A decade of exploring the cancer epigenome—biological and translational implications
Open accessAbstract
The past decade has highlighted the central role of epigenetic processes in cancer causation, progression and treatment. Next-generation sequencing is providing a window for visualizing the human epigenome and how it is altered in cancer. This view provides many surprises, including linking epigenetic abnormalities to mutations in genes that control DNA methylation, the packaging and the function of DNA in chromatin, and metabolism. Epigenetic alterations are leading candidates for the development of specific markers for cancer detection, diagnosis and prognosis. The enzymatic processes that control the epigenome present new opportunities for deriving therapeutic strategies designed to reverse transcriptional abnormalities that are inherent to the cancer epigenome.
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Disruption of chromosomal topology and oncogene insulation may be more generally relevant to methylator phenotypes observed in colorectal and renal cell carcinomas, leukemia, and other malignancies.
“Conversely, disruption of chromosomal topology and oncogene insulation may be more generally relevant to methylator phenotypes observed in colorectal and renal cell carcinomas, leukemia and other malignancies28.”
From Insulator dysfunction and oncogene activation in IDH mutant gliomas (2016) · cites this paper as [28]
In “Promoter CpG island DNA hypermethylation” (page unavailable), the paper describes methylation of an H19 insulator, loss of CTCF binding, and IGF2 activation in pre-neoplastic kidneys, with a link to colon cancer progression. In “Genetics meets epigenetics” (page unavailable), it discusses methylator phenotypes in gliomas and increased DNA hypermethylation in leukaemia. It does not link disrupted chromosomal topology or oncogene insulation to methylator phenotypes across the named cancers, and its kidney example concerns Wilms’ tumour rather than renal cell carcinoma. (LLM, conf=0.84)
Experimental — accuracy not yet measuredEnhanced histone acetylation induced by HDACi allows overexpression of genes involved in cell cycle arrest, such as cyclin-dependent kinase inhibitors or the GADD45 gene family.
“Previous studies showed that enhanced histone acetylation induced by HDACi allowed the overexpression of genes involved in cell cycle arrest such as cyclin-dependent kinase inhibitors or the growth arrest and DNA damage-inducible protein GADD45 gene family (11, 28, 40, 45-49).”
From Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability (2013) · cites this paper as [11]
In ‘The potential for epigenetic therapy for cancer’ (page unavailable), the review says HDAC inhibitors inhibit histone deacetylation and can augment gene reactivation when combined with DNA methyltransferase inhibitors. It does not say that HDAC inhibitors cause overexpression of cell-cycle-arrest genes, or identify cyclin-dependent kinase inhibitors or GADD45 as examples. (LLM, conf=0.82)
Experimental — accuracy not yet measuredInsulator dysfunction may also be accompanied by promoter silencing events and by alterations to other pathways affected by 2-HG.
“Insulator dysfunction may also be accompanied by promoter silencing events28,29, and by alterations to other pathways affected by 2-HG7,30.”
From Insulator dysfunction and oncogene activation in IDH mutant gliomas (2016) · cites this paper as [28]
Novel selective benzamide-based HDAC1/2 inhibitors have been described that exhibit greater than 100-fold selectivity relative to other HDACs.
“Among them, novel selective benzamide-based HDAC1/2 inhibitors have been described that exhibit greater than 100-fold selectivity relative to other HDACs (11, 28).”
From Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability (2013) · cites this paper as [11]
The section 'The potential for epigenetic therapy for cancer' discusses HDAC inhibitors generally, but does not describe benzamide-based HDAC1/2 inhibitors or their selectivity. Searches for benzamide, HDAC1/2, and 100-fold selectivity found no passage addressing those details; page numbers are unavailable in our copy. (LLM, conf=0.73)
Experimental — accuracy not yet measuredHDAC inhibitors such as SAHA and MS-275 promote cell cycle arrest and apoptosis.
“It has previously been shown that HDAC inhibitors such as SAHA and MS-275 promote cell cycle arrest and apoptosis”
From Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability (2013) · cites this paper as [11]
In “The potential for epigenetic therapy for cancer” (page not available), the review discusses HDAC inhibitors and vorinostat, identified as SAHA in the References. It does not say that SAHA or MS-275 promotes cell-cycle arrest or apoptosis; searches for those effects and MS-275 found no supporting passage. (LLM, conf=0.74)
Experimental — accuracy not yet measured
Among activated genes that subside with pulsed HDACi administration are genes known to be powerful effectors of cell cycle arrest in multiple cell types and may promote apoptosis.
“Among activated genes that subside with pulsed HDACi administration are genes known to be powerful effectors of cell cycle arrest in multiple cell types and may promote apoptosis (11, 50).”
From Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability (2013) · cites this paper as [11]
In “The potential for epigenetic therapy for cancer” (page unavailable), the review discusses HDAC inhibitors and gene reactivation, but not the claimed decline in activated genes after pulsed administration. Searches for pulsed treatment, cell-cycle arrest and apoptosis found no passage linking those effects to HDAC inhibitors in our copy. (LLM, conf=0.72)
Experimental — accuracy not yet measuredThree general processes have major effects on cancer initiation and progression: somatic mutations, epigenetic alterations, and alterations in the tumor microenvironment.
