Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · see citing works

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300 · see citing works

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000 · see citing works

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works

HIF‐1α is required for solid tumor formation and embryonic vascularization

Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · see citing works

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.001 · Cited by 1,545 · see citing works

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385 · see citing works

Oxidative Phosphorylation at the fin de siècle

Saraste, M. (1999) · Science · doi:10.1126/science.283.5407.1488 · Cited by 1,318 · see citing works

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

Breier, G., Albrecht, U., Sterrer, S., & Risau, W. (1992) · Development · doi:10.1242/dev.114.2.521 · Cited by 1,087 · see citing works

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., & Ratcliffe, P. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5197 · Cited by 1,014 · see citing works

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781 · see citing works

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

Brunelle, J. K., Bell, E. L., Quesada, N. M., Vercauteren, K., Tiranti, V., Zeviani, M., Scarpulla, R. C., & Chandel, N. S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.002 · Cited by 763 · see citing works

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., & Kaelin, W. G. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00043-0 · Cited by 761 · see citing works

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A., & Poellinger, L. (2001) · Nature · doi:10.1038/35107085 · Cited by 705 · see citing works

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704 · see citing works

Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes

Duranteau, J., Chandel, N. S., Kulisz, A., Shao, Z., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11619 · Cited by 679 · see citing works

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

Yu, A. Y., Shimoda, L. A., Iyer, N. V., Huso, D. L., Sun, X., McWilliams, R. M., Beaty, T. H., Sham, J. S. K., Wiener, C. M., Sylvester, J. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5912 · Cited by 645 · see citing works

Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

Wiesener, M. S., Turley, H., Allen, W. E., Willam, C., Eckardt, K., Talks, K., Wood, S. M., Gatter, K. C., Harris, A. L., Pugh, C. W., et al. (1998) · Blood · doi:10.1182/blood.v92.7.2260 · Cited by 629 · see citing works

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19253 · Cited by 629 · see citing works

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

Mansfield, K. D., Guzy, R. D., Pan, Y., Young, R. M., Cash, T. P., Schumacker, P. T., & Simon, M. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.003 · Cited by 606 · see citing works

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell · doi:10.1016/j.cell.2004.08.025 · Cited by 588 · see citing works

Methods of Detection of Vascular Reactive Species

Tarpey, M. M., & Fridovich, I. (2001) · Circulation Research · doi:10.1161/hh1501.094365 · Cited by 552 · see citing works

Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Conaway, J. W., Klausner, R. D., & Pause, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12436 · Cited by 508 · see citing works

Suppression of tumor growth through disruption of hypoxia-inducible transcription

Kung, A. L., Wang, S., Klco, J. M., Kaelin, W. G., & Livingston, D. M. (2000) · Nature Medicine · doi:10.1038/82146 · Cited by 501 · see citing works

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

Freedman, S. J., Sun, Z., Poy, F., Kung, A. L., Livingston, D. M., Wagner, G., & Eck, M. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082117899 · Cited by 457 · see citing works

The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

Maranchie, J. K., Vasselli, J. R., Riss, J., Bonifacino, J. S., Linehan, W. M., & Klausner, R. D. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00044-2 · Cited by 433 · see citing works

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegansPreprint

Lum, D. H., Kuwabara, P. E., Zarkower, D. A., & Spence, A. M. (2000) · Genes & Development · doi:10.1101/gad.853700 · Cited by 392 · see citing works

Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro

Pan, Y., Mansfield, K. D., Bertozzi, C. C., Rudenko, V., Chan, D. A., Giaccia, A. J., & Simon, M. C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01223-06 · Cited by 332 · see citing works

Regulation of Hypoxia-inducible Factor-1α Protein Level during Hypoxic Conditions by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Pathway in HepG2 Cells

Mottet, D., Dumont, V., Deccache, Y., Demazy, C., Ninane, N., Raes, M. J., & Michiels, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300763200 · Cited by 316 · see citing works

Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing

Michelakis, E. D., Hampl, V., Nsair, A., Wu, X., Harry, G., Haromy, A., Gurtu, R., & Archer, S. L. (2002) · Circulation Research · doi:10.1161/01.res.0000024689.07590.c2 · Cited by 309 · see citing works

Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA

King, M. P., & Attardi, G. M. (1988) · Cell · doi:10.1016/0092-8674(88)90423-0 · Cited by 286 · see citing works

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

Schroedl, C., McClintock, D. S., Budinger, G. R. S., & Chandel, N. S. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00014.2002 · Cited by 266 · see citing works

Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling

Emerling, B. M., Platanias, L. C., Black, E. V. I., Nebreda, Á. R., Davis, R. J., & Chandel, N. S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.4853-4862.2005 · Cited by 257 · see citing works

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

O'Rourke, J. F., Tian, Y.-M., Ratcliffe, P. J., & Pugh, C. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2060 · Cited by 242 · see citing works

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

Fandrey, J., Frede, S., & JELKMANN, W. E. B. (1994) · Biochemical Journal · doi:10.1042/bj3030507 · Cited by 226 · see citing works

Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis

Semenza, G. L. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90091-9 · Cited by 203 · see citing works

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

Vaux, E. C., Metzen, E., Yeates, K. M., & Ratcliffe, P. J. (2001) · Blood · doi:10.1182/blood.v98.2.296 · Cited by 198 · see citing works

Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1

Hirota, K., & Semenza, G. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100677200 · Cited by 169 · see citing works

HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma

Turcotte, S., Desrosiers, R. R., & Béliveau, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00427 · Cited by 144 · see citing works

Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway

Srinivas, V., Leshchinsky, I., Sang, N., King, M. P., Minchenko, О. H., & Caro, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100177200 · Cited by 143 · see citing works

Molecular Oxygen Modulates Cytochrome c Oxidase Function

Chandel, N. S., Budinger, G. R. S., & Schumacker, P. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18672 · Cited by 139 · see citing works

A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF‐1α

Sanjuán-Pla, A., Cervera, A. M., Apostolova, N., Garcia-Bou, R., Víctor, V. M., Murphy, M. P., & McCreath, K. J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.088 · Cited by 134 · see citing works

Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis

Semenza, G. L. (1994) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30134-5 · Cited by 133 · see citing works

Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

Doege, K., Heine, S., Jensen, I., Jelkmann, W., & Metzen, E. (2005) · Blood · doi:10.1182/blood-2005-03-1138 · Cited by 128 · see citing works

Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

Adelman, D. M., Gertsenstein, M., Nagy, A., Simon, M. C., & Maltepe, E. (2000) · Genes & Development · doi:10.1101/gad.853700a · Cited by 128 · see citing works

Free radical production in hypoxic pulmonary artery smooth muscle cells

Killilea, D. W., Hester, R. B., Balczon, R., Babál, P., & Gillespie, M. N. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.2.l408 · Cited by 114 · see citing works

Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation

Wood, J. G., Johnson, J. S., Mattioli, L., & González, N. C. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1734 · Cited by 96 · see citing works

Hypoxic induction of hypoxia-inducible factor-1α and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells

Enomoto, N., Koshikawa, N., Gassmann, M., Hayashi, J., & Takenaga, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02186-1 · Cited by 48 · see citing works

Modulation of oxidative stress as an anticancer strategy

Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579 · see citing works

Redox regulation of cell survival

Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781 · see citing works

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272 · see citing works

Hypoxia, DNA repair and genetic instability

Bristow, R. G., & Hill, R. P. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2344 · Cited by 1,140 · see citing works

Regulation of hypoxia-inducible factor-1α by NF-κB

van Uden, P., Kenneth, N. S., & Rocha, S. (2008) · Biochemical Journal · doi:10.1042/bj20080476 · Cited by 729 · see citing works

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

Chiche, J., Brahimi-Horn, M. C., & Pouysségur, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00994.x · Cited by 671 · see citing works

The ever-expanding role of HIF in tumour and stromal biology

LaGory, E. L., & Giaccia, A. J. (2016) · Nature Cell Biology · doi:10.1038/ncb3330 · Cited by 432 · see citing works

