The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Causes and consequences of micronuclei
Open accessAbstract
Micronuclei are small membrane-bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long been linked to chromosome instability, genome rearrangements, and mutagenesis. They are frequently found in cancers, during senescence, and after genotoxic stress. Compromised integrity of the micronuclear envelope delays or disrupts DNA replication, inhibits DNA repair, and exposes micronuclear DNA directly to cytoplasm. Micronuclei play a central role in tumorigenesis, with micronuclear DNA being a source of complex genome rearrangements (including chromothripsis) and promoting a cyclic GMP-AMP synthase (cGAS)-mediated cellular immune response that may contribute to cancer metastasis. Here, we discuss recent findings on how micronuclei are generated, what the consequences are, and what cellular mechanisms can be applied to protect against micronucleation.
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Cites
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Self-citationMitotic progression following DNA damage enables pattern recognition within micronuclei
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Cited by
Inflammation and DNA damage: cause, effect or both
Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212
Telomeric 8-Oxoguanine Drives Rapid Premature Senescence In The Absence Of Telomere Shortening
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Human dermal fibroblast senescence in response to single and recurring oxidative stress
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Metadata
- Authors
- Krupina, K., Goginashvili, A., & Cleveland, D. W.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 70
- Pages
- 91-99
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W3130960912
- Cited by
- 313
- References
- 75
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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