Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres
Wu, Ling, Multani, Asha S., He, Hua, Cosme-Blanco, Wilfredo, Deng, Yu, Deng, Jian Min, Bachilo, Olga, Pathak, Sen +5 more·2006·Cell
Cited by (422)
Items 201–300 of 422
- To Join or Not to Join: Decision Points Along the Pathway to Double-Strand Break Repair vs. Chromosome End ProtectionStephanie M. Ackerson, Carlan V. Romney, P. Logan Schuck, Jason A. Stewart · 2021 · Frontiers in Cell and Developmental Biology
- Telomere dysfunction in human diseases: the long and short of it!Kathryn A Carroll, Hinh Ly · 2009 · Europe PMC (PubMed Central)
- POT1‐independent single‐strand telomeric DNA binding activities in BrassicaceaeEugene V. Shakirov, Thomas D. McKnight, Dorothy E. Shippen · 2009 · The Plant Journal
- Dual roles of telomere dysfunction in initiation and suppression of tumorigenesisWilfredo Cosme‐Blanco, Sandy S. Chang · 2008 · Experimental Cell Research
- Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosisVlangos, Christopher N., O'Connor, Bridget C., Morley, Madeleine J., Krause, Andrea S., Osawa, Gail A., Keegan, Catherine E. · 2009 · Developmental Biology
- The Terminal Telomeric DNA Sequence Determines the Mechanism of Dysfunctional Telomere FusionBradley A. Stohr, Lifeng Xu, Elizabeth Helen Blackburn · 2010 · Molecular Cell
- Caenorhabditis elegans POT-1 and POT-2 Repress Telomere Maintenance PathwaysLudmila Shtessel, Mia Rochelle Lowden, Chen Cheng, Matt Simon, Kyle Wang, Shawn Cameron Ahmed · 2013 · G3 Genes Genomes Genetics
- Essential roles for Pot1b in HSC self-renewal and survivalYang Wang, Mei‐Feng Shen, Sandy S. Chang · 2011 · Blood
- Age-Related Changes in Subtelomeric Methylation in the Normal Japanese PopulationTakuya Maeda, J. Z. Guan, J.-i. Oyama, Yoshinori Higuchi, Naoki Makino · 2009 · The Journals of Gerontology Series A
- DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombeJayakrishnan Nandakumar, Thomas R. Cech · 2011 · Nucleic Acids Research
- Means to the ends: The role of telomeres and telomere processing machinery in metastasisNathaniel J Robinson, William P. Schiemann · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- G-quadruplex-mediated regulation of telomere binding protein POT1 gene expressionQingqing He, Ping Zeng, Jia‐Heng Tan, Tian‐Miao Ou, Lian‐Quan Gu, Zhi‐Shu Huang, Ding Li · 2014 · Biochimica et Biophysica Acta (BBA) - General Subjects
- ZNF365 Promotes Stability of Fragile Sites and TelomeresYuqing Zhang, Sandra Jean Shin, Debra Liu, Elena V. Ivanova, Friedrich Foerster, Haoqiang Ying, Hongwu Zheng, Yonghong Xiao, Zhengming Chen, Alexei I. Protopopov et al. · 2013 · Cancer Discovery
- The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouseEsra Gozde Kosebent, Fatma Uysal, Saffet Öztürk · 2020 · Experimental Gerontology
- Telomere Length Is Shorter in Affected Members of Families with Familial Nonmedullary Thyroid CancerMei He, Brent Bian, Krisana Gesuwan, Neelam Gulati, Lisa Zhang, Naris Nilubol, Electron Kebebew · 2012 · Thyroid
- Telomeric recombination induced by dysfunctional telomeresMarie Eve Brault, Chantal Autexier · 2010 · Molecular Biology of the Cell
- Essential role for the <scp>TRF</scp>2 telomere protein in adult skin homeostasisMartínez, Paula, Ferrara‐Romeo, Iole, Flores, Juana M., Blasco, Maria A. · 2014 · Aging Cell
- The role of recombination in telomere length maintenanceNicola J. Royle, Aarón Méndez-Bermúdez, Athanasia Gravani, Clara Lopes Novo, Jenny L Foxon, Jonathan P. Williams, Victoria E. Cotton, Alberto Hidalgo · 2009 · Biochemical Society Transactions
- Defending the end zone: Studying the players involved in protecting chromosome endsSuzanne Chan, Sandy S. Chang · 2010 · FEBS Letters
- Cellular senescence, telomere recombination and maintenanceQin Yang · 2008 · Cytogenetic and Genome Research
