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Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer
Open accessAbstract
DNA methylation in promoters is well known to silence genes and is the presumed therapeutic target of methylation inhibitors. Gene body methylation is positively correlated with expression, yet its function is unknown. We show that 5-aza-2'-deoxycytidine treatment not only reactivates genes but decreases the overexpression of genes, many of which are involved in metabolic processes regulated by c-MYC. Downregulation is caused by DNA demethylation of the gene bodies and restoration of high levels of expression requires remethylation by DNMT3B. Gene body methylation may, therefore, be an unexpected therapeutic target for DNA methylation inhibitors, resulting in the normalization of gene overexpression induced during carcinogenesis. Our results provide direct evidence for a causal relationship between gene body methylation and transcription.
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“Increased CGI gene body methylation positively correlates with transcriptional activation [6, 25, 55]”
From Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression (2024) · cites this paper as [55]
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“It is well-known that promoter CGI hypermethylation represses transcription [43, 45], whereas hypermethylation at gene body CGIs activates gene expression [6, 55].”
From Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression (2024) · cites this paper as [55]
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“and that the location of these CGIs determines the direction of this regulation [6, 43, 45, 55]”
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“Another study demonstrated a positive correlation between gene expression and gene body methylation.55”
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“it is widely accepted that the level of methylation in the regions known as CGI regulates gene expression”
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061
Self-citationConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
Wilkerson, M. D., & Hayes, D. N. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq170 · Cited by 5,645
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888
A decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871
Self-citationCellular differentiation, cytidine analogs and DNA methylation
Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831
Self-citation
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Cited by
Sorted by citations
The diverse roles of DNA methylation in mammalian development and disease
Greenberg, M., & Bourc’his, D. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0159-6 · Cited by 2,272
Function and information content of DNA methylation
Schübeler, D. (2015) · Nature · doi:10.1038/nature14192 · Cited by 2,060
Roulois, D., Loo Yau, H., Singhania, R., Wang, Y., Danesh, A., Shen, S. Y., Han, H., Liang, G., Jones, P. A., Pugh, T. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.056 · Cited by 1,527
Self-citationTargeting the cancer epigenome for therapy
Jones, P. A., Issa, J. J., & Baylin, S. B. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.93 · Cited by 1,153
Self-citationEpigenetics of colorectal cancer: biomarker and therapeutic potential
Jung, G., Hernández-Illán, E., Moreira, L., Balaguer, F., & Goel, A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0230-y · Cited by 813
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
Baubec, T., Colombo, D. F., Wirbelauer, C., Schmidt, J., Burger, L., Krebs, A. R., Akalin, A., & Schübeler, D. (2015) · Nature · doi:10.1038/nature14176 · Cited by 705
DNA Methylation Clocks in Aging: Categories, Causes, and Consequences
Field, A. E., Robertson, N., Wang, T., Havas, A. P., Ideker, T., & Adams, P. D. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.008 · Cited by 644
Epigenetic therapy in immune-oncology
Jones, P. A., Ohtani, H., Chakravarthy, A., & Carvalho, D. D. D. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0109-9 · Cited by 559
Self-citationAging Hallmarks and the Role of Oxidative Stress
Maldonado, E., Morales, S., Urbina, F., & Solari, A. (2023) · Antioxidants · doi:10.3390/antiox12030651 · Cited by 491
CpG and non-CpG methylation in epigenetic gene regulation and brain function
Jang, H., Shin, W., Lee, J., & Do, J. (2017) · Genes · doi:10.3390/genes8060148 · Cited by 427
DNA methyltransferases and their roles in tumorigenesis
Zhang, W., & Xu, J. (2017) · Biomarker Research · doi:10.1186/s40364-017-0081-z · Cited by 396
