The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Necroptosis as an alternative form of programmed cell death
Open accessAbstract
Summary The family of death receptors plays a critical role in regulating cell number and eliminating harmful or virally infected cells. Agonistic stimulation of death receptors is known to lead two alternative cell fates by either activating NF-κB to promote cell survival or inducing apoptosis to lead to cell death; and now a third pathway, termed necroptosis or programmed necrosis has been identified. Interestingly, a death-domain containing kinase, RIP1, is involved in mediating all 3 pathways, with its kinase activity specifically involved in regulating necroptosis. The availability of necrostatin-1, a specific inhibitor of RIP1 kinase, made it possible to dissect the distinct functional domains of RIP1. Recent genome-wide siRNA screens have identified multiple players of necroptosis that may interact with and/or regulate RIP1 kinase and mediate the signaling pathway and execution of necroptosis. Necroptosis and necrostatins provide an exciting new opportunity for developing new treatments for multiple human diseases involving necrosis and inflammation.
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Cites
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
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Self-citationInduction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
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Identification of RIP1 kinase as a specific cellular target of necrostatins
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Self-citationRIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931
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Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation
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Cited by
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382
Crosstalk between apoptosis.; necrosis and autophagy
Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.001 · Cited by 1,366
“Binding of TNF α to TNFR1 leads to its internalization and the formation of a cytosolic death-inducingsignalingcomplex(DISC), alsoknown as complex II [24,31].”
BackgroundPlasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Cai, Z., Jitkaew, S., Zhao, J., Chiang, H.-C., Choksi, S., Liu, J., Ward, Y., Wu, L.-G., & Liu, Z.-G. (2014) · Nature Cell Biology · doi:10.1038/ncb2883 · Cited by 1,322
The development of the concept of ferroptosis
Hirschhorn, T., & Stockwell, B. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.043 · Cited by 1,052
Metadata
- Authors
- Christofferson, D. E., & Yuan, J.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 22
- Issue
- 2
- Pages
- 263-268
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2010766264
- Cited by
- 770
- References
- 9
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
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