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

Al‐Mehdi, A., Pastukh, V. M., Swiger, B. M., Reed, D., Patel, M., Bardwell, G. C., Pastukh, V. V., ALEXEYEV, M. F., & Gillespie, M. N. (2012) · Science Signaling · doi:10.1126/scisignal.2002712 · Cited by 386 · see citing works

Mechanistic investigations of the mitochondrial complex i inhibitor rotenone in the context of pharmacological and safety evaluation

Heinz, S., Freyberger, A., Lawrenz, B., Schladt, L., Schmuck, G., & Ellinger-Ziegelbauer, H. (2017) · Scientific Reports · doi:10.1038/srep45465 · Cited by 334 · see citing works

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

Favaro, E., Ramachandran, A., McCormick, R., Gee, H., Blancher, C., Crosby, M., Devlin, C., Blick, C., Buffa, F., Li, J.-L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010345 · Cited by 324 · see citing works

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆

Pathania, D., Millard, M., & Neamati, N. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.010 · Cited by 265 · see citing works

Turn me on: regulating HIF transcriptional activity

Lisy, K., & Peet, D. J. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402315 · Cited by 235 · see citing works

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

Iommarini, L., Porcelli, A. M., Gasparre, G., & Kurelac, I. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00286 · Cited by 231 · see citing works

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

Ebbesen, P., Pettersen, E. O., Gorr, T. A., Jobst, G., Williams, K. J., Kieninger, J., Wenger, R. H., Pastoreková, S., Dubois, L. J., Lambin, P., et al. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360902784425 · Cited by 220 · see citing works

Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1α Differentially in Cancer and Ischemia

Qutub, A. A., & Popel, A. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00060-08 · Cited by 190 · see citing works

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

Zhao, F., Mancuso, A., Bui, T. V., Tong, X., Gruber, J. J., Swider, C. R., Sanchez, P. V., Lum, J. J., Sayed, N., Melo, J. V., et al. (2010) · Oncogene · doi:10.1038/onc.2010.67 · Cited by 179 · see citing works

Hypoxia-inducible factors: key regulators of myeloid cells during inflammation

Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170 · see citing works

Hypoxia and hypoxia inducible factors in tumor metabolism

Zeng, W., Liu, P., Pan, W., Singh, S. R., & Wei, Y. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.01.032 · Cited by 170 · see citing works

Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function

Ushio‐Fukai, M., & Urao, N. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2582 · Cited by 142 · see citing works

Relationship between oxidative stress and HIF-1α mRNA during sustained hypoxia in humans

Pialoux, V., Mounier, R., Brown, A. D., Steinback, C. D., Rawling, J. M., & Poulin, M. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.10.047 · Cited by 137 · see citing works

Lipid Raft Redox Signaling: Molecular Mechanisms in Health and Disease

Jin, S., Zhou, F., Katirai, F., & Li, P. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3619 · Cited by 129 · see citing works

Src redox regulation: Again in the front line

Giannoni, E., Taddei, M. L., & Chiarugi, P. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.025 · Cited by 121 · see citing works

Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain

Chenna, S., Koopman, W. J. H., Prehn, J. H. M., & Connolly, N. M. C. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00455.2021 · Cited by 118 · see citing works

Low Oxygen Response Mechanisms in Green Organisms

Banti, V., Giuntoli, B., Gonzali, S., Loreti, E., Magneschi, L., Novi, G., Paparelli, E., Parlanti, S., Pucciariello, C., Santaniello, A., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034734 · Cited by 109 · see citing works

Multiple facets of anoxic metabolism and hydrogen production in the unicellular green alga Chlamydomonas reinhardtii

Grossman, A. R., Catalanotti, C., Yang, W., Dubini, A., Magneschi, L., Subramanian, V., Posewitz, M. C., & Seibert, M. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03534.x · Cited by 106 · see citing works

Hypoxia in the regulation of neural stem cells

Filippis, L. D., & Delia, D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0723-5 · Cited by 105 · see citing works

Mitigating hypoxic stress on pancreatic islets via in situ oxygen generating biomaterial

Coronel, M. M., Geusz, R. J., & Stabler, C. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.018 · Cited by 104 · see citing works