“Three general processes have major effects on cancer initiation and progression. First, discrete somatic mutations lead to tumor suppressor loss-of-function and oncoprotein gain-of-function [1]; second, epigenetic alterations change patterns of gene expression [2]; and third, alterations in the tumor microenvironment also lead to broad changes in gene expression [3].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [2]
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Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735 · see citing works
<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma
Hegi, M. E., Diserens, A.-C., Gorlia, T., Hamou, M.-F., de Tribolet, N., Weller, M., Kros, J. M., Hainfellner, J. A., Mason, W., Mariani, L., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043331 · Cited by 7,405 · see citing works
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works
<i>IDH1</i> and <i>IDH2</i> Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847 · see citing works
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836 · see citing works
The fundamental role of epigenetic events in cancer
Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648 · see citing works
Self-citationA bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361 · see citing works
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Gupta, R. A., Shah, N., Wang, K., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,203 · see citing works
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673 · see citing works
Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515 · see citing works
Self-citationSelective inhibition of BET bromodomains
Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature · doi:10.1038/nature09504 · Cited by 4,262 · see citing works
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129 · see citing works
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051 · see citing works
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works
Esteller, M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072067 · Cited by 3,681 · see citing works
The Genomic Landscapes of Human Breast and Colorectal Cancers
Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., Leary, R. J., Shen, D., Boca, S. M., Barber, T., Ptak, J., et al. (2007) · Science · doi:10.1126/science.1145720 · Cited by 2,833 · see citing works
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
Sharma, S. V., Lee, D. Y., Li, B., Quinlan, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.027 · Cited by 2,770 · see citing works
Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766 · see citing works
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700 · see citing works
Fenaux, P., Mufti, G. J., Hellstrom-Lindberg, E., Santini, V., Finelli, C., Giagounidis, A., Schoch, R., Gattermann, N., Sanz, G., List, A., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70003-8 · Cited by 2,663 · see citing works
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536 · see citing works
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533 · see citing works
The history of cancer epigenetics
Feinberg, A. P., & Tycko, B. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1279 · Cited by 2,350 · see citing works
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Noushmehr, H., Weisenberger, D. J., Diefes, K., Phillips, H. S., Pujara, K., Berman, B. P., Pan, F., Pelloski, C. E., Sulman, E. P., Bhat, K. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.017 · Cited by 2,337 · see citing works
Self-citationLinking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · see citing works
Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents
Esteller, M., García‐Foncillas, J., Andion, E., Goodman, S. N., Hidalgo, O. F., Vanaclocha, V., Baylin, S. B., & Herman, J. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011093431901 · Cited by 2,256 · see citing works
Self-citationIrizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177 · see citing works
<i>DNMT3A</i> Mutations in Acute Myeloid Leukemia
Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983 · see citing works
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
Guelen, L., Pagie, L., Brasset, É., Meuleman, W. R. A., Faza, M. B., Talhout, W., Eussen, B. H. J., de Klein, A., Wessels, L. F. A., de Laat, W. L., et al. (2008) · Nature · doi:10.1038/nature06947 · Cited by 1,959 · see citing works
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R., & Young, R. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.042 · Cited by 1,946 · see citing works
Fraga, M. F., Ballestar, E., Villar‐Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C. E., Ropero, S., Petrie, K. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,926 · see citing works
The NIH Roadmap Epigenomics Mapping Consortium
Bernstein, B. E., Stamatoyannopoulos, J. A., Costello, J. F., Ren, B., Milosavljevic, A., Meissner, A., Kellis, M., Marra, M. A., Beaudet, A. L., Ecker, J. R., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt1010-1045 · Cited by 1,892 · see citing works
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. (2011) · Nature · doi:10.1038/nature10334 · Cited by 1,870 · see citing works
Cameron, E. E., Bachman, K. E., Myöhänen, S., Herman, J. G., & Baylin, S. B. (1999) · Nature Genetics · doi:10.1038/5047 · Cited by 1,857 · see citing works
Self-citationThe epigenetic progenitor origin of human cancer
Feinberg, A. P., OHLSSON, R. I., & Henikoff, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1748 · Cited by 1,851 · see citing works
Cellular differentiation, cytidine analogs and DNA methylation
Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831 · see citing works
Self-citationMethylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
Bell, A. C., & Felsenfeld, G. (2000) · Nature · doi:10.1038/35013100 · Cited by 1,746 · see citing works
Conserved role of intragenic DNA methylation in regulating alternative promoters
Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743 · see citing works
Jiao, Y., Shi, C., Edil, B. H., de Wilde, R. F., Klimstra, D. S., Maitra, A., Schulick, R. D., Tang, L. H., Wolfgang, C. L., Choti, M. A., et al. (2011) · Science · doi:10.1126/science.1200609 · Cited by 1,717 · see citing works
<i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas
Wiegand, K. C., Shah, S. P., Al-Agha, O. M., Zhao, Y., Tse, K., Zeng, T., Senz, J., McConechy, M. K., Anglesio, M. S., Kalloger, S. E., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1008433 · Cited by 1,712 · see citing works
Fabbri, M., Garzon, R., Cimmino, A., Liu, Z., Zanesi, N. A. O., Callegari, E., Liu, S., Alder, H., Costinean, S., Fernandez-Cymering, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707628104 · Cited by 1,676 · see citing works
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
Ooi, S. K. T., Qiu, C., Bernstein, E., Li, K., Jia, D., Yang, Z., Erdjument‐Bromage, H., Tempst, P., Lin, S., Allis, C. D., et al. (2007) · Nature · doi:10.1038/nature05987 · Cited by 1,558 · see citing works
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
Versteege, I., Sévenet, N., Lange, J., Rousseau-Merck, M.-F., Ambros, P. F., Handgretinger, R., Aurias, A., & Delattre, O. (1998) · Nature · doi:10.1038/28212 · Cited by 1,552 · see citing works
The power and the promise of DNA methylation markers
Laird, P. W. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1045 · Cited by 1,548 · see citing works
Dissecting direct reprogramming through integrative genomic analysis
