Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres

Wu, Ling, Multani, Asha S., He, Hua, Cosme-Blanco, Wilfredo, Deng, Yu, Deng, Jian Min, Bachilo, Olga, Pathak, Sen +5 more·2006·Cell

Cited by (422)

Items 101–200 of 422

  1. RecQ helicases in DNA double strand break repair and telomere maintenance
    Dharmendra Kumar Singh, Avik K. Ghosh, Deborah L. Croteau, Vilhelm A. Bohr · 2011 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
  2. Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance
    John R. Walker, Xu‐Dong Zhu · 2012 · Mechanisms of Ageing and Development
  3. Role of POT1 in Human Cancer
    Yangxiu Wu, Rebecca C. Poulos, Roger R. Reddel · 2020 · Cancers
  4. Pot1 and telomere maintenance
    Peter Baumann, Carolyn Mary Price · 2010 · FEBS Letters
  5. Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury
    Uryga, Anna K., Grootaert, Mandy O. J., Garrido, Abel M., Oc, Sebnem, Foote, Kirsty, Chappell, Joel, Finigan, Alison, Rossiello, Francesca, d’Adda di Fagagna, Fabrizio, Aravani, Dimitra et al. · 2021 · Communications Biology
  6. Functional characterization of human CTC 1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease C oats plus
    Peili Gu, Sandy S. Chang · 2013 · Aging Cell
  7. Telomere Recognition and Assembly Mechanism of Mammalian Shelterin
    Fabian Erdel, Katja Kratz, Smaranda Willcox, Jack D. Griffith, Eric C. Greene, Titia de Lange · 2017 · Cell Reports
  8. Heart-Breaking Telomeres
    Paula Martínez, Marı́a A. Blasco · 2018 · Circulation Research
  9. Telomeric Overhang Length Determines Structural Dynamics and Accessibility to Telomerase and ALT-Associated Proteins
    Helen H. Hwang, Alex Kreig, Jacob S. Calvert, Justin D Lormand, Yongho Kwon, James M. Daley, Patrick Sung, Patricia Lynn Opresko, Sua Myong · 2014 · Structure
  10. Pot1 and cell cycle progression cooperate in telomere length regulation
    Churikov, Dmitri, Price, Carolyn M · 2008 · Nature Structural & Molecular Biology
  11. DNA Repair at Telomeres: Keeping the Ends Intact
    C. J. Webb, Y. Wu, Virginia A. Zakian · 2013 · Cold Spring Harbor Perspectives in Biology
  12. Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres
    Caitlin M. Roake, Steven E. Artandi · 2017 · Cold Spring Harbor Perspectives in Medicine
  13. Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore
    Alexandra M. Pinzaru, Mike Kareh, Noa Lamm, Eros Lazzerini Denchi, Anthony J. Cesare, Agnel J. Sfeir · 2020 · Genes & Development
  14. Telomere Loops and Homologous Recombination-Dependent Telomeric Circles in a Kluyveromyces lactis Telomere Mutant Strain
    Anthony J. Cesare, Cindy Groff-Vindman, Sarah A. Compton, Michael J. McEachern, Jack D. Griffith · 2007 · Molecular and Cellular Biology
  15. Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN
    Nausica Arnoult, Carole Saintomé, Isabelle Ourliac‐Garnier, Jean‐François Riou, Arturo Londoño‐Vallejo · 2009 · Genes & Development
  16. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability
    Jin-Na Min, Yanyan Tian, Yang Ze Xiao, Ling Wu, Lei Li, Sandy S. Chang · 2013 · Cell Research
  17. Cancer chromosomes going to POT1
    Sandy S. Chang · 2013 · Nature Genetics
  18. Mir‐23a induces telomere dysfunction and cellular senescence by inhibiting TRF 2 expression
    Zhenhua Luo, Xuyang Feng, Haoli Wang, Weiyi Xu, Yong Bo Zhao, Wenbin Ma, Songshan Jiang, Dan Liu, Junjiu Huang, Zhou Songyang · 2015 · Aging Cell
  19. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA
    Jayakrishnan Nandakumar, Elaine R. Podell, Thomas R. Cech · 2009 · Proceedings of the National Academy of Sciences
  20. Genetic p53 Deficiency Partially Rescues the Adrenocortical Dysplasia Phenotype at the Expense of Increased Tumorigenesis
