Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres

Wu, Ling, Multani, Asha S., He, Hua, Cosme-Blanco, Wilfredo, Deng, Yu, Deng, Jian Min, Bachilo, Olga, Pathak, Sen +5 more·2006·Cell

DOI 10.1016/j.cell.2006.05.037

Cited by (422)

Items 301–400 of 422

Stirring the POT1: surprises in telomere protection
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POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang
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The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders
Toyoki Maeda, Jun‐ichi Oyama, Y. Higuchi, T. Arima, Koshi Mimori, Naoki Makino · 2010 · The journal of nutrition health & aging
Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development
Jusik Kim, Inseo Choi, Youngsoo Lee · 2017 · Histochemistry and Cell Biology
Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP)
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Interaction hub critical for telomerase recruitment and primer-template handling for catalysis
Shilpa Padmanaban, Valerie M. Tesmer, Jayakrishnan Nandakumar · 2023 · Life Science Alliance
The telomere protein tankyrase 1 regulates DNA damage responses at telomeres
Sandy S. Chang · 2010 · Aging
Telomeres and Double-Strand Breaks – All's Well that “Ends” Well. …
Susan M. Bailey · 2007 · Radiation Research
Expression of various protection of telomeres 1 variants is associated with telomere length and radiosensitivity in colon and gastric adenocarcinoma cells in vitro
HAN LEI, Fuxiang Zhou, Hui Xu, Xiaohong Peng, ZHI-GUO ZHANG, WEN-BO WANG, Haijun Yu, Conghua Xie, Yunfeng Zhou · 2015 · Biomedical Reports
Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy
Maria Fadri-Moskwik Qing Zhou · 2013 · Journal of Molecular and Genetic Medicine
Correction: Zebrafish as a Model System to Study the Physiological Function of Telomeric Protein TPP1
Yiying Xie, Dong Joo Yang, Quanyuan He, Zhou Songyang · 2011 · PLoS ONE
Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita
Adrián Sanz‐Moreno, Lore Becker, Kan Xie, Patricia da Silva‐Buttkus, Nathalia Romanelli Vicente Dragano, Juan Antonio Aguilar‐Pimentel, Oana Veronica Amarie, Julia Calzada‐Wack, Markus Kraiger, Stefanie Leuchtenberger et al. · 2025 · Science Advances
Shelterin complex at telomeres: Roles in cancers
Emad Khodadadi, Seyed Mostafa Mir, Mohammad Yousef Memar, Hossein Sadeghi, Meysam Kashiri, Mehri Faeghiniya, Zahra Jamalpoor, Mehdi Sheikh Arabi · 2021 · Gene Reports
Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion
Mónica Cabrero, Yiting Yu, Amit K. Verma, Hui Yang, Simona Colla, Yu Jia, Hong Zheng, Zach Bohannan, Irene Gañán‐Gómez, P. Andrew Futreal et al. · 2015 · British Journal of Haematology
Chaperones and Their Role in Telomerase Ribonucleoprotein Biogenesis and Telomere Maintenance
Maria Alejandra Viviescas, Maria Isabel Nogueira Cano, Marcela Segatto · 2018 · Current Proteomics
Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
Evan H. Lister‐Shimauchi, Michael Dinh, Paul S. Maddox, Shawn Cameron Ahmed · 2021 · Communications Biology
Telomere and Telomerase for the Regulation of Stem Cells
Eiso Hiyama, Keiko Hiyama · 2009 · Humana Press eBooks
To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?
Lakxmi Subramanian · 2010 · Frontiers in bioscience
Telomere Maintenance and Genome Stability
Wilnelly M. Hernandez-Sanchez, Mengyuan Xu, Derek J. Taylor · 2016 · Elsevier eBooks
Introduction to Telomeres and Telomerase
Zhou Songyang · 2017 · Methods in molecular biology
POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis
Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S. Stumpf et al. · 2023 · Communications Biology
Associations of measured and genetically predicted leukocyte telomere length with vascular phenotypes: a population-based study
Dan Liu, N. Ahmad Aziz, Mohammed Aslam Imtiaz, Gökhan Pehlivan, Monique M.B. Breteler · 2023 · GeroScience
Detection of Circular Telomeric DNA without 2D Gel Electrophoresis
Margit Dlaska, Conrad Anderl, Wolfgang Eisterer, Oliver Edgar Bechter · 2008 · DNA and Cell Biology
Chromosome ends teach unexpected lessons on DNA damage signalling
Sandy S. Chang · 2012 · The EMBO Journal
[ALT--alternative lengthening of telomere].
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Alternative Lengthening of Telomeres: The Need for ATRX Mutations Is Lineage-Dependent
Ion Udroiu, Antonella Sgura · 2025 · International Journal of Molecular Sciences