Mikkelsen, T. S., Hanna, J. H., Zhang, X., Ku, M., Wernig, M., Schorderet, P., Bernstein, B., Jaenisch, R., Lander, E. S., & Meissner, A. (2008) · Nature · doi:10.1038/nature07056 · Cited by 1,472 · see citing works
Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391 · see citing works
Chromatin signatures of pluripotent cell lines
Azuara, V., Perry, P., Sauer, S., Spivakov, M., Jørgensen, H. F., John, R. M., Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1403 · Cited by 1,357 · see citing works
Saito, Y., Liang, G., Egger, G., Friedman, J. M., Chuang, J. C., Coetzee, G. A., & Jones, P. A. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.020 · Cited by 1,328 · see citing works
Self-citationEpigenetic therapy of cancer: past, present and future
Yoo, C. B., & Jones, P. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1930 · Cited by 1,291 · see citing works
Self-citationJmjC-domain-containing proteins and histone demethylation
Klose, R. J., Kallin, E. M., & Zhang, Y. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1945 · Cited by 1,290 · see citing works
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Varela, I., Tarpey, P. S., Raine, K. M., Huang, D., Ong, C. K., Stephens, P., Davies, H. R., Jones, D., Lin, M., Teague, J. W., et al. (2011) · Nature · doi:10.1038/nature09639 · Cited by 1,278 · see citing works
Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226 · see citing works
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
Jones, S., Wang, T., Shih, I., Mao, T., Nakayama, K., Roden, R. B. S., Glas, R., Slamon, D. J., Diaz, L. A., Vogelstein, B., et al. (2010) · Science · doi:10.1126/science.1196333 · Cited by 1,218 · see citing works
Doi, A., Park, I., Wen, B., Murakami, P. N., Aryee, M. J., Irizarry, R. A., Herb, B. R., Ladd‐Acosta, C., Rho, J., Loewer, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.471 · Cited by 1,173 · see citing works
Roesch, A., Fukunaga‐Kalabis, M., Schmidt, E. C., Zabierowski, S. E., Brafford, P. A., Vultur, A., Basu, D., Gimotty, P. A., VOGT, T. M., & Herlyn, M. (2010) · Cell · doi:10.1016/j.cell.2010.04.020 · Cited by 1,162 · see citing works
Epigenetic stem cell signature in cancer
Widschwendter, M., Fiegl, H., Egle, D., Mueller-Holzner, E., Spizzo, G., Marth, C., Weisenberger, D. J., Campan, M., Young, J., Jacobs, I., et al. (2007) · Nature Genetics · doi:10.1038/ng1941 · Cited by 1,143 · see citing works
Duvic, M., Talpur, R., Ni, X., Zhang, C., Hazarika, P., Kelly, C., Chiao, J. H., Reilly, J. F., Ricker, J. L., Richon, V. M., et al. (2007) · Blood · doi:10.1182/blood-2006-06-025999 · Cited by 1,141 · see citing works
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Ernst, T., Chase, A. J., Score, J., Hidalgo-Curtis, C. E., Bryant, C., Jones, A. V., Waghorn, K., Zoi, K., Ross, F. M., Reiter, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.621 · Cited by 1,139 · see citing works
Ohm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K. E., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., et al. (2007) · Nature Genetics · doi:10.1038/ng1972 · Cited by 1,130 · see citing works
Self-citationDynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
Ficz, G., Branco, M. R., Seisenberger, S., Santos, F., Krueger, F., Hore, T. A., Marques, C. J., Andrews, S., & Reik, W. (2011) · Nature · doi:10.1038/nature10008 · Cited by 1,123 · see citing works
CpG island methylator phenotype in cancer
Issa, J. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1507 · Cited by 1,107 · see citing works
Global histone modification patterns predict risk of prostate cancer recurrence
Seligson, D. B., Horvath, S., Shi, T., Yu, H., Tze, S., Grunstein, M. R., & Kurdistani, S. K. (2005) · Nature · doi:10.1038/nature03672 · Cited by 1,090 · see citing works
A microRNA DNA methylation signature for human cancer metastasis
Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez‐Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803055105 · Cited by 1,078 · see citing works
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Suzuki, H., Watkins, D. N., Jair, K.-W., Schuebel, K. E., Markowitz, S. D., Chen, W. D., Pretlow, T. P., Yang, B., Akiyama, Y., van Engeland, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1330 · Cited by 1,070 · see citing works
Self-citationOlsen, E. A., Kim, Y. H., Kuzel, T. M., Pacheco, T. R., Foss, F. M., Parker, S. R. S., Frankel, S. R., Chen, C., Ricker, J. L., Arduino, J. M., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.10.2434 · Cited by 1,057 · see citing works
Increased methylation variation in epigenetic domains across cancer types
Hansen, K. D., Timp, W., Bravo, H. C., Sabunciyan, S., Langmead, B., McDonald, O. G., Wen, B., Wu, H., Liu, Y., Diep, D. H., et al. (2011) · Nature Genetics · doi:10.1038/ng.865 · Cited by 1,053 · see citing works
Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
Varambally, S., Cao, Q., Mani, R. S., Shankar, S., Wang, X., Ateeq, B., Laxman, B., Cao, X., Jing, X., Ramnarayanan, K., et al. (2008) · Science · doi:10.1126/science.1165395 · Cited by 1,048 · see citing works
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
Whetstine, J. R., Nottke, A. C., Lan, F., Huarte, M., Smolikov, S., Chen, Z., Spooner, E., Li, E., Zhang, G., Colaiácovo, M. P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.03.028 · Cited by 1,046 · see citing works
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021 · see citing works
Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Meshorer, E., Yellajoshyula, D., George, E. M., Scambler, P. J., Brown, D. T., & Misteli, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.10.017 · Cited by 1,008 · see citing works
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L. H., Lerach, S., Tang, H., Ma, J., et al. (2011) · Nature · doi:10.1038/nature09730 · Cited by 949 · see citing works
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Daigle, S. R., Olhava, E. J., Therkelsen, C. A., Majer, C. R., Sneeringer, C. J., Song, J. J., Johnston, L. D., Scott, M. P., Smith, J. J., Xiao, Y., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.009 · Cited by 926 · see citing works
hDOT1L Links Histone Methylation to Leukemogenesis
Okada, Y., Feng, Q. F., Lin, Y.-H., Jiang, Q., Li, Y., Coffield, V. M., Su, L., Xu, G., & Zhang, Y. (2005) · Cell · doi:10.1016/j.cell.2005.02.020 · Cited by 819 · see citing works
Ligtenberg, M. J. L., Kuiper, R. P., Chan, T. L., Goossens, M., Hebeda, K. M., Voorendt, M., Lee, T. Y. H., Bodmer, D., Hoenselaar, E., Hendriks-Cornelissen, S. J. B., et al. (2009) · Nature Genetics · doi:10.1038/ng.283 · Cited by 818 · see citing works
Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.020 · Cited by 809 · see citing works
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Yu, W., Gius, D. R., Onyango, P. O., Muldoon‐Jacobs, K., Karp, J. E., Feinberg, A. P., & Cui, H. (2008) · Nature · doi:10.1038/nature06468 · Cited by 801 · see citing works
Epigenetic modifications as therapeutic targets
Kelly, T. K., Carvalho, D. D. D., & Jones, P. A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1678 · Cited by 796 · see citing works
Self-citationSomatic mutations of the histone H3K27 demethylase gene UTX in human cancer
van Haaften, G., Dalgliesh, G. L., Davies, H., Chen, L., Bignell, G., Greenman, C., Edkins, S., Hardy, C., O'Meara, S., Teague, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.349 · Cited by 784 · see citing works
Garzon, R., Liu, S., Fabbri, M., Liu, Z., Heaphy, C. E. A., Callegari, E., Schwind, S., Pang, J., Yu, J., Muthusamy, N., et al. (2009) · Blood · doi:10.1182/blood-2008-07-170589 · Cited by 781 · see citing works
