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Evidence-Based Dentistry Update on Silver Diamine Fluoride
Open accessAbstract
This article reviews current evidence on the effectiveness of silver diamine fluoride (SDF) as a caries arresting and preventive agent. It provides clinical recommendations around SDF's appropriate use as part of a comprehensive caries management program. Systematic reviews confirm that SDF is effective for caries arrest on cavitated lesions in primary teeth and root caries in the elderly. It may also prevent new lesions. Application is easy, noninvasive, affordable, and safe. Although it stains the lesions dark as it arrests them, it provides clinicians with an additional tool for caries management when esthetics are not a primary concern.
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“For instance, SDF a non-invasive, cost-effective topical agent has been shown to arrest caries progression in primary teeth by up to 80%, making it particularly valuable for underserved populations and children with dental anxiety or special healthcare needs [7,8].”
From Minimally Invasive Techniques for Managing Dental Caries in Children: Efficacy, Applications, and Future Directions (2025) · cites this paper as [7]
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“Studies show that applying it twice a year can greatly lower the risk of cavities by keeping a high level of fluoride on teeth for a long time.7,8”
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“For instance, SDF a non-invasive, cost-effective topical agent has been shown to arrest caries progression in primary teeth by up to 80%, making it particularly valuable for underserved populations and children with dental anxiety or special healthcare needs [7,8].”
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Cömert, H., & Ölmez, A. (2024) · European Archives of Paediatric Dentistry · doi:10.1007/s40368-024-00951-1 · Cited by 4
The preventive effect of silver diamine fluoride-modified salivary pellicle on dental erosion
Chawhuaveang, D. D., Lam, W. Y. H., Chu, C. H., & Yu, O. Y. (2024) · Dental Materials · doi:10.1016/j.dental.2024.10.014 · Cited by 4
Devan, I., Janakiram, C., Ramanarayanan, V., Varma, B. R., & Vasudevan, S. (2025) · Contemporary Clinical Dentistry · doi:10.4103/ccd.ccd_535_24 · Cited by 4
Varughese, A., Janakiram, C., Karuveettil, V., & James, A. (2025) · JBI Evidence Synthesis · doi:10.11124/jbies-24-00299 · Cited by 4
Sahebalam, R., Ghorbani, M., Shirazi, A. S., Khosrojerdi, M., & Mowji, M. (2025) · BMC Oral Health · doi:10.1186/s12903-025-06832-3 · Cited by 4
Bagattoni, S., Lardani, L., Cappiello, M. C., Gatto, M. R., Montevecchi, M., & Piana, G. (2021) · International Journal of Paediatric Dentistry · doi:10.1111/ipd.12841 · Cited by 4
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The Role of Silver Diamine Fluoride in Contemporary Dental Practice: A Comprehensive Review
Brar, A., Singh, A. P., Narad, C., & Singh, R. (2024) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_123_24 · Cited by 4
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Soni, A., Paul, S., & Sachdeva, P. (2021) · Contemporary Pediatric Dentistry · doi:10.51463/cpd.2021.51 · Cited by 4
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Metadata
- Authors
- Crystal, Y. O., & Niederman, R.
- Affiliations
- New York University (US)
- Corresponding author
- Crystal, Yasmi O.
- Venue
- Dental Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 63
- Issue
- 1
- Pages
- 45-68
- ISSN
- 0011-8532 (ISSN-L)
- PMC
- PMC6500430
- OpenAlex
- W2901262305
- Cited by
- 253
- References
- 64
- Citations by year
- 2026: 28 · 2025: 38 · 2024: 38 · 2023: 47 · 2022: 46 · 2021: 35 · 2020: 17 · 2019: 4
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Dental Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01MD011526)
- Patient-Centered Outcomes Research Institute (PCS-1609-36824)
- Topics
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Health Sciences › Dentistry › General Dentistry › Dental materials and restorations
- Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
- Keywords
- silver diamine fluoride, caries arrest, dental caries prevention, primary teeth, root caries, cavitated lesions, caries management, dental caries
- MeSH terms
- Aged, Quaternary Ammonium Compounds, Anti-Bacterial Agents, Cariostatic Agents, Child, Dental Caries, Fluorides, Topical, Humans, Pediatric Dentistry, Tooth Remineralization, Tooth, Deciduous, Patient Satisfaction, Root Caries, Silver Compounds, Evidence-Based Dentistry
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