Mechanisms regulating T-cell infiltration and activity in solid tumors
Lanitis, E., Dangaj, D., Irving, M., & Coukos, G. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx238 · Cited by 369
Air pollution and DNA methylation: effects of exposure in humans
Rider, C. F., & Carlsten, C. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0713-2 · Cited by 368
The DNA methylation landscape of advanced prostate cancer
Zhao, S. G., Chen, W. S., Li, H., Foye, A., Zhang, M., Sjöström, M., Aggarwal, R. R., Playdle, D., Liao, A., Alumkal, J. J., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0648-8 · Cited by 357
Epigenetic drivers of tumourigenesis and cancer metastasis
Chatterjee, A., Rodger, E. J., & Eccles, M. R. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.004 · Cited by 340
High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma
Nasu, M., Emi, M., Pastorino, S., Tanji, M., Powers, A. A., Luk, H., Baumann, F., Zhang, Y.-A., Gazdar, A. F., Kanodia, S., et al. (2015) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000471 · Cited by 324
Targeting epigenetic regulators to overcome drug resistance in cancers
Wang, N., Ma, T., & Yu, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01341-7 · Cited by 334
Statistical and integrative system-level analysis of DNA methylation data
Teschendorff, A. E., & Relton, C. L. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.86 · Cited by 297
Nucleic Acid Modifications in Regulation of Gene Expression
Chen, K., Zhao, B. S., & He, C. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.11.007 · Cited by 290
Epigenetic responses and the developmental origins of health and disease
Goyal, D., Limesand, S. W., & Goyal, R. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0009 · Cited by 301
DNA Methylation Profiling: An Emerging Paradigm for Cancer Diagnosis
Papanicolau‐Sengos, A., & Aldape, K. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042220-022304 · Cited by 285
Molecular mechanisms of environmental exposures and human disease
Wu, H., Eckhardt, C. M., & Baccarelli, A. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00569-3 · Cited by 296
The Role of DNA Methylation in Cancer
Lakshminarasimhan, R., & Liang, G. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-43624-1_7 · Cited by 281
Self-citationH19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase
Zhou, J., Yang, L., Zhong, T., Mueller, M., Men, Y., Zhang, N., Xie, J., Giang, K., Chung, H., Sun, X., et al. (2015) · Nature Communications · doi:10.1038/ncomms10221 · Cited by 254
TET proteins and the control of cytosine demethylation in cancer
Scourzic, L., Mouly, E., & Bernard, O. (2015) · Genome Medicine · doi:10.1186/s13073-015-0134-6 · Cited by 263
Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis
Xiao, Y., Bi, M., Guo, H., & Li, M. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104001 · Cited by 261
Gong, J., Li, Y., Liu, C., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D. H., Park, P. K., Diao, L., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.070 · Cited by 253
Nongenetic inheritance and transgenerational epigenetics
Szyf, M. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.004 · Cited by 238
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
“55 In clinical studies, variable associations of DNA methylation and MDD have been shown to occur in regions outside the promoter.”
BackgroundVeselovska, L., Smallwood, S. A., Saadeh, H., Stewart-Morgan, K. R., Krueger, F., Maupetit‐Mehouas, S., Arnaúd, P., Tomizawa, S.-I., Andrews, S., & Kelsey, G. (2015) · Genome biology · doi:10.1186/s13059-015-0769-z · Cited by 231
Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine
Liu, M., Ohtani, H., Zhou, W., Ørskov, A. D., Charlet, J., Zhang, Y. W., Shen, H., Baylin, S. B., Liang, G., Grønbæk, K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612262113 · Cited by 225
Self-citationTargeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
Zhang, H., Pandey, S., Travers, M. E., Sun, H., Morton, G. C., Madžo, J., Chung, W., Khowsathit, J., Pérez, Ó. C., Barrero, C. A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.051 · Cited by 223
DNA methylation methods: Global DNA methylation and methylomic analyses
Li, S., & Tollefsbol, T. O. (2020) · Methods · doi:10.1016/j.ymeth.2020.10.002 · Cited by 230
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Mafficini, A., & Scarpa, A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00160 · Cited by 221
The role of DNA methylation in ageing and cancer
Morgan, A. E., Davies, T. J., & Auley, M. T. M. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000150 · Cited by 211