Rethinking how DNA methylation patterns are maintained
Jones, P. A., & Liang, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2651 · Cited by 767 · see citing works
Self-citationSomatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
Nikoloski, G., Langemeijer, S. M. C., Kuiper, R. P., Knops, R., Massop, M., Tönnissen, E., van der Heijden, A., Scheele, T. N., Vandenberghe, P., de Witte, T., et al. (2010) · Nature Genetics · doi:10.1038/ng.620 · Cited by 754 · see citing works
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Gui, Y., Guo, G., Huang, Y., Hu, X., Tang, A., Gao, S., Wu, R., Chen, C., Li, X., Zhou, L., et al. (2011) · Nature Genetics · doi:10.1038/ng.907 · Cited by 748 · see citing works
Berman, B. P., Weisenberger, D. J., Aman, J. F., Hinoue, T., Ramjan, Z., Liu, Y., Noushmehr, H., Lange, C. P. E., van Dijk, C. M., Tollenaar, R. A. E. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.969 · Cited by 660 · see citing works
Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
Wilson, B. G., Wang, X., Shen, X., McKenna, E. S., Lemieux, M. E., Cho, Y., Koellhoffer, E. C., Pomeroy, S. L., Orkin, S. H., & Roberts, C. W. M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.09.006 · Cited by 649 · see citing works
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
Wu, H., D’Alessio, A. C., Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Eve Sun, Y., & Zhang, Y. (2011) · Nature · doi:10.1038/nature09934 · Cited by 646 · see citing works
5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes
Rideout, W. M., Coetzee, G. A., Olumi, A. F., & Jones, P. A. (1990) · Science · doi:10.1126/science.1697983 · Cited by 640 · see citing works
Self-citationCui, K., Zang, C., Roh, T., Schones, D. E., Childs, R. W., Peng, W., & Zhao, K. (2009) · Cell stem cell · doi:10.1016/j.stem.2008.11.011 · Cited by 620 · see citing works
Kondo, Y., Shen, L., Cheng, A. S. L., Ahmed, S., Boumber, Y., Charo, C., Yamochi, T., Urano, T., Furukawa, K., Kwabi‐Addo, B., et al. (2008) · Nature Genetics · doi:10.1038/ng.159 · Cited by 618 · see citing works
Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation
Bartke, T., Vermeulen, M., Xhemalce, B., Robson, S. C., Mann, M., & Kouzarides, T. (2010) · Cell · doi:10.1016/j.cell.2010.10.012 · Cited by 611 · see citing works
Yap, D., Chu, J., Berg, T., Schapira, M., Cheng, S., Moradian, A., Morin, R. D., Mungall, A. J. J., Meissner, B., Boyle, M., et al. (2010) · Blood · doi:10.1182/blood-2010-11-321208 · Cited by 609 · see citing works
Toyota, M., Suzuki, H., Sasaki, Y., Maruyama, R., Imai, K., Shinomura, Y., & Tokino, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0325 · Cited by 600 · see citing works
DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer
Brock, M. V., Hooker, C. M., Ota-Machida, E., Han, Y. K., Guo, M., Ames, S., Glöckner, S. C., Piantadosi, S., Gabrielson, E. W., Pridham, G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706550 · Cited by 594 · see citing works
Self-citationWidespread and tissue specific age-related DNA methylation changes in mice
Maegawa, S., Hinkal, G., Kim, H. S., Shen, L., Zhang, L., Zhang, J., Zhang, N., Liang, S., Donehower, L. A., & Issa, J.-P. J. (2010) · Genome Research · doi:10.1101/gr.096826.109 · Cited by 553 · see citing works
DNA Methylation Biomarkers for Blood-Based Colorectal Cancer Screening
Lofton–Day, C., Model, F., deVos, T., Tetzner, R., Distler, J., Schuster, M., Song, X., Lesche, R., Liebenberg, V., Ebert, M., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.095992 · Cited by 494 · see citing works
Gore, S. D., Baylin, S. B., Sugar, E. A., Carraway, H. E., Miller, C. B., Carducci, M. A., Grever, M. R., Galm, O., Dauses, T., Karp, J. E., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0080 · Cited by 475 · see citing works
Self-citationSteenman, M., Rainier, S. R., Dobry, C. J., Grundy, P., Horon, I. L., & Feinberg, A. P. (1994) · Nature Genetics · doi:10.1038/ng0794-433 · Cited by 459 · see citing works
A DNA methylation fingerprint of 1628 human samplesPreprint
Fernández, A. F., Assenov, Y., Martín-Subero, J. I., Bálint, B., Siebert, R., Taniguchi, H., Yamamoto, H., Hidalgo, M. M., Tan, A. C., Galm, O., et al. (2011) · Genome Research · doi:10.1101/gr.119867.110 · Cited by 415 · see citing works
Frigola, J., Song, J. Z., Stirzaker, C., Hinshelwood, R. A., Peinado, M. A., & Clark, S. J. (2006) · Nature Genetics · doi:10.1038/ng1781 · Cited by 409 · see citing works
Friedman, J. M., Liang, G., Liu, C.-C., Wolff, E. M., Tsai, Y., Ye, W., Zhou, X. J., & Jones, P. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3114 · Cited by 381 · see citing works
Self-citationGal‐Yam, E. N., Egger, G., Iniguez, L., Holster, H., Einarsson, S. O., Zhang, X., Lin, J., Liang, G., Jones, P. A., & Tanay, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806437105 · Cited by 380 · see citing works
Self-citationGenome-wide approaches to studying chromatin modifications
Schones, D. E., & Zhao, K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2270 · Cited by 370 · see citing works
Sparago, A., Cerrato, F., Vernucci, M., Ferrero, G. B., Silengo, M., & Riccio, A. (2004) · Nature Genetics · doi:10.1038/ng1410 · Cited by 366 · see citing works
Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer
Schuebel, K. E., Chen, W., Cope, L., Glöckner, S. C., Suzuki, H., Yi, J.-M., Chan, T. A.-T., Neste, L. V., Criekinge, W. V., van den Bosch, S., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030157 · Cited by 347 · see citing works
Self-citationSensitive digital quantification of DNA methylation in clinical samples
Li, M., Chen, W.-D., Papadopoulos, N., Goodman, S. N., Bjerregaard, N. C., Laurberg, S., Levin, B., Juhl, H., Arber, N., Moinova, H., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1559 · Cited by 341 · see citing works
Jankowska, A. M., Makishima, H., Tiu, R. V., Szpurka, H., Huang, Y., Traina, F., Visconte, V., Sugimoto, Y., Prince, C. J., O’Keefe, C. L., et al. (2011) · Blood · doi:10.1182/blood-2010-10-311019 · Cited by 329 · see citing works
Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
Chan, T. L., Yuen, S. T., Kong, C. K., Chan, Y. W., Chan, A. S., Ng, W. F., Tsui, W. Y., Lo, M. W., Tam, W. Y., Li, V. S., et al. (2006) · Nature Genetics · doi:10.1038/ng1866 · Cited by 324 · see citing works
Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice
Sakatani, T., Kaneda, A., Iacobuzio–Donahue, C. A., Carter, M. G., Witzel, S. D. B., Okano, H., Ko, M. S. H., OHLSSON, R. I., Longo, D. L., & Feinberg, A. P. (2005) · Science · doi:10.1126/science.1108080 · Cited by 322 · see citing works
CTCF maintains differential methylation at the Igf2/H19 locus
Schoenherr, C. J., Levorse, J. M., & Tilghman, S. M. (2003) · Nature Genetics · doi:10.1038/ng1057 · Cited by 320 · see citing works
Epigenetic lesions at the H19 locus in Wilms' tumour patients
Moulton, T. A., Crenshaw, T., Hao, Y., Moosikasuwan, J., Lin, N., Dembitzer, F. R., Hensle, T., Weiss, L. M., McMorrow, L. E., Loew, T. H., et al. (1994) · Nature Genetics · doi:10.1038/ng0794-440 · Cited by 316 · see citing works
Leary, R. J., Lin, J., Cummins, J. M., Boca, S. M., Wood, L. D., Parsons, D. W., Jones, S., Sjöblom, T., Park, B.-H., Parsons, R. E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808041105 · Cited by 305 · see citing works
CpG-Island Methylation in Aging and Cancer
Issa, J. J. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59696-4_7 · Cited by 301 · see citing works
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation.
