Mind the GAP: Wnt Steps onto the mTORC1 Train

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666 · see citing works

Ras, PI(3)K and mTOR signalling controls tumour cell growth

Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019 · see citing works

Phosphorylation and Functional Inactivation of TSC2 by Erk

Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P., & Pandolfi, P. P. (2005) · Cell · doi:10.1016/j.cell.2005.02.031 · Cited by 1,268 · see citing works

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

Zeng, X., Tamai, K., Doble, B. W., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. R., & He, X. (2005) · Nature · doi:10.1038/nature04185 · Cited by 849 · see citing works

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600633 · Cited by 594 · see citing works

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

Hahn-Windgassen, A., Nogueira, V., Chen, C.-C., Skeen, J. E., Sonenberg, N., & Hay, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502876200 · Cited by 539 · see citing works

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Cai, S.-L., Tee, A. R., Short, J. D., Bergeron, J. M., Kim, J., Shen, J., Guo, R., Johnson, C. L., Kiguchi, K., & Walker, C. L. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200507119 · Cited by 359 · see citing works

Tuberous Sclerosis: from Tubers to mTOR

Kwiatkowski, D. J. (2003) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2003.00012.x · Cited by 340 · see citing works

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

Patel, S., Doble, B. W., & Woodgett, J. R. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320803 · Cited by 153 · see citing works

Aberrant β-Catenin Signaling in Tuberous Sclerosis

Mak, B. C., Kenerson, H. L., Aicher, L. D., Barnes, E. A., & Yeung, R. S. W. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62958-6 · Cited by 102 · see citing works

Wnt signal transduction pathways

Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works

Signalling to translation: How signal transduction pathways control the protein synthetic machinery

Proud, C. G. (2007) · Biochemical Journal · doi:10.1042/bj20070024 · Cited by 520 · see citing works

mTOR signaling and its roles in normal and abnormal brain development

Takei, N., & Nawa, H. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00028 · Cited by 317 · see citing works

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

Ma, T., Hoeffer, C. A., Capetillo-Zarate, E., Yu, F., Wong, H., Lin, M. T., Tampellini, D., Klann, E., Blitzer, R. D., & Gouras, G. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012845 · Cited by 262 · see citing works

Wnt signalling and the control of cellular metabolism

Sethi, J. K., & Vidal‐Puig, A. (2010) · Biochemical Journal · doi:10.1042/bj20091866 · Cited by 246 · see citing works

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

Behrooz, A. B., Talaie, Z., Jusheghani, F., Łoś, M., Klonisch, T. C., & Ghavami, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031353 · Cited by 246 · see citing works

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

Buller, C. L., Loberg, R. D., Fan, M., Zhu, Q., Park, J. L., Vesely, E. D., Inoki, K., Guan, K., & Brosius, F. C. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00554.2007 · Cited by 238 · see citing works

Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin

Jin, T., Fantus, I. G., & Sun, J. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.04.014 · Cited by 215 · see citing works

The mTOR pathway and its role in human genetic diseases

ROSNER, M., Hanneder, M., Siegel, N., Valli, A., Fuchs, C., & HENGSTSCHLAGER, M. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.001 · Cited by 182 · see citing works

Protein kinase B: signalling roles and therapeutic targeting

Sale, E. M., & Sale, G. J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7274-9 · Cited by 144 · see citing works

Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon

Kipp, A. P., Banning, A., van Schothorst, E. M., Méplan, C., Schomburg, L., Evelo, C. T., Coort, S. L., Gaj, S., Keijer, J., Hesketh, J. E., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900105 · Cited by 117 · see citing works

PI3K/mTORC1 activation in hamartoma syndromes: Therapeutic prospects

Krymskaya, V. P., & Goncharova, E. A. (2009) · Cell Cycle · doi:10.4161/cc.8.3.7555 · Cited by 86 · see citing works

Smooth Muscle–like Cells in Pulmonary Lymphangioleiomyomatosis

Krymskaya, V. P. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200705-061vs · Cited by 68 · see citing works