Mitochondria as targets for cancer therapy

Ralph, S. J., & Neužil, J. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800044 · Cited by 97 · see citing works

Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 96 · see citing works

Redox-Based Escape Mechanism from Death: The Cancer Lesson

Pani, G., Giannoni, E., Galeotti, T., & Chiarugi, P. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2739 · Cited by 89 · see citing works

A potential role for reactive oxygen species and the HIF-1α–VEGF pathway in hypoxia-induced pulmonary vascular leak

Irwin, D. C., McCord, J. M., Nozik‐Grayck, E., Beckly, G., Foreman, B., Sullivan, T., White, M., Crossno, J. T., Bailey, D. M., Flores, S. C., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.027 · Cited by 78 · see citing works

Redox and Reactive Oxygen Species Regulation of Mitochondrial Cytochrome c Oxidase Biogenesis

Bourens, M., Fontanesi, F., Soto, I. C., Liu, J., & Barrientos, A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4847 · Cited by 79 · see citing works

Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis

Galluzzo, M., Pennacchietti, S., Rosano, S., Comoglio, P. M., & Michieli, P. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36579 · Cited by 73 · see citing works

Redox Circuitries Driving Src Regulation

Giannoni, E., & Chiarugi, P. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5525 · Cited by 69 · see citing works

Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism

Pollard, P. J., Yang, M. H., Su, H., Soga, T., & Kranc, K. R. (2014) · Hypoxia · doi:10.2147/hp.s47968 · Cited by 65 · see citing works

Tumor Hypoxia Drives Genomic Instability

Tang, M., Bolderson, E., O'Byrne, K. J., & Richard, D. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.626229 · Cited by 63 · see citing works

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

Carvalho, C., Correia, S. C., Santos, R. X., Cardoso, S., Moreira, P. I., Clark, T. A., Zhu, X., Smith, M. A., & Perry, G. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9247-1 · Cited by 72 · see citing works

Redox control of chondrocyte differentiation and chondrogenesis

Bai, Y., Gong, X., Dou, C., Cao, Z., & Dong, S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.443 · Cited by 57 · see citing works

Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease

Li, P., & Zhang, Y. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1511-4_9 · Cited by 55 · see citing works

Tehranolide inhibits proliferation of MCF-7 human breast cancer cells by inducing G0/G1 arrest and apoptosis

Noori, S., & Hassan, Z. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.026 · Cited by 53 · see citing works

Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor

Mauchart, P., Vass, R. A., Nagy, B., Sulyok, E., Bódis, J., & Kovács, K. A. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45020083 · Cited by 51 · see citing works

Src Redox Regulation: There Is More Than Meets the Eye

Chiarugi, P. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)14004-0 · Cited by 49 · see citing works

Redox Control of Protein–DNA Interactions: From Molecular Mechanisms to Significance in Signal Transduction, Gene Expression, and DNA Replication

Shlomai, J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3029 · Cited by 47 · see citing works

Transcriptional Regulation of Yeast Oxidative Phosphorylation Hypoxic Genes by Oxidative Stress

Liu, J., & Barrientos, A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4589 · Cited by 46 · see citing works

Effect of antioxidants on preimplantation embryo developmentin vitro: a review

Zarbakhsh, S. (2021) · Zygote · doi:10.1017/s0967199420000660 · Cited by 47 · see citing works

Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy

Huang, M., Yang, L., Peng, X., Wei, S., Fan, Q., Yang, S., Li, X., Li, B., Jin, H., Wu, B., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01698-5 · Cited by 52 · see citing works

Hypoxia Inducible Factors as Central Players in the Pathogenesis and Pathophysiology of Cardiovascular Diseases

Garcia-Rojas, E. Y. L., Villanueva, C., & Bond, R. A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.709509 · Cited by 46 · see citing works

Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation

Yao, L., Zhu, X., Shan, Y., Zhang, L., Yao, J., & Xiong, H. (2024) · Small · doi:10.1002/smll.202310018 · Cited by 44 · see citing works

Characterization of complex III deficiency and liver dysfunction in GRACILE syndrome caused by a BCS1L mutation

