PINK1/Parkin-mediated mitophagy in mammalian cells

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000298 · Cited by 2,944

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C. A., Sou, Y.-S., Saiki, S., Kawajiri, S., Sato, F., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910140 · Cited by 1,969

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., de Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911187107 · Cited by 1,616

Ubiquitin is phosphorylated by PINK1 to activate parkin

Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., et al. (2014) · Nature · doi:10.1038/nature13392 · Cited by 1,477

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008084 · Cited by 1,375

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Kane, L. A., Lazarou, M., Fogel, A. I., Li, Y., Yamano, K., Sarraf, S. A., Banerjee, S., & Youle, R. J. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201402104 · Cited by 1,298

The multifaceted roles of natural products in mitochondrial dysfunction

Chen, Q., Ruan, D., Shi, J., Du, D., & Bian, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1093038 · Cited by 39

Dietary Tributyrin Attenuates Intestinal Inflammation, Enhances Mitochondrial Function, and Induces Mitophagy in Piglets Challenged with Diquat

Wang, C., Cao, S., Zhang, Q., Shen, Z., Feng, J., Hong, Q., Lu, J., Xie, F., Peng, Y., & Hu, C. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b06208 · Cited by 37

VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions

Xie, J., Cui, Y., Chen, X., Yu, H., Chen, J., Huang, T., He, M., Zhang, L., & Meng, Q. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108640 · Cited by 36

Anthocyanin Extract from Purple Sweet Potato Exacerbate Mitophagy to Ameliorate Pyroptosis in Klebsiella pneumoniae Infection

Dong, G., Xu, N., Wang, M., Zhao, Y., Jiang, F., Bu, H., Liu, J., Yuan, B., & Li, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111422 · Cited by 36

The Role of Mitophagy in Viral Infection

Li, Y., Wu, K., Zeng, S., Zou, L., Li, X., Xu, C., Li, B., Liu, X., Li, Z., Zhu, W., et al. (2022) · Cells · doi:10.3390/cells11040711 · Cited by 35

Calcium/calmodulin‐dependent protein kinase regulates the PINK1/Parkin and DJ‐1 pathways of mitophagy during sepsis

Zhang, X., Yuan, D., Sun, Q., Xu, L., Lee, E. J., Lewis, A., Zuckerbraun, B. S., & Rosengart, M. R. (2017) · The FASEB Journal · doi:10.1096/fj.201601096rrr · Cited by 35

Testosterone ameliorates age-related brain mitochondrial dysfunction

Yan, W., Zhang, T., Kang, Y., Zhang, G., Ji, X., Feng, X., & Shi, G. (2021) · Aging · doi:10.18632/aging.203153 · Cited by 35

Positive regulation of human PINK1 and Parkin gene expression by nuclear respiratory factor 1

Lu, Y., Ding, W., Wang, B., Wang, L., Kan, H., Wang, X., Wang, D., & Zhu, L. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.12.002 · Cited by 34

PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling

Duan, T., Hu, T., Wu, C., Yeh, Y., Lu, J., Zhang, Q., Li, X., Jian, W., & Luo, P. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104857 · Cited by 35

Dual Role of Mitophagy in Cardiovascular Diseases

Li, Y., Meng, W., Hou, Y., Li, D., Wang, X., Wu, K., Sun, S., Liu, H., Li, X., Lin, F., et al. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001046 · Cited by 33

Hypoxia Inducible Factor-1α Is a Regulator of Autophagy in Osteoarthritic Chondrocytes

Lu, J., Peng, Y., Zou, J., Wang, J., Lu, S., Fu, T., Jiang, L., Zhang, C., & Zhang, J. (2021) · Cartilage · doi:10.1177/19476035211035434 · Cited by 35

MitoTEMPO protects against podocyte injury by inhibiting NLRP3 inflammasome via PINK1/Parkin pathway-mediated mitophagy

Liu, B., Wang, D., Cao, Y., Wu, J., Zhou, Y., Wu, W., Wu, J., Zhou, J., & Qiu, J. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175136 · Cited by 34

Mitochondria–Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1 ‐PD or PRKN ‐PD Neurons

Großmann, D., Malburg, N., Glaß, H., Weeren, V., Sondermann, V., Pfeiffer, J. F., Petters, J., Lukáš, J., Seibler, P., Klein, C., et al. (2023) · Movement Disorders · doi:10.1002/mds.29525 · Cited by 34

Hepatic autophagy and mitophagy status in dairy cows with subclinical and clinical ketosis