Molecular targets of metformin antitumor action

Sośnicki, S., Kapral, M., & Węglarz, L. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.04.021 · Cited by 56 · see citing works

The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001

de Angel, R. E., Conti, C. J., Wheatley, K. E., Brenner, A. J., Otto, G. M., deGraffenried, L. A., & Hursting, S. D. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21878 · Cited by 53 · see citing works

Pulmonary lymphangioleiomyomatosis (LAM): Progress and current challenges

Goncharova, E. A., & Krymskaya, V. P. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21419 · Cited by 53 · see citing works

A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network

Nijhout, H. F., & Callier, V. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00245 · Cited by 47 · see citing works

Targeting c-Met in melanoma

Etnyre, D., Stone, A. L., Fong, J., Jacobs, R. J., Uppada, S. B., Botting, G. M., Rajanna, S., Moravec, D. N., Shambannagari, M. R., Crees, Z. D., et al. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.29451 · Cited by 46 · see citing works

Alternative Signaling Pathways as Potential Therapeutic Targets for Overcoming EGFR and c-Met Inhibitor Resistance in Non-Small Cell Lung Cancer

Fong, J., Jacobs, R. J., Moravec, D. N., Uppada, S. B., Botting, G. M., Nlend, M., & Puri, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078398 · Cited by 45 · see citing works

Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-Met Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

Botting, G. M., Rastogi, I., Chhabra, G., Nlend, M., & Puri, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136155 · Cited by 44 · see citing works

FSIP1 regulates autophagy in breast cancer

Liu, C., Sun, L., Yang, J., Liu, T., Yang, Y., Kim, S., Ou, X., Wang, Y., Sun, L., Zaidi, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809681115 · Cited by 41 · see citing works

Why diabetes patients are more prone to the development of colon cancer?

Jin, T. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.03.025 · Cited by 37 · see citing works

PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin

Lee, J., Bartholomeusz, C., Krishnamurthy, S., Liu, P., Saso, H., LaFortune, T. A., Hortobágyi, G. N., & Ueno, N. T. (2012) · Oncogenesis · doi:10.1038/oncsis.2012.22 · Cited by 33 · see citing works

Knockdown of the α5 laminin chain affects differentiation of colorectal cancer cells and their sensitivity to chemotherapy

Maltseva, D. V., Raigorodskaya, M. P., Knyazev, E. N., Zgoda, V. G., Tikhonova, O. V., Zaidi, S., Nikulin, S. V., Baranova, A. V., Turchinovich, A. A., Rodin, S., et al. (2020) · Biochimie · doi:10.1016/j.biochi.2020.04.016 · Cited by 32 · see citing works

Rosiglitazone, an Agonist of PPAR γ , Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2

Han, S., Zheng, Y., & Roman, J. (2007) · PPAR Research · doi:10.1155/2007/29632 · Cited by 25 · see citing works

Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke

Mao, Y., Kong, Q., Li, R., Zhang, X., Gui, Y., Li, Y., Li, C., Zhao, Y., Liu, L., & Ding, Z. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.03.006 · Cited by 21 · see citing works

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

Tavares, M. K., dos Reis, S., Platt, N., Heinrich, I. A., Wolin, I. A. V., Leal, R. B., Kaster, M. P., Rodrigues, A. L. S., & Freitas, A. E. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.05.006 · Cited by 21 · see citing works

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2

Riva, B., Dominici, M. D., Gnemmi, I., Mariani, S. A., Minassi, A., Minieri, V., Salomoni, P., Canonico, P. L., Genazzani, A. A., Calabretta, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13146 · Cited by 18 · see citing works

Exploring cell death pathways in oral cancer: mechanisms, therapeutic strategies, and future perspectives

Zhao, C. (2025) · Discover Oncology · doi:10.1007/s12672-025-02022-3 · Cited by 17 · see citing works

Synthetic mRNAs; Their Analogue Caps and Contribution to Disease

Kyriakopoulos, A. M., & McCullough, P. A. (2021) · Diseases · doi:10.3390/diseases9030057 · Cited by 15 · see citing works