Cairns, P., Esteller, M., Herman, J. G., Schoenberg, M., Jerónimo, C., Sánchez‐Céspedes, M., Chow, N. ‐., Grasso, M., Wu, L. J., Westra, W. B., et al. (2001) · PubMed · Cited by 294 · see citing works
Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
Cui, H., Horon, I. L., OHLSSON, R. I., Hamilton, S. R., & Feinberg, A. P. (1998) · Nature Medicine · doi:10.1038/3260 · Cited by 285 · see citing works
Array-based genomic resequencing of human leukemia
Yamashita, Y., Yuan, J., Suetake, I., Suzuki, H., Ishikawa, Y., Choi, Y. L., Ueno, T., Soda, M., Hamada, T., Haruta, H., et al. (2010) · Oncogene · doi:10.1038/onc.2010.117 · Cited by 250 · see citing works
Akiyama, Y., Watkins, N., Suzuki, H., Jair, K.-W., van Engeland, M., Esteller, M., Sakai, H., Ren, C.-Y., Yuasa, Y., Herman, J. G., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8429-8439.2003 · Cited by 246 · see citing works
Self-citationFrequent epigenetic inactivation of Wnt antagonist genes in breast cancer
Suzuki, H., Toyota, M., Caraway, H., Gabrielson, E. W., Ohmura, T., Fujikane, T., Nishikawa, N., Sogabe, Y., Nojima, M., Sonoda, T., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604259 · Cited by 239 · see citing works
Self-citationThe emerging functions of histone demethylases
Agger, K., Christensen, J. F., Cloos, P. A., & Helin, K. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.12.003 · Cited by 231 · see citing works
Glöckner, S. C., Dhir, M., Yi, J. M., McGarvey, K. M., Neste, L. V., Louwagie, J., Chan, T. A.-T., Kleeberger, W., A, A. P. D. B., Smits, K. M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-0142 · Cited by 230 · see citing works
Self-citationDifferentiation of NUT Midline Carcinoma by Epigenomic Reprogramming
Schwartz, B. E., Hofer, M. D., Lemieux, M. E., Bauer, D. E., Cameron, M. J., West, N. H., Agoston, E. S., Reynoird, N., Khochbin, S., Ince, T. A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3513 · Cited by 216 · see citing works
Histone Lysine Demethylases and Their Impact on Epigenetics
Trojer, P., & Reinberg, D. (2006) · Cell · doi:10.1016/j.cell.2006.04.003 · Cited by 212 · see citing works
Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island
Lin, J., Jeong, S., Liang, G., Takai, D., Fatemi, M., Tsai, Y., Egger, G., Gal‐Yam, E. N., & Jones, P. A. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.10.014 · Cited by 206 · see citing works
Self-citationPcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping
Tiwari, V. K., McGarvey, K. M., Licchesi, J. D. F., Ohm, J. E., Herman, J. G., Schübeler, D., & Baylin, S. B. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060306 · Cited by 205 · see citing works
Self-citationGriffiths, E. A., & Gore, S. D. (2008) · Seminars in Hematology · doi:10.1053/j.seminhematol.2007.11.007 · Cited by 204 · see citing works
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors
Chen, W., Zeng, X., Carter, M. G., Morrell, C. N., Yen, R.-W. C., Esteller, M., Watkins, D. N., Herman, J. G., Mankowski, J. L., & Baylin, S. B. (2003) · Nature Genetics · doi:10.1038/ng1077 · Cited by 201 · see citing works
Self-citationSelective Anchoring of DNA Methyltransferases 3A and 3B to Nucleosomes Containing Methylated DNA
Jeong, S., Liang, G., Sharma, S., Lin, J., Choi, S. H., Han, H., Yoo, C. B., Egger, G., Yang, A. S., & Jones, P. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00484-09 · Cited by 194 · see citing works
Self-citationLujambio, A., Portela, A., Liz, J., Melo, S. A., Rossi, S., Spizzo, R., Croce, C. M., Calin, G. A., & Esteller, M. (2010) · Oncogene · doi:10.1038/onc.2010.361 · Cited by 193 · see citing works
Hitchins, M. P., Rapkins, R. W., Kwok, C., Srivastava, S., Wong, J. J. L., Khachigian, L. M., Polly, P., Goldblatt, J., & Ward, R. L. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.07.003 · Cited by 182 · see citing works
Coolen, M. W., Stirzaker, C., Song, J. Z., Statham, A. L., Kassir, Z., Moreno, C. S., Young, A. N., Varma, V. A., Speed, T. P., Cowley, M. J., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2023 · Cited by 178 · see citing works
Chan, T. A.-T., Glöckner, S. C., Yi, J. M., Chen, W., Neste, L. V., Cope, L., Herman, J. G., Velculescu, V. E., Schuebel, K. E., Ahuja, N., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050114 · Cited by 166 · see citing works
Self-citationEpigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis
Chen, W., Cooper, T. K., Zahnow, C. A., Overholtzer, M., Zhao, Z., Ladanyi, M., Karp, J. E., Gökgöz, N., Wunder, J. S., Andrulis, I. L., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.030 · Cited by 162 · see citing works
Self-citationCaligiuri, M. A., Schichman, S. A., Strout, M. P., Mrózek, K., Baer, M. R., Frankel, S. R., Barcos, M. P., Herzig, G. P., Croce, C. M., & Bloomfield, C. D. (1994) · PubMed · Cited by 159 · see citing works
Stumpel, D. J. P. M., Schneider, P., Roon, E. H. J. V., Boer, J. M., Lorenzo, P. D., Valsecchi, M. G., de Menezes, R. X., Pieters, R., & Stam, R. W. (2009) · Blood · doi:10.1182/blood-2009-06-227660 · Cited by 157 · see citing works
Genomic and Epigenomic Integration Identifies a Prognostic Signature in Colon Cancer
Yi, J. M., Dhir, M., Neste, L. V., Downing, S. R., Jeschke, J., Glöckner, S. C., Calmon, M. F., Hooker, C. M., Funes, J. M., Boshoff, C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2509 · Cited by 145 · see citing works
Self-citationH2A.Z Maintenance during Mitosis Reveals Nucleosome Shifting on Mitotically Silenced Genes
Kelly, T. K., Miranda, T. B., Liang, G., Berman, B. P., Lin, J., Tanay, A., & Jones, P. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.026 · Cited by 137 · see citing works
Self-citationMS-qFRET: A quantum dot-based method for analysis of DNA methylationPreprint
Bailey, V. J., Easwaran, H., Zhang, Y., Griffiths, E. A., Belinsky, S. A., Herman, J. G., Baylin, S. B., Carraway, H. E., & Wang, T. (2009) · Genome Research · doi:10.1101/gr.088831.108 · Cited by 135 · see citing works
Self-citationRosenbaum, E., Hoque, M. O., Cohen, Y., ZAHURAK, M. L., Eisenberger, M. A., Epstein, J. I., Partin, A. W., & Sidransky, D. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1183 · Cited by 134 · see citing works
Carter, M. G. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.3.413 · Cited by 125 · see citing works
Schafer, E. S., Irizarry, R. A., Negi, S., McIntyre, E., Small, D., Figueroa, M. E., Melnick, A. M., & Brown, P. A. (2010) · Blood · doi:10.1182/blood-2009-09-243634 · Cited by 122 · see citing works
Banine, F., Bartlett, C. S., Gunawardena, R. W., Muchardt, C., Yaniv, M., Knudsen, E. S., Weissman, B. E., & Sherman, L. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3554 · Cited by 118 · see citing works
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastomaPreprint
Briggs, K. J., Corcoran-Schwartz, I. M., Zhang, W., Harcke, T., Devereux, W. L., Baylin, S. B., Eberhart, C. G., & Watkins, D. N. (2008) · Genes & Development · doi:10.1101/gad.1640908 · Cited by 110 · see citing works
Self-citationStem Cell Chromatin Patterns: An Instructive Mechanism for DNA Hypermethylation?