Shen, T., Xu, F., Fang, Z., Loor, J. J., Ouyang, H., Chen, M., Jin, B., Wang, X., Shi, Z., Zhu, Y., et al. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19150 · Cited by 34

A Peptide HEPFYGNEGALR from Apostichopus japonicus Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice

Zhu, Q., Zhuo, H., Yang, L., Ouyang, H., Chen, J., Liu, B., & Huang, H. (2022) · Molecules · doi:10.3390/molecules27185839 · Cited by 34

Oxidative phosphorylation mediated pathogenesis of Parkinson's disease and its implication via Akt signaling

Ali, M. Z., & Dholaniya, P. S. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105344 · Cited by 33

Shaping Up Mitochondria in Diabetic Nephropathy

Mise, K., Galvan, D. L., & Danesh, F. R. (2020) · Kidney360 · doi:10.34067/kid.0002352020 · Cited by 33

Baicalin mitigated IL‐1β‐Induced osteoarthritis chondrocytes damage through activating mitophagy

He, J., & He, J. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14215 · Cited by 33

Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy

Xin, R., Xu, Y., Long, D., Mao, G., Liao, H., Zhang, Z., & Kang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.911716 · Cited by 32

Chitosan-P407-PNIPAM hydrogel loaded with AgNPs/lipid complex for antibacterial, inflammation regulation and alveolar bone regeneration in periodontitis treatment

Zhang, C., Fei, Y., Li, M., Li, J., Tang, M., Wang, G., Li, J., Wang, Y., Ding, Y., Peng, C., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142080 · Cited by 34

Lanthanum chloride impairs spatial learning and memory by inducing [Ca2+]m overload, mitochondrial fission–fusion disorder and excessive mitophagy in hippocampal nerve cells of rats

Yu, M., Yang, J., Gao, X., Sun, W., Liu, S., Han, Y., Lu, X., Jin, C., Wu, S., & Cai, Y. (2020) · Metallomics · doi:10.1039/c9mt00291j · Cited by 32

Roles of microglial mitophagy in neurological disorders

Liu, Y., Wang, M., Hou, X., & Hu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.979869 · Cited by 31

Metformin-induced AMPK activation promotes cisplatin resistance through PINK1/Parkin dependent mitophagy in gastric cancer

Xiao, Y.-Y., Xiao, J.-X., Wang, X., Wang, T., Qu, X.-H., Jiang, L., Tou, F., Chen, Z., & Han, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.956190 · Cited by 32

Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms

Dong, Y. J., Zhuang, X., Wang, Y.-T., Tan, J., Feng, D., Li, M., Zhong, Q., Song, Z., Shen, H., Fang, E. F., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106835 · Cited by 36

Kaempferol induces mitochondrial dysfunction and mitophagy by activating the LKB1 / AMPK / MFF pathway in breast precancerous lesions

Cao, J., Ma, X., Yan, X., Zhang, G., Hong, S. K., Ma, R., Wang, Y., & Ma, M. (2023) · Phytotherapy Research · doi:10.1002/ptr.7838 · Cited by 33

The SATB1‐MIR22‐GBA axis mediates glucocerebroside accumulation inducing a cellular senescence‐like phenotype in dopaminergic neurons

Russo, T., Kolisnyk, B., Aswathy, B. S., Kim, T. W., Martin, J., Plessis‐Belair, J., Ni, J., Pearson, J. A., Park, E. J., Sher, R. B., et al. (2024) · Aging Cell · doi:10.1111/acel.14077 · Cited by 30

Metformin: From diabetes to cancer to prolongation of life

Sirtori, C. R., Castiglione, S., & Pavanello, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107367 · Cited by 38

Quercetin: A Promising Candidate for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Markowska, J., Kasprzak‐Drozd, K., Niziński, P., Dragan, M., Kondracka, A., Gondek, E., Oniszczuk, T., & Oniszczuk, A. (2024) · Molecules · doi:10.3390/molecules29225245 · Cited by 32

Defective lysosomal storage in Fabry disease modifies mitochondrial structure, metabolism and turnover in renal epithelial cells

Schumann, A., Schaller, K., Belche, V., Cybulla, M., Grünert, S. C., Moers, N., Sass, J. O., Kaech, A., Hannibal, L., & Spiekerkoetter, U. (2021) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12373 · Cited by 31

VDAC1 promotes cardiomyocyte autophagy in anoxia/reoxygenation injury via the PINK1/Parkin pathway