How to stomach an epigenetic insult: the gastric cancer epigenome
Padmanabhan, N., Ushijima, T., & Tan, P. B. O. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.53 · Cited by 209
Wang, T., Zeng, Y., Li, Z., Jing, D., Fan, G., Liu, M., Zhuo, Q., Ji, S., Yu, X., Xu, X., et al. (2023) · Cell Proliferation · doi:10.1111/cpr.13478 · Cited by 217
The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome
Gujar, H., Weisenberger, D. J., & Liang, G. (2019) · Genes · doi:10.3390/genes10020172 · Cited by 210
Self-citationPrognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor
Karpathakis, A., Dibra, H. K., Pipinikas, C., Feber, A., Morris, T. J., Francis, J., Oukrif, D., Mandair, D., Pericleous, M., Mohmaduvesh, M., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0373 · Cited by 196
A DNA methylation‐based definition of biologically distinct breast cancer subtypes
Stefánsson, Ó. A., Morán, S., Gómez, A., Sayols, S., Arribas-Jorba, C., Sandoval, J., Hilmarsdóttir, H., Ólafsdóttir, E. J., Tryggvadóttír, L., Jonasson, J. G., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.10.012 · Cited by 193
Hannon, E. J., Gorrie-Stone, T. J., Smart, M., Burrage, J., Hughes, A., Bao, Y., Meena Kumari, B., Schalkwyk, L. C., & Mill, J. S. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.09.007 · Cited by 191
Guler, G. D., Ning, Y., Ku, C., Phillips, T. C., McCarthy, E., Ellison, C. K., Bergamaschi, A., Collin, F., Lloyd, P., Scott, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18965-w · Cited by 177
The Epigenetic Hallmarks of Cancer
Esteller, M., Dawson, M. A., Kadoch, C., Rassool, F. V., Jones, P. A., & Baylin, S. B. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0296 · Cited by 202
Self-citationKristensen, L. S., Okholm, T. L. H., Venø, M. T., & Kjems, J. (2017) · RNA Biology · doi:10.1080/15476286.2017.1409931 · Cited by 170
Epigenetic regulation of melanogenesis
Zhou, S., Zeng, H., Huang, J., Lei, L., Tong, X., Li, S., Zhou, Y., Guo, H., Khan, M., Luo, L., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101349 · Cited by 171
DNA Hypomethylating Drugs in Cancer TherapyPreprint
Sato, T., Issa, J. J., & Kropf, P. L. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026948 · Cited by 169
Connolly, R. M., Li, H., Jankowitz, R. C., Zhang, Z., Rudek, M. A., Jeter, S. C., Slater, S. A., Powers, P., Wolff, A. C., Fetting, J. H., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1729 · Cited by 163
Self-citationKong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.03.003 · Cited by 166
Duymich, C. E., Charlet, J., Yang, X., Jones, P. A., & Liang, G. (2016) · Nature Communications · doi:10.1038/ncomms11453 · Cited by 165
Self-citationArechederra, M., Daian, F., Yim, A., Bazai, S. K., Richelme, S., Dono, R., Saurin, A. J., Habermann, B. H., & Maina, F. (2018) · Nature Communications · doi:10.1038/s41467-018-05550-5 · Cited by 221
Choi, J., Lyons, D. B., Kim, M. Y., Moore, J. D., & Zilberman, D. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.011 · Cited by 159
Pan, W.-H., Sommer, F., Falk-Paulsen, M., Ulas, T., Best, L., Fazio, A., Kachroo, P., Luzius, A., Jentzsch, M., Rehman, A., et al. (2018) · Genome Medicine · doi:10.1186/s13073-018-0534-5 · Cited by 157
Prediction of genome-wide DNA methylation in repetitive elements
Zheng, Y., Joyce, B. T., Liu, L., Zhang, Z., Kibbe, W. A., Zhang, W., & Hou, L. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx587 · Cited by 154
A review of DNA methylation in depression
Chen, D., Meng, L., Pei, F., Zheng, Y., & Leng, J. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.05.022 · Cited by 160
Husquin, L. T., Rotival, M., Fagny, M., Quach, H., Zidane, N., McEwen, L. M., MacIsaac, J. L., Kobor, M. S., Aschard, H., Patin, É., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1601-3 · Cited by 149
Gene body methylation in cancer: molecular mechanisms and clinical applications
Wang, Q., Xiong, F., Wu, G., Liu, W., Chen, J., Wang, B., & Chen, Y. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01382-9 · Cited by 150
Arpón, A., Riezu‐Boj, J. I., Milagro, F. I., Martí, A., Razquín, C., Martínez‐González, M. Á., Corella, D., Estruch, R., Casas, R. M., Fitó, M., et al. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0552-6 · Cited by 149
A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development
Yang, Y., Fan, X., Yan, J., Chen, M., Zhu, M., Tang, Y., Liu, S., & Tang, Z. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1203 · Cited by 146
Dynamic DNA methylation during aging: A "prophet" of age-related outcomes