Ohm, J. E., & Baylin, S. B. (2007) · Cell Cycle · doi:10.4161/cc.6.9.4210 · Cited by 102 · see citing works
Self-citationMLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression
Erfurth, F. E., Popovic, R., Grembecka, J. E., Cierpicki, T., Theisler, C. M., Xia, Z., Stuart, T., Dı́az, M. O., Bushweller, J. H., & Zeleznik‐Le, N. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800090105 · Cited by 101 · see citing works
Wartman, L. D., Larson, D. E., Xiang, Z., Ding, L., Chen, K., Lin, L., Cahan, P., Klco, J. M., Welch, J. S., Li, C., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45284 · Cited by 99 · see citing works
Teng, I.-W., Hou, P., Lee, K., Chu, P., Yeh, K., Jin, V. X., Tseng, M., Tsai, S., Chang, Y., Wu, C., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3418 · Cited by 98 · see citing works
Uno, K., Takita, J., Yokomori, K., Tanaka, Y., Ohta, S., Shimada, H., Gilles, F. H., Sugita, K., Abe, S., Sako, M., et al. (2002) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10052 · Cited by 79 · see citing works
Methylation inhibitor therapy in the treatment of myelodysplastic syndrome
Silverman, L. R., & Mufti, G. J. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0347 · Cited by 76 · see citing works
Ren, X., & Kerppola, T. K. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05088-11 · Cited by 72 · see citing works
Epimutations and cancer predisposition: importance and mechanisms
Hesson, L. B., Hitchins, M. P., & Ward, R. L. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.02.005 · Cited by 69 · see citing works
Chi, A. S., & Bernstein, B. (2009) · Science · doi:10.1126/science.1166261 · Cited by 54 · see citing works
Issa, J. J., Kantarjian, H. M., & Kirkpatrick, P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1726 · Cited by 54 · see citing works
Epigenetic variation and cellular Darwinism
Issa, J. J. (2011) · Nature Genetics · doi:10.1038/ng.897 · Cited by 51 · see citing works
DNA demethylases: a new epigenetic frontier in drug discovery
Carey, N., Marques, C. J., & Reik, W. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.05.004 · Cited by 48 · see citing works
Zhang, W., Zeng, X., Briggs, K., Beaty, R. M., Simons, B. W., Yen, R.-W. C., Tyler, M. A., Tsai, H.-C., Ye, Y., Gesell, G. S., et al. (2010) · Oncogene · doi:10.1038/onc.2010.12 · Cited by 46 · see citing works
Self-citationBarekati, Z., Radpour, R., Kohler, C., Zhang, B., Toniolo, P. G., Lenner, P., Lv, Q., Zheng, H. Y., & Zhong, X. Y. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq199 · Cited by 46 · see citing works
Guenther, M. G., & Young, R. A. (2010) · Science · doi:10.1126/science.1193995 · Cited by 45 · see citing works
Cancer is a functional repair tissue
Meng, X., & Riordan, N. H. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.09.041 · Cited by 42 · see citing works
Fujimura, Y., Isono, K., Vidal, M., Endoh, M., Kajita, H., Mizutani-Koseki, Y., Takihara, Y., van Lohuizen, M., Otte, A. P., Jenuwein, T., et al. (2006) · Development · doi:10.1242/dev.02405 · Cited by 40 · see citing works
Easwaran, H., Neste, L. V., Cope, L., Sen, S., Mohammad, H. P., Pageau, G. J., Lawrence, J. B., Herman, J. G., Schuebel, K. E., & Baylin, S. B. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0765 · Cited by 33 · see citing works
Self-citationLoss of a single Hic1 allele accelerates polyp formation in ApcΔ716 mice
Mohammad, H. P., Zhang, W., Prevas, H., Leadem, B. R., Zhang, M., Herman, J. G., Hooker, C. M., Watkins, D. N., Karim, B. O., Huso, D. L., et al. (2011) · Oncogene · doi:10.1038/onc.2010.633 · Cited by 24 · see citing works
Self-citationStem cells, cancer, and epigenetics
Baylin (2009) · StemBook · doi:10.3824/stembook.1.50.1 · Cited by 20 · see citing works
Emerging Role of Epigenetic Therapy: Focus on Decitabine
Issa, J. J., & Kantarjian, H. M. (2005) · Seminars in Hematology · doi:10.1053/j.seminhematol.2005.05.003 · Cited by 11 · see citing works
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- [2]Allis C Jenuwein T Reinberg D Caparros M Epigenetics Cold Spring Harbor Laboratory Press 2007
- [29]Allis CD Jenuwein T Reinberg D Overview and concepts Cold Spring Harbor Laboratory Press New York 2007
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Sorted by citations
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061 · see citing works
Self-citationCancer epigenetics: from mechanism to therapy
Dawson, M. A., & Kouzarides, T. (2012) · Cell · doi:10.1016/j.cell.2012.06.013 · Cited by 3,203 · see citing works
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961 · see citing works
The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809 · see citing works
Evolution of the Cancer Stem Cell Model
Kreso, A., & Dick, J. E. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.006 · Cited by 2,212 · see citing works
Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L. M., Snyder, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.011 · Cited by 2,022 · see citing works
Self-citationEpigenetics and the environment: emerging patterns and implications
Feil, R., & Fraga, M. F. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3142 · Cited by 1,929 · see citing works
Adoptive immunotherapy for cancer: harnessing the T cell response
Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688 · see citing works
TET enzymes, TDG and the dynamics of DNA demethylation
Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623 · see citing works
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Falkenberg, K. J., & Johnstone, R. W. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4360 · Cited by 1,564 · see citing works
Current and future perspectives of liquid biopsies in genomics-driven oncology
Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0071-5 · Cited by 1,557 · see citing works
Feng, Y., Spezia, M., Huang, S., Yuan, C., Zeng, Z., Zhang, L., Ji, X., Liu, W., Huang, B., Luo, W., et al. (2018) · Genes & Diseases · doi:10.1016/j.gendis.2018.05.001 · Cited by 1,538 · see citing works
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
Lyko, F. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.80 · Cited by 1,475 · see citing works
Epigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works
Insulator dysfunction and oncogene activation in IDH mutant gliomas
Flavahan, W. A., Drier, Y., Liau, B. B., Gillespie, S. M., Venteicher, A. S., Stemmer-Rachamimov, A. O., Suvà, M. L., & Bernstein, B. E. (2016) · Nature · doi:10.1038/nature16490 · Cited by 1,288 · see citing works
Epigenetic Determinants of CancerPreprint
Baylin, S. B., & Jones, P. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019505 · Cited by 1,363 · see citing works
Self-citationGene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer
Yang, X., Han, H., De Carvalho, D. D., Lay, F. D., Jones, P. A., & Liang, G. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.07.028 · Cited by 1,199 · see citing works
Self-citationCancer Genetics and Epigenetics: Two Sides of the Same Coin?