Expression of hPOT1 in HeLa Cells and the Probability of Gene Variation of hpot1 Exon14 in Endometrial Cancer are Much Higher than in Other Cancers
Fei Liu, Xiaoyun Pu, Shaoguang Huang, Guiming Xiang, Dongneng Jiang, Gou Hou, Huang Di-nan · 2012 · Asian Pacific Journal of Cancer Prevention
Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms
Javier Rodríguez-Centeno, Cristina Manguán-García, Rosario Perona, Leandro Sastre · 2019 · PLoS ONE
Murine Models of Dysfunctional Telomeres and Telomerase
Yie Liu, Lea A. Harrington · 2012 · Wiley eBooks
RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility
Anna‐Sophia Briod, Galina Glousker, Joachim Lingner · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells
Benura Azeroglu, Wei Wu, Raphael Pavani, Ranjodh Singh Sandhu, Tadahiko Matsumoto, André Nussenzweig, Eros Lazzerini Denchi · 2025 · eLife
Telomere Dynamics in Cardiovascular Aging: From Molecular Mechanisms to Precision Medicine
Abbas Mohammadi, Daniel Thomas Jones, Somayeh Mohammadi, Giv Heidari‐Bateni, William H. Frishman, Wilbert S. Aronow · 2025 · Cardiology in Review
The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes
Esra Gozde Kosebent, Saffet Öztürk · 2021 · Andrologia
Telomere Metabolism and DNA Damage Response
Tej Krishan Pandita · 2009 · Springer eBooks
Critical role of the POT1 OB domain in maintaining genomic stability
Tej Krishan Pandita · 2016 · Oncogene
Protection of telomeres 1 (POT1) of Pinus tabuliformis bound the telomere ssDNA
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Genome Conformity of In Vitro Cultures of Date Palm
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Telomere Binding Proteins and Disease
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Of wombats and whales: telomere tales in Madrid
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Telomere Dynamics in Zebrafish Aging and Disease
Miguel Godinho Ferreira · 2024 · Cold Spring Harbor Perspectives in Biology
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations
Raúl Sánchez-Vazquez, Sonia Burgaz García-Oteyza, Rosa Serrano, Juana María Flores, Paula Martínez, Marı́a A. Blasco · 2025 · Genes & Development
Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1
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Telomeres and Chromosome Stability
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TPP1 as a versatile player at the ends of chromosomes
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Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt
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Telomeres Shortening: A Mere Replicometer?
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Tocotrienol-Rich Fraction Supplementation Improves the Quality of Oocytes and Maintains Telomere Length in Ovaries from Aging Mice
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High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype
Ceren Sucularlı, Peedikayil E. Thomas, Hande Koçak, James S. White, Bridget C. O’Connor, Catherine E. Keegan · 2018 · Gene
Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe
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The Telomerase Complex: An Overview
Johanna Mancini, Chantal Autexier · 2012 · Wiley eBooks
Biochemical and structural analysis of shelterin subcomplexes
Oviya Inian · 2018
Telomere relocalization to the nuclear pore complex in response to replication stress
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Regulation and inhibition of pro-tumorigenic microenvironments
Oster Alspach · 2014 · Open Scholarship Institutional Repository (Washington University in St. Louis)
Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism
Sandy S. Chang · 2009 · Springer eBooks
Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae
Jennell Talley · 2011
Control of gene expression in prostate epithelial cell differentiation hierarchy
Jayant K. Rane · 2012 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Telomere Structure in Telomerase Regulation
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Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells
Benura Azeroglu, Wei Wu, Raphael Pavani, Ranjodh Singh Sandhu, Tadahiko Matsumoto, André Nussenzweig, Eros Lazzerini Denchi · 2025 · eLife
Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells
Benura Azeroglu, Wei Wu, Raphael Pavani, Ranjodh Singh Sandhu, Tadahiko Matsumoto, André Nussenzweig, Eros Lazzerini Denchi · 2025 · eLife