The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
PINK1/Parkin-mediated mitophagy in mammalian cells
Abstract
Mitochondria-specific autophagy (mitophagy) is a fundamental process critical for maintaining mitochondrial fitness in a myriad of cell types. Particularly, mitophagy contributes to mitochondrial quality control by selectively eliminating dysfunctional mitochondria. In mammalian cells, the Ser/Thr kinase PINK1 and the E3 ubiquitin ligase Parkin act cooperatively in sensing mitochondrial functional state and marking damaged mitochondria for disposal via the autophagy pathway. Notably, ubiquitin and deubiquitinases play vital roles in modulating Parkin activity and mitophagy efficiency. In this review, we highlight recent breakthroughs addressing the key issues of how PINK1 activates Parkin in response to mitochondrial malfunction, how Parkin localizes specifically to impaired mitochondria, and how ubiquitination and deubiquitination regulate PINK1/Parkin-mediated mitophagy.
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“There are apparently several pathways to mitophagy [169,170], but the most important and the better understood one is the canonical PINK1/PARKIN pathway [171,172,173,174,175,176].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [173]
Citations
Cites
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Metadata
- Authors
- Eiyama, A., & Okamoto, K.
- Affiliations
- The University of Osaka (JP)
- Corresponding author
- Okamoto, Koji
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 33
- Pages
- 95-101
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2013642338
- Cited by
- 603
- References
- 61
- Citations by year
- 2026: 45 · 2025: 66 · 2024: 71 · 2023: 74 · 2022: 83 · 2021: 68 · 2020: 57 · 2019: 36 · 2018: 38 · 2017: 22 · 2016: 29 · 2015: 14
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25291045, 25650067)
- Ministry of Education, Culture, Sports, Science and Technology (26111513)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- mitophagy, PINK1, Parkin, mitochondrial quality control, mitochondrial dysfunction, ubiquitination, deubiquitination, E3 ubiquitin ligase, Ser/Thr kinase, mammalian cells
- MeSH terms
- PTEN-Induced Putative Kinase, Animals, Enzyme Activation, Humans, Mammals, Mitochondria, Phosphorylation, Protein Kinases, Ubiquitin, Ubiquitin-Protein Ligases, Ubiquitination, Mitophagy, Ubiquitin-Specific Proteases
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