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Cited by 9Indigenous Health, Education, and RightsHIV, Drug Use, Sexual RiskSubstance Abuse Treatment and Outcomes

A randomized comparison trial of culturally adapted HIV prevention approaches for Native Americans reducing trauma symptoms versus substance misuse: The Healing Seasons protocol

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Pearson, C.R., Kaysen, D., Huh, D., Bedard-Gillgan, M., Walker, D., Marin, R., Saluskin, K.·2020·Contemporary Clinical Trials
DOI 10.1016/j.cct.2020.106070PMC PMC8893012
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Abstract

Native Americans (NA) experience interrelated risks of trauma exposure, substance use, and HIV risk behaviors that put them at increased risk for HIV infection. Despite these known risk factors, there are very few published randomized trials testing interventions to reduce trauma-related symptoms and substance misuse among NA.Methods The Healing Seasons study is a randomized comparsion trial of two counseling strategies, Narrative Exposure Therapy (NET) addressing PTSD or Motivational interviewing with cognitive behavioral therapy skills training (MIST) addressing substance misuse as a means to prevent HIV among NA. Using a community-based participatory research approach, we adapted both evidence-based interventions to be specific to the risk contexts and realities of NA and to include psychoeducational and skill-building components that include cultural-specific stories, virtues, and traditional treatment strategies. Participants, 16 years and older, were recruited from a Pacific Northwest tribal community, screened over the phone, enrolled in person, and randomized in equal numbers to NET or MIST. We stratified by age (16-29 years and 30 or older) and gender (male or female identified) to ensure balance between treatment arms. The primary outcomes were number of sex partners and frequency of sexual acts (with and without condoms), sex under the influence of substances, frequency of substance use, and PTSD severity.Discussion Behavioral interventions for NA are needed to prevent HIV risk behaviors when faced with trauma symptoms and substance misuse. This study will provide evidence to determine feasibility and efficacy of addressing related risk factors as part of counseling-based HIV prevention intervention to reduce sexual risk among this population.Trial registration ClinicalTrials.gov number, NCT03112369, registered April 12, 2017.

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  • Ongoing studies are evaluating interventions adapted for indigenous youth, girls in the juvenile justice system, homeless youth, and unaccompanied refugee youth.

    “Ongoing studies are evaluating interventions adapted for indigenous youth [95], girls in the juvenile justice system, homeless youth [96], and unaccompanied refugee youth [97].”

    From Interventions for prevention and treatment of substance use in youth with traumatic childhood experiences: a systematic review and synthesis of the literature (2024) · cites this paper as [95]

    The Methods/design section describes an ongoing randomized trial of culturally adapted interventions for Native Americans, and Identification and recruitment of participants says it enrolls people aged 16 and older, with at least half intended to be aged 16–30. The interventions are adapted for Native Americans broadly, not specifically for youth; this citation supports only the indigenous-youth portion of the citing sentence. (LLM, conf=0.84)

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Research works printed but not linked: 3

  1. [34]Pearson CR,, Randomized control trial of culturally-adapted Cognitive Processing Therapy for PTSD, substance misuse and HIV sexual risk behavior for American Indian women, AIDS Behav. 23 (3) (2019) 695– 706, 10.1007/s10461-018-02382-8. 30607757 PMC6407746 · DOI
  2. [45]Foa EB,, Concurrent naltrexone and prolonged exposure therapy for patients with comorbid alcohol dependence and PTSD: a randomized clinical trial, J. Am. Med. Assoc. 310 (5) (2013) 488– 495. 23925619
  3. [49]Schauer M, Neuner F, Elbert T, Narrative Exposure Therapy: A Short-term Tretamnt for Truamatic Stress Disorders, 2nd edition and expanded edition, Cambridge, Hogrefe, MA, 2011.

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Authors
Pearson, C. R., Kaysen, D., Huh, D., Bedard-Gillgan, M., Walker, D., Marin, R., & Saluskin, K.
Affiliations
  • University of Washington (US)
  • Stanford Medicine (US)
Corresponding author
Pearson, C.R.
ORCID
Venue
Contemporary Clinical Trials
Publisher
Elsevier BV
Published
2020-08
Volume
95
Pages
106070
ISSN
1551-7144 (ISSN-L)
DOI
10.1016/j.cct.2020.106070
PMC
PMC8893012
OpenAlex
W3035969526
Cited by
9
References
47
Citations by year
2026: 1 · 2025: 2 · 2023: 3 · 2022: 1 · 2021: 2
FWCI
0.83
Type
journal article
Language
en
Open access
Licence
Locations
  • Contemporary Clinical Trials (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Minority Health and Health Disparities of the National Institutes of Health (MD011574)
Topics
  • Social Sciences › Health › Indigenous Health, Education, and Rights
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
HIV prevention, Native Americans, trauma symptoms, post-traumatic stress disorder, substance abuse, narrative exposure therapy, motivational interviewing, cognitive behavioral therapy, culturally tailored interventions, sexual risk behavior, condom use, community-based participatory research
MeSH terms
Female, Humans, Infant, Newborn, Male, Seasons, Sexual Behavior, HIV Infections, Substance-Related Disorders, American Indian or Alaska Native

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