Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

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DNA methylation and gene expression profiles characterize epigenetic regulation of lncRNAs in colon adenocarcinoma

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Global RNA Expression and DNA Methylation Patterns in Primary Anaplastic Thyroid Cancer

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Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease

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Regulation of cisplatin resistance in lung cancer by epigenetic mechanisms

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Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism

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Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome

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Angiogenic Transformation in Human Brain Micro Endothelial Cells: Whole Genome DNA Methylation and Transcriptomic Analysis

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Unravelling the Epigenome of Myelodysplastic Syndrome: Diagnosis, Prognosis, and Response to Therapy

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Role and Diagnostic Performance of Host Epigenome in Respiratory Morbidity after RSV Infection: The EPIRESVi Study

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DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancer

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The Role of DNA Methylation and DNA Methyltransferases in Cancer

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Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma

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Role of DNA Methylation in Genome Stability

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Postnatal Diet Remodels Hepatic DNA Methylation in Metabolic Pathways Established by a Maternal High-Fat Diet

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Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles

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Temporal DNA methylation pattern and targeted therapy in colitis-associated cancer

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Comprehensive proteomic signature and identification of CDKN2A as a promising prognostic biomarker and therapeutic target of colorectal cancer

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Methylation analysis of histone 4-related gene HIST1H4F and its effect on gene expression in bladder cancer

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Intragenic sequences in the trophectoderm harbour the greatest proportion of methylation errors in day 17 bovine conceptuses generated using assisted reproductive technologies

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Is maternal microbial metabolism an early-life determinant of health?

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To live or let die? Epigenetic adaptations to climate change—a review

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Comparison of current methods for genome-wide DNA methylation profiling

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Fluctuations of epigenetic regulations in human gastric Adenocarcinoma: How does it affect?

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Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl

Curtis, S. W., Gerkowicz, S. A., Cobb, D. O., Kilaru, V., Terrell, M. L., Marder, M. E., Barr, D. B., Marsit, C. J., Marcus, M., Conneely, K. N., et al. (2020) · Epigenomics · doi:10.2217/epi-2019-0179 · Cited by 23

A Deep Learning–Based Framework for Supporting Clinical Diagnosis of Glioblastoma Subtypes

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Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

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Role of epigenetics in OSCC: an understanding above genetics

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A Multi-Omics Overview of Colorectal Cancer to Address Mechanisms of Disease, Metastasis, Patient Disparities and Outcomes

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SETD2 Deficiency Confers Sensitivity to Dual Inhibition of DNA Methylation and PARP in Kidney Cancer

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Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia

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Role of epigenome in tumorigenesis and drug resistance

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Species-Specific 5 mC and 5 hmC Genomic Landscapes Indicate Epigenetic Contribution to Human Brain Evolution

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The molecular hallmarks of epigenetic effects mediated by antiepileptic drugs

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The DNA Methylation Status of Wnt and Tgfβ Signals Is a Key Factor on Functional Regulation of Skeletal Muscle Satellite Cell Development

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DNA methylation in hematopoietic development and disease

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SnoRNAs: The promising targets for anti-tumor therapy

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DNA methylation of methylation complex genes in relation to stress and genome‐wide methylation in mother–newborn dyads

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(Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution

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DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder

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Comprehensive analysis of LAMC1 expression and prognostic value in kidney renal papillary cell carcinoma and clear cell carcinoma

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Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes

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Phenotypic plasticity for improved light harvesting, in tandem with methylome repatterning in reef‐building corals

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Omics-based molecular classifications empowering in precision oncology

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Personalized treatment for colorectal cancer: novel developments and putative therapeutic strategies

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Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-wide DNA Methylation Analysis

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Targeting DNA Methylation Depletes Uterine Leiomyoma Stem Cell–enriched Population by Stimulating Their Differentiation

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DNA methylation at enhancer regions Novel avenues for epigenetic biomarker development

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Sex-differentiated placental methylation and gene expression regulation has implications for neonatal traits and adult diseases

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Analysis of Bladder Cancer Tumor CpG Methylation and Gene Expression within The Cancer Genome Atlas Identifies GRIA1 as a Prognostic Biomarker for Basal-Like Bladder Cancer

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Genome‐wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine‐phosphate‐guanine methylation and histological subtypes

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Epigenome‐Wide Association Study for All‐Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 ( CASZ1 )

Abdulrahim, J. W., Kwee, L. C., Grass, E. A., Siegler, I. C., Williams, R. B., Karra, R., Kraus, W. E., Gregory, S. G., & Shah, S. H. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013228 · Cited by 20

Systematic screening identifies a 2‐gene signature as a high‐potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma

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Integrative analyses identify a DNA damage repair gene signature for prognosis prediction in lower grade gliomas

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Aberrantly Methylated and Expressed Genes as Prognostic Epigenetic Biomarkers for Colon Cancer