    Else, Tobias, Trovato, Alessia, Kim, Alex C., Wu, Yipin, Ferguson, David O., Kuick, Rork D., Lucas, Peter C., Hammer, Gary D. · 2009 · Cancer Cell
  21. The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1
    Richard J. Giannone, William Hayes McDonald, Gregory B. Hurst, Rong‐Fong Shen, Yisong Wang, Yie Liu · 2010 · PLoS ONE
  22. Distinct Roles of TRF1 in the Regulation of Telomere Structure and Lengthening
    Keiji Okamoto, Tomohiko Iwano, Makoto Tachibana, Yoichi Shinkai · 2008 · Journal of Biological Chemistry
  23. Similarities and differences between “uncapped” telomeres and DNA double-strand breaks
    James M. Dewar, David A. Lydall · 2011 · Chromosoma
  24. Telomere dysfunction and genome instability
    Cristina Frías-López · 2012 · Frontiers in bioscience
  25. Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes
    Ramon Velasquez Tiu, Lukasz P. Gondek, C. O'Keefe, Jaroslaw Pawel Maciejewski · 2007 · Leukemia
  26. The shelterin complex and hematopoiesis
    Morgan Jones, Kamlesh Kumar Bisht, Sharon A. Savage, Jayakrishnan Nandakumar, Catherine E. Keegan, Ivan P. Maillard · 2016 · Journal of Clinical Investigation
  27. Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis
    P Gu, Y Wang, Kamlesh Kumar Bisht, L Wu, Lidiya Kukova, Eric M. Smith, Y Xiao, Susan M. Bailey, Ming Lei, Jayakrishnan Nandakumar et al. · 2016 · Oncogene
  28. NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
    Rekha Rai, Chunyi Hu, Cayla Broton, Yong Chen, Ming Lei, Sandy S. Chang · 2017 · Molecular Cell
  29. Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes
    Sahn‐Ho Kim, Albert R. Davalos, Seok‐Jin Heo, Françis Rodier, Ying S. Zou, Christian M. Beausejour, Patrick G. Kaminker, Steven M. Yannone, Judith Campisi · 2008 · The Journal of Cell Biology
  30. Involvement of human ORC and TRF2 in pre‐replication complex assembly at telomeres
    Yasutoshi Tatsumi, Kai Ezura, Kazumasa Yoshida, Takashi Yugawa, Mako Narisawa‐Saito, Tohru Kiyono, Satoshi Ohta, Chikashi Obuse, Masatoshi Fujita · 2008 · Genes to Cells
  31. Telomeric armor: the layers of end protection
    Liana Oganesian, Jan Karlseder · 2009 · Journal of Cell Science
  32. Give me a break: How telomeres suppress the DNA damage response
    Eros Lazzerini Denchi · 2009 · DNA repair
  33. The end protection problem—an unexpected twist in the tail
    Ruis, Phil, Boulton, Simon J. · 2021 · Genes & Development
  34. POT1-TPP1 telomere length regulation and disease
    Tomas M. Aramburu, Sarah M. Plucinsky, Emmanuel Skordalakes · 2020 · Computational and Structural Biotechnology Journal
  35. Induction of telomere‐mediated chromosomal truncation and stability of truncated chromosomes in Arabidopsis thaliana
    Chee How Teo, Lu Ma, Eszter Kapusi, Göetz Hensel, Jochen Kumlehn, Ingo A. Schubert, Andreas Houben, Michael Florian Mette · 2011 · The Plant Journal
  36. Composition of plant telomeres
    Barbara Zellinger, Karel Říha · 2007 · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
  37. Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells
    Hyeung Kim, Feng Li, Quanyuan He, Tingting Deng, Jun Qiang Xu, Feng Jin, Cristian Coarfa, Nagireddy Putluri, Dan Liu, Zhou Songyang · 2017 · Cell Discovery
  38. Taming the tiger by the tail: modulation of DNA damage responses by telomeres
    David A. Lydall · 2009 · The EMBO Journal
  39. Telomere function and regulation from mouse models to human ageing and disease
    Corey Winston Jones-Weinert, Laura Mainz, Jan Karlseder · 2024 · Nature Reviews Molecular Cell Biology
  40. Hyper telomere recombination accelerates replicative senescence and may promote premature aging
