Chandel, Navdeep S.

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 6,931

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Fundamentals of Cancer Metabolism

DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 3,013

Mitochondrial TCA cycle metabolites control physiology and disease

Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 2,813

Physiological Roles of Mitochondrial Reactive Oxygen Species

Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 2,632

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 2,000

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 1,926

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 1,742

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M., & Winterbourn, C. (2022) · Nature Reviews Molecular Cell Biology

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 1,735

Mitochondria are required for antigen-specific t cell activation through reactive oxygen species signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity

T-cell and B-cell ImmunologyMitochondrial Function and Pathology

Cited by 1,338

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 1,328

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 1,272

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 1,133

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Jeon, S.-M., Chandel, N. S., & Hay, N. (2012) · Nature

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 1,132

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Wheaton, W. W., Weinberg, S. E., Hamanaka, R. B., Soberanes, S., Sullivan, L. B., Anso, E., Glasauer, A., Dufour, E., Mutlu, G. M., Budigner, G. S., et al. (2014) · eLife

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 1,105

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 1,011

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 1,002

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 960

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

Brunelle, J. K., Bell, E. L., Quesada, N. M., Vercauteren, K., Tiranti, V., Zeviani, M., Scarpulla, R. C., & Chandel, N. S. (2005) · Cell Metabolism

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 763

The Two Faces of Reactive Oxygen Species in Cancer

Reczek, C. R., & Chandel, N. S. (2017) · Annual Review of Cancer Biology

Redox biology and oxidative stressCancer and biochemical research

Cited by 602

Mitochondria as signaling organelles

Chandel, N. S. (2014) · BMC Biology

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 576

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

Bell, E. L., Klimova, T. A., Eisenbart, J., Moraes, C. T., Murphy, M. P., Budinger, G. R. S., & Chandel, N. S. (2007) · The Journal of Cell Biology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 568

Evolution of Mitochondria as Signaling Organelles

Chandel, N. S. (2015) · Cell Metabolism

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 555

The role of nuclear lamin B1 in cell proliferation and senescence

Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes & Development

Nuclear Structure and FunctionTelomeres, Telomerase, and Senescence

Cited by 547