Kotarsky, H., Karikoski, R., Mörgelin, M., Marjavaara, S. K., Bergman, P., Zhang, D., Smet, J., Coster, R. V., & Fellman, V. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.009 · Cited by 43 · see citing works

Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas

Lee, S.-S., Tsai, C., Yang, S., Ho, Y., & Chang, Y.-C. (2010) · Oral Diseases · doi:10.1111/j.1601-0825.2010.01680.x · Cited by 36 · see citing works

More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis

Takasaki, T., Hagihara, K., Satoh, R., & Sugiura, R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4397159 · Cited by 36 · see citing works

HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors

Xu, K., He, Z., Chen, M., Wang, N., Zhang, D., Yang, L., Xu, Z., & Xu, H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02768-4 · Cited by 34 · see citing works

Aged garlic extract and S-allylcysteine prevent apoptotic cell death in a chemical hypoxia model

Orozco‐Ibarra, M., Muñoz‐Sánchez, J., Zavala-Medina, M. E., Pineda, B., Magaña-Maldonado, R., Vázquez‐Contreras, E., Maldonado, P. D., Pedraza‐Chaverrí, J., & Chánez‐Cárdenas, M. E. (2016) · Biological Research · doi:10.1186/s40659-016-0067-6 · Cited by 32 · see citing works

Mitochondria-targeted antioxidant MitoQ radiosensitizes tumors by decreasing mitochondrial oxygen consumption

Rondeau, J. D., Lipari, S., Mathieu, B., Beckers, C., de Velde, J. A. V., Mignion, L., Morais, M., Kreuzer, M., Colauzzi, I., Capelôa, T., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02277-9 · Cited by 32 · see citing works

Factor Xa in Mouse Fibroblasts May Induce Fibrosis More Than Thrombin

Kitasato, L., Yamaoka‐Tojo, M., Hashikata, T., Ishii, S., Kameda, R., Shimohama, T., Tojo, T., & Ako, J. (2014) · International Heart Journal · doi:10.1536/ihj.13-351 · Cited by 29 · see citing works

Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory

Benoit, C.-É., Rowe, W. B., Ménard, C., Sarret, P., & Quirion, R. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.10.002 · Cited by 29 · see citing works

A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress

Jiang, W., Zhang, M., Gao, C., Yan, C., Gao, R., He, Z., Wei, X. L., Xiong, J., Ruan, Z.-L., Yang, Q., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023113743 · Cited by 30 · see citing works

Direct measurement of oxygen consumption rates from attached and unattached cells in a reversibly sealed, diffusionally isolated sample chamber

Strovas, T. J., McQuaide, S. C., Anderson, J. B., Nandakumar, V., Kalyuzhnaya, M., Burgess, L. W., Holl, M. R., Meldrum, D. R., & Lidstrom, M. E. (2010) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2010.15053 · Cited by 25 · see citing works

Role of Oxygen in Cancer: Looking Beyond Hypoxia

López‐Lázaro, M. (2009) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152009788451806 · Cited by 24 · see citing works

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia‐Ischemia in Neonatal Rat Brains

Bratek, E., Bronisz, A., Ziembowicz, A., & Salińska, E. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8848015 · Cited by 20 · see citing works

Hypoxic Hookup

Guarente, L. (2009) · Science · doi:10.1126/science.1175679 · Cited by 19 · see citing works

Intermittent hypobaric hypoxia applicability in myocardial infarction prevention and recovery

Sanchis‐Gomar, F., Viña, J., & Lippi, G. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01508.x · Cited by 18 · see citing works

Phytochemical analysis of Artemisia kopetdaghensis: Sesquiterpene lactones with proapoptotic activity against prostate cancer cells

Fattahian, M., Ghanadian, M., Zolfaghari, B., Aghaei, M., Zulfiqar, F., Khan, I. A., & Ali, Z. (2022) · Phytochemistry · doi:10.1016/j.phytochem.2022.113411 · Cited by 18 · see citing works

Hypoxia/Reoxygenation-Induced Mutations in Mammalian Cells Detected by the Flow Cytometry Mutation Assay and Characterized by Mutant Spectrum