Yang, X., Zhou, Y., Liang, H., Meng, Y., Liu, H., Zhou, Y., Huang, C., An, B., Mao, H., & Liao, Z. (2021) · Cell Biology International · doi:10.1002/cbin.11583 · Cited by 30

Sesamol promotes browning of white adipocytes to ameliorate obesity by inducing mitochondrial biogenesis and inhibition mitophagy via β3-AR/PKA signaling pathway

Lin, C., Chen, J., Hu, M., Zheng, W., Song, Z., & Qin, H. (2021) · Food & Nutrition Research · doi:10.29219/fnr.v65.7577 · Cited by 32

Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease

Ito, M., Gurumani, M. Z., Merscher, S., & Fornoni, A. (2022) · Biomolecules · doi:10.3390/biom12030351 · Cited by 34

Mitochondrial regulatory mechanisms in spinal cord injury: A narrative review

Chengjiang, L., Liu, Y., Ma, B., Zhou, M., Zhao, X., Fu, X., Kan, S.-L., Hu, W., & Zhu, R. (2022) · Medicine · doi:10.1097/md.0000000000031930 · Cited by 31

Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination

Tan, T., Zimmermann, M., & Reichert, A. S. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0125 · Cited by 33

PINK1/Parkin-mediated mitophagy was activated against 1,4-Benzoquinone-induced apoptosis in HL-60 cells

Zhang, C., Yu, X., Gao, J., Zhang, Q., Sun, S., Zhu, H., Yang, X., & Yan, H. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.03.002 · Cited by 31

Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension

Pei, Y., Ren, D., Yin, Y., Shi, J., Ai, Q., Hao, W., Luo, X., Zhang, C., Zhao, Y., Bai, C., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.325156 · Cited by 31

Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Li, L., Yang, S., Lu, X., Zhang, Y., & Li, T. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.698601 · Cited by 31

FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy

Zhou, L., Su, W., Wang, Y., Zhang, Y., Xia, Z., & Lei, S. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15369 · Cited by 29

Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats

Liang, J.-H., Yu, H., Xia, C., Zheng, Y., Zhang, Z., Chen, Y., Raza, M. A., Wu, L. H., & Yan, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117006 · Cited by 30

Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors

Lee, J., Ham, S., Lee, M. H., Kim, S. J., Park, J. H., Lee, S. E., Chang, J. Y., Joung, K. H., Kim, T. Y., Kim, J., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv122 · Cited by 33

Exposure of zebrafish to a cold environment triggered cellular autophagy in zebrafish liver

Chen, H., Zhao, F., Chen, K., Guo, Y., Liang, Y., Zhao, H., & Chen, S. (2022) · Journal of Fish Diseases · doi:10.1111/jfd.13620 · Cited by 29

ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease

Thapa, R., Moglad, E. H. O., Afzal, M., Gupta, G., Bhat, A. A., Almalki, W. H., Kazmi, I. A., Alzarea, S. I., Pant, K., Ali, H., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102327 · Cited by 29

Corn peptides attenuate non-alcoholic fatty liver disease via PINK1/Parkin-mediated mitochondrial autophagy

Yao, Z., Li, X., Wang, W., Ren, P., Song, S., Wang, H., Xie, Y., Li, X., & Li, Z. (2023) · Food & Nutrition Research · doi:10.29219/fnr.v67.9547 · Cited by 28

Double-edged alliance: mitochondrial surveillance by the UPS and autophagy

Franz, A., Kevei, É., & Hoppe, T. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.08.004 · Cited by 29

Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Su, Y., Lin, H. L., Tu, Y., Wang, M., Zhang, G., Yang, J., Liu, H., & Su, Z. (2022) · Chemical Science · doi:10.1039/d1sc06722b · Cited by 28

Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health

Russo, C., Valle, M. S., Casabona, A., Spicuzza, L., Sambataro, G., & Malaguarnera, L. (2022) · Biomedicines · doi:10.3390/biomedicines10040898 · Cited by 32

Knockdown of miRNA-134-5p rescues dendritic deficits by promoting AMPK-mediated mitophagy in a mouse model of depression

Wang, G., Liu, Y., Zhu, X., Lin, K., Li, M., Wu, Z., Zhang, R., Zheng, Q., Li, D., & An, T. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109154 · Cited by 31

Serum starvation induces anti-apoptotic cIAP1 to promote mitophagy through ubiquitination

