Near infrared fluorescent probes for detecting and imaging active small molecules

Modulation of oxidative stress as an anticancer strategy

Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579

In vivo near-infrared fluorescence imaging

Frangioni, J. V. (2003) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2003.08.007 · Cited by 2,701

Luminescent Chemodosimeters for Bioimaging

Yang, Y., Zhao, Q., Feng, W., & Li, F. (2012) · Chemical Reviews · doi:10.1021/cr2004103 · Cited by 2,244

Multiphoton Absorbing Materials: Molecular Designs, Characterizations, and Applications

He, G. S., Tan, L., Zheng, Q., & Prasad, P. N. (2008) · Chemical Reviews · doi:10.1021/cr050054x · Cited by 2,200

Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging

Yuan, L., Lin, W., Zheng, K., He, L., & Huang, W. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35313j · Cited by 1,825

Recent progress in the development of near-infrared fluorescent probes for bioimaging applications

Guo, Z., Park, S., Yoon, J., & Shin, I. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60271k · Cited by 1,812

Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes

Li, X., Gao, X., Shi, W. S., & Ma, H. (2013) · Chemical Reviews · doi:10.1021/cr300508p · Cited by 1,745

A new trend in rhodamine-based chemosensors: application of spirolactam ring-opening to sensing ions

Kim, H. N., Lee, M. H., Kim, H. J., Kim, J. S., & Yoon, J. (2008) · Chemical Society Reviews · doi:10.1039/b802497a · Cited by 1,652

Cyanines during the 1990s: A Review

Mishra, A., Behera, R. K., Behera, P. K., Mishra, B. K., & Behera, G. B. (2000) · Chemical Reviews · doi:10.1021/cr990402t · Cited by 1,565

Synthesis and applications of Rhodamine derivatives as fluorescent probes

Beija, M., Afonso, C. A. M., & Martinho, J. M. G. (2009) · Chemical Society Reviews · doi:10.1039/b901612k · Cited by 1,498

A near-infrared AIE fluorescent probe for selective peroxynitrite (ONOO−) detection and bioimaging with anti-counterfeiting applications

Zou, J., Liu, Y., Sun, Y., Liu, H., Chen, Z., Liu, G., & Pu, S. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.128633 · Cited by 1

Visualizing sulfur dioxide derivatives in multiplex environments through diverse small-molecule fluorescent probes

Liang, X., Wang, C., Liang, T., Tian, M., Wu, C., Li, Y., Zhong, K., Shen, T., & Tang, L. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.119116 · Cited by 1

Theranostic advances in Alzheimer's disease: structure-guided design of near-infrared fluorescent probes targeting amyloid-β and cholinergic dysfunction

Mandloi, U., Giri, N., Kumar, S., & Modi, G. P. (2026) · RSC Medicinal Chemistry · doi:10.1039/d5md00713e · Cited by 1

Dynamic visualization of butyrylcholinesterase activity in neuroinflammation and Alzheimer's disease with an activatable near-infrared fluorogenic probe

Peng, W., Zhang, J., Wen, Z., Liu, M., Ye, B., Zhang, X., Wang, F., Liu, H., & Yu, F. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.139615 · Cited by 1

Indocyanine Green–Inspired Polymeric Chromophores With Intrinsic Photostability for Near‐Infrared Imaging

Lee, S. B., Choi, M., Son, Y. H., Kim, M., Park, H. K., Kim, S. H., Juraev, O. O. U., Jung, H., Bae, H. E., Jeong, J., et al. (2026) · Small · doi:10.1002/smll.202512617 · Cited by 1

π‐Extended COUPY Fluorophores for Targeted Near‐Infrared Fluorescence and Lifetime Imaging in Live Cells

Abad-Montero, D., Bosch, M., Garcés‐Castellanos, R., Schottenhamel, M. Q., Pedraza‐Arévalo, S., Ibáñez‐Costa, A., Castano, J. P., Garcia‐Becerra, T., Rebollo, E., Alberto, M. E., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.9647759 · Cited by 1

An Innovative Near-Infrared Fluorescent Probe for the Continuous Detection of Zn2+ and PPI, and its Applications in Biological Imaging and Real SamplesPreprint