Keysar, S. B., Trncic, N., LaRue, S. Μ., & Fox, M. H. (2009) · Radiation Research · doi:10.1667/rr1838.1 · Cited by 18 · see citing works

Targeting Mitochondrial ROS Production to Reverse the Epithelial-Mesenchymal Transition in Breast Cancer Cells

Monti, E., Mancini, A., Marras, E., & Gariboldi, M. B. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44110359 · Cited by 14 · see citing works

Characteristics of the transcription factor HIF-1α expression in the rat brain during the development of a depressive state and the antidepressive effects of hypoxic preconditioning

Baranova, K. A., Mironova, V. I., Rybnikova, E. A., & Самойлов, М. О. (2010) · Neurochemical Journal · doi:10.1134/s1819712410010071 · Cited by 13 · see citing works

In vitro, ex vivo and in vivo models: A comparative analysis of Paracoccidioides spp. proteomic studies

Parente-Rocha, J. A., Tomazett, M. V., Pigosso, L. L., Bailão, A. M., de Souza, A. F., Paccez, J. D., Baeza, L. C., Pereira, M., Bailão, M. G. S., Borges, C. L., et al. (2017) · Fungal Biology · doi:10.1016/j.funbio.2017.10.009 · Cited by 11 · see citing works

Lipopeptides in promoting signals at surface/interface of micelles: Their roles in repairing cellular and nuclear damages

Saâdi, S., Saari, N., Ghazali, H. M., Mohammed, A. S., Hamid, A. A., Nacer, N. E., & Anwar, F. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101522 · Cited by 7 · see citing works

The dynamics of HIF-1α expression in the rat brain at different stages of experimental posttraumatic stress disorder and its correction with moderate hypoxia

Baranova, K. A., Rybnikova, E. A., & Самойлов, М. О. (2017) · Neurochemical Journal · doi:10.1134/s1819712417020027 · Cited by 7 · see citing works

Insights into Algal Fermentation

Yang, W., Catalanotti, C., Posewitz, M. C., Alric, J., & Grossman, A. R. (2013) · Plant cell monographs · doi:10.1007/978-3-7091-1254-0_8 · Cited by 6 · see citing works

Intracellular Mechanisms of Oxygen Sensing

Vjotosh, A. N. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920010046 · Cited by 6 · see citing works

INTERACTION OF OXYGEN-SENSING MECHANISMS IN CELLS

Николаевич, В. А. (2019) · Ulyanovsk Medico-biological Journal · doi:10.34014/2227-1848-2019-3-52-62 · Cited by 5 · see citing works

A multiscale model of the role of microenvironmental factors in cell segregation and heterogeneity in breast cancer development

Romero-Arias, J. R., González-Castro, C. A., & Ramı́rez-Santiago, G. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011673 · Cited by 4 · see citing works

N-Substituted Indole-3-imine Derivatives and their Amine Congeners: Antioxidant and Src Kinase Inhibitory Effects

Kılıç, Z., Şener, F., Isgor, Y. G., Çoban, T., & Ölgen, S. (2010) · Zeitschrift für Naturforschung C - A Journal of Biosciences · doi:10.1515/znc-2010-5-606 · Cited by 3 · see citing works

Stem Cells, Hypoxia and Hypoxia-Inducible Factors

Watt, S. M., Tsaknakis, G., Forde, S. P., & Carpenter, L. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-227-8_18 · Cited by 4 · see citing works

HIF inhibition: Current strategies and clinical challenges

Więch-Walów, A., Bartoszewska, S., Barton, A., Czechowicz, P., Dudzik, J., Wielockx, B., Collawn, J. F., & Bartoszewski, R. (2026) · Redox biology · doi:10.1016/j.redox.2026.104220 · Cited by 3 · see citing works

Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia.