Mukhopadhyay, S., Naik, P. P., Panda, P. K., Sinha, N., Das, D. N., & Bhutia, S. K. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.143 · Cited by 28

Enhanced Mitophagy Activity in Prion-Infected Cultured Cells and Prion-Infected Experimental Mice via a Pink1/Parkin-Dependent Mitophagy Pathway

Gao, L., Xiao, K., Wu, Y.-Z., Chen, D., Yang, X., Shi, Q., & Dong, X. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00039 · Cited by 27

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease

Blondelle, J., Biju, A., & Lange, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217936 · Cited by 27

GPD1L inhibits renal cell carcinoma progression by regulating PINK1/Parkin‐mediated mitophagy

Liu, T., Zhu, H., Ge, M., Pan, Z., Zeng, Y., Leng, Y., Yang, K., & Fan, C. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17813 · Cited by 25

Molecular mechanisms of silver nanoparticle-induced neurotoxic injury and new perspectives for its neurotoxicity studies: A critical review

Yang, H., Niu, S., Guo, M., & Xue, Y. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124934 · Cited by 26

Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation

Liu, M., & Wu, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.819454 · Cited by 27

Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders

Yu, X., Sun, Y., Cai, Q., Zhao, X., Liu, Z., Xue, X., & Fu, J. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4766 · Cited by 25

Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress

Hou, S., Song, Y., Sun, D., Zhu, S., & Wang, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094506 · Cited by 25

The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology

Blume, L., & Meyer‐Schwesinger, C. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000432 · Cited by 26

PINK1/Parkin pathway-mediated mitophagy by AS-IV to explore the molecular mechanism of muscle cell damage

Li, L., Huang, T., Yang, J., Yang, P., Lan, H., Liang, J., Cai, D., Zhong, H., Jiao, W., & Song, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114533 · Cited by 24

Endometrial Aging and Reproductive Decline: The Central Role of Mitochondrial Dysfunction

Kobayashi, H., Nishio, M., Umetani, M., Shigetomi, H., Imanaka, S., & Hashimoto, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115060 · Cited by 28

Silicon-rhodamine-enabled identification for near-infrared light controlled proximity labeling in vitro and in vivo

Wang, W., Guo, H., Yan, X., Pan, X., Wang, X., Rong, Y., Bai, Z., Zhang, L., Wu, Z., Zhao, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63496-x · Cited by 29

Mitochondrial unfolded protein response gene CLPP changes mitochondrial dynamics and affects mitochondrial function

Wu, G., Xiong, Q., Wei, X., Wang, Y., Hu, X., He, G., Liu, L., Lai, Q., Dai, Z., Anushesh, D., et al. (2019) · PeerJ · doi:10.7717/peerj.7209 · Cited by 23

Inflammatory injury and mitophagy induced by Cr(VI) in chicken liver

Wang, Y., Hao, J., Zhang, S., Li, L., Wang, R., Zhu, Y., Liu, Y., & Liu, J. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08544-3 · Cited by 24

Mitophagy: A Novel Therapeutic Target for Treating DN

Yang, M., Li, C., Yang, S., Xiao, Y., Chen, W., Gao, P., Jiang, N., Xiong, S., Wei, L., Zhang, Q., et al. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666201006152656 · Cited by 26

Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication

Wang, X., Wang, M., Cai, M., Shao, R., Xia, G., & Zhao, W. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.009 · Cited by 24

E3 ubiquitin ligases and their therapeutic potential in disease Management

Madhukar, G., Haque, M. A., Khan, S., Kim, J.-J., & Danishuddin (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116875 · Cited by 26

CaMKIV regulates mitochondrial dynamics during sepsis

Zhang, X., Griepentrog, J. E., Zou, B., Xu, L., Cyr, A. R., Chambers, L., Zuckerbraun, B. S., Shiva, S., & Rosengart, M. R. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102286 · Cited by 23

Glioma cells are resistant to inflammation‑induced alterations of mitochondrial dynamics

Fan, W., Song, Y., Ren, Z., Cheng, X., Li, P., Song, H., & Jia, L. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5134 · Cited by 23

Cigarette smoke extract mediates cell premature senescence in chronic obstructive pulmonary disease patients by up-regulating USP7 to activate p300-p53/p21 pathway

Zeng, M., Zhang, X., Xing, W., Wang, Q., Liang, G.-B., & He, Z. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.01.017 · Cited by 23

PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity

Zhang, X., Du, J., Li, B., Huo, S., Zhang, J., Cui, Y., Song, M., Shao, B., & Li, Y. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113078 · Cited by 23