- Telomeric Repeat-Containing RNA (TERRA): A Review of the Literature and First Assessment in Cutaneous T-Cell LymphomasAlain Chebly, Joana Ropio, Lyla Baldasseroni, Martina Prochazkova‐Carlotti, Yamina Idrissi, Jacky Ferrer, Chantal Farra, Marie Beylot-Barry, Jean‐Philippe Merlio, Edith Chevret · 2022 · Genes
- Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic CellsHaritha Vallabhaneni, Fang Zhou, Robert W. Maul, Jaya Sarkar, Jinhu Yin, Ming Lei, Lea A. Harrington, Patricia J. Gearhart, Yie Liu · 2015 · Journal of Biological Chemistry
- Structural and functional association of androgen receptor with telomeres in prostate cancer cellsJunying Zhou, Michelle Richardson, Vidyavathi Reddy, Mani Menon, Evelyn R. Barrack, G. Prem‐Veer Reddy, Sahn‐Ho Kim · 2013 · Aging
- 53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage responsePaula Martínez, Juana María Flores, Marı́a A. Blasco · 2012 · The Journal of Cell Biology
- Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor‑promoting factors (Review)Zhengyi Wang, Xiaoying Wu · 2021 · Oncology Reports
- Human Telomere POT1-TPP1 Complex and Its Role in Telomerase Activity RegulationFeng Wang, Ming Lei · 2011 · Methods in molecular biology
- Telomerase recruitment to telomeresJosh Lewis Stern, Tracy M. Bryan · 2008 · Cytogenetic and Genome Research
- Bacterial quorum‐sensing signal IQS induces host cell apoptosis by targeting POT1–p53 signalling pathwayJianhe Wang, Chao Wang, Hong‐Bing Yu, Stephen Dela Ahator, Xiaoyan Wu, Shumei Lv, Lian‐Hui Zhang · 2019 · Cellular Microbiology
- DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcriptsHsiang-Ying Chen, Yueh‐Hsiang Yu, Pauline Hsiao Yen · 2013 · Nucleic Acids Research
- Tobacco GTBP1, a Homolog of Human Heterogeneous Nuclear Ribonucleoprotein, Protects Telomeres from Aberrant Homologous RecombinationYong Woo Lee, Woo Taek Kim · 2010 · The Plant Cell
- Clostridium difficile TcdC protein binds four-stranded G-quadruplex structuresHans C. van Leeuwen, Dennis Bakker, P.S. Steindel, Ed J. Kuijper, Jeroen Corver · 2013 · Nucleic Acids Research
- Cell cycle deregulation by methyl isocyanate: Implications in liver carcinogenesisHariom Panwar, Gorantla Venkata Raghuram, Deepika Kumari Jain, Alok K. Ahirwar, Saba Khan, Subodh Kumar Jain, Neelam Pathak, Smita Banerjee, Kewal Krishan MAUDAR, Pradyumna Kumar Mishra · 2012 · Environmental Toxicology
- TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangTapas Paul, Wilson Liou, Xinyi Cai, Patricia Lynn Opresko, Sua Myong · 2021 · Nucleic Acids Research
- The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertensionToyoki Maeda, Jun‐ichi Oyama, M. Sasaki, T. Arima, Naoki Makino · 2010 · The journal of nutrition health & aging
- The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage responseAlessandro Cicconi, Emanuela Micheli, Fiammetta Vernı̀, Alison Jackson, Ana‐Citlali Gradilla, Francesca Cipressa, Domenico Raimondo, Giuseppe Bosso, James G. Wakefield, Laura Ciapponi et al. · 2016 · Nucleic Acids Research
- The potential role of senescence in limiting fibrosis caused by agingXinghua Meng, Haoran Wang, Xiaopeng Song, Alancia Carol Clifton, Jianhua Xiao · 2019 · Journal of Cellular Physiology
- Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephalyAlessandro Cicconi, Rekha Rai, Xuexue Xiong, Cayla Broton, Amer Al-Hiyasat, Chunyi Hu, Siying Dong, Wenqi Sun, Jennifer M. Garbarino, Ranjit S. Bindra et al. · 2020 · Nature Communications
- The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN FunctionRekha Rai, Peili Gu, Cayla Broton, Chandan Kumar‐Sinha, Yong Chen, Sandy S. Chang · 2019 · Cell Reports
- Telomeres in Drag: dressing as DNA damage to engage telomeraseOfer Rog, Julia Promisel Cooper · 2008 · Current Opinion in Genetics & Development
- ssDNA fragments induce cell senescence by telomere uncappingTsolou, Avgi, Passos, João F., Nelson, Glyn, Arai, Yasumichi, Zglinicki, Thomas von · 2008 · Experimental Gerontology
