Mitochondrial reactive oxygen species regulate hypoxic signaling

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · cited 1×

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549

Redox regulation of the tumor suppressor p53

Shi, T. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/966

Treating the Placenta with a Nanoparticle-Encapsulated Mitochondrial Antioxidant Improves Placental Function and Fetal Cardiomyocyte Development in a Rat Model of Prenatal Hypoxia

Ganguly, E. (2021) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-xz0j-fs36

Vascular and Endothelial Regeneration

Casteilla, L., Laharrague, P. F., & Planat‐Benard, V. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8069-3_8

https://medcraveonline.com/JSRT/novel-technique-of-aesthetic-skin-rejuvenation-with-cellular-extracted-compounds-enriched-with-peptides-and-hyaluronic-acid.html

Chernykh, V., Nallenthiran, L., Yefimov, S., & Yemeliyanova, M. (2020) · Journal of Stem Cell Research & Therapeutics · doi:10.15406/jsrt.2020.06.00142

Mitochondrial UQCC3 Controls Angiogenesis During Embryonic Development and Tumor GrowthPreprint

Zhang, G., Yang, Y., Xie, S., Chen, L., Luo, H. B., Zhong, J. Q., Wei, Y., Guo, F., Gan, J., Zhu, F., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2686313/v1

Efecto de la vitamina C en células endoteliales microvasculares de cerebro humano en modelo de isquemia-reperfusión in vitro.

Rocco, C. R., & Pérez, E. I. (2023) · doi:10.29393/tmudec-65as1ev65

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisationPreprint

Grimm, F., Asuaje, A., Jain, A., dos Santos, M. S., Kleinjung, J., Nunes, P. M., Gehrig, S. M., Fets, L., MacRae, J. I., & Anastasiou, D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.06.556522

Stress, Autoimmunity and Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease

Alvarado, A. (2023) · Cellular and Molecular Medicine Research · doi:10.14740/cmmr17e

Función de las proteínas VQ1 y VQ10 codificadas por genes inducibles por hipoxia, óxido nítrico, y estrés oxidativo en la regulación del desarrollo y las respuestas a estrés en Arabidopsis thaliana

Gayubas, B. (2023) · doi:10.4995/thesis/10251/202571

Toxicity Mechanism of Microcystin-Lr to Lettuce ( Lactuca Sativa L.): Active Transmembrane Transport, Blockage of the Electron Transport Chain, and Reactive Oxygen Species BurstPreprint

Zheng, Q., Li, Y.-W., Zheng, N., Liu, B., Liu, X., Zhao, H.-M., Feng, N.-X., Cai, Q.-Y., Xiang, L., Mo, C.-H., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4789099

Cardiac p16 Expression Following Vape Exposure with Nicotine Shows Sex-Specific Induction in Males but not FemalesPreprint

Shain, A. G., Savko, C., Rokaw, S., Jaafar, F., Rieder, A., Wright, M., Phillips, J. A., Konja, N., Michael, S., Mathews, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.01.606074

The role of reactive oxygen species and nitric oxide in the realization of the adaptation mechanisms of bone-derived multipotent mesenchymal stromal cells to hypoxia under cultivation with growth factor bFGF

Poleshko, А. G., & Volotovski, I. D. (2015) · Genes and Cells · doi:10.23868/gc120483

Antioxidant of the endosymbiotic dinoflagellate Symbiodinium sp. from the sea anemone Stichodactyla haddoni Saville-Kent

Soostani, S. B., Darki, B. Z., Yousefzadi, M., & Ranjbar, M. S. (2025) · Algologia · doi:10.15407/alg35.01.015

The translational inhibitor 4EBP/Thor is required for Drosophila adaptation to hypoxia

Sorianello, E., Katz, M., Acevedo, J. M., Melani, M., Perez-Perri, J. I., & Wappner, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-94457-5 · Cited by 1

Antioxidant of the Endosymbiotic Dinoflagellate Symbiodinium sp. from the Sea Anemone Stichodactyla haddoni Saville-Kent

Soostani, S. B., Darki, B. Z., Yousefzadi, M., & Ranjbar, M. S. (2025) · International Journal on Algae · doi:10.1615/interjalgae.v27.i3.80

Additive cardioprotection by dapagliflozin and pioglitazone co-therapy in streptozotocin-induced diabetic rats

Kralova, E., Čináková, A., Klimas, J., & Křenek, P. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf091

Synthesis of Retigabine Analogues for the Treatment of Tinnitus and Progress Towards a Concise Route to XJB-5-131