A Role of the Mammalian Target of Rapamycin (mTOR) in Glutamate-Induced Down-regulation of Tuberous Sclerosis Complex Proteins 2 (TSC2)

Ru, W., Peng, Y., Zhong, L., & Tang, S. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9753-1 · Cited by 13 · see citing works

Developmental Manganese Exposure Causes Lasting Attention Deficits Accompanied by Dysregulation of mTOR Signaling and Catecholaminergic Gene Expression in Brain Prefrontal CortexPreprint

Santiago, N. A., He, B., Howard, S. L., Beaudin, S. A., Strupp, B. J., & Smith, D. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.16.549215 · Cited by 13 · see citing works

Conversion of dendritic cells into tolerogenic or inflammatory cells depends on the activation threshold and kinetics of the mTOR signaling pathway

Wixler, V., Boergeling, Y., Dantas, R. L., Varga, G., & Ludwig, S. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01655-1 · Cited by 10 · see citing works

Dysregulation of Neuronal Protein Synthesis in Alzheimer’s Disease

Ma, T. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.18 · Cited by 5 · see citing works

Metabolic programming in tooth development: a regulatory network from energy substrates to signaling instructions

Cao, X., Gao, Y., Liu, W., & Sun, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1779410 · Cited by 3 · see citing works

Effects of gestational protein restriction on autophagy dynamics during odontogenesis

Calsa, B., Gontijo, J. A. R., Santamaria, M., & Boer, P. A. (2026) · Cell and Tissue Research · doi:10.1007/s00441-026-04079-0 · Cited by 2 · see citing works

Proteomic Analysis of Wnt-Dependent Dishevelled-Based Supermolecular Complexes

Yokoyama, N. N. (2012) · InTech eBooks · doi:10.5772/30271 · Cited by 2 · see citing works

Deciphering Concurrent Tuberous Sclerosis Complex and Bipolar Disorder with a Genetic Approach

Frolov, A., Vanka, D., Roumany, H., Guzman, M. A., & Martin, J. R. (2026) · Open Journal of Pathology · doi:10.4236/ojpathology.2026.162015 · Cited by 1 · see citing works

mTORC1: A Signaling Integration Node Involved in Cell Growth

Kubica, N., & Blenis, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-271-1_1 · Cited by 1 · see citing works

Impact of obesity on MMTV-Wnt-1 mammary cancer : role of the insulin-like growth factor-1 (IGF-1)/Akt/mTOR pathway

Angel, D., & Elena, R. (2010)

mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesisPreprint

Kikani, C. K., Wu, X., Fogarty, S., Kang, S. A. W., Dephoure, N., Gygi, S. P., Sabatini, D. M., & Rutter, J. P. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/232173

Additional file 1 of Conversion of dendritic cells into tolerogenic or inflammatory cells depends on the activation threshold and kinetics of the mTOR signaling pathway

Wixler, V., Boergeling, Y., Leite Dantas, R., Varga, G., & Ludwig, S. (2024) · Figshare · doi:10.6084/m9.figshare.25876166

IN VIVO HEMATOPOIETIC CELL ENGRAFTMENT IS MODULATED BY DPPIV/CD26 INHIBITION AND RHEB2 OVEREXPRESSION

Campbell, T. (2009) · doi:10.7912/c2/1687

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.055 · Cited by 1,377 · see citing works

TSC2: filling the GAP in the mTOR signaling pathway

Li, Y. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.11.007 · Cited by 418 · see citing works

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

Huang, J., Dibble, C. C., Matsuzaki, M., & Manning, B. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00289-08 · Cited by 504 · see citing works

Novel roles for the tumor suppressor APC through regulation of GSK-3

Valvezan, A. J. (2013) · ScholarlyCommons (University of Pennsylvania)

Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors

Huang, J., Wu, S., Wu, C., & Manning, B. D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0975 · Cited by 123 · see citing works