Mitochondrial-Dependent and Independent Functions of PINK1

Chen, X., Wang, Q., Li, S., Li, X., & Yang, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.954536 · Cited by 24

Oxidative Biomarkers Associated with the Pulmonary Manifestation of Post-COVID-19 Complications

Siekacz, K., Kumor‐Kisielewska, A., Miłkowska-Dymanowska, J., Pietrusińska, M., Bartczak, K. T., Majewski, S., Stańczyk, A., Piotrowski, W. J., & Białas, A. J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134253 · Cited by 25

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu, Z., Zhu, Y., Liu, W., Balasubramanian, B., Xu, X. L., Yao, J., & Lei, X. J. (2024) · Antioxidants · doi:10.3390/antiox13030352 · Cited by 26

Unexpected mitochondrial matrix localization of Parkinson's disease‐related DJ ‐1 mutants but not wild‐type DJ ‐1

Kojima, W., Kujuro, Y., Okatsu, K., Queliconi, B. B., Koyano, F., Kimura, M., Yamano, K., Tanaka, K., & Matsuda, N. (2016) · Genes to Cells · doi:10.1111/gtc.12382 · Cited by 22

Mitochondrial Bioenergetics, Redox Balance, and Calcium Homeostasis Dysfunction with Defective Ultrastructure and Quality Control in the Hippocampus of Aged Female C57BL/6J Mice

Torres, A. K., Jara, C., Llanquinao, J., Lira, M., Cortés-Díaz, D., & Tapia‐Rojas, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065476 · Cited by 25

MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease

Lin, M., Xian, H., Chen, Z., Wang, S., Liu, M., Liang, W., Tang, Q., Liu, Y., Huang, W., Che, D., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00314-x · Cited by 23

Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer

Sun, X., Ye, G., Li, J., Shou, H., Bai, G., & Zhang, J. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1457 · Cited by 22

Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1′10-phenanthroline-treated cells

Jo, D. S., Bae, D., Park, S. J., Seo, H. M., Kim, H. B., Oh, J. S., Chang, J. W., Kim, S., Shin, J.-W., & Cho, D. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.153 · Cited by 22

Apigenin attenuates myocardial infarction-induced cardiomyocyte injury by modulating Parkin-mediated mitochondrial autophagy

Wang, Z., Zhang, H., Liu, Z., Ma, Z., An, D., & Xu, D. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00047-0 · Cited by 22

Modulation of Autophagy: A Novel “Rejuvenation” Strategy for the Aging Liver

Xu, F., Tautenhahn, H., Dirsch, O., & Dahmen, U. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6611126 · Cited by 21

RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss

Li, J., Liu, C., Müller, U., & Zhao, B. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.08.011 · Cited by 23

Notch1 Protects against Ischemic-Reperfusion Injury by Suppressing PTEN-Pink1-Mediated Mitochondrial Dysfunction and Mitophagy

Xu, Q., Liu, S., Gong, Q., Zhu, R., Liu, J., Wu, Q., & Zhou, X. (2022) · Cells · doi:10.3390/cells12010137 · Cited by 21

MIR494 reduces renal cancer cell survival coinciding with increased lipid droplets and mitochondrial changes

Dutta, P., Haller, E. M., Sharp, A., & Nanjundan, M. (2016) · BMC Cancer · doi:10.1186/s12885-016-2053-3 · Cited by 22

Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells

Clementino, M., Kim, D., & Zhang, Z. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz032 · Cited by 21

PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity

Zhang, Y., Liu, Q., Li, Y., Li, C., Zhu, Y., Xia, F., Xu, S., & Li, W. (2019) · Medical Science Monitor · doi:10.12659/msm.918536 · Cited by 21

Deficiency of MIF Accentuates Overloaded Compression‐Induced Nucleus Pulposus Cell Oxidative Damage via Depressing Mitophagy

Wang, Y., Hu, Y., Wang, H., Liu, N., Luo, L., Zhao, C., Zhou, D., Tong, H., Li, P., & Zhou, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6192498 · Cited by 21

ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway

Dong, Y., Hu, M., Tan, K., & Dai, R. (2023) · Epigenetics · doi:10.1080/15592294.2023.2239592 · Cited by 20

Targeting the PINK1/Parkin pathway: A new perspective in the prevention and therapy of diabetic retinopathy