    Robert Tanner Hagelstrom, Krastan B. Blagoev, Laura J. Niedernhofer, Edwin H. Goodwin, Susan M. Bailey · 2010 · Proceedings of the National Academy of Sciences
  41. Tetrahymena POT1a Regulates Telomere Length and Prevents Activation of a Cell CycleCheckpoint
    Naduparambil Korah Jacob, Rachel Lescasse, Benjamin R. Linger, Carolyn Mary Price · 2006 · Molecular and Cellular Biology
  42. Telomere and Telomerase as Targets for Cancer Therapy
    Xiaoping Tian, Bo Chen, Xiaochuan Liu · 2009 · Applied Biochemistry and Biotechnology
  43. Telomerase inhibitors and ‘T-oligo’ as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity
    Andrew M. Rankin, Douglas V. Faller, Remco A. Spanjaard · 2008 · Anti-Cancer Drugs
  44. Human shelterin protein POT1 prevents severe telomere instability induced by homology‐directed DNA repair
    Glousker, Galina, Briod, Anna‐Sophia, Quadroni, Manfredo, Lingner, Joachim · 2020 · The EMBO Journal
  45. Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome
    Andrew J. Ramsay, Alejandra Martínez‐Trillos, Pedro Jares, David Rodrı́guez, Agnieszka Kwarciak, Vı́ctor Quesada · 2012 · Clinical & Translational Oncology
  46. p16INK4a protects against dysfunctional telomere–induced ATR-dependent DNA damage responses
    Yang Wang, Norman E. Sharpless, Sandy S. Chang · 2013 · Journal of Clinical Investigation
  47. Human POT1 protects the telomeric ds-ss DNA junction by capping the 5′ end of the chromosome
    Valerie M. Tesmer, Kirsten Ann Brenner, Jayakrishnan Nandakumar · 2023 · Science
  48. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death
    Laurent Gauthier, Christine Granotier-Beckers, Françoise Hoffschir, Olivier Etienne, Ali Ayouaz, Chantal Desmaze, Patrick Mailliet, Denis S.F. Biard, François Dominique Boussin · 2011 · Cellular and Molecular Life Sciences
  49. Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere Elongation
    Christina Soohoo, Rong Shi, Tae Ho Lee, Pengyu Huang, Kun Ping Lu, Xiao Zhen Zhou · 2010 · Journal of Biological Chemistry
  50. CST–Polα/Primase: the second telomere maintenance machine
    Sarah W. Cai, T. de Lange · 2023 · Genes & Development
  51. Non-canonical roles of canonical telomere binding proteins in cancers
    Semih Can Akıncılar, Claire Hian Tzer Chan, Qin Feng Ng, Kerem Fidan, Vinay Tergaonkar · 2021 · Cellular and Molecular Life Sciences
  52. Shelterin is a dimeric complex with extensive structural heterogeneity
    Zinder, John C., Olinares, Paul Dominic B., Svetlov, Vladimir, Bush, Martin W., Nudler, Evgeny, Chait, Brian T., Walz, Thomas, de Lange, Titia · 2022 · Proceedings of the National Academy of Sciences
  53. Protection against chromosome degradation at the telomeres
    Nathalie Grandin, Michel Charbonneau · 2007 · Biochimie
  54. Survival and Growth of Yeast without Telomere Capping by Cdc13 in the Absence of Sgs1, Exo1, and Rad9
    Hien-Ping Ngo, David A. Lydall · 2010 · PLoS Genetics
  55. No Overt Nucleosome Eviction at Deprotected Telomeres
    Peng V. Wu, Titia de Lange · 2008 · Molecular and Cellular Biology
  56. Multiple POT1–TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA
    Derek J. Taylor, Elaine R. Podell, Dylan J. Taatjes, Thomas R. Cech · 2011 · Journal of Molecular Biology
  57. If the cap fits, wear it: an overview of telomeric structures over evolution
    Nick Fulcher, Elisa Derboven, Sona Bukovcakova Valuchova, Karel Říha · 2013 · Cellular and Molecular Life Sciences
  58. Plant chromosomes from end to end: telomeres, heterochromatin and centromeres
    J LAMB, Weichang Yu, F HAN, James A. Birchler · 2007 · Current Opinion in Plant Biology
  59. Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair
    Douglas L. Miller, Gloria E. Reynolds, Ricardo Mejı́a, Jeremy M. Stark, John P. Murnane · 2011 · DNA repair
