B., Nam, S., Lim, J. H., & Lim, J. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2015.105 · Cited by 8
Tumor proliferation and diffusion on percolation clusters
Jiang, C., Cui, C., Zhong, W.-R., Li, G., Li, L., & Shao, Y. (2016) · Journal of Biological Physics · doi:10.1007/s10867-016-9427-2 · Cited by 8
Pathobiology of Osteolytic and Osteoblastic Bone Metastases
Chiechi, A., & Guise, T. A. (2015) · Springer eBooks · doi:10.1007/978-1-4614-5662-9_2 · Cited by 7
Bone niche and bone metastases
Han, Y., & Kang, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821666-8.00041-4 · Cited by 6
Russo, R., Zito, F., & Lampiasi, N. (2021) · Biology · doi:10.3390/biology10111080 · Cited by 6
Zhou, Q., Zu, L., Li, L., Chen, X., Chen, X., Li, Y., Liu, H., & Sun, Z.-L. (2014) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2014.03.20 · Cited by 6
Mercatali, L., Spadazzi, C., Miserocchi, G., Liverani, C., Vita, A. D., Bongiovanni, A., Recine, F., Amadori, D., & Ibrahim, T. (2017) · Journal of Visualized Experiments · doi:10.3791/56311 · Cited by 6
Li, Y., Long, X., Wang, J., Peng, J. Y., & Shen, K. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-02164-w · Cited by 6
Akter, A., Kamal, T., Akter, S., Auwal, A., & Islam, F. (2025) · Future Oncology · doi:10.1080/14796694.2025.2520150 · Cited by 5
MicroRNA Exert Macro Effects on Cancer Bone Metastasis
Baier, S. R., & Wan, Y. (2016) · Current Osteoporosis Reports · doi:10.1007/s11914-016-0316-1 · Cited by 5
Molecular Involvement of the Bone Marrow Microenvironment in Bone Metastasis
Miler, S. F., Thomas, C. Y., & Shiozawa, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804003-4.00014-1 · Cited by 5
Vallone, V. B. F., Borzone, F. R., Martinez, L. M., Giorello, M. B., Choi, H., Dimase, F., Feldman, L. J., Bordenave, R. H., Chudzinski‐Tavassi, A. M., Batagelj, E., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1073793 · Cited by 5
Schwarzenbach, H. (2016) · Journal of Laboratory Medicine · doi:10.1515/labmed-2016-0033 · Cited by 4
Haider, M., Zarrer, J., & Taipaleenmäki, H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11250-4 · Cited by 4
Cheung, D. G., Buzzetti, M., & Leva, G. D. (2017) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2017.1383893 · Cited by 3
Mapping bone marrow niches of disseminated tumor cells
Zhang, W., Lo, H. C., & Zhang, X. H.-F. (2017) · Science China Life Sciences · doi:10.1007/s11427-017-9180-5 · Cited by 3
Xu, Y., Wang, Z., Bi, Y., Duan, Z., & Yue, X. (2018) · Oncology Letters · doi:10.3892/ol.2018.8863 · Cited by 3
Delivering RNA through exosomes for cancer therapy
Zhao, T., & Wang, J. (2025) · Journal of Nanoparticle Research · doi:10.1007/s11051-025-06281-7 · Cited by 2
Liu, K., Wang, Y., Li, Q., Wang, Y., Liu, J., Zhou, J., Song, F., Kong, N., Wang, Z., & Kong, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-97488-0 · Cited by 5
Lu, F., Yang, Z., Hou, N., Wang, H., Bai, S., Lu, X., Wang, Y., Lin, S., Tortorella, M. D., & Li, G. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101754 · Cited by 2
Zhao, Z., Zheng, Z.-Y., Lei, J. T., Baik, M. J., Wu, Y.-H., Somes, L. K., Paternina, A. F. M., Harb, O. A., Chang, O. A., Liu, F., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218636 · Cited by 3
Setareh Shojaei, A., Zandieh, M.-R., Jamshidi, S., Taherkhani, A., & Azadian, Z. (2024) · European Journal of Cancer Care · doi:10.1155/2024/3727684 · Cited by 2
Mechanisms Underlying Osteolytic and Osteoblastic Bone Metastases
Loots, G. G., & Guise, T. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-52001-3_2 · Cited by 2
Huang, Q., & Ouyang, X. (2015) · Future Oncology · doi:10.2217/fon.14.161 · Cited by 2
Tumor–bone interactions: there is no place like bone
Fournier, P. G. J., Juárez, P., & Guise, T. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00002-9 · Cited by 2
Windrichová, J., Kučera, R., Fuchsová, R., Topolčan, O., Fiala, O., Svobodová, J., Fínek, J., & Slipkova, D. (2018) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818807466 · Cited by 2
Su, R. J., Li, Z., Chen, P., Li, Y., Hu, C., Wang, Y., Arnovitz, S., He, M., Gurbuxani, S. K., Zuo, Z., et al. (2015) · Blood · doi:10.1182/blood.v126.23.3667.3667 · Cited by 2
Bone Metastasis in Thyroid Cancer: A Literature Review
Göktaş, S. S. (2018) · Otolaryngology Open Access Journal · doi:10.23880/ooaj-16000169 · Cited by 2
Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer
Meng, F., Zhang, M., Pu, D., Shi, G., & Li, J. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1680908 · Cited by 1
MicroRNAs for the Treatment and Diagnosis of Cancer in Bone Metastasis
Goel, P., & Mandal, C. C. (2026) · Advances in biochemistry in health and disease · doi:10.1007/978-3-032-08824-6_15 · Cited by 1
Current and Emerging Bone-Targeted Therapies for The Treatment of Bone Metastases From Solid Tumors
Clézardin, P., Sousa, S., Croset, M., Pantano, F., & Confavreux, C. B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62257-2 · Cited by 1
Oncodynamic Changes in Skeleton
Seidlitz, E. P., Popović, S., Clemons, M. J., & Singh, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-28558-0_9
Sterling, J. A. R., & Johnson, R. W. (2018) · Wiley eBooks · doi:10.1002/9781119266594.ch97
Novel Biomarkers Predicting the Development of Bone Metastasis in Early Breast Cancer
Iuliani, M., Manca, P., Ribelli, G., Simonetti, S., Pantano, F., Vincenzi, B., Tonini, G., & Santini, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811785-9.00026-0
Cancer-Associated Muscle Dysfunction
Hain, B. A., Narasimhan, A., Ballinger, T. J., Guise, T. A., & Waning, D. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11242-5
Osteoclasts in Cardiovascular Calcification
Atkins, S. K., Iqbal, F., Barrientos, J., Giachelli, C. M., & Aïkawa, E. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-46725-8_18
Regulatory Functions of MicroRNAs in Cancer Pathogenesis
Maralani, M., Baradaran, B., Hajiasgharzadeh, K., & Peeters, M. (2021) · ACTA MEDICA IRANICA · doi:10.18502/acta.v58i11.5140
Ma, Z., Wei, K., Yang, F., Guo, Z., Pan, C., He, Y., Wang, J., Li, Z., Chen, L., Xia, Y., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-61544/v1
Aminuddin, A., Masre, S. F., Teow, S., & Ng, P. Y. (2021) · Springer eBooks · doi:10.1007/978-981-33-6827-9_8
Expression of circulating Mir-139-5p is associated with Postmenopausal Osteoporosis in Indian women
Rupakala, B. M., Anbazhaganb, K., Prabhakarac, S., & Sailakshmia, M. (2021) · MOJ Women s Health · doi:10.15406/mojwh.2021.10.00297
Bone as a New Milieu for Disseminated Tumor Cells: An Overview of Bone Metastasis
Wang, H., Zhang, W., Bado, I. L., & Zhang, X. H.-F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11548-x
Cardozo, C. P., & Gasperi, R. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62205-5
Regulation of Bone Homeostasis and Regeneration by MicroRNAs
Inoue, K., & Zhao, B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-820719-2.00027-2
Liao, L., Xu, Y., 廖进登, Liu, X., Cheng, J., & Zhao, J. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag049
Clinical metastatic cancer from initiation to colonization: emerging challenges and breakthroughs
Niu, G., & Hagerling, C. (2026) · Oncogene · doi:10.1038/s41388-026-03944-0
Li, X., Li, J., Zeng, Y., Dong, J., Xie, S., Ran, Z., Chen, F., Tang, J., Lu, G., Fu, X., et al. (2026) · Small · doi:10.1002/smll.75689
Engineered exosomes for breast cancer immunotherapy: Emerging strategies and translational potential
Orooji, N., Ghasemian-Irani, M., Salari, N., Eskandari, T., Shams, M., Razavi, F. T., & Haghmorad, D. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102822
Metadata
- Authors
- Ell, B., Mercatali, L., Ibrahim, T., Campbell, N., Schwarzenbach, H., Pantel, K., Amadori, D., & Kang, Y.
- Affiliations
- Princeton University (US)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Rutgers Cancer Institute (US)
- Universität Hamburg (DE)
- Corresponding author
- Kang, Yibin
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 24
- Issue
- 4
- Pages
- 542-556
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3832956
- OpenAlex
- W2054148405
- Cited by
- 266
- References
- 41
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 27 · 2020: 25 · 2019: 23 · 2018: 31 · 2017: 22 · 2016: 30 · 2015: 31 · 2014: 33 · 2013: 2
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA141062, R01CA134519, P30CA072720)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- osteoclastogenesis, osteolytic bone metastasis, microRNA, tumor-conditioned medium, NF-κB signaling, miR-16, miR-378, serum biomarkers, microRNA delivery, therapeutic target
- MeSH terms
- Animals, Bone Neoplasms, Bone Resorption, Humans, Neoplasm Metastasis, Osteoclasts, Osteolysis, Biomarkers, Tumor, NF-kappa B, Culture Media, Conditioned, Intercellular Adhesion Molecule-1, CD18 Antigens, MicroRNAs, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