- Shedding light into the relevance of telomeres in human reproduction and male factor infertility†Ana Catarina Lopes, Pedro Fontes Oliveira, Mário Sousa · 2018 · Biology of Reproduction
- Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaksKeiko Muraki, Limei Han, Douglas Miller, John P. Murnane · 2015 · Nucleic Acids Research
- PinX1: a sought-after major tumor suppressor at human chromosome 8p23Xiao Zhen Zhou · 2011 · Oncotarget
- The role of shelterin in maintaining telomere integrityMaria Pia Longhese · 2011 · Frontiers in bioscience
- Telomere maintenance and the DNA damage response: a paradoxical allianceAshley Harman, Tracy M. Bryan · 2024 · Frontiers in Cell and Developmental Biology
- Telomere sister chromatid exchange and the process of agingKrastan B. Blagoev, Edwin H. Goodwin, Susan M. Bailey · 2010 · Aging
- How homologous recombination maintains telomere integrityEliana MC Tacconi, Madalena Tarsounas · 2014 · Chromosoma
- Telomeres and telomerase in adrenocortical tissue maintenance, carcinogenesis, and agingTobias Else · 2009 · Journal of Molecular Endocrinology
- Telomere replication: poised but puzzlingShilpa Sampathi, Weihang Chai · 2010 · Journal of Cellular and Molecular Medicine
- The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to AgingShreya Deb, Joseph Berei, Edward Miliavski, Muhammad Jawad Khan, Taylor J. Broder, Thomas A. Akurugo, Cody Lund, Sara E. Fleming, Robert Hillwig, Joseph Ross et al. · 2024 · Cells
- POT1 deficiency alters telomere length and telomere-associated gene expression in human gastric cancer cellsXiaoyan Ning, Shiming Yang, Rongquan Wang, Rugang Zhang, Liping Guo, Jun Tie, Cheng Yongbo, Guoan Wang, Shunmei Wan, Dian-Chun Fang · 2010 · European Journal of Cancer Prevention
- CGGBP1 phosphorylation constitutes a telomere-protection signalUmashankar Singh, Varun Maturi, Rhiannon E. Jones, Ylva Paulsson, Duncan M. Baird, Bengt Westermark · 2013 · Cell Cycle
- Pot1a Prevents Telomere Dysfunction and ATM-Dependent Neuronal LossYoungsoo Lee, Eric J. Brown, Sandy S. Chang, Peter J. McKinnon · 2014 · Journal of Neuroscience
- Fission Yeast Pot1 and RecQ Helicase Are Required for Efficient Chromosome SegregationKatsunori Takahashi, Ryota Imano, Tatsuya Kibe, Hiroyuki Seimiya, Yukiko Muramatsu, Naoki Kawabata, Genki Tanaka, Yoshitake Matsumoto, Taisuke Hiromoto, Yuka Koizumi et al. · 2010 · Molecular and Cellular Biology
- Coordinated Interactions of Multiple POT1-TPP1 Proteins with Telomere DNAMark Corriveau, Michael R. Mullins, Diane Baus, Michael E. Harris, Derek J. Taylor · 2013 · Journal of Biological Chemistry
- Evolution of Arabidopsis protection of telomeres 1 alters nucleic acid recognition and telomerase regulationAmit Arora, Mark A. Beilstein, Dorothy E. Shippen · 2016 · Nucleic Acids Research
- Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of Trypanosoma bruceiBibo Li · 2021 · Frontiers in Cell and Developmental Biology
- Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesisElisa Gobbini, Camilla Trovesi, Corinne Cassani, Maria Pia Longhese · 2014 · Molecular & Cellular Oncology
- On BLM helicase in recombination-mediated telomere maintenanceSarallah Rezazadeh · 2012 · Molecular Biology Reports
- Tetrahymena Pot2 Is a Developmentally Regulated Paralog of Pot1 That Localizes to Chromosome Breakage Sites but Not to TelomeresStacey A. Cranert, Serena R. Heyse, Benjamin R. Linger, Rachel Lescasse, Carolyn Mary Price · 2014 · Eukaryotic Cell
- Genetic and Epigenetic Inheritance at TelomeresEvan H. Lister‐Shimauchi, Ben McCarthy, Michael J. Lippincott, Shawn Cameron Ahmed · 2022 · Epigenomes
- Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1Luana Spano, Cynthia Marie-claire A, Ophélia Godin, Apolline Lebras, Cindie Courtin, Jean Laplanche, Marion Leboyer, Bruno Aouizerate, Antoine Lefrere A, Raoul Belzeaux-R et al. · 2024 · Translational Psychiatry
