The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.
Mitochondrial reactive oxygen species regulate hypoxic signaling
Open accessAbstract
Physiological hypoxia results in a host of responses that include increased ventilation, constriction of the pulmonary artery, and a cellular transcriptional program that promotes glycolysis, angiogenesis, and erythropoiesis. Mitochondria are the primary consumers of cellular oxygen and have thus been speculated for years to be the site of cellular oxygen sensing. Many of the cellular responses to hypoxia are now known to be mediated by the production of reactive oxygen species at mitochondrial complex III. While the mechanism by which cytosolic oxidant concentration is increased during hypoxia is unknown, the importance of the maintenance of cellular oxygen supply requires further investigation into the role of ROS as hypoxia signaling molecules. The following is a brief overview of the current understanding of the role of mitochondrial-produced ROS in cellular oxygen signaling.
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“These functions are intimately coupled to redox regulation, as HIFs both sense and remodel intracellular ROS levels through effects on mitochondrial activity, antioxidant pathways, and metabolic flux [252,253].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [252]
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Cites
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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Lu, X., Naidis, G. V., Laroussi, M., Reuter, S., Graves, D. B., & Ostrikov, K. (2016) · Physics Reports · doi:10.1016/j.physrep.2016.03.003 · Cited by 1,247
Oxygen Sensing, Homeostasis, and Disease
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How cancer metabolism is tuned for proliferation and vulnerable to disruption
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SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.014 · Cited by 782
Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction
Chen, C., Gao, J., Liu, M., Li, S., Xuan, X., Zhang, X., Zhang, X.-Y., Wei, Y., Zhen, C., Jin, J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479536 · Cited by 782
Metadata
- Authors
- Hamanaka, R. B., & Chandel, N. S.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Chandel, Navdeep S
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 21
- Issue
- 6
- Pages
- 894-899
- ISSN
- 0955-0674 (ISSN-L)
- PMC
- PMC2787901
- OpenAlex
- W2107708548
- Cited by
- 332
- References
- 58
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 24 · 2023: 24 · 2022: 23 · 2021: 25 · 2020: 23 · 2019: 10 · 2018: 18 · 2017: 20 · 2016: 20 · 2015: 14 · 2014: 20 · 2013: 20 · 2012: 27
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01CA123067-03, RO1GM60472-10)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial reactive oxygen species, hypoxia signaling, cellular oxygen sensing, mitochondrial complex III, glycolysis, angiogenesis, erythropoiesis, pulmonary vasoconstriction
- MeSH terms
- Animals, Hypoxia, Humans, Mitochondria, Models, Biological, Signal Transduction, Reactive Oxygen Species, Basic Helix-Loop-Helix Proteins
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