Reed, N. L. (2015) · D-Scholarship@Pitt (University of Pittsburgh)

Expression of yeast NADH dehydrogenase and ascidian alternative oxidase affects metabolism and free radical processes in Drosophila

Lushchak, O. V., Gospodaryov, D. V., Yurkevych, I. S., & Strilbytska, O. M. (2026) · BMC Research Notes · doi:10.1186/s13104-026-07692-y

The effects of the “living high–training low” model on key proteins involved in cellular aerobic and anaerobic metabolism in male C 57 BL /6 J mice

Scariot, P. P. M., Papoti, M., Polisel, E. E. C., Orsi, J. B., Hill, D. W., Manchado-Gobatto, F. D. B., & Gobatto, C. A. (2026) · Physiological Reports · doi:10.14814/phy2.70812

Caractérisation de l'effet cytoprotecteur des cellules souches mésenchymateuses sur l'apoptose et sur les altérations phénotypiques des cellules épithèliales alvéolaires soumises à l'hypoxie

Bernard, O. (2016) · theses.fr (ABES) · doi:10.70675/f3cd3724z249ez43f5z8d8dz501c15f6c976 · Cited by 1

The regulation of the p53 isoform p47 following Endoplasmic Reticulum (ER) stress, and physiological implication of single cancer-derived synonymous mutations in initiation of p53 mRNA translation

Fusée, L. T. S. (2020) · theses.fr (ABES) · doi:10.70675/7d11d779zac70z4ae9zba4bzd0c51b4ce40b

Exploring the Role of Intercellular and Intracellular Signaling in the Sustenance of Glioblastoma Stem-like Cells

Jacobs, K. (2020) · theses.fr (ABES) · doi:10.70675/7d25afb8z3349z41abz9a2fz667e402f1463

Hypoxia-on-chip : from technological developments to biological applications

Bouquerel, C. (2023) · theses.fr (ABES) · doi:10.70675/d7d58b5dzd927z4235z8c54z8dbb6fd4757e

Angiogenic Doping: Plausible Yet Difficult to Detect

Lehto, S., Sima, S., Künnapuu, J., Iljukov, S., & Jeltsch, M. (2026) · Sports Medicine · doi:10.1007/s40279-026-02447-y

MitoNEET in cardiac mitochondria: Linking mitochondrial function and cardiac disease

Su, L., Huang, Y., Zhou, H., & 廖章萍 (2026) · Metabolism · doi:10.1016/j.metabol.2026.156669

Loss of HIF1α signaling drives oxidative stress and expansion of smooth muscle cells in murine atherosclerosisPreprint

Izquierdo-Serrano, R., Sharysh, D., Cumbicus, V., Hernansanz‐Agustín, P., Sluimer, J. C., Martı́n-Puig, S., Carramolino, L., Morales‐Cano, D., & Bentzon, J. F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.26.734925

Nanozymes for extracellular matrix and cell sheet engineering: biomedical potential and complementary enzymatic strategies

Choi, S. M., Zo, S. M., Sood, A., & Han, S. S. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1900627

Fibrotic Remodeling in Retinal Vascular Diseases: Cellular Origins, Molecular Mechanisms, and Therapeutic Perspectives

Ning, J. Y., Wang, B., Yamamoto, M. I., & Yamada, K. H. (2026) · Cells · doi:10.3390/cells15191772

Insights into HIF Prolyl Hydroxylase Inhibitors: Recent Advances and Expanding Therapeutic Applications beyond Anemia

Wei, L., 胡玉清, Lyu, Y., Qian, H., Qin, H., Wu, Y., & Zhang, X. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01656

BindingDB Entry 50004353: The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway.

BindingDB (2020) · UC San Diego · doi:10.7270/q2cf9sxj

BindingDB Entry 50004767: Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells.

BindingDB (2020) · UC San Diego · doi:10.7270/q2th8qkk

Role of stromal fibroblasts in prostate carcinoma progression and metabolic reprogramming of cancer cells

Marini, A. (2014) · UnissResearch (Università degli Studi di Sassari)

O 2 sensing, mitochondria and ROS signaling: The fog is lifting

Waypa, G. B., Smith, K. A., & Schumacker, P. T. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.01.002 · Cited by 190

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia

Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033506 · Cited by 881

Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling

Hoffman, D. L., Salter, J. D., & Brookes, P. S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00699.2006 · Cited by 165

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.001 · Cited by 1,545

Mitochondrial complex III regulates hypoxic activation of HIF

Klimova, T., & Chandel, N. S. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402307 · Cited by 433