Xiao, F.-H., Wang, H.-T., & Kong, Q.-P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00107 · Cited by 140
Wang, X., Li, Q., Lian, J., Li, L., Jin, L., Cai, H., Xu, F., Qi, H., Zhang, L., Wu, F., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1119 · Cited by 145
Gurung, R., Choong, A. M. T. L., Woo, C. C., Foo, R., & Sorokin, V. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176334 · Cited by 144
DNA methylation aberrancies as a guide for surveillance and treatment of human cancers
Liang, G., & Weisenberger, D. J. (2017) · Epigenetics · doi:10.1080/15592294.2017.1311434 · Cited by 145
Self-citationNashun, B., Hill, P. W. S., Smallwood, S. A., Dharmalingam, G., Amouroux, R., Clark, S. J., Sharma, V., Ndjetehe, E., Pelczar, P., Festenstein, R., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.010 · Cited by 139
Sun, W., Dong, H., Becker, A. S., Dapito, D. H., Modica, S., Grandl, G., Opitz, L., Efthymiou, V., Straub, L. G., Sarker, G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0102-y · Cited by 139
Lan, T., Yuan, K., Yan, X., Xu, L., Liao, H., Hao, X., Wang, J., Liu, H., Chen, X., Xie, K., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-4044 · Cited by 133
Natanzon, Y., Goode, E. L., & Cunningham, J. M. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.003 · Cited by 138
Homeobox oncogene activation by pan-cancer DNA hypermethylation
Su, J., Huang, Y., Cui, X., Wang, X., Zhang, X., Lei, Y., Xu, J., Lin, X., Chen, K., Lv, J., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1492-3 · Cited by 130
Charlet, J., Duymich, C. E., Lay, F. D., Mundbjerg, K., Dalsgaard Sørensen, K., Liang, G., & Jones, P. A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.033 · Cited by 128
Self-citationLiu, M., Thomas, S. L., DeWitt, A. K., Zhou, W., Madaj, Z. B., Ohtani, H., Baylin, S. B., Liang, G., & Jones, P. A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3953 · Cited by 127
Self-citationStructure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
Xu, T.-H., Liu, M., Zhou, X. E., Liang, G., Zhao, G., Xu, H. E., Melcher, K., & Jones, P. A. (2020) · Nature · doi:10.1038/s41586-020-2747-1 · Cited by 131
Self-citationEpigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg
Fernández-Barrena, M. G., Arechederra, M., Colyn, L., Berasain, C., & Avila, M. A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100167 · Cited by 126
Aberrant DNA Methylation in Colorectal Cancer: What Should We Target?
Tse, J. W. T., Jenkins, L. J., Chionh, F. J. M., & Mariadason, J. M. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.08.003 · Cited by 125
Prenatal epigenetics diets play protective roles against environmental pollution
Li, S., Chen, M., Li, Y., & Tollefsbol, T. O. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0659-4 · Cited by 129
Smith, A. R., Smith, R. G., Pishva, E., Hannon, E. J., Roubroeks, J. A. Y., Burrage, J., Troakes, C., Al‐Sarraj, S., Sloan, C., Mill, J. S., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0636-y · Cited by 118
Blagitko‐Dorfs, N., Schlosser, P., Greve, G., Pfeifer, D., Meier, R., Baude, A., Brocks, D., Plass, C., & Lübbert, M. (2018) · Leukemia · doi:10.1038/s41375-018-0293-8 · Cited by 120
DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
Zhou, W., Hinoue, T., Barnes, B., Mitchell, O. D., Iqbal, W., Lee, S. M., Foy, K. K., Lee, K., Moyer, E. J., VanderArk, A., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100144 · Cited by 116
Self-citationChildhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5)
Tyrka, A. R., Ridout, K. K., Parade, S. H., Paquette, A., Marsit, C. J., & Seifer, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000991 · Cited by 118
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Barwick, B. G., Scharer, C. D., Martinez, R. J., Price, M. J., Wein, A. N., Haines, R. R., Bally, A. P. R., Kohlmeier, J. E., & Boss, J. M. (2018) · Nature Communications · doi:10.1038/s41467-018-04234-4 · Cited by 128
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Vasanthakumar, A., & Godley, L. A. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.02.009 · Cited by 116
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Ali, M. M., Akhade, V. S., Kosalai, S. T., Subhash, S., Statello, L., Meryet‐Figuière, M., Abrahamsson, J., Mondal, T., & Kanduri, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03265-1 · Cited by 115
Bronner, C., Alhosin, M., Hamiche, A., & Mousli, M. (2019) · Genes · doi:10.3390/genes10010065 · Cited by 117
Effects of 5-Aza-2′-deoxycytidine (decitabine) on gene expression