  60. The telomeric transcriptome and SMG proteins at the crossroads
    Raghav Chawla, Claus M. Azzalin · 2008 · Cytogenetic and Genome Research
  61. Telomere dysfunction implicates POT1 in patients with idiopathic pulmonary fibrosis
    Joseph M. Kelich, Tomas M. Aramburu, Joanne J. van der Vis, Louise C. Showe, Andrew V. Kossenkov, Jasper J. van der Smagt, Maarten P.G. Massink, Angela E. Schoemaker, Eric A. M. Hennekam, Marcel Veltkamp et al. · 2022 · The Journal of Experimental Medicine
  62. The evolution of metazoan shelterin
    Logan R. Myler, Charles G. Kinzig, N. Sasi, George Zakusilo, Sarah W. Cai, T. de Lange · 2021 · Genes & Development
  63. Functional Diversity of Human Protection of Telomeres 1 Isoforms in Telomere Protection and Cellular Senescence
    Qin Yang, Ran Zhang, Izumi Horikawa, Kaori Fujita, Yalda Afshar, Antti Kokko, Päivi Laiho, Lauri A. Aaltonen, Curtis C. Harris · 2007 · Cancer Research
  64. Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell
    Petra Procházková Schrumpfová, Šárka Schořová, Jiřı́ Fajkus · 2016 · Frontiers in Plant Science
  65. Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
    Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer, Jayakrishnan Nandakumar, Yong Chen, Sandy S. Chang · 2021 · Nature Communications
  66. Role of telomeres in vascular senescence
    Tohru Minamino · 2007 · Frontiers in bioscience
  67. Distinct Functions of POT1 at Telomeres
    Katharine S. Barrientos, Megan F. Kendellen, Brian D. Freibaum, Blaine N. Armbruster, Katherine T. Etheridge, Christopher M. Counter · 2008 · Molecular and Cellular Biology
  68. Telomeres as hotspots for innate immunity and inflammation
    Joe Nassour, Sara Przetocka, Jan Karlseder · 2023 · DNA repair
  69. Senescence; an endogenous anticancer mechanism.
    J. Vargas, B. C. Feltes, J. de Faria Poloni, G. Lenz, D. Bonatto · 2012 · Frontiers in Bioscience
  70. Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis
    Esra A. Akbay, Christopher G. Peña, Dennis Ruder, Jan Michel, Yuji Nakada, Sen Pathak, Asha S. Multani, Sandy S. Chang, Diego H. Castrillón · 2012 · Oncogene
  71. Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
    Shiaw‐Yih Lin, Yulong Liang, Kaiyi Li · 2010 · Yonsei Medical Journal
  72. Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening
    Fatma Uysal, Esra Gozde Kosebent, Havva Serap Toru, Saffet Öztürk · 2020 · Journal of Assisted Reproduction and Genetics
  73. Tpp1/Acd maintains genomic stability through a complex role in telomere protection
    Tobias Else, Brian K. Theisen, Yipin Wu, Janna Hutz, Catherine E. Keegan, Gary Douglas Hammer, David O. Ferguson · 2007 · Chromosome Research
  74. Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres
    Peili Gu, Wei Wen Deng, Ming Lei, Sandy S. Chang · 2013 · Cell Research
  75. Impact of Gln94Glu mutation on the structure and function of protection of telomere 1, a cause of cutaneous familial melanoma
    Mohd. Amir, Shahnawaz Ahmad, Shahzaib Ahamad, Vijay Kumar, Taj Mohammad, Ravins Dohare, Mohamed Fahad Alajmi, Md Tabish Rehman, Afzal Hussain, Asimul Islam et al. · 2019 · Journal of Biomolecular Structure and Dynamics
  76. Telomeres and Cancer
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  77. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells
    Kumiko Anno, Akane Hayashi, Tomoko Takahashi, Youji Mitsui, Toshinori Ide, Hidetoshi Tahara · 2006 · Biochemical and Biophysical Research Communications
  78. Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein–Protein Interaction
    Mark A. Beilstein, Kyle B. Renfrew, Xiangyu Song, Eugene V. Shakirov, Michael J. Zanis, Dorothy E. Shippen · 2015 · Molecular Biology and Evolution