D’Amico, A. G., Maugeri, G., Magrì, B., Bucolo, C., & D’Agata, V. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110024 · Cited by 22

Ginsenoside Rg1 ameliorates cerebral ischemia-reperfusion injury by regulating Pink1/ Parkin-mediated mitochondrial autophagy and inhibiting microglia NLRP3 activation

Sui, C., Liu, Y., Jiang, J., Tang, J., Yu, L., & Lv, G. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111043 · Cited by 21

scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila

Yadav, A. K., & Srikrishna, S. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.01.006 · Cited by 19

Cyclosporine attenuates Paraquat-induced mitophagy and pulmonary fibrosis

Liu, K., Zhan, Z., Gao, W., Feng, J., & Xie, X. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1729176 · Cited by 20

l-Arginine Alleviates Hydrogen Peroxide–Induced Oxidative Damage in Ovine Intestinal Epithelial Cells by Regulating Apoptosis, Mitochondrial Function, and Autophagy

Zhang, H., Liu, X., Fan, Y., Yu, Y., Loor, J. J., Loor, J. J., Peng, A., & Wang, H. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa428 · Cited by 20

Mitophagy: An Emergence of New Player in Alzheimer’s Disease

Sharma, B., Pal, D., Sharma, U., & Kumar, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.921908 · Cited by 21

Activation of β2-adrenergic Receptor Ameliorates Amyloid-β-induced Mitophagy Defects and Tau Pathology in Mice

Chai, G., Wu, J., Gong, J., Zhou, J.-L., Jiang, Z.-Q., Yi, H., Gu, Y., Huang, H.-H., Yao, Z.-Y., Zhang, Y., et al. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.09.020 · Cited by 23

Formononetin Inhibits Hepatic I/R‐Induced Injury through Regulating PHB2/PINK1/Parkin Pathway

Ma, Z., Zhang, D., Sun, J., Zhang, Q., Qiao, Y., Zhu, Y., Niu, J., Ren, Q., Zhou, L., Wen, A., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6481192 · Cited by 21

The mechanism by which miR-494-3p regulates PGC1-α-mediated inhibition of mitophagy in cardiomyocytes and alleviation of myocardial ischemia—reperfusion injury

Mu, N., Zhang, T., Zhu, Y., Lu, B., Zheng, Q., & Duan, J. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03226-7 · Cited by 20

The potential role of hydrogen sulfide in regulating macrophage phenotypic changes via PINK1/parkin-mediated mitophagy in sepsis-related cardiorenal syndrome

Chen, Y., Cao, W., Li, B., Qiao, X., Wang, X., Yang, G., & Li, S. (2023) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2023.2281901 · Cited by 20

Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway

Gu, R., Bai, L., Yan, F., Zhang, S., Zhang, X., Deng, R., Zeng, X., Sun, B., Hu, X., Li, Y., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01848-0 · Cited by 23

Targeting NKAα1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis

Zhang, X., Li, G., Chen, H., Nie, X.-W., & Bian, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.002 · Cited by 22

Characterization of RING-Between-RING E3 Ubiquitin Transfer Mechanisms

Reiter, K. H., & Klevit, R. E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8706-1_1 · Cited by 21

Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients

Bordoni, M., Pansarasa, O., Scarian, E., Cristofani, R., Leone, R., Fantini, V., Garofalo, M., Diamanti, L., Bernuzzi, S., Gagliardi, S., et al. (2022) · Cells · doi:10.3390/cells11081272 · Cited by 19

Mitochondrial proteotoxicity: implications and ubiquitin-dependent quality control mechanisms

Karbowski, M., Oshima, Y., & Verhoeven, N. A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04604-8 · Cited by 21

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

Nguyen, T. N., Padman, B. S., & Lazarou, M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.008 · Cited by 758

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

Yamano, K., Matsuda, N., & Tanaka, K. (2016) · EMBO Reports · doi:10.15252/embr.201541486 · Cited by 253

Ubiquitin signaling in PINK1/Parkin-dependent mitophagy

Okatsu, K., & Fukai, S. (2025) · The Journal of Biochemistry · doi:10.1093/jb/mvaf079 · Cited by 20

PINK1 and Parkin: team players in stress-induced mitophagy

Bader, V., & Winklhofer, K. F. (2020) · Biological Chemistry · doi:10.1515/hsz-2020-0135 · Cited by 56

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis

Gegg, M. E., & Schapira, A. H. V. (2011) · Autophagy · doi:10.4161/auto.7.2.14332 · Cited by 106