- TRF2–RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM–DNA2-dependent 5′-end resectionFengshan Liang, Rekha Rai, Tori Sodeinde, Sandy S. Chang · 2024 · Nucleic Acids Research
- Evolutionary rates of mammalian telomere-stability genes correlate with karyotype features and female germline expressionChiara Pontremoli, Diego Forni, Rachele Cagliani, Uberto Pozzoli, Mario Clerici, Manuela Sironi · 2018 · Nucleic Acids Research
- Telomeric 3′ overhangs in chronic HBV‐related hepatitis and hepatocellular carcinomaJae‐Eun Lee, Bong‐Kyeong Oh, Jinsub Choi, Young Nyun Park · 2008 · International Journal of Cancer
- Telomere dynamics: the means to an endMaja Matulić, Mary Sopta, Ivica Rubelj · 2007 · Cell Proliferation
- Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging ResearchBaomin Li, Sonali P. Jog, José Candelario, S Reddy, Lucio Comai · 2009 · The Scientific World JOURNAL
- Telomerase-Dependent 3′ G-Strand Overhang Maintenance Facilitates GTBP1-Mediated Telomere Protection from Misplaced Homologous RecombinationYong Woo Lee, Woo Taek Kim · 2013 · The Plant Cell
- Suppression of hPOT1 in Diploid Human Cells Results in an hTERT-Dependent Alteration of Telomere Length DynamicsRichard Possemato, Jamie C. Timmons, Erica L. Bauerlein, Naoya Wada, Amy E. Baldwin, Kenkichi Masutomi, William C. Hahn · 2008 · Molecular Cancer Research
- Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stabilityRama Rao Damerla, Kelly E. Knickelbein, Devin Kepchia, Abbe Jackson, Bruce A. Armitage, Kristin A. Eckert, Patricia Lynn Opresko · 2010 · DNA repair
- Trf1 Is Not Required for Proliferation or Functional Telomere Maintenance in Chicken DT40 CellsCarol Cooley, Katie M. Baird, Virginie Faure, Thomas Wenner, Jillian L Stewart, Sonie Modino, Predrag Slijepčević, Christine J. Farr, Ciaran G. Morrison · 2009 · Molecular Biology of the Cell
- TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesisSherilyn Grill, Shilpa Padmanaban, Ann D. Friedman, Eric Perkey, Frederick Allen, Valerie M. Tesmer, Jennifer Chase, Rami N. Khoriaty, Catherine E. Keegan, Ivan P. Maillard et al. · 2021 · JCI Insight
- Pot1b −/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongationTaylor Takasugi, Peili Gu, Fengshan Liang, Isabelle Staco, Sandy S. Chang · 2023 · Nucleic Acids Research
- Telomerase regulation and the intimate relationship with agingGarrett Morgan · 2013 · Research and Reports in Biochemistry
- Introduction to Telomeres and TelomeraseZhou Songyang · 2011 · Methods in molecular biology
- Unusual suspects in hereditary melanoma: POT1, POLE, BAP1Ellie J. Maas, Brigid Betz‐Stablein, Lauren G. Aoude, H. Peter Soyer, Aideen M McInerney-Leo · 2022 · Trends in Genetics
- Roles of DNA Repair Proteins in Telomere MaintenanceMasaru Ueno · 2010 · Bioscience Biotechnology and Biochemistry
- Telomere Crisis Shapes Cancer EvolutionJoe Nassour, Jan Karlseder · 2025 · Cold Spring Harbor Perspectives in Biology
- Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated LeukemiaChristophe Nicot · 2015 · International Journal of Cancer and Oncology
- The role of telomere binding molecules for normal and abnormal hematopoiesisKentaro Hosokawa, Fumio Arai · 2018 · International Journal of Hematology
- Telomeres cooperate with the nuclear envelope to maintain genome stabilityRekha Rai, Tori Sodeinde, Ava Millicent Boston, Sandy S. Chang · 2023 · BioEssays
- Tethering Telomeric Double- and Single-stranded DNA-binding Proteins Inhibits Telomere ElongationKatherine T. Etheridge, Sarah A. Compton, Katharine S. Barrientos, Sezgin Özgür, Jack D. Griffith, Christopher M. Counter · 2008 · Journal of Biological Chemistry
