Discher, Dennis E.

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell

Cellular Mechanics and InteractionsMesenchymal stem cell research

Cited by 13,915

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science

Cellular Mechanics and InteractionsForce Microscopy Techniques and Applications

Cited by 6,382

Shape effects of filaments versus spherical particles in flow and drug delivery

Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., & Discher, D. E. (2007) · Nature Nanotechnology

Nanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers

Cited by 2,565

Mesenchymal stem cell perspective: cell biology to clinical progress

Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019) · npj Regenerative Medicine

Mesenchymal stem cell researchPeriodontal Regeneration and Treatments

Cited by 2,008

Myotubes differentiate optimally on substrates with tissue-like stiffness

Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology

Cellular Mechanics and InteractionsMuscle Physiology and Disorders

Cited by 1,743

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Harding, S. M., Benci, J. L., Irianto, J., Discher, D. E., Minn, A. J., & Greenberg, R. A. (2017) · Nature

interferon and immune responsesDNA Repair Mechanisms

Cited by 1,508

Polymersomes

Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering

Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and Characterization

Cited by 844

Self-porating polymersomes of peg–pla and peg–pcl: Hydrolysis-triggered controlled release vesicles

Ahmed, F., & Discher, D. E. (2004) · Journal of Controlled Release

Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and Characterization

Cited by 667

Polymer vesicles in vivo: correlations with PEG molecular weight

Photos, P. J., Bacakova, L., Discher, B., Bates, F. S., & Discher, D. E. (2003) · Journal of Controlled Release

Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and Characterization

Cited by 527

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

Tsai, R. K., & Discher, D. E. (2008) · The Journal of Cell Biology

Phagocytosis and Immune RegulationCellular transport and secretion

Cited by 486

Cross-linked polymersome membranes: Vesicles with broadly adjustable properties

Discher, B. M., Bermudez, H., Hammer, D. A., Discher, D. E., Won, Y.-Y., & Bates, F. S. (2002) · The Journal of Physical Chemistry B

Advanced Polymer Synthesis and CharacterizationLipid Membrane Structure and Behavior

Cited by 262

Polymeric worm micelles as nano-carriers for drug delivery

Kim, Y., Dalhaimer, P., Christian, D. A., & Discher, D. E. (2005) · Nanotechnology

Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Cited by 207

Heart-Specific Stiffening in Early Embryos Parallels Matrix and Myosin Expression to Optimize Beating

Majkut, S., Idema, T., Swift, J., Krieger, C., Liu, A., & Discher, D. E. (2013) · Current Biology

Cellular Mechanics and InteractionsTissue Engineering and Regenerative Medicine

Cited by 198

Challenges and opportunities for the next generation of cardiovascular tissue engineering

Cho, S., Discher, D. E., Leong, K. W., Vunjak-Novakovic, G., & Wu, J. C. (2022) · Nature Methods

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 176

Nanoparticle shape improves delivery: rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles

Loverde, S. M., Klein, M. L., & Discher, D. E. (2012) · Advanced Materials

Nanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers

Cited by 162

Tension in fibrils suppresses their enzymatic degradation – A molecular mechanism for ‘use it or lose it’

Saini, K., Cho, S., Dooling, L. J., & Discher, D. E. (2020) · Matrix Biology

Cellular Mechanics and InteractionsCollagen: Extraction and Characterization

Cited by 90

Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling

Zajac, A. L., & Discher, D. E. (2008) · Current Opinion in Cell Biology

Cellular Mechanics and InteractionsForce Microscopy Techniques and Applications

Cited by 88

Shape Effects of Filaments Versus Spherical Particles in Flow and Drug Delivery

Discher, D. E. (2008) · ASME 2008 Summer Bioengineering Conference, Parts A and B

Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Cited by 44

Small fat droplets interact with structural filaments in macrophages with cytoskeletal dysfunction contributing to perturbed phagocytosis and migration

Tobin, M. P., Ivanovska, I. L., & Discher, D. E. (2023) · Biophysical Journal

Lipid metabolism and biosynthesisCellular Mechanics and Interactions

Cited by 1