Yang, Q., Yao, Y., Zeng, F., Ma, J., Wu, L., Xing, S., Yang, H., Li, Y., Du, J., & Li, Y. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4617495

A novel carbopyronin-based mitochondria-targeting fluorescent probe for highly reactive oxygen species and its application in living cells and zebrafish

Zhu, Y., Rong, X., Zheng, M., Liu, C., Wang, Y., Wen, H., Sheng, W., & Zhu, B. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108704

A fluorescent probe with a vanillin–pyridine–imidazole core structure for carboxylesterase detection in macrophage polarization during bone homeostasis

Xia, H., Wang, X., Huang, W., Jiang, X., Han, X., & Wang, C. (2025) · Frontiers in Chemistry · doi:10.3389/fchem.2025.1666238

Selective Coupling of Aminophosphole-Based Fluorophores to Unprotected Peptides through P–S Bond Formation

Rosales‐Hurtado, M., Liénart, L., Lunova, V., Banères, J., Cuminal, Y., Clément, S., Fehrentz, J., van der Lee, A., Cavelier, F., & Rémond, E. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00342

Dual-Modal Therapeutic Nanoplatform: Harnessing Caspase-1/GSDMD Pyroptosis and Photothermal Effects for Tumor Treatment

Sun, C., Yang, S., Yan, X., Liao, H., Xia, T., Xun, Y., Chen, X., Yan, S., Liu, L., & Bai, J. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c14666

A novel near-infrared COX-2 targeting probe for tumor and metastatic lymph node monitoring

Yu, A., Li, Y., Wang, Y., He, J., Zhou, Y., Cai, H., Wang, Y., Dai, B., & Shen, Y. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109645

Dihydropyrimidinone as a precursor in the synthesis of BODIPY: Study of photophysical properties and DNA interaction

Arruda, C., Müer, P. H., Pietezak, D. F., Xavier, F. R., Oliboni, R. S., Santos, A. A. D., & Gariani, R. A. (2026) · Dyes and Pigments · doi:10.1016/j.dyepig.2026.113765

Development of a novel near-infrared probe for butyrylcholinesterase accurate detection in vitro and in vivo

Bai, S., Feng, B., Dong, Q., & Liu, M. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109922

A near-infrared fluorescent probe lights up protective carbon monoxide during inflammation in live systems

Lv, S., Yang, L., Wu, C., Liu, Y., He, Y., Cao, Y., Li, P., Wang, Z., & Zhu, H. (2026) · Analytica Chimica Acta · doi:10.1016/j.aca.2026.345613

An ICT + ESIPT synergistic NIR ratiometric probe for mitochondrial MAOs imaging in vivo and in vitro

Cao, T., Li, M., Ma, H., & Fan, Z. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-026-06537-8

Strong penetrability, narrow band-width and high color-purity up-conversion emission

Ming, C., Chen, X., Zhou, A., Xie, N., Xia, Q., Ren, X., 蔡元学, & Song, F. (2026) · Journal of Russian Laser Research · doi:10.1007/s10946-026-10298-1

Exploiting the intramolecular charge transfer direction to amplify the BODIPY probe response

Liu, X., Zhu, P., Guo, M., Li, Q., Hu, G., Zhu, L., Yin, H., & Shi, Y. (2026) · Applied Physics Letters · doi:10.1063/5.0320936

Advances in near-infrared fluorescent probes for the tumor microenvironment

Hu, H., Zhang, C., Kong, X., Chen, Y., & Chen, R. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08240-9

Near-Infrared and Shortwave Infrared Building Blocks for Activity-Based Sensors in Animals

Wang, T., Li, X. L., Guo, L., & Jia, S. (2026) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6c00039

Scenario-driven fluorescent probes for formaldehyde: From food safety testing to biomedical imaging

Lian, Q., Weng, Q., He, M., Li, L., Huang, Z., Li, D., & Lu, B. (2026) · Talanta · doi:10.1016/j.talanta.2026.130046

Peptide‐based responsive molecular fluorescent probes for precision oncology

Wang, X., Liu, W., Zhang, J., Wang, W., Jin, Z., Tang, Y., & Li, Q. (2026) · Responsive materials · doi:10.1002/rpm2.70064

Benzothiazole–based molecular rotor as near-infrared (NIR) fluorescent probes for viscosity sensing