  79. Dysfunctional telomeres induce p53‐dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation
    Yang Wang, Xinwei Wang, Elsa Renee Flores, Jian Yu, Sandy S. Chang · 2016 · Aging Cell
  80. Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle
    Christopher W. Pitt, Julia Promisel Cooper · 2010 · Nucleic Acids Research
  81. Telomere Profiling: Toward Glioblastoma Personalized Medicine
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  82. Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
    Gregory A. Sowd, Ming Lei, Patricia Lynn Opresko · 2008 · Nucleic Acids Research
  83. Telomere protein complexes and interactions with telomerase in telomere maintenance
    Alexander Ruvantha Pinto · 2010 · Frontiers in bioscience
  84. The Connection Between Cell Fate and Telomere
    Ayşe Başak Engin, Atilla Engin · 2021 · Advances in experimental medicine and biology
  85. POT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNA
    Eugene V. Shakirov, Xiangyu Song, Jessica A. Joseph, Dorothy E. Shippen · 2009 · Nucleic Acids Research
  86. Protection of Telomeres 1 Is Required for Telomere Integrity in the Moss Physcomitrella patens
    Eugene V. Shakirov, Pierre‐François Perroud, Andrew D. L. Nelson, Maren E. Cannell, Ralph S. Quatrano, Dorothy E. Shippen · 2010 · The Plant Cell
  87. Taking apart Rap1
    Shaheen Kabir, Agnel J. Sfeir, Titia de Lange · 2010 · Cell Cycle
  88. Telomeres at a glance
    Agnel J. Sfeir · 2012 · Journal of Cell Science
  89. Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons
    Anastasia Lobanova, Robert She, Simon Pieraut, Charlie Clapp, Anton Maximov, Eros Lazzerini Denchi · 2017 · Genes & Development
  90. FANCC suppresses short telomere-initiated telomere sister chromatid exchange
    David B. Rhee, Yisong Wang, Melissa C. Mizesko, Fang Zhou, Laura S. Haneline, Yie Liu · 2009 · Human Molecular Genetics
  91. The structural biology of the shelterin complex
    Yong Chen · 2018 · Biological Chemistry
  92. Investigation of conformational dynamics of Tyr89Cys mutation in protection of telomeres 1 gene associated with familial melanoma
    Mohd. Amir, Shahzaib Ahamad, Taj Mohammad, Deeba Shamim Jairajpuri, Gulam Mustafa Hasan, Ravins Dohare, Asimul Islam, Faizan Ahmad, Md. Imtaiyaz Hassan · 2019 · Journal of Biomolecular Structure and Dynamics
  93. MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence
    Tingting Li, Zhenhua Luo, Lin Song, Chujun Li, Shenkun Dai, Haoli Wang, Junjiu Huang, Wenbin Ma, Zhou Songyang, Yan Y. Huang · 2020 · Aging
  94. RPA and POT1
    Rachel Litman Flynn, Sandy S. Chang, Lee Zou · 2012 · Cell Cycle
  95. Telomere length maintenance – an ALTernative mechanism
    Nicola J. Royle, Jenny L Foxon, Jennie N. Jeyapalan, Aarón Méndez-Bermúdez, Clara Lopes Novo, Jonathan P. Williams, Victoria E. Cotton · 2008 · Cytogenetic and Genome Research
  96. The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line
    Keiko Muraki, Limei Han, Douglas Miller, John P. Murnane · 2013 · PLoS Genetics
  97. WRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation
    April Renee Sandy Gocha, Samir Acharya, Joanna Louise Groden · 2014 · PLoS ONE
  98. Nonspecific Recognition Is Achieved in Pot1pC through the Use of Multiple Binding Modes
    Thayne H. Dickey, Marissa A. McKercher, Deborah S. Wuttke · 2012 · Structure
  99. The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
    Kentaro Hosokawa, Ben D. MacArthur, Yoshiko Matsumoto Ikushima, Hirofumi Toyama, Yoshikazu Masuhiro, Shigemasa Hanazawa, Toshio Suda, Fumio Arai · 2017 · Nature Communications
  100. Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding
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