Barbakadze, T., Goloshvili, G., Narmania, N., Zhuravliova, E., & Mikeladze, D. (2017) · PubMed Central · doi:10.22074/cellj.2017.4546 · Cited by 3 · see citing works

Organ preservation solutions attenuate accumulation and nuclear translocation of hypoxia‐inducible factor‐1α in the hepatoma cell line HepG2

Paddenberg, R., Howold, N., Hoger, C., Janßen, H., Grau, V., & Kummer, W. (2009) · Cell Biochemistry and Function · doi:10.1002/cbf.1608 · Cited by 3 · see citing works

Oxygen-Dependent Adaptation Processes in a Human Organism in Normal Living Conditions and during Space Flight

Ларина, И. М., Buravkova, L. B., & Grigoriev, A. I. (2022) · Human Physiology · doi:10.1134/s0362119722070118 · Cited by 2 · see citing works

Avenaciolide Induces Apoptosis in Human Malignant Meningioma Cells through the Production of Reactive Oxygen Species

Katsuzawa, T., Kujirai, K., Kamisuki, S., & Shinoda, Y. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-01039 · Cited by 2 · see citing works

Mitochondria as Targets for Cancer Therapy

Ralph, S. J., & Neužil, J. (2008) · Springer eBooks · doi:10.1007/978-0-387-84835-8_12 · Cited by 2 · see citing works

The effect of mitoTEMPO on the development of hypoxia‐induced pulmonary hypertension in male mice

Zeidan, E. M., Nagarajan, S. A., Sydykov, A. S., Bier, J., Brosien, M., Taye, A., Pak, O., Ghofrani, H. A., SCHERMULY, R. T., Seeger, W., et al. (2026) · Physiological Reports · doi:10.14814/phy2.70804 · Cited by 1 · see citing works

REMOTE ISCHEMIC PRE- AND POSTCONDITIONING ABOLISHED DELAYED HIF-1a EXPRESSION IN THE RAT HIPPOCAMPUS ALONGSIDE WITH THE CORRECTION OF EXPERIMENTAL POST-TRAUMATIC STRESS DISORDER

Baranova, K. A., & Rybnikova, E. A. (2018) · Medical academic journal · doi:10.17816/maj18248-53 · Cited by 1 · see citing works

Regulation of Inflammatory Responses in Shock-Related Syndromes by Synthetic Oligopeptides and Steroids

van der Zee, M. (2010)

MATERNAL OBESITY AND OXIDATIVE STRESS IN THE FETUS: MECHANISMS UNDERLYING EARLY LIFE SHIFTS IN SKELETAL MUSCLE METABOLISM

Boyle, K. E., & Friedman, J. E. (2011) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539511000118

Gene Expression Signature and Molecular Mechanism of Redox Homeostasis in Colorectal CancerPreprint

Piran, M., Darayee, M., Piran, M., Sepahi, N., & Rahimi, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.28.920553

Sensitivity to and functional effects of tricyclic agents on glioma: an immunohistochemical and in vitro study

Peregrin, K. (2011) · UPT. Syiah Kuala University Library (Syiah Kuala University)

Microenvironmental factors in cell segregation and heterogeneity in breast cancer developmentPreprint

Romero-Arias, J. R., González-Castro, C. A., & Ramı́rez-Santiago, G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.01.470838

Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia

Lai, Y., Loy, F., Isola, M., Noli, R., Rinaldi, A. C., Lobina, C., Vargiu, R., Marincola, F. C., & Isola, R. (2023) · Biomedicines · doi:10.3390/biomedicines11123149

Regulation of Cytochrome C Oxidase Composition by Oxygen and Oxidative Stress

Liu, J. (2012)

Mitochondrial complex III regulates hypoxic activation of HIF

Klimova, T., & Chandel, N. S. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402307 · Cited by 433 · see citing works

Mitochondrial Regulation of Oxygen Sensing

Chandel, N. S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-60761-500-2_22 · Cited by 91 · see citing works

Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization

Celeste Simon, M. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-34817-9_15 · Cited by 97 · see citing works

Oxygen versus Reactive Oxygen in the Regulation of HIF-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">α</mml:mi></mml:mrow></mml:math>: The Balance Tips

Hagen, T. (2012) · Biochemistry Research International · doi:10.1155/2012/436981 · Cited by 100 · see citing works

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

Vaux, E. C., Metzen, E., Yeates, K. M., & Ratcliffe, P. J. (2001) · Blood · doi:10.1182/blood.v98.2.296 · Cited by 198 · see citing works