Wu, Y., Wan, X., Jia, G., Xu, Z., Tao, Y., Song, Z., & Du, T. (2020) · DNA and Cell Biology · doi:10.1089/dna.2020.5591 · Cited by 21

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

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Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages

Friedman, M. J., Lee, H., Lee, J., & Oh, S. (2023) · Immune Network · doi:10.4110/in.2023.23.e5 · Cited by 22

Comprehensive pan-cancer analysis of STAT3 as a prognostic and immunological biomarker

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DNA Methylation and Sex Allocation in the Parasitoid Wasp Nasonia vitripennis

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Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity

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Lipopolysaccharide (LPS) disrupts particle transport, cilia function and sperm motility in an ex vivo oviduct model

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5-Hydroxymethylcytosine preferentially targets genes upregulated in isocitrate dehydrogenase 1 mutant high-grade glioma

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The Impact of Nutritional Interventions in Pregnant Women on DNA Methylation Patterns of the Offspring: A Systematic Review

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Relationship of DNA methylation to mutational changes and transcriptional organization in fusion‐positive and fusion‐negative rhabdomyosarcoma

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Identification of Prognostic Markers in Cholangiocarcinoma Using Altered DNA Methylation and Gene Expression Profiles

Mishra, N. K., Niu, M., Southekal, S., Bajpai, P., Elkholy, A., Manne, U., & Guda, C. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.522125 · Cited by 21

Integrative Analysis of Proteomics and DNA Methylation in Orbital Fibroblasts From Graves’ Ophthalmopathy

Virakul, S., Somparn, P., Pisitkun, T., van der Spek, P. J., Dalm, V. A. S. H., Paridaens, D. A., van Hagen, P. M., Hirankarn, N., Palaga, T., & Dik, W. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.619989 · Cited by 21

Diverse facets of cortical interneuron migration regulation – Implications of neuronal activity and epigenetics

Zimmer‐Bensch, G. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.001 · Cited by 22

Hemimethylation: DNA's lasting odd couple

Sharif, J., & Koseki, H. (2018) · Science · doi:10.1126/science.aat0789 · Cited by 19

Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy

Rondelet, G., & Wouters, J. (2017) · Biochimie · doi:10.1016/j.biochi.2017.06.003 · Cited by 21

Relationship Between DNA Methylation in Key Region and the Differential Expressions of Genes in Human Breast Tumor Tissue

Jin, W. Y., Li, Q., Zuo, Y., Cao, Y., Zhang, L.-Q., Hou, R., & Su, W. (2018) · DNA and Cell Biology · doi:10.1089/dna.2018.4276 · Cited by 20

DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis

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ENPP2 Methylation in Health and Cancer

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Increased ATG5 Expression Predicts Poor Prognosis and Promotes EMT in Cervical Carcinoma

Zhou, S., Wang, X., Ding, J., Yang, H., & Xie, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.757184 · Cited by 21

RGS10 suppression by DNA methylation is associated with low survival rates in colorectal carcinoma

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Epigenomics: a new tool for the generation of climate resilient grapevines

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Regulation of alternative splicing: Functional interplay with epigenetic modifications and its implication to cancer

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Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations

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Extensive Inter-Cyst DNA Methylation Variation in Autosomal Dominant Polycystic Kidney Disease Revealed by Genome Scale Sequencing

Bowden, S. A., Stockwell, P. A., Rodger, E. J., Parry, M. F., Eccles, M. R., Stayner, C., & Chatterjee, A. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00348 · Cited by 20

Epigenetic Mechanisms in Canine Cancer

Xavier, P. L. P., Müller, S., & Fukumasu, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.591843 · Cited by 20

Differential DNA methylation and transcriptional signatures characterize impairment of muscle stem cells in pediatric human muscle contractures after brain injury

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Differential Methylation and Transcriptome Integration Analysis Identified Differential Methylation Annotation Genes and Functional Research Related to Hair Follicle Development in Sheep

Tian, Y., Yang, X., Du, J., Zeng, W., Wu, W., Di, J., Huang, X., & Tian, K. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.735827 · Cited by 20

EXT1 methylation promotes proliferation and migration and predicts the clinical outcome of non‐small cell lung carcinoma via WNT signalling pathway

Kong, W., Chen, Y., Zhao, Z., Zhang, L., Lin, X., Luο, X., Wang, S., Song, Z., Lin, X., Lai, G., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16277 · Cited by 19

DNA Methylation and Demethylation Underlie the Sex Difference in Estrogen Receptor Alpha in the Arcuate Nucleus

Cortes, L. R., Cisternas, C. D., Cabahug, I. N. K. V., Mason, D., Ramlall, E. K., Castillo‐Ruiz, A., & Forger, N. G. (2021) · Neuroendocrinology · doi:10.1159/000519671 · Cited by 23

Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation

An, J., & Ko, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021727 · Cited by 21

DNA methylation dynamics: identification and functional annotation

Liu, H., Li, S., Wang, X., Zhu, J., Wei, Y., Wang, Y., Wen, Y., Wang, L., Huang, Y., Zhang, B., et al. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw029 · Cited by 19

Pre-implantation alcohol exposure and developmental programming of FASD: an epigenetic perspective

Legault, L., Bertrand-Lehouillier, V., & McGraw, S. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0141 · Cited by 19

Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma

Deng, H., Zeng, J., Zhang, T., Gong, L., Zhang, H., Cheung, E. C. W., Jones, C., & Li, G. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0460 · Cited by 19

Epigenetic influences on genetically triggered thoracic aortic aneurysm

Portelli, S. S., Robertson, E., Malecki, C., Liddy, K. A., Hambly, B. D., & Jeremy, R. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0460-1 · Cited by 19

Aberrant DNA methylation defines isoform usage in cancer, with functional implications

Chen, Y.-C., & Elnitski, L. L. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007095 · Cited by 19

Epigenetic Regulation of Endothelial Cell Function by Nucleic Acid Methylation in Cardiac Homeostasis and Disease

Russell‐Hallinan, A., Watson, C. J., O’Dwyer, D., Grieve, D., & O’Neill, K. M. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07019-4 · Cited by 18

Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia

Shimizu, R., Muto, T., Aoyama, K., Choi, K., Takeuchi, M., Koide, S., Hasegawa, N., Isshiki, Y., Togasaki, E., Kawajiri‐Manako, C., et al. (2016) · Leukemia Research · doi:10.1016/j.leukres.2016.09.018 · Cited by 19

Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis

Kulecka, M., O’Sullivan, J., Fitzgerald, R. S., Velikonja, A., Huseyin, C. E., Mendieta, E. J. L., Ruiz‐Limón, P., Eckenberger, J., Vidal-Marín, M., Truppel, B.-A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62533-z · Cited by 20

Multi-Omics Analysis of Primary Cell Culture Models Reveals Genetic and Epigenetic Basis of Intratumoral Phenotypic Diversity

Liu, S., Yang, Z., Li, G., Li, C., Luo, Y., Gong, Q., Xin, W., Li, T., Zhang, Z., Xing, B., et al. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.07.008 · Cited by 18

Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action

Altıntaş, A., Liu, J., Fabre, O., Chuang, T., Wang, Y., Sakurai, R., Chehabi, G. N., Barrès, R., & Rehan, V. K. (2021) · The FASEB Journal · doi:10.1096/fj.202100215r · Cited by 19

Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia

Lin, M., Zhong, H.-Y., Yim, R., Chen, Q., Du, H., He, H., Lin, K., Zhao, P., Gao, R., Gao, F., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-10155-9 · Cited by 19

The Interplay between Dysregulated Metabolism and Epigenetics in Cancer

Bassal, M. A. (2023) · Biomolecules · doi:10.3390/biom13060944 · Cited by 19

SGLT2 is upregulated to acquire cisplatin resistance and SGLT2 inhibition reduces cisplatin resistance in hepatoblastoma

Fujiyoshi, S., Honda, S., Ara, M., Kondo, T., Kobayashi, N., & Taketomi, A. (2023) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.1391 · Cited by 18

Alterations in DNA methylation patterns and gene expression in spermatozoa of subfertile males

Laqqan, M. M., & Hammadeh, M. E. (2017) · Andrologia · doi:10.1111/and.12934 · Cited by 19

The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

Ye, X., Mo, M., Xu, S., Yang, Q., Wu, M., Zhang, J., Chen, B., Li, J., Zhong, Y., Huang, Q., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-4921-5 · Cited by 18

Abstract B56: DNA demethylation in gene bodies is of therapeutic significance

Zhang, H. H., Yang, X., Carvalho, D. D. D., Jones, P. A., & Liang, G. (2013) · Cancer Research · doi:10.1158/1538-7445.cec13-b56 · Cited by 1

Up and down for DNA methylation inhibitors

Burgess, D. J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3845 · Cited by 2

5-Aza-CdR Delivers a Gene Body Blow

Kasinathan, S., & Henikoff, S. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.004 · Cited by 11

Putative promoters within gene bodies control exon expression via TET1‐mediated H3K36 methylation

Ma, L., Muhammad, T., Wang, H., Du, G., Sakhawat, A., Wei, Y., Khan, A. A., Cong, X., & Huang, Y. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29566 · Cited by 3

Combination Treatment of AML Cells with Dnmt and HDAC Inhibitors: Synergistic Target Gene Downregulation Associated with Gene Body Demethylation

Blagitko‐Dorfs, N., Schlosser, P., Pfeifer, D., & Lübbert, M. (2015) · Blood · doi:10.1182/blood.v126.23.2432.2432