You, J. S., & Jones, P. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.06.008 · Cited by 1,163 · see citing works
Self-citationTargeting the cancer epigenome for therapy
Jones, P. A., Issa, J. J., & Baylin, S. B. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.93 · Cited by 1,132 · see citing works
Self-citationTargeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Cheng, Y., He, C., Wang, M., Ma, X., Mo, F., Yang, S., Han, J., & Wei, X. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0095-0 · Cited by 1,097 · see citing works
Cancer stem cells: impact, heterogeneity, and uncertainty
Magee, J. A., Piskounova, E., & Morrison, S. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.003 · Cited by 1,137 · see citing works
Role of TET enzymes in DNA methylation, development, and cancer
Rasmussen, K. D., & Helin, K. (2016) · Genes & Development · doi:10.1101/gad.276568.115 · Cited by 1,040 · see citing works
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065 · see citing works
Reinius, L. E., Acevedo, N., Joerink, M., Pershagen, G., Dahlén, S., Greco, D., Söderhäll, C., Scheynius, A., & Kere, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041361 · Cited by 1,019 · see citing works
Donohoe, D. R., Collins, L. B., Wali, A., Bigler, R., Sun, W., & Bultman, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.033 · Cited by 993 · see citing works
DNA Methylation in MammalsPreprint
Li, E., & Zhang, Y. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019133 · Cited by 952 · see citing works
Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
Easwaran, H., Tsai, H.-C., & Baylin, S. B. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.015 · Cited by 915 · see citing works
Self-citationDNA methylation and healthy human aging
Jones, M. J., Goodman, S. J., & Kobor, M. S. (2015) · Aging Cell · doi:10.1111/acel.12349 · Cited by 937 · see citing works
Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
Rotem, A., Ram, O., Shoresh, N., Sperling, R. A., Goren, A., Weitz, D. A., & Bernstein, B. E. (2015) · Nature Biotechnology · doi:10.1038/nbt.3383 · Cited by 854 · see citing works
Interplay between the Cancer Genome and Epigenome
Shen, H., & Laird, P. W. (2013) · Cell · doi:10.1016/j.cell.2013.03.008 · Cited by 912 · see citing works
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
Xu, R., Wei, W., Krawczyk, M., Wang, W., Luo, H., Flagg, K., Yi, S., Shi, W. T., Quan, Q., Li, K., et al. (2017) · Nature Materials · doi:10.1038/nmat4997 · Cited by 859 · see citing works
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782 · see citing works
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
Lee, S., Rauch, J., & Kölch, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031102 · Cited by 807 · see citing works
Intra-tumor heterogeneity from a cancer stem cell perspective
Prasetyanti, P. R., & Medema, J. P. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0600-4 · Cited by 801 · see citing works
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Clark, D. J., Dhanasekaran, S. M., Petralia, F., Pan, J., Song, X., Hu, Y., da Veiga Leprevost, F., Reva, B., Lih, T.-S. M., Chang, H.-Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.007 · Cited by 730 · see citing works
DNA methylation profiling in the clinic: applications and challenges
Heyn, H., & Esteller, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3270 · Cited by 747 · see citing works
Tumor biomarkers for diagnosis, prognosis and targeted therapy
Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 772 · see citing works
Simon, J. A., & Kingston, R. E. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.02.013 · Cited by 727 · see citing works
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance
Rose, M., Burgess, J. T., O'Byrne, K. J., Richard, D. J., & Bolderson, E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.564601 · Cited by 726 · see citing works
Epigenetic reprogramming in cancer
Suvà, M. L., Riggi, N., & Bernstein, B. E. (2013) · Science · doi:10.1126/science.1230184 · Cited by 706 · see citing works
Morán, S., Arribas, C., & Esteller, M. (2015) · Epigenomics · doi:10.2217/epi.15.114 · Cited by 701 · see citing works
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
Sheng, W., LaFleur, M. W., Nguyen, T. H., Chen, S., Chakravarthy, A., Conway, J. R., Li, Y., Chen, H., Yang, H., Hsu, P.-H., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.052 · Cited by 693 · see citing works
Cancer stem cell definitions and terminology: the devil is in the details
Valent, P., Bonnet, D. A., Maria, R. D., Lapidot, T., Copland, M., Melo, J. V., Chomienne, C., Ishikawa, F., Schuringa, J. J., Stassi, G., et al. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3368 · Cited by 695 · see citing works
Histone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680 · see citing works
Kim, K., Skora, A. D., Li, Z., Liu, Q., Tam, A. J., Blosser, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410626111 · Cited by 676 · see citing works
Medulloblastomics: the end of the beginning
Northcott, P. A., Jones, D., Kool, M., Robinson, G. W., Gilbertson, R. J., Cho, Y., Pomeroy, S. L., Korshunov, A., Lichter, P., Taylor, M. D., et al. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3410 · Cited by 661 · see citing works
Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
Puissant, A., Frumm, S. M., Alexe, G., Bassil, C. F., Qi, J., Chanthery, Y. H., Nekritz, E. A., Zeid, R., Gustafson, W. C., Greninger, P., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0418 · Cited by 637 · see citing works
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
Bouwman, P., & Jonkers, J. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3342 · Cited by 615 · see citing works
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
Timp, W., & Feinberg, A. (2013) · Nature Reviews. Cancer · doi:10.1038/nrc3486 · Cited by 586 · see citing works
Mechanisms Governing Metastatic Dormancy and Reactivation
Giancotti, F. G. (2013) · Cell · doi:10.1016/j.cell.2013.10.029 · Cited by 586 · see citing works
Effect of Mutation Order on Myeloproliferative Neoplasms
Ortmann, C. A., Kent, D. G., Nangalia, J., Silber, Y., Wedge, D. C., Grinfeld, J., Baxter, E. J., Massie, C. E., Papaemmanuil, E., Menon, S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1412098 · Cited by 577 · see citing works
Analysing and interpreting DNA methylation data
Bock, C. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3273 · Cited by 580 · see citing works
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
Kulis, M., Heath, S. C., Bibikova, M. V., Queirós, A. C., Navarro, A., Clot, G., Martínez‐Trillos, A., Castellano, G., Heath, I. B., Pinyol, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2443 · Cited by 568 · see citing works
The hypoxic tumor microenvironment: A driving force for breast cancer progression
Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.036 · Cited by 535 · see citing works
Cancer stem cells in the development of liver cancer
Yamashita, T., & Wang, X. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66024 · Cited by 526 · see citing works
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies
Zappasodi, R., Merghoub, T., & Wolchok, J. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.005 · Cited by 519 · see citing works
MicroRNAs in the p53 network: micromanagement of tumour suppression
Hermeking, H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3318 · Cited by 518 · see citing works
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
Mohammad, H. P., Smitheman, K. N., Kamat, C. D., Soong, D., Federowicz, K., Aller, G. S. V., Schneck, J., Carson, J. D., Liu, Y., Butticello, M., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.06.002 · Cited by 514 · see citing works
Dynamic regulation of transcriptional states by chromatin and transcription factors
Voss, T. C., & Hager, G. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3623 · Cited by 504 · see citing works
Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics
Shen, L., Wu, H., Diep, D., Yamaguchi, S., D’Alessio, A. C., Fung, H.-L., Zhang, K., & Zhang, Y. (2013) · Cell · doi:10.1016/j.cell.2013.04.002 · Cited by 497 · see citing works
Epigenetic mechanisms in diabetic complications and metabolic memory
Reddy, M. A., Zhang, E., & Natarajan, R. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3462-y · Cited by 498 · see citing works
Mao, C., Wang, X., Liu, Y., Wang, M., Yan, B., Jiang, Y., Shi, Y., Shen, Y., Liu, X., Lai, W., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3454 · Cited by 493 · see citing works
Dedifferentiation and reprogramming: origins of cancer stem cells
Friedmann‐Morvinski, D., & Verma, I. M. (2014) · EMBO Reports · doi:10.1002/embr.201338254 · Cited by 488 · see citing works
Regulation of chromatin and gene expression by metabolic enzymes and metabolites
Li, X., Egervári, G., Wang, Y., Berger, S. L., & Lu, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0029-7 · Cited by 486 · see citing works
Unravelling the biology of SCLC: implications for therapy
Sabari, J. K., Lok, B. H., Laird, J. H., Poirier, J. T., & Rudin, C. M. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.71 · Cited by 495 · see citing works
Cancer epigenetics: Moving forward
Nebbioso, A., Tambaro, F. P., Dell’Aversana, C., & Altucci, L. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007362 · Cited by 481 · see citing works
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Wu, D., Hu, D., Chen, H., Shi, G., Fetahu, I. S., Wu, F., Rabidou, K., Fang, R., Tan, L., Xu, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0350-5 · Cited by 477 · see citing works
Pre-mRNA splicing in disease and therapeutics
Singh, R. K., & Cooper, T. A. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.006 · Cited by 456 · see citing works
Histone lysine demethylases as targets for anticancer therapy
Højfeldt, J. W., Agger, K., & Helin, K. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4154 · Cited by 461 · see citing works
Plass, C., Pfister, S. M., Lindroth, A. M., Bogatyrova, O., Claus, R., & Lichter, P. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3554 · Cited by 448 · see citing works
Riggi, N., Knoechel, B., Gillespie, S. M., Rheinbay, E., Boulay, G., Suvà, M. L., Rossetti, N. E., Boonseng, W. E., Oksuz, O., Cook, E., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.004 · Cited by 447 · see citing works
Luo, H., Zhao, Q., Wei, W., Zheng, L., Yi, S., Li, G. L., Wang, W., Sheng, H., Pu, H., Mo, H., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax7533 · Cited by 436 · see citing works
The emerging role of epigenetic therapeutics in immuno-oncology
Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R., & Baylin, S. B. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0266-5 · Cited by 433 · see citing works
Self-citationChromatin proteins and modifications as drug targets
Helin, K., & Dhanak, D. (2013) · Nature · doi:10.1038/nature12751 · Cited by 435 · see citing works
Li, H., Chiappinelli, K. B., Guzzetta, A. A., Easwaran, H., Yen, R.-W. C., Vatapalli, R. J., Topper, M. J., Luo, J., Connolly, R. M., Azad, N. S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1782 · Cited by 428 · see citing works
Self-citationLauffer, B. E. L., Mintzer, R., Fong, R., Mukund, S., Tam, C., Zilberleyb, I., Flicke, B., Ritscher, A., Fedorowicz, G., Vallero, R., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.490706 · Cited by 429 · see citing works
“We thank Yvonne Franke and Krista Bowman at Genentech for cloning and expression of HDACs.”