- NSC746364, a G-Quadruplex-Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells Through Activation of the ATR/Chk1-Dependent PathwayYun-Lung Chung, Chun Pan, Wei-Hung Liou, Ming‐Jyh Sheu, Wen‐Hsin Lin, Tsung‐Chih Chen, Hsu‐Shan Huang, Chieh‐Hsi Wu · 2014 · Journal of Pharmacological Sciences
- Telomere Dynamics in MammalsDavid Carlos Silvestre, Arturo Londoño‐Vallejo · 2012 · Genome dynamics
- Guarding chromosomes from oxidative DNA damage to the very endRong Tan, Li Lan · 2016 · Acta Biochimica et Biophysica Sinica
- H2A.Z is essential for oocyte maturation and fertility in female mouseQianhua Xu, Chunyi Huang, Jia Ming, Xukun Lu, Ling Liu, Zhenhai Du, Zhen Chen, Jie Na, Guohong Li, Yunlong Xiang et al. · 2025 · Nature Structural & Molecular Biology
- Non-coding DNA – a brief reviewShanmugam Anandakumar, Nagarajan Arumugam, P. Shanmughavel · 2017 · Journal of Applied Biology & Biotechnology
- Expression of telomere binding proteins in gastric cancer and correlation with clinicopathological parametersJinbo Gao, Jinghui Zhang, Yaoping Long, Xiaoming Lu · 2011 · Asia-Pacific Journal of Clinical Oncology
- Uterine Sarcoma With a Novel WWOX-NTRK2 Fusion in a Postmenopausal Woman With Li-Fraumeni–Like Syndrome: A Case That Expands the Spectrum of NTRK-Rearranged Uterine TumorsMichelle Moh, Colin M. Johnson, Jennifer L. Geurts, Erin A. Bishop · 2021 · AJSP Review and Reports
- Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseasesMing Chen, Yiliang Zhang, Taylor Sterling Adams, Dingjue Ji, Wei Jiang, Louise V. Wain, Michael H. Cho, Naftali Kaminski, Hongyu Zhao · 2022 · Thorax
- The Physical Ability of Japanese Female Elderly with Cerebrovascular Disease Correlates with the Telomere Length and Subtelomeric Methylation Status in Their Peripheral Blood LeukocytesToyoki Maeda, Jun‐ichi Oyama, Yoshihiro Higuchi, Yasuhiro Nishiyama, Yoshihiro Kudo, Tomoko Yamori, Takashi Nakazono, Takahiro Arima, Koshi Mimori, Naoki Makino · 2010 · Gerontology
- POT of gold: modeling dyskeratosis congenita in the mouse: Figure 1.Chantal Autexier · 2008 · Genes & Development
- Ustilago maydis telomere protein Pot1 harbors an extra N-terminal OB fold and regulates homology-directed DNA repair factors in a dichotomous and context-dependent mannerSyed Zahid, Sarah Aloe, J. Sutherland, W. Holloman, N. Lue · 2022 · PLoS Genetics
- A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutationsPaula Martínez, Raúl Sánchez-Vazquez, Iole Ferrara‐Romeo, Rosa Serrano, Juana María Flores, Marı́a A. Blasco · 2022 · PLoS Genetics
- Molecular Diagnosis and Precision Therapeutic Approaches for Telomere Biology DisordersRosario Perona, Laura Iarriccio, Laura Pintado‐Berninches, Javier Rodríguez-Centeno, Cristina Manguán-García, Elena Garcia, Blanca D. López‐Ayllón, Leandro Sastre · 2016 · InTech eBooks
- Recent emergence and extinction of the protection of telomeres 1c gene in Arabidopsis thalianaCallie Kobayashi, Claudia Castillo-González, Yulia Survotseva, Elijah Canal, Andrew D. L. Nelson, Dorothy E. Shippen · 2019 · Plant Cell Reports
- The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular eventsToyoki Maeda, Jun‐ichi Oyama, Yoshihiro Higuchi, Masamichi Koyanagi, Makoto Sasaki, Takahiro Arima, Koshi Mimori, Naoki Makino · 2010 · The Aging Male
- Zebrafish as a Model System to Study the Physiological Function of Telomeric Protein TPP1Yiying Xie, Dong Yang, Quanyuan He, Zhou Songyang · 2011 · PLoS ONE
- The crosstalk between telomeres and DNA repair mechanisms: an overview to mammalian somatic cells, germ cells, and preimplantation embryosBetul Tire, Günel Talibova, Saffet Öztürk · 2024 · Journal of Assisted Reproduction and Genetics
- POT1 Regulates Proliferation and Confers Sexual Dimorphism in GliomaAli Jalali, Kwanha Yu, Vivek B. Beechar, Navish A. Bosquez Huerta, Anthony Grichuk, Deepika Mehra, Brittney Lozzi, Kathleen Kong, Kenneth L. Scott, Ganesh Rao et al. · 2021 · Cancer Research