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Cited by 88Cellular Mechanics and InteractionsForce Microscopy Techniques and ApplicationsAdvanced Materials and Mechanics

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Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling

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Zajac, Allison L, Discher, Dennis E·2008·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2008.09.006PMC PMC3967913
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Abstract

Cells may lack eyes to see and ears to hear, but cells do seem to have a sense of 'touch' that allows them to feel their microenvironment. This is achieved in part through contractility coupled adhesion to physically flexible 'soft' tissue. Here we summarize some of the known variations in elasticity of solid tissue and review some of the long-term effects of cells 'feeling' this elasticity, focusing on differentiation processes of both committed cell types and stem cells. We then highlight what is known of molecular remodeling in cells under stress on short time scales. Key roles for forces generated by ubiquitous and essential myosin-II motors in feedback remodeling are emphasized throughout.

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  • The substrate stiffness values of the hydrogels were comparable to the tissues of collagen fibers, osteoid, and pre-calcified bone.

    “which was comparable to the tissues of collagen fibers, osteoid and pre-calcified bone respectively [8,33,34].”

    From Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway (2020) · cites this paper as [33]

    In “Soft tissue E Measurements and Model systems” (page not provided), the paper gives osteoid an elasticity of about 20–40 kPa and describes it as compliant, pre-calcified bone. It discusses gels designed to mimic tissue elasticity, but the cited passages do not establish a separate stiffness comparison for collagen fibers; they also treat osteoid and pre-calcified bone as the same material, not two distinct tissues. (LLM, conf=0.83)

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References 48 · Cited by 88

Research works printed but not linked: 44

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Metadata

Authors
Zajac, A. L., & Discher, D. E.
Affiliations
University of Pennsylvania (US)
ORCID
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2008-12
Volume
20
Issue
6
Pages
609-615
ISSN
0955-0674 (ISSN-L)
DOI
10.1016/j.ceb.2008.09.006
PMC
PMC3967913
OpenAlex
W2021551044
Cited by
88
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 9 · 2017: 3 · 2016: 1 · 2015: 10 · 2014: 2 · 2013: 7 · 2012: 6
FWCI
0.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL062352)
  • National Institute of Allergy and Infectious Diseases (R21AI087516)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR056128)
  • National Institute of Biomedical Imaging and Bioengineering (R21EB003164, R01EB007049, R21EB004489, R21EB004000)
  • National Center for Research Resources (S10RR022575)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Force Microscopy Techniques and Applications
  • Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
Keywords
cell differentiation, tissue stiffness, mechanotransduction, myosin II, contractility, cell adhesion, stem cells, cell mechanics, extracellular matrix stiffness
MeSH terms
Animals, Biomechanical Phenomena, Cell Adhesion, Cell Differentiation, Cell Physiological Phenomena, Elasticity, Humans, Models, Biological, Myosins, Stem Cells

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