BackgroundInfluentialThe nexus of chromatin regulation and intermediary metabolism
Gut, P., & Verdin, E. M. (2013) · Nature · doi:10.1038/nature12752 · Cited by 419 · see citing works
Pang, B., Qiao, X., Janssen, L., Velds, A., Groothuis, T. A., Kerkhoven, R. M., Nieuwland, M., Ovaa, H., Rottenberg, S., van Tellingen, O., et al. (2013) · Nature Communications · doi:10.1038/ncomms2921 · Cited by 417 · see citing works
New concepts in DNA methylation
Jeltsch, A., & Jurkowska, R. Z. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.05.002 · Cited by 420 · see citing works
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 438 · see citing works
Epigenetics and cardiovascular disease
Ordovás, J. M., & Smith, C. E. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.104 · Cited by 402 · see citing works
Cancer genetics and genomics of human FOX family genes
Katoh, M., Igarashi, M., Fukuda, H., Nakagama, H., & Katoh, M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.09.017 · Cited by 401 · see citing works
Targeting Epigenetic Readers in Cancer
Dawson, M. A., Kouzarides, T., & Huntly, B. J. P. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1112635 · Cited by 400 · see citing works
Mazur, P., Herner, A., Mello, S., Wirth, M., Hausmann, S., Sánchez-Rivera, F. J., Lofgren, S. M., Kuschma, T., Hahn, S., Vangala, D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3952 · Cited by 378 · see citing works
Landau, D. A., Clement, K., Ziller, M. J., Boyle, P., Fan, J., Gu, H., Stevenson, K. E., Sougnez, C. L., Wang, L., Li, S., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.012 · Cited by 385 · see citing works
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Yang, J., Xu, J., Wang, W. T., Zhang, B., Yu, X., & Shi, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01480-x · Cited by 404 · see citing works
Only three driver gene mutations are required for the development of lung and colorectal cancers
Tomasetti, C., Marchionni, L., Nowak, M. A., Parmigiani, G., & Vogelstein, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421839112 · Cited by 395 · see citing works
Transposable elements drive widespread expression of oncogenes in human cancers
Jang, H. J., Shah, N. M., Du, A. Y., Dailey, Z. Z., Pehrsson, E. C., Godoy, P. M., Zhang, D., Li, D., Xing, X., Kim, S., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0373-3 · Cited by 395 · see citing works
Anticancer drug resistance: An update and perspective
Nussinov, R., Tsai, C., & Jang, H. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100796 · Cited by 395 · see citing works
DNA methyltransferases and their roles in tumorigenesis
Zhang, W., & Xu, J. (2017) · Biomarker Research · doi:10.1186/s40364-017-0081-z · Cited by 387 · see citing works
Quantitative Proteomic Analysis of Histone Modifications
Huang, H., Lin, S., Garcia, B. A., & Zhao, Y. (2015) · Chemical Reviews · doi:10.1021/cr500491u · Cited by 372 · see citing works
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
Ntziachristos, P., Tsirigos, A., Welstead, G. G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B., et al. (2014) · Nature · doi:10.1038/nature13605 · Cited by 366 · see citing works
Epigenetic Therapeutics: A New Weapon in the War Against Cancer
Ahuja, N., Sharma, A. R., & Baylin, S. B. (2016) · Annual Review of Medicine · doi:10.1146/annurev-med-111314-035900 · Cited by 364 · see citing works
Self-citationEMT‐associated microRNAs and their roles in cancer stemness and drug resistance
Pan, G., Liu, Y., Shang, L., Zhou, F., & Yang, S. (2021) · 癌症：英文版 · doi:10.1002/cac2.12138 · Cited by 362 · see citing works
Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation
Shen, L., Song, C., He, C., & Zhang, Y. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035513 · Cited by 359 · see citing works
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Saghafinia, S., Mina, M., Riggi, N., Hanahan, D., & Ciriello, G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.082 · Cited by 350 · see citing works
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Pon, J. R., & Marra, M. A. (2014) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040312 · Cited by 356 · see citing works
Alabert, C., Bukowski-Wills, J.-C., Lee, S.-B., Kustatscher, G., Nakamura, K., Alves, F. D. L., Ménard, P., Mejlvang, J., Rappsilber, J., & Groth, A. (2014) · Nature Cell Biology · doi:10.1038/ncb2918 · Cited by 334 · see citing works
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Mill, J. S., & Heijmans, B. T. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3405 · Cited by 347 · see citing works
Meiners, S., Eickelberg, O., & Königshoff, M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186914 · Cited by 340 · see citing works
- Authors
- Baylin, S. B., & Jones, P. A.
- Affiliations
- Johns Hopkins University (US)
- University of Southern California (US)
- Corresponding author
- Baylin, Stephen B.
- Jones, Peter A.
- Venue
- Nature Reviews Cancer
- Published
- 2011-09-23
- Volume
- 11
- Issue
- 10
- Pages
- 726-734
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC3307543
- OpenAlex
- W2041686632
- Cited by
- 2,871
- References
- 166
- Citations by year
- 2026: 105 · 2025: 107 · 2024: 130 · 2023: 148 · 2022: 179 · 2021: 207 · 2020: 175 · 2019: 209 · 2018: 192 · 2017: 233 · 2016: 241 · 2015: 248 · 2014: 288 · 2013: 231 · 2012: 171
- FWCI
- 20.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Entertainment Industry Foundation
- National Institutes of Health
- National Cancer Institute (R01CA043318, R37CA082422)
- National Institute of Environmental Health Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- cancer epigenome, DNA methylation, chromatin, epigenetic therapy, tumor markers, cancer diagnosis and prognosis, tumor progression, DNA packaging, epigenetic enzymes, cancer metabolism, epigenetic mutations
- MeSH terms
- Animals, Humans, Neoplasms, Genome, Epigenesis, Genetic, History, 20th Century, History, 21st Century, Translational Research, Biomedical, Epigenomics
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