Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release
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Hu and coworkers developed mussel-inspired hydrogels based on chitosan quaternary ammonium salt (HTCC) and oxidized dextran-dopamine (OD-DA); the hydrogel was double-crosslinked by catechol-catechol adducts and Schiff base reaction between the aldehyde group in OD-DA and the amino group in HTCC; owing to the double-crosslinking, the hydrogel exhibited great mechanical properties.
“For example, Hu and coworkers developed mussel-inspired hydrogels based on chitosan quaternary ammonium salt (HTCC) and oxidized dextran–dopamine (OD-DA). The hydrogel was double-crosslinked by the catechol–catechol adducts and Schiff base reaction between the aldehyde group in OD-DA and the amino group in HTCC. Owing to the double-crosslinking, the hydrogel exhibited great mechanical properties [”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [73]
The healing of diabetic wounds is a significant challenge in clinical practice.
“The healing of diabetic wounds is a significant challenge in clinical practice [73].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [73]
Cites
Stimulus-responsive hydrogels: theory, modern advances, and applications
Koetting, M. C., Peters, J. T., Steichen, S. D., & Peppas, N. A. (2015) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2015.04.001 · Cited by 1,191 · see citing works
Gan, D., Xing, W., Jiang, L., Fang, J., Zhao, C., Ren, F., Fang, L., Wang, K., & Lu, X. (2019) · Nature Communications · doi:10.1038/s41467-019-09351-2 · Cited by 1,029 · see citing works
Gan, D., Wang, Z., Xie, C., Wang, X., Xing, W., Ge, X., Yuan, H., Wang, K., Tan, H., & Lu, X. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201901103 · Cited by 106 · see citing works
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Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing
Ni, Z., Yu, H., Wang, L., Huang, Y., Lu, H., Zhou, H., & Liu, Q. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c15686 · Cited by 137 · see citing works
Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“The hydrogel was double-crosslinked by the catechol–catechol adducts and Schiff base reaction between the aldehyde group in OD-DA and the amino group in HTCC. Owing to the double-crosslinking, the hydrogel exhibited great mechanical properties [73].”
BackgroundMethodInfluentialZhao, Y., Lu, W., Shen, S., & Wei, L. (2021) · Cellulose · doi:10.1007/s10570-021-04258-y · Cited by 11 · see citing works
- Authors
- Hu, C., Long, L., Cao, J., Zhang, S., & Wang, Y.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Wang, Yunbing
- Venue
- Chemical Engineering Journal
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 411
- Pages
- 128564
- ISSN
- 1385-8947 (ISSN-L)
- OpenAlex
- W3122301016
- Cited by
- 329
- References
- 3
- Citations by year
- 2026: 28 · 2025: 64 · 2024: 84 · 2023: 70 · 2022: 60 · 2021: 23
- FWCI
- 31.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Engineering Journal (publishedVersion)
- Funders
- Department of Science and Technology of Sichuan Province
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- mussel-inspired hydrogel, dual crosslinking, chronic diabetic wounds, infected wound healing, antibacterial hydrogel, angiogenesis, pH-responsive drug release, silver nanoparticles, deferoxamine, Schiff base crosslinking, quaternary ammonium chitosan, HIF-1α, vascular endothelial growth factor, Staphylococcus aureus, Escherichia coli
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