Seelan, R. S., Mukhopadhyay, P., Pisano, M., & Greene, R. M. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1437446 · Cited by 118
Jiao, X., Zhang, S., Jiao, J., Zhang, T., Qu, W., Guy, M. M., Kong, B., Zhang, Q. H., & Cui, B. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0719-9 · Cited by 114
DNMT Inhibitors Increase Methylation in the Cancer Genome
Giri, A. K., & Aittokallio, T. A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00385 · Cited by 111
Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Wong, J. J. L., Gao, D., Nguyen, T. V., Kwok, C., van Geldermalsen, M., Middleton, R., Pinello, N., Thoeng, A., Nagarajah, R., Holst, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15134 · Cited by 110
DNMT3B Functions: Novel Insights From Human Disease
Gagliardi, M., Strazzullo, M., & Matarazzo, M. R. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00140 · Cited by 107
Daskalakis, N. P., & Yehuda, R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00369 · Cited by 108
Fang, F., Cárdenas, H., Huang, H., Jiang, G., Perkins, S. M., Zhang, C., Keer, H. N., Liu, Y., Nephew, K. P., & Matei, D. E. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1492 · Cited by 110
Lurbe, E., & Ingelfinger, J. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14592 · Cited by 106
Gabriele, M., Lopez Tobon, A., D'Agostino, G., & Testa, G. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.12.013 · Cited by 103
Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer
Croes, L., Beyens, M., Fransén, E., Ibrahim, J., Berghe, W. V., Suls, A., Peeters, M., Pauwels, P., Camp, G. V., & de Beeck, K. O. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0479-y · Cited by 104
Li, P., Liu, S., Du, L., Mohseni, G., Zhang, Y., & Wang, C. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01337-0 · Cited by 106
Wu, H., Zhang, W., Wu, Z., Liu, Y., Shi, Y., Gong, J., Shen, W., & Liu, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1281-7 · Cited by 99
DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex
Nanavaty, V., Abrash, E. W., Hong, C., Park, S., Fink, E. E., Li, Z., Sweet, T. J., Bhasin, J., Singuri, S., Lee, B., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.024 · Cited by 101
Vitamin C – A new player in regulation of the cancer epigenome
Gillberg, L., Ørskov, A. D., Liu, M., Harsløf, L. B. S., Jones, P. A., & Grønbæk, K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.001 · Cited by 100
Self-citationLee, M. S., McGuffey, E. J., Morris, J. S., Manyam, G. C., Baladandayuthapani, V., Wei, W., Morris, V. K., Overman, M. J., Maru, D. M., Jiang, Z.-Q., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.87 · Cited by 97
Impacts of Epigenetic Processes on the Health and Productivity of Livestock
Wang, M., & Ibeagha-Awemu, E. M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.613636 · Cited by 105
Massart, R., Dymov, S., Millecamps, M., Suderman, M. J., Grégoire, S., Koenigs, K., Alvarado, S. G., Tajerian, M., Stone, L. S., & Szyf, M. (2016) · Scientific Reports · doi:10.1038/srep19615 · Cited by 95
The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy
Yau, H. L., Ettayebi, I., & Carvalho, D. D. D. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.07.006 · Cited by 99
Estill, M. S., Bolnick, J. M., Waterland, R. A., Bolnick, A. D., Diamond, M. P., & Krawetz, S. A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.05.006 · Cited by 97
Metadata
- Authors
- Yang, X., Han, H., De Carvalho, D. D., Lay, F. D., Jones, P. A., & Liang, G.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Jones, Peter A.
- Liang, Gangning
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 26
- Issue
- 4
- Pages
- 577-590
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC4224113
- OpenAlex
- W2055986128
- Cited by
- 1,199
- References
- 62
- Citations by year
- 2026: 61 · 2025: 77 · 2024: 104 · 2023: 109 · 2022: 105 · 2021: 120 · 2020: 120 · 2019: 134 · 2018: 128 · 2017: 97 · 2016: 79 · 2015: 55 · 2014: 8
- FWCI
- 32.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Princess Margaret Cancer Foundation
- National Institutes of Health
- National Cancer Institute (R01CA170550, R01CA124518, R01CA082422, P30CA014089, R37CA082422)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- gene body methylation, DNA methylation, decitabine, DNA demethylation, DNMT3B, c-Myc, gene overexpression, transcriptional regulation, DNA methylation inhibitors, cancer therapy, carcinogenesis, metabolic genes
- MeSH terms
- Cell Division, Colonic Neoplasms, Humans, Promoter Regions, Genetic, Gene Expression, DNA Methylation
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