Junjai, W., Sangtawesin, S., Aryamueang, S., Trakarnthai, N., Kusoltech, C., Saengboonmee, C., & Kamkaew, A. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110152

π‐Extended COUPY Fluorophores for Targeted Near‐Infrared Fluorescence and Lifetime Imaging in Live Cells

Abad-Montero, D., Bosch, M., Garcés‐Castellanos, R., Schottenhamel, M. Q., Pedraza‐Arévalo, S., Ibáñez‐Costa, A., Castano, J. P., Garcia‐Becerra, T., Rebollo, E., Alberto, M. E., et al. (2026) · Angewandte Chemie · doi:10.1002/ange.9647759

TCF-based cyanine dyes: design strategies and phototheranostic applications

Wan, F., He, J., Liu, Y., Zhu, J., & Li, Z. L. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.218248

Unveiling the competitive reaction pathways and photophysical evolution of a naphthalene-benzothiazole fluorescent probe for sulfite: A combined experimental and DFT/TD-DFT study

Li, Q., Cui, D.-X., Leng, Y., Shou-jun, L. A. I., Deng, T., Niu, T., Yang, S., & Dong, H. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146955

A General Strategy for Developing Si-Rhodamine-Based Fluorogenic Dyes for Advanced Bioimaging and Biosensing

Chen, Z., Shi, Y., Jiang, L., Yin, Y., Yang, L., Huang, X., Jiang, L., guo, W., Liu, X., Fu, R., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c06089

A lipid droplet-targeted NIR polarity-responsive probe for hepatic disease model monitoring and ex vivo acute alcoholic liver injury imaging

Wang, F., Jiang, X., Yu, K., Wang, Y., Li, J., Ling, Y., Feng, Z., Hu, L., & Wang, H. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.147015

Emission-tunable aromatic thiadiazole derivatives based on triphenylimidazole with aggregation-induced emission activity and their application in osteosarcoma imaging

ZHANG, C., & Wang, J. (2026) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-026-00951-8

A fast-response and highly selective near-infrared fluorescent probe for imaging peroxynitrite in living cells and mice

Liu, J., Zhai, P., Pan, R., Li, X., Tang, S., & Shu, W. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.128445

In vivo detection of reactive oxygen species using turn-on luminescent probes based on IR783-modified upconversion nanoparticles

Nie, C., Yan, S., Xing, G., Ji, K., Yang, X., Tang, J., Chen, J., Zhao, Y., Hu, J., & Liu, J. (2026) · Journal of Luminescence · doi:10.1016/j.jlumin.2026.122086

Engineering a water-soluble cyanine-based probe for plasma butyrylcholinesterase detection and liver injury visualization

Chen, K., Yuwen, Z., Lu, C., Zhang, Z., Zhang, D., Yang, Y., & Liu, H. (2026) · Analytical Methods · doi:10.1039/d6ay01510g

Spiro-helicenoid Carbofluoresceins: CPL-Active Emitters for Bioimaging

Erviti-Marticorena, L., Simón‐Fuente, S., Míguez‐Lago, S., Paredes, J. M., Ribagorda, M., Girón, M. D., Millán, A., Cuerva, J. M., & Miguel, D. (2026) · Organic Letters · doi:10.1021/acs.orglett.6c02744

Recent Advances in Camphor‐Derived Small‐Molecule Organic Fluorescent Probes

Ma, W., Gu, Q., Lv, Q., Duan, Q.-C., Cao, Z., Sun, K., & Yu, B. (2026) · Chemistry - A European Journal · doi:10.1002/chem.71600

Application of optical probes for imaging analysis under cadmium–selenium stress in the environment and biosystems: a review

Pang, Y., & Zhou, L. (2026) · The Analyst · doi:10.1039/d6an00706f

Multi‐Stimuli Responsive Phosphate Hybrids With Visible‐Light‐Excited Dual‐Mode Afterglow Toward Multifunctional Applications

Zhao, H., Jiang, M., Song, A., Sun, W. Y., Li, G., Li, J., Yang, X., Zhang, X., Li, S., & Zhao, Q. (2026) · Advanced Functional Materials · doi:10.1002/adfm.77953

β-Galactosidase-responsive AIE fluorescent probe for tumor-targeted imaging and photodynamic therapy

Yang, L., Lu, X., Chen, N., Zhu, H., Liu, T., & Li, Z. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113342

Construction of a corrosion signal network based on ultra-sensitive near-infrared fillers for rapid diagnosis of early corrosion of magnesium alloy

Wang, B., Sun, J., Ding, C., Zhang, Y., Zhu, Q., Zhang, T., & Wang, F. (2026) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2026.08.041

Peroxynitrite-activated near-infrared fluorescence sensing platform for early non-invasive IBD diagnosis, herbal formula efficacy evaluation and anti-enteritis bioactive components screening

Hu, L., Li, T., Zeng, S., Ouyang, J., Huang, S., Sun, D., Yang, Z., Wang, Q., Yao, Z., & Li, C. (2026) · Talanta · doi:10.1016/j.talanta.2026.130568

An excitation-customized ICT-type turn-on probe for visualization of cysteine fluctuation in diverse drug-induced ferroptosis pathways

Gong, Y., Shi, W., Ma, A., Wang, Q., Lou, W., & Zhang, M. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-026-06782-x

Rational construction of a chlorine-modulated isophorone-based near-infrared fluorescent probe for smartphone-assisted environmental monitoring of hydrazine hydratePreprint

Zeng, Y., Zhou, Z., Yu, J., Jiang, H., Shen, Y., & Liu, X. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7499769

Diene-Extended Chalcones Enable Red Fluorescence Detection of Human Serum Albumin Through FA1 Binding

Corbin, B., Mason, J., Houglan, P. M., Murphey, A., & Pang, Y. (2026) · Biosensors · doi:10.3390/bios16100533

Hypoxia-Responsive Fluorescent Prodrugs: Self-Reporting Drug Delivery or Activation in Living Systems

Hu, X., Song, X., Qiu, Y., & Du, W. (2026) · Biosensors · doi:10.3390/bios16100540

An excitation-customized turn-on type ICT probe for highly sensitive and selective visualizing biothiols fluctuation in diversified drug-induced ferroptosis

Gong, Y., Shi, W., Ma, A., Wang, Q., & Zhang, M. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.140998

A highly selective fluorescent probe based on rhodamine derivatives for HClO detection in water, food, plants, live cells and zebrafish

Zuo, X., Li, Y., 阮馨平, Zhao, B., Li, X., Wang, W., & Zhang, Y. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.128871

One-Pot Michael Addition–Elimination Approach to 4-Carboranylcoumarin-Derived Luminescent Systems

Fatykhov, R. F., Lavrinchenko, I. A., Gurina, E. M., Sharapov, A. D., Khalymbadzha, I. А., Вараксин, М. В., Гавико, В. С., Moseev, T. D., & Чупахин, О. Н. (2026) · Organic Letters · doi:10.1021/acs.orglett.6c03900

Structural engineering strategies of near-infrared two-photon probes

Yan, F., Liu, Y., Zhang, Y., Su, D., Wang, C., Ma, S., Wang, L., Miao, Q., Chen, P., Tang, B., et al. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.218682

Recent progress in the development of near-infrared fluorescent probes for bioimaging applications

Guo, Z., Park, S., Yoon, J., & Shin, I. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60271k · Cited by 1,812

Functional Near‐Infrared Fluorescent Probes

Kiyose, K., Kojima, H., & Nagano, T. (2008) · Chemistry - An Asian Journal · doi:10.1002/asia.200700267 · Cited by 248

Development and application of several fluorescent probes in near infrared region

Wang, Y., Yu, H., Zhang, Y., Jia, C., & Ji, M. (2021) · Dyes and Pigments · doi:10.1016/j.dyepig.2021.109284 · Cited by 59

A pyridine-Si-rhodamine-based near-infrared fluorescent probe for visualizing reactive oxygen species in living cells

Zhou, Z., Yuan, X., Long, D., Liu, M., Li, K., & Xie, Y. (2020) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2020.118927 · Cited by 24

Recent progress of near-infrared fluorescent probes in the determination of reactive oxygen species for disease diagnosis

Lin, S.-F., Ye, C., Lin, Z., Huang, L., & Li, D. (2023) · Talanta · doi:10.1016/j.talanta.2023.125264 · Cited by 66