The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Control of cell adhesion dynamics by Rap1 signaling
Open accessAbstract
Summary Individual cells in their particular environments adhere to the extracellular matrix (ECM) and their neighbors via integrin- and cadherin-containing complexes, respectively. The dynamics of these interactions regulate the formation and maintenance of complex tissues. An expanding body of evidence accentuates the role of the small Rap1 GTPase and its associated signaling network in many of these processes. In this review we will discuss more recently revealed roles of Rap1 signaling by primarily focusing on functions of the Rap1 effectors RIAM, KRIT-1/CCM1 and AF-6/Afadin in junctional regulation of the vascular system and in epithelial cells. Furthermore, we will describe novel findings on the Rap activator PDZ-GEF in the regulation of cell-cell adhesion between epithelial cells and within a stem cell niche.
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Cites
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Cited by
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Metadata
- Authors
- Boettner, B., & Van Aelst, L.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 21
- Issue
- 5
- Pages
- 684-693
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2042570069
- Cited by